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Claudia Langenberg Appointed as the Director of the new Precision Healthcare University Research Institute

Queen Mary welcomes Professor Claudia Langenberg as the Director of the newly established Precision Healthcare University Research Institute (PHURI).

Professor Claudia Langenberg, Director of the Precision Healthcare University Research Institute

PHURI is the second University Research Institute at Queen Mary, joining the Digital Environment Research Institute (DERI) which official launched earlier this year.

The new cross-faculty institute builds on the powerful partnership between Queen Mary and Barts NHS Trust. It will continue the organisations’ shared focus on accelerating the latest healthcare innovations from bench to bedside to deliver better health for all.

PHURI will drive research to better understand how disease impacts different patient groups and work in close partnership with the Trust to use real-world clinical data to drive the development and targeted prescription of treatments based on patients’ needs. This will help to build a stronger health service for the people of East London, the UK and the world.

PHURI will be co-located with DERI in Empire House on the Whitechapel Campus until their dedicated building is finalised.

Professor Langenberg joins Queen Mary from Berlin Institute of Health at Charité (BIH) where she was a Professor of Computational Medicine, and the University of Cambridge where she was the Medical Research Council (MRC) Investigator and Programme Leader at the MRC Epidemiology Unit. Professor Langenberg is also a public health clinician by training, and her research is focused on the genetic basis of metabolic control.

Professor Langenberg, Director of the Precision Health University Research Institute, said of her appointment:  “Every patient deserves a precise diagnosis that enables targeted therapy and an informed answer to the simple question ‘how serious is my problem, doctor?’. Currently, this isn’t the case for many patients.

"We know that population groups in East London are underrepresented in research, and we want to change this. The creation of the PHURI allows us to focus on research that matters to our local population, treat patients according to their specific diagnosis, and generate knowledge that helps to achieve precision health care and better health for all. ‘From Whitechapel to the world’ is a phrase that immediately inspired me to take on this exciting opportunity.”

Professor Andrew Livingston, Vice-Principal for Research and Innovation, said:  “We are thrilled Claudia is joining Queen Mary as Director of PHURI. She brings exceptional leadership experience and research expertise, all rooted in a passion for delivering better healthcare for patients, locally, nationally and internationally. I am very much looking forward to working with her in her new role.”

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Institute for Precision Health

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The concept of Precision Health, delivering the right intervention to the right individual at the right time, underpins our inclusive, inspiring and impactful research and delivery strategy. This will enable earlier and more accurate diagnoses, more effective and kinder treatments, and will harness the creativity and collective expertise of our world-leading clinical research teams.   

Working closely with the University of Leicester’s Biomedical Research Centre, we strive to enhance our portfolios in clinical and fundamental science, diagnostic expertise, data science and artificial intelligence, advancing research across priority areas including cancer, cardiovascular and respiratory disorders, diabetes, ethnic health, and infectious diseases.  

The University of Leicester was ranked second in the UK for our Clinical Medicine research in the Research Excellence Framework 2021 (REF2021 analysis by Times Higher Education). 

What does Precision Health involve?

Precision health incorporates targeted strategies aimed at all stages of the patient pathway, from risk stratification and preventive interventions in healthy populations, through to delivery of targeted therapies in a clinical trial setting. 

How we deliver Precision Health 

The Institute for Precision Health is harnessing the power of health data informatics, discovering, developing and testing new diagnostics, and forwarding novel medicines and technologies to the clinic in order to improve healthcare provision, patient treatment and clinical outcomes.

We focus on our areas of excellence in Cancer, Respiratory, Cardiovascular, Infectious diseases, Diabetes and Lifestyle research in our diverse local population. We invest in inter-disciplinary research and platform technologies that include; clinical imaging, liquid biopsy, drug and diagnostics discovery, genomics and next generation sequencing, proteomics, metabolomics, phenomics, data analytics, health and biomedical informatics and environmental impact on disease.

Learn more about what Precision Health involves (Powerpoint, 55.2kb)

UCI announces launch of Institute for Precision Health

Individually tailored wellness approach is giant leap in patient control, improved outcomes

Tom Andriola and Leslie Thompson

Irvine, Calif., Feb. 15, 2022 — The University of California, Irvine today announced the launch of the Institute for Precision Health, an endeavor that marries UCI’s powerhouse health sciences, engineering, machine learning, artificial intelligence, clinical genomics and data science capabilities to deliver the most effective health and wellness strategy for each individual person and, in doing so, confronts the linked challenges of health equity and the high cost of care.

The institute will bring a multifaceted, integrated approach to what many call the next great advancement in healthcare. Precision medicine collects patient data – history, exams, demographics, molecular and diagnostic tests – and uses the power of computer algorithms, predictive modeling and AI to develop personalized treatment and lifelong health maintenance plans.

“What we’re doing at the Institute for Precision Health is perhaps the most important step we’ll take in this generation to improve health and well-being,” said Steve A.N. Goldstein, M.D., Ph.D., FAAP, UCI’s vice chancellor for health affairs. “The ever-evolving capabilities of the IPH herald a future of personally tailored care that fundamentally alters the healthcare landscape to place the patient at the center and in control.

“In the past, individuals were treated based on approaches thought to be best for groups of patients. Now we begin the IPH epoch of patient-centric care designed to continuously improve the health of the individual within their community, even as new knowledge accrues, whereby rights, incentives, transparency and control remain the purview of the patient,” Goldstein added.

IPH is an ecosystem for collaboration across disciplines that comprises seven areas:

  • SMART (statistics, machine learning, artificial intelligence) develops novel statistical methodology to integrate and analyze health records, molecular data and observational clinical outcomes. The unit is led by Daniel Gillen, professor and chair of statistics, and Zhaoxia Yu, associate professor of statistics.
  • A2IR (applied artificial intelligence research) translates machine learning methods into deployable solutions addressing clinical problems and matching the cost of care to its value. This unit is led by Peter Chang, assistant professor-in-residence of radiological sciences.
  • A3 (advanced analytics and artificial intelligence) brings novel solutions to improve health and wellbeing to ambulatory and impatient settings. The unit is led by Daniel Chow, assistant professor-in-residence of radiological sciences.
  • Precision omics generates and translates genomic, proteomic and metabolomic research results into clinical applications. This unit is led by Suzanne Sandmeyer, professor in biological chemistry and director of the genomics high-throughput facility, and Leslie Thompson, Donald Bren professor and Chancellor’s Professor in psychiatry & human behavior and neurobiology & behavior.
  • Collaboratory for health and wellness (powered by Syntropy) provides the ecosystem that fosters collaboration across disciplines through the integration of health-related data sources. The unit is led by Kai Zheng, chief research information officer of Health Affairs, and Tom Andriola, vice chancellor for information technology and data.
  • Deployable equity  engages community stakeholders and health-equity groups to create solutions that narrow the disparities gap in the health and wellbeing of underserved and at-risk populations. The unit is led by Dan Cooper, professor of pediatrics and director of the UCI Institute for Clinical and Translational Science, and Bernadette Boden-Albala, professor and director of the Program of Public Health and founding dean of the planned School of Population & Public Health.
  • Education and training , with leadership from each of the above areas, brings courses, seminars, certificates and degrees in statistics, machine learning-artificial intelligence, omics, and bioinformatics to practitioners and students.

UCI_PH_Infographic_v5-2

Because the disciplines included in IPH already existed at UCI, Goldstein noted, it was in many ways only a small step to join them together and build a resource across campus. The synergy created, however, is no small matter. “This is the giant leap for healthcare. It’s glaringly clear that precision health is how to increase the quality of care, to decrease the cost of care – by both improving how it’s delivered and matching cost to value – and to deliver quality healthcare to the underserved,” he said, adding that the institute’s success will be measured by improvements in individual and community health.

A major goal is revealing new approaches to tackle ailments that lack successful therapies. “For many diseases – especially neurodegenerative ones like Alzheimer’s, Parkinson’s and even Huntington’s, where the causal gene is known – there are simply no treatments available that change their course. We’re excited because we know that with precision health, we have the potential to define diseases better, understand them better and treat them far better,” said Thompson, IPH co-director. “We expect major breakthroughs.”

While the vision idea for IPH has long been in the works, the COVID-19 pandemic was a beta test demonstrating how rapidly critical medical needs could be addressed. In early 2020, with elements of IPH in place, UCI clinicians, biomedical and computer scientists, and public health experts joined forces to create an AI-driven tool to assess the critical care needs of COVID patients. This app-based tool, the COVID Vulnerability Index, demonstrated that a data-driven approach coupled with world-class clinical therapeutics could help yield the best outcomes for individuals.

“We couldn’t have had a ‘proof of concept’ with higher stakes than the pandemic,” said Tom Andriola, IPH co-director. “We saw in real time how mobilizing our capabilities to analyze health data and make customized decisions could complement leading-edge clinical treatments to save lives and reduce hospital stays.”

“Additionally, there is an explosion of data in healthcare, and we’re still only using a small fraction in decision-making,” he added. “IPH is including not only data from traditional healthcare settings but also the data coming from a new generation of empowered health consumers who are tracking and managing their own health journey.”

The plan is for IPH to have a brick-and-mortar home on the UCI campus that will serve as a hub for educating data-informed clinicians to practice at the top of their licenses, a site for the infrastructure to facilitate translational research, a place for community outreach and a venue for commercial collaborations. Already, industry leaders such as Syntropy and MITRE and community partners such as Children’s Health of Orange County and the VA Long Beach Healthcare System are working with IPH to leverage UCI’s capabilities and commitment as a fair broker for health data, placing individuals first.

“For patients, the message is that UCI’s Institute for Precision Health is the future of your care and well-being,” Goldstein said. “For the research community, IPH is a wide-open opportunity for discoveries that matter. For the business community, IPH is ready to partner to advance new, cost-effective care. And for the philanthropic community – the folks who are determined to change the world – this is it. This is your chance.”

About UCI’s Brilliant Future campaign:  Publicly launched on Oct. 4, 2019, the Brilliant Future campaign aims to raise awareness and support for UCI. By engaging 75,000 alumni and garnering $2 billion in philanthropic investment, UCI seeks to reach new heights of excellence in student success, health and wellness, research and more. Learn more by visiting  brilliantfuture.uci.edu .

Media:  Please see the accompanying infographic detailing IPH’s structure. Additional resources for journalists may be found at  communications.uci.edu/for-journalists . Radio programs/stations may, for a fee, use an on-campus ISDN line to interview UCI faculty and experts, subject to availability and university approval. For more UCI news, visit  news.uci.edu .

About the University of California, Irvine: Founded in 1965, UCI is the youngest member of the prestigious Association of American Universities and is ranked among the nation’s top 10 public universities by U.S. News & World Report . The campus has produced five Nobel laureates and is known for its academic achievement, premier research, innovation and anteater mascot. Led by Chancellor Howard Gillman, UCI has more than 36,000 students and offers 224 degree programs. It’s located in one of the world’s safest and most economically vibrant communities and is Orange County’s largest employer, contributing $7 billion annually to the local economy and $8 billion statewide. For more on UCI, visit www.uci.edu .

About UCI Health Affairs:  Founded in 2017 with a $200 million gift from Orange County philanthropists Susan and Henry Samueli, UCI Health Affairs is a first-of-its-kind health science enterprise and is unique to Orange County, California. Together, the  Susan & Henry Samueli College of Health Sciences , UCI Health,  and   health-focused centers and institutes   form  UCI Health Affairs , led by Vice Chancellor Steve A.N. Goldstein, M.D., Ph.D., FAAP. Health Affairs has a tripartite mission to “discover, teach, heal” in the service of creating the diverse healthcare workforce of the future and driving scientific discoveries to advance wellness, precision care and health equity. The college comprises the School of Medicine, the Sue & Bill Gross School of Nursing, the recently launched School of Pharmacy & Pharmaceutical Sciences, the planned School of Population & Public Health and the Susan Samueli Integrative Health Institute. The research centers and institutes are focused on cancer, clinical translational science, precision health informatics, clinical trials and stem cells.  UCI Health  is the only academic health system in Orange County, the sixth-largest county in the nation. UCI Health Affairs is transforming education, discovery and patient care to benefit the region, state and nation. For more, visit https://www.cohs.uci.edu/about/index.php .

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Institute for Population and Precision Health

University of Chicago Masters of Science in Precision Health

One of the first programs of its kind, the UChicago Masters of Science in Precision Health (MSPH) applies precision medicine technologies and methodologies to a broader population health context. The program’s core curriculum focuses on epidemiology, data science/AI, biostatistics, population health, bioinformatics, and equity and inclusion. Courses are primarily taught by renowned faculty in the University’s Institute for Population and Precision Health. In addition to the core curriculum, students are encouraged to choose one of the program’s three concentrations: data science, clinical research, or entrepreneurship in medicine. The MSPH can be completed in one academic year, culminating in a summer capstone project.

The MSPH prepares graduates for careers in clinical and academic research, pharmaceutical research and development, and medical start-ups, among other fields. MSPH graduates may also be well-positioned to move on to a doctoral program or medical school.

To learn more about the MSPH or to apply for the program visit: https://precisionhealth.bsd.uchicago.edu/

precision health university research institute (puri)

Institute for Population and Precision Health Laboratory (IPPH)

Welcome to the institute for population and precision health laboratory, driving advancements in precision health.

The Institute for Population and Precision Health (IPPH) at the University of Chicago is dedicated to supporting equitable health around the world through research in preventive and population health. The IPPH laboratory is a state-of-the-art facility designed for cutting-edge molecular genomics analyses. Access to the lab’s equipment, bio-bank, and staff supports researchers in the ongoing search for discoveries related to the early diagnosis of disease and personalized treatments.

CAPABILITIES

Our expert research team performs a range of studies related to molecular genomics and proteomics. With an extensive, high-quality, bio-bank of research specimens and up-to-date technology and equipment, our lab is well-suited for large-scale population health…

PRECISION MEDICINE AND BIOMARKER STUDIES

The lab research group leverages molecular genomic analyses to shed light on biomarkers for potential therapeutic targets, which can have significant implications for individualized and precision medicine in many disciplines…

IPPH ACCELERATOR

To improve competitive advantage and capital efficiency our IPPH Accelerator provides a new pathway to integrate excellent industry and academic resources that will innovate biomedical discovery, its clinical development, and translation into treatments for people worldwide…

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The BIPH’s research is organized around five main themes: molecular mining, molecular recognition, microbiome and human health, micro- and nanoscale biomedical instrumentation, and point-of-use platforms. Each theme fosters cross-cutting exploration and integration across multiple disease areas and health challenges.

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Molecular Mining

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U-M launches new Precision Health research initiative

Researchers across campus will combine biomedical expertise with big data and social science approaches to tailor health solutions for the population.

The University of Michigan has launched a new initiative to harness campus-wide research aimed at finding personalized solutions to improve the health and wellness of individuals and communities.

Precision Health at the University of Michigan will bring together researchers from across the university to facilitate this new and exciting type of research.

University of Michigan President Mark Schlissel announced the new initiative today during his annual Leadership Breakfast, when he outlines plans for the coming years.

“The University of Michigan is perfectly positioned to be a global leader in precision health because of our spectacular breadth and collaborative ethos. We have faculty excellence across all the related disciplines, and schools, colleges, institutes and departments that are already leading the way in discovery and education related to society’s biggest problems,” Schlissel says.

Precision health brings together genomics with other big data. It involves taking millions of data points to understand what factors influence an individual’s health and wellness. Researchers then apply that knowledge to make specific, personalized recommendations for prevention, diagnosis and treatment.

Beyond a traditional approach

Precision Health at the University of Michigan is about more than traditional personalized medicine. It takes a baseline of genomic and medical factors and incorporates data from sensors and wearables and weaves in social and environmental factors as well as behavior and lifestyle strategies.

There will be three complementary components to Precision Health at U-M:

  • Discovery : Facilitate basic science breakthroughs in biology, genetics, engineering, machine learning, and social sciences to impact healthcare.
  • Treatment : Translate research into treatment and prevention strategies to test them in the real world.
  • Implementation : Share validated treatments and prevention tools to the communities U-M serves across the state and world. 

A large amount of precision-related research is already occurring throughout the university, including expertise in precision health for cancer, mental health and metabolic disease, among other areas.

Opioid crisis to be initial project

Precision Health will focus on building capabilities, including data sets, tools and resources that researchers can use to facilitate collaborative work.

The initial Precision Health project will focus on opioid prescribing to manage pain from surgery. Research shows that about 6 percent of patients who have not previously taken opioids find themselves dependent on these drugs long after they have recovered from surgery. Further, about 70 percent of opioids prescribed after surgery are unused, leaving a large pool of pills vulnerable to diversion.

Through Precision Health, researchers will identify risk factors that might increase the likelihood of someone becoming a chronic opioid user – based on each patient’s health, genetics, social, environmental and lifestyle factors. From there, they can create guidelines to tailor pain management plans and reduce opioid prescriptions.

Fostering a culture of collaboration

U-M’s unique breadth of world-class programs along with a culture of collaboration – including among disciplines that don’t traditionally work together – will allow the initiative to cover the spectrum of precision health from discovery to implementation to improving the health of the community and the world. For example, social work researchers can explore the social implications of precision health approaches while law school faculty examine privacy issues.

Initial support for the initiative will come from the university’s Office of the Provost, Medical School, School of Public Health and College of Engineering. Many more of the university’s 19 schools and colleges, plus world-class programs such as the Institute for Social Research and Institute for Healthcare Policy and Innovation, also will be involved.

Sachin Kheterpal

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U-M launches new Precision Health research initiative

Researchers across campus will combine biomedical expertise with big data and social science approaches to tailor health solutions for the population

ANN ARBOR—The University of Michigan has launched a new initiative to harness campuswide research aimed at finding personalized solutions to improve the health and wellness of individuals and communities.

Precision Health at the University of Michigan will bring together researchers from across the university to facilitate this new and exciting type of research.

U-M President Mark Schlissel announced the new initiative today during his annual Leadership Breakfast, when he outlines plans for the coming years.

“The University of Michigan is perfectly positioned to be a global leader in precision health because of our spectacular breadth and collaborative ethos,” he said. “We have faculty excellence across all the related disciplines, and schools, colleges, institutes and departments that are already leading the way in discovery and education related to society’s biggest problems.”

Precision health brings together genomics with other big data. It involves taking millions of data points to understand what factors influence an individual’s health and wellness. Researchers then apply that knowledge to make specific, personalized recommendations for prevention, diagnosis and treatment.

Beyond a traditional approach Precision Health at the University of Michigan is about more than traditional personalized medicine. It takes a baseline of genomic and medical factors and incorporates data from sensors and wearables and weaves in social and environmental factors as well as behavior and lifestyle strategies.

There will be three complementary components to Precision Health at U-M:

  • Discovery: Facilitate basic science breakthroughs in biology, genetics, engineering, machine learning, and social sciences to impact health care
  • Treatment: Translate research into treatment and prevention strategies to test them in the real world
  • Implementation: Share validated treatments and prevention tools to the communities U-M serves across the state and world

A large amount of precision-related research is already occurring throughout the university, including expertise in precision health for cancer, mental health and metabolic disease, among other areas.

Opioid crisis to be initial project Precision Health will focus on building capabilities, including data sets, tools and resources that researchers can use to facilitate collaborative work.

The initial Precision Health project will focus on opioid prescribing to manage pain from surgery. Research shows that about 6 percent of patients who have not previously taken opioids find themselves dependent on these drugs long after they have recovered from surgery. Further, about 70 percent of opioids prescribed after surgery are unused, leaving a large pool of pills vulnerable to diversion.

Through Precision Health, researchers will identify risk factors that might increase the likelihood of someone becoming a chronic opioid user—based on each patient’s health, genetics, social, environmental and lifestyle factors. From there, they can create guidelines to tailor pain management plans and reduce opioid prescriptions.

Fostering a culture of collaboration U-M’sbreadth of world-class programs along with a culture of collaboration—including among disciplines that don’t traditionally work together—will allow the initiative to cover the spectrum of precision health from discovery to implementation to improving the health of the community and the world. For example, social work researchers can explore the social implications of precision health approaches while law school faculty examine privacy issues.

The initiative will be led by three co-directors:

  • Goncalo Abecasis , the Felix E. Moore Collegiate Professor of Biostatistics at the U-M School of Public Health. Abecasis’ research focuses on the development of statistical tools for the identification and study of genetic variants important in human disease.
  • Sachin Kheterpal , associate professor of anesthesiology and associate dean for research information technology at the U-M Medical School. Kheterpal’s career has been focused on the novel use of IT and electronic health records for patient care, quality improvement and research.
  • Eric Michielssen , the Louise Ganiard Johnson Professor of Engineering at the U-M College of Engineering and associate vice president for advanced research computing for the U-M Office of Research. Michielssen, a computational scientist by training, coordinates research initiatives and educational programs in computational and data science across U-M’s 19 schools and colleges.

Initial support for the initiative will come from the university’s Office of the Provost, Medical School, School of Public Health and College of Engineering. Many more of the university’s 19 schools and colleges, plus world-class programs such as the Institute for Social Research and Institute for Healthcare Policy and Innovation, also will be involved.

More information:

  • Precision Health

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Institute for Precision Health Pilot Study Awards

We are pleased to announce a call for pilot project proposals by the Institute for Precision Health (IPH) in partnership with the School of Medicine, UCI Health, and the UCI Office of Research. One-year awards in the amount of up to $75,000 will be conferred in this round.  The target start date for awards will be March 1, 2024.

The Institute for Precision Health (IPH) at UCI was initiated in 2021 to position UCI as a leading center of informatics and data science expertise to advance personalized health through discovery, implementation, and outreach. A goal of IPH is to foster synergies that occur from integrating research, clinical and phenotypic data to achieve major advances in patient-specific care.

The IPH Pilot Awards are designed specifically to support multidisciplinary research projects. The ideal project will leverage the resources of IPH and include partnerships of health scientists, translational researchers, and computational scientists across UCI. Projects should address clinical and research needs using data, machine learning, artificial intelligence, and/or statistics. Projects using Real-World Data and Evidence will be viewed favorably.  Real-world data  are data relating to patient health status and/or the delivery of health care routinely collected from a variety of sources. Examples of RWD include data derived from electronic health records, medical claims data, data from product or disease registries, and data gathered from other sources (such as digital health technologies) that can inform on health status. 

Real-world evidence  is the clinical evidence about the usage and potential benefits or risks of a medical product derived from analysis of RWD.

Proposed precision health research projects should be multi-disciplinary and identify and fill knowledge and practice gaps in health data theory and analytics. We particularly encourage projects that employ novel approaches to health data to address health disparities and inequities. We will consider a wide range of projects from basic research (animal studies excluded) to quality improvement, and each of the projects should explain how the project outcomes may add immediate or long-term value for clinical outcomes. Both the creation of new data (e.g. omics) and use of existing data (e.g. health data) are allowed.  

Access to data can be obtained through IPH’s E2E unit or other relevant data infrastructure and platforms of IPH. Syntropy, a unified platform for curated health data recently implemented at UCI, may be utilized. Multidisciplinary teams must include faculty from at least two different academic units or UCI partner organizations (i.e., CHOC, VA) with a concrete plan to develop a research team, preliminary data, and a plan for a future extramural funding opportunity (or, if it is a quality improvement project, plans for revenue generation/cost reduction). 

infographic showing IPH components

The structure and focused themes of the Institute are represented in the figure above . More information about each resource will be provided during the mandatory workshop on Oct. 19.

  • S tatistics, M L, and A I R esearch T echnologies (SMART). Leverage UCI’s world class leadership in Statistics and ML/AI technology development to create methodologic solutions to the unique problems posed by the integration of EHR and observational data.
  • Applied Artificial Intelligence Research (A 2 IR). Research focused on the application and development of ML/AI-enabled solutions to specific clinical healthcare problems. Leverages Center for Artificial Intelligence in Diagnostic Medicine (CAIDM).
  • Applied Advanced analytics & Artificial Intelligence (A3 ). Operationalize, validate, and integrate developing IPH solutions driven by analytics and AI into healthcare settings, including inpatient, ambulatory, and community settings.
  • Precision Omics. Leverage emerging data-intensive omics technologies at the Genomics High Throughput Facility to provide for expanded omics and bioinformatics research development, as well as expanded systems administration for genomic data sharing and analysis.
  • E2E (End-to-End). Sitting at the intersection of clinical decisions, healthcare operations, and health data research, E2E supports the enterprise by providing access to critical health data assets.   The core mission of E2E is to provide the infrastructure and architecture to provision and manage health data assets as well as partner with clinicians, researchers, operational leaders, and external partners to drive the next generation of analytics insights. This unit can utilize the Syntropy platform.
  • UCI Collaboratory for Health & Wellness. A data and analytics platform that is designed to create an ecosystem around data common research area to support rich human interaction, foster collaboration, and provide access to dynamic data sources, artifacts, and tools required to accomplish advanced analytical tasks. This activity is powered by Syntropy.
  • Health Equity. Brings ML/AI into communities to create solutions to narrow disparities gap in the health and wellbeing of vulnerable populations.

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U-M launches new Precision Health research initiative

Researchers combine biomedical expertise, big data, social science for tailored health solutions.

By Nicole Fawcett Precision Health Communications

  • Campus News

The university has launched a new initiative to harness campuswide research aimed at finding personalized solutions to improve the health and wellness of individuals and communities.

Precision Health at the University of Michigan will bring together researchers from across the university to facilitate this new and exciting type of research.

more information

Precision Health at the University of Michigan

President Mark Schlissel announced the new initiative Tuesday during his annual Leadership Breakfast, when he outlines plans for the coming years.

“U-M is perfectly positioned to be a global leader in this area because of our spectacular breadth and our collaborative ethos,” Schlissel said.

“We have faculty excellence across all of the related disciplines, and schools, colleges, institutes and departments that are already leading the way in discovery and education related to society’s biggest problems.”

Precision health brings together genomics with other big data. It involves taking millions of data points to understand what factors influence an individual’s health and wellness. Researchers then apply that knowledge to make specific, personalized recommendations for prevention, diagnosis and treatment.

Beyond a traditional approach

Precision Health at U-M is about more than traditional personalized medicine. It takes a baseline of genomic and medical factors and incorporates data from sensors and wearables, and weaves in social and environmental factors as well as behavior and lifestyle strategies.

There will be three complementary components to Precision Health at U-M:

• Discovery: Facilitate basic science breakthroughs in biology, genetics, engineering, machine learning, and social sciences to impact health care.

• Treatment: Translate research into treatment and prevention strategies to test them in the real world.

• Implementation: Share validated treatments and prevention tools to the communities U-M serves across the state and world.

A large amount of precision-related research already is occurring throughout the university, including expertise in precision health for cancer, mental health and metabolic disease, among other areas.

Opioid crisis to be initial project

Precision Health at U-M will focus on building capabilities, including data sets, tools and resources that researchers can use to facilitate collaborative work.

The initiative’s first project will focus on opioid prescribing to manage pain from surgery. Research shows that about 6 percent of patients who have not previously taken opioids find themselves dependent on these drugs long after they have recovered from surgery. Further, about 70 percent of opioids prescribed after surgery are unused, leaving a large pool of pills vulnerable to diversion.

Through Precision Health, researchers will identify risk factors that might increase the likelihood of someone becoming a chronic opioid user — based on each patient’s health, genetics, social, environmental and lifestyle factors. From there, they can create guidelines to tailor pain management plans and reduce opioid prescriptions.

Fostering a culture of collaboration

U-M’s unique breadth of world-class programs along with a culture of collaboration — including among disciplines that don’t traditionally work together — will allow the initiative to cover the spectrum of precision health from discovery to implementation to improving the health of the community and the world.

For example, School of Social Work researchers can explore the social implications of precision health approaches while Law School faculty examine privacy issues.

precision health university research institute (puri)

Sachin Kheterpal

precision health university research institute (puri)

The initiative will be led by three co-directors:

• Gonçalo Abecasis, Felix E. Moore Collegiate Professor of Biostatistics, School of Public Health. Abecasis’ research focuses on the development of statistical tools for the identification and study of genetic variants important in human disease.

• Sachin Kheterpal, associate professor of anesthesiology and associate dean for research information technology, Medical School. Kheterpal’s career has been focused on the novel use of information technology and electronic health records for patient care, quality improvement and research.

• Eric Michielssen, Louise Ganiard Johnson Professor of Engineering, College of Engineering; and associate vice president for advanced research computing, Office of Research. Michielssen, a computational scientist by training, coordinates research initiatives and educational programs in computational and data science across U-M’s 19 schools and colleges.

Initial support for the initiative will come from the Office of the Provost, Medical School, School of Public Health and College of Engineering. Many more of the university’s 19 schools and colleges, plus world-class programs such as the Institute for Social Research and Institute for Healthcare Policy and Innovation, also will be involved.

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David Erdody

See: https://genesforgood.sph.umich.edu/

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  18. Life Sciences Institute

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    U-M launches new Precision Health research initiative Share This Page. image/svg+xml image/svg+xml image/svg+xml image/svg+xml. Researchers across campus will combine biomedical expertise with big data and social science approaches to tailor health solutions for the population ...

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