A Comprehensive Literature Review on Transportation Problems

  • Review Article
  • Published: 24 September 2021
  • Volume 7 , article number  206 , ( 2021 )

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transportation management research paper topics

  • Yadvendra Kacher 1 &
  • Pitam Singh 1  

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A systematic and organized overview of various existing transportation problems and their extensions developed by different researchers is offered in the review article. The article has gone through different research papers and books available in Google scholar, Sciencedirect, Z-library Asia, Springer.com, Research-gate, shodhganga, and many other E-learning platforms. The main purpose of the review paper is to recapitulate the existing form of various types of transportation problems and their systematic developments for the guidance of future researchers to help them classify the varieties of problems to be solved and select the criteria to be optimized.

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transportation management research paper topics

Preface: operations research for transportation

transportation management research paper topics

On Optimization Problems in Urban Transport

transportation management research paper topics

Computational Intelligence and Optimization for Transportation Big Data: Challenges and Opportunities

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Acknowledgements

First author (Yadvendra Kacher) acknowledges the financial support as Junior research fellowship (JRF) received from CSIR (Govt. of India) through HRDG(CSIR) senction Letter No./File No.: 09/1032(0019)/2019-EMR-I.

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Kacher, Y., Singh, P. A Comprehensive Literature Review on Transportation Problems. Int. J. Appl. Comput. Math 7 , 206 (2021). https://doi.org/10.1007/s40819-021-01134-y

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Aggregate Planning B2B B2E Management Barriers to Entry Best Practices Brainstorming Business Plan Capacity Planning Content Management System Decision Rules and Decision Analysis Decision Support Systems Diversification Strategy Divestment Downsizing and Rightsizing Economies of Scale and Economies of Scope Environmentalism and Sustainability Exit Strategy Exporting and Importing Franchising Free Trade Agreements and Trading Blocs Futuring Gap Analysis Generic Competitive Strategies Globalization Goals and Goal Setting Group Decision Making Knowledge-Based View of the Firm Location Strategy Long Tail Macroenvironmental Forces Make-or-Buy Decisions Manufacturing Resources Planning Market Share Mergers and Acquisitions Miles and Snow Typology Multiple-Criteria Decision Making New Product Development Open and Closed Systems Operations Strategy Opportunity Cost Order-Winning and Order-Qualifying Criteria Porter’s Five Forces Model Product Life Cycle and Industry Life Cycle Production Planning and Scheduling Results-Only Work Environment Strategic Integration Strategic Planning Failure Strategic Planning Tools Strategy Formulation Strategy Implementation Strategy in the Global Environment Strategy Levels SWOT Analysis Synergy Upselling Zero-Based Budgeting

EMERGING TOPICS IN MANAGEMENT

Activity-Based Costing Affirmative Action Angel Investors and Venture Capitalists Artificial Intelligence Assessment Centers B2B B2E Management Balanced Scorecard Bar Coding and Radio Frequency Identification Business Process Reengineering Cafeteria Plan—Flexible Benefits Cellular Manufacturing Chaos Theory Coalition Building Communities of Interest/Communities of Practice Complexity Theory Concurrent Engineering and Design Consulting Contingency Approach to Management Continuing Education and Lifelong Learning Trends Corporate Governance Corporate Social Responsibility Customer Relationship Management Decision Support Systems Diversity Electronic Commerce Electronic Data Interchange and Electronic Funds Transfer Empowerment Enterprise Resource Planning Entrepreneurship Environmentalism and Sustainability Ethics Expatriates Expert Systems Five S Framework Flexible Spending Accounts Futuring Handheld Computers Health Savings Accounts Human Resource Information Systems Innovation Instant Messaging Intellectual Property Rights Intrapreneurship Knowledge-Based View of the Firm Leadership in Energy and Environmental Design Metadata or Meta-Analysis Mobile Commerce Multiple-Criteria Decision Making Non-Compete Agreements Outsourcing and Offshoring Paradigm Shift Popular Press Management Books Quality of Work Life Results-Only Work Environment Robotics Social Networking Spirituality in Leadership Succession Planning Telecommunications Vendor Rating Virtual Corporations Women and Minorities in Management

ENTREPRENEURSHIP

Angel Investors and Venture Capitalists Balance Sheets Brainstorming Break-Even Point Budgeting Business Plan Business Structure Cafeteria Plan—Flexible Benefits Case Method of Analysis Cash Flow Analysis and Statements Competitive Advantage Consumer Behavior Cost Accounting Customer Relationship Management Diversification Strategy Domestic Management Societies and Associations Due Diligence Economics Economies of Scale and Economies of Scope Effectiveness and Efficiency Financial Issues for Managers Financial Ratios First-Mover Advantage Futuring Gap Analysis Generic Competitive Strategies Income Statements Initial Public Offering Innovation Intellectual Property Rights International Business International Management Societies and Associations Intrapreneurship Inventory Management Joint Ventures and Strategic Alliances Knowledge Management Knowledge Workers Leveraged Buyouts Licensing and Licensing Agreements Location Strategy Macroenvironmental Forces Make-or-Buy Decisions Market Share Marketing Concept and Philosophy Marketing Research Miles and Snow Typology Mission and Vision Statements New Product Development Non-Compete Agreements Organizational Development Outsourcing and Offshoring Patents and Trademarks Planning Poison Pill Strategies Popular Press Management Books Porter’s Five Forces Model Pricing Policy and Strategy Problem Solving Process Management Product Design Product Life Cycle and Industry Life Cycle Profit Sharing Research Methods and Processes Scenario Planning Securities and Exchange Commission Shareholders Stakeholders Strategic Planning Tools Strategy Levels Succession Planning SWOT Analysis Synergy Technology Transfer Value Creation Venture Capital Virtual Organizations

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FINANCIAL MANAGEMENT AND ACCOUNTING

Activity-Based Costing Angel Investors and Venture Capitalists Balance Sheets Balanced Scorecard Break-Even Point Budgeting Capacity Planning Cash Flow Analysis and Statements Corporate Social Responsibility Cost Accounting Cost-Volume-Profit Analysis Debt vs. Equity Financing Domestic Management Societies and Associations Due Diligence Economics Electronic Data Interchange and Electronic Funds Transfer Employee Benefits Employee Compensation Executive Compensation Exit Strategy Financial Issues for Managers Financial Ratios Flexible Spending Accounts Health Savings Accounts Income Statements Initial Public Offering Insider Trading Internal Auditing International Management Societies and Associations International Monetary Fund Inventory Types Leveraged Buyouts Licensing and Licensing Agreements Long Tail Make-or-Buy Decisions Management Control Nonprofit Organizations Opportunity Cost Patents and Trademarks Profit Sharing Purchasing and Procurement Risk Management Securities and Exchange Commission Stakeholders Succession Planning Venture Capital Zero-Based Budgeting

GENERAL MANAGEMENT TOPICS

Aggregate Planning The Art and Science of Management Autonomy B2B B2E Management Balanced Scorecard Barriers to Entry Best Practices Black Friday Brainstorming Budgeting Business Plan Business Structure Communication Competitive Advantage Competitive Intelligence Contingency Approach to Management Continuous Improvement Corporate Governance Corporate Social Responsibility Delegation Disaster Recovery Diversity Divestment Downsizing and Rightsizing Economics Effectiveness and Efficiency Electronic Commerce Empowerment Financial Issues for Managers Financial Ratios Forecasting Generic Competitive Strategies Globalization Goals and Goal Setting Human Resource Management Innovation International Management Knowledge-Based View of the Firm Knowledge Management Leadership Styles and Bases of Power Leadership Theories and Studies Line-and-Staff Organizations Logistics and Transportation Management Control Management Functions Management Information Systems Management Science Management Styles Management Thought Managing Change Mission and Vision Statements Motivation and Motivation Theory Operations Management Organization Theory Organizational Analysis and Planning Organizational Behavior Organizational Chart Organizational Culture Organizational Learning Organizational Structure Organizational Development Organizing Paradigm Shift Participative Management Patents and Trademarks Paternalism Pioneers of Management Planning Process Management Quality and Total Quality Management Request for Proposal/Quotation Social Networking Strategic Integration Strategy Formulation Strategy Implementation Strategy in the Global Environment Strategy Levels Subject Matter Expert Succession Planning Training Delivery Methods Trends in Organizational Change

HUMAN RESOURCE MANAGEMENT

Affirmative Action Artificial Intelligence Assessment Centers Autonomy Nonverbal Communication Brainstorming Cafeteria Plan—Flexible Benefits Coalition Building Communication Continuing Education and Lifelong Learning Trends Discrimination Diversity Downsizing and Rightsizing Electronic Data Interchange and Electronic Funds Transfer Employee Assistance Programs Employee Benefits Employee Compensation Employee Evaluation and Performance Appraisals Employee Handbook and Orientation Employee Recruitment Employee Screening and Selection Employment Law and Compliance Empowerment Executive Compensation Flexible Spending Accounts Group Dynamics Health Savings Accounts Human Resource Information Systems Human Resource Management Japanese Management Job Analysis Knowledge-Based View of the Firm Knowledge Workers Mentoring Morale Motivation and Motivation Theory Nepotism Non-Compete Agreements Organizational Behavior Organizational Chart Organizational Culture Performance Measurement Personality and Personality Tests Privacy, Privacy Laws, and Workplace Privacy Quality of Work Life Reinforcement Theory Results-Only Work Environment Safety in the Workplace Scalable or JIT Workforce Sensitivity Training Social Networking Stress Succession Planning Sweatshops Task Analysis Teams and Teamwork Theory X and Theory Y Theory Z Time Management Training Delivery Methods Virtual Organizations Women and Minorities in Management

INNOVATION AND TECHNOLOGY

Artificial Intelligence Bandwidth Bar Coding and Radio Frequency Identification Communication Competitive Intelligence Complexity Theory Computer Networks Computer Security Computer-Aided Design and Manufacturing Computer-Integrated Manufacturing Content Management System Data Processing and Data Management Decision Rules and Decision Analysis Decision Support Systems Delegation Electronic Commerce Electronic Data Interchange and Electronic Funds Transfer Environmentalism and Sustainability Experience and Learning Curves Expert Systems Forecasting Fuzzy Logic Handheld Computers Information Assurance Innovation The Internet Knowledge Centers Knowledge Management Knowledge Workers Leadership in Energy and Environmental Design Management Information Systems Manufacturing Control via the Internet Metadata or Meta-Analysis Mobile Commerce Nanotechnology Product Design Project Management Robotics Service-Oriented Architecture Technology Management Technology Transfer Telecommunications Virtual Corporations Virtual Organizations Web 2.0 WiMax

INTERNATIONAL AND GLOBAL MANAGEMENT

B2B Competitive Advantage Diversity European Union Expatriates Exporting and Importing First-Mover Advantage Franchising Free TradeAgreements and Trading Blocs Futuring Globalization International Business International Management International Management Societies and Associations International Monetary Fund International Organization for Standards Japanese Management Licensing and Licensing Agreements Location Strategy Macroenvironmental Forces Outsourcing and Offshoring Patents and Trademarks Popular Press Management Books Profit Sharing Strategy in the Global Environment Sweatshops Transnational Organization Value-Added Tax Vendor Rating Virtual Organizations World-Class Manufacturer

LEADERSHIP RESEARCH TOPICS

The Art and Science of Management Assessment Centers Best Practices Communication Contingency Approach to Management Corporate Governance Corporate Social Responsibility Delegation Domestic Management Societies and Associations Entrepreneurship Executive Compensation Expert Systems Goals and Goal Setting Human Resource Management International Management Societies and Associations Japanese Management Job Analysis Joint Ventures and Strategic Alliances Knowledge Management Knowledge Workers Leadership Styles and Bases of Power Leadership Theories and Studies Line-and-Staff Organizations Management and Executive Development Management Functions Management Levels Management Styles Management Thought Managing Change Mechanistic Organizations Mentoring Mission and Vision Statements Morale Motivation and Motivation Theory Open and Closed Systems Operant Conditioning Organizational Culture Paradigm Shift Participative Management Personality and Personality Tests Pioneers of Management Problem Solving Reinforcement Theory Sensitivity Training Span of Control Spirituality in Leadership Strategy Formulation Succession Planning Teams and Teamwork Theory X and Theory Y Theory Z Women and Minorities in Management

LEGAL ISSUES

Affirmative Action Cafeteria Plan—Flexible Benefits Computer Networks Computer Security Corporate Governance Corporate Social Responsibility Discrimination Diversity Downsizing and Rightsizing Due Diligence Electronic Data Interchange and Electronic Funds Transfer Employee Assistance Programs Employee Benefits Employee Compensation Employee Evaluation and Performance Appraisals Employee Recruitment Employee Screening and Selection Employment Law and Compliance Ethics Executive Compensation Human Resource Management Insider Trading Intellectual Property Rights Job Analysis Leveraged Buyouts Management Audit Management Control Mergers and Acquisitions Nepotism Non-Compete Agreements Patents and Trademarks Personality and Personality Tests Privacy, Privacy Laws, and Workplace Privacy Quality of Work Life Risk Management Safety in the Workplace Stress Succession Planning Sunshine Laws Sweatshops Technology Transfer Whistle Blower Women and Minorities in Management

MANAGEMENT INFORMATION SYSTEMS

Balanced Scorecard Bandwidth Bar Coding and Radio Frequency Identification Barriers to Entry Complexity Theory Computer Networks Computer Security Computer-Aided Design and Manufacturing Computer-Integrated Manufacturing Content Management System Data Processing and Data Management Decision Rules and Decision Analysis Decision Support Systems Distribution and Distribution Requirements Planning Electronic Commerce Electronic Data Interchange and Electronic Funds Transfer Service-Oriented Architecture Statistical Process Control and Six Sigma Systems Design, Development, and Implementation Technology Management Technology Transfer

MANAGEMENT SCIENCE AND OPERATIONS RESEARCH

Bar Coding and Radio Frequency Identification Business Process Reengineering Computer-Aided Design and Manufacturing Concurrent Engineering and Design Decision Rules and Decision Analysis Decision Support Systems Distribution and Distribution Requirements Planning Expert Systems Location Strategy Logistics and Transportation Maintenance Make-or-Buy Decisions Manufacturing Resources Planning Models and Modeling Multiple-Criteria Decision Making New Product Development Operating System Operations Management Operations Scheduling Operations Strategy Product Design Production Planning and Scheduling Productivity Concepts and Measures Product-Process Matrix Project Management Purchasing and Procurement Quality and Total Quality Management Research Methods and Processes Reverse Supply Chain Logistics Scenario Planning Service Operations Service Process Matrix Simulation Statistical Process Control and Six Sigma Statistics Subject Matter Expert Systems Analysis Systems Design, Development, and Implementation Technology Transfer Warehousing and Warehouse Management World-Class Manufacturer

PERFORMANCE MEASURES AND ASSESSMENT

Activity-Based Costing Balance Sheets Balanced Scorecard Benchmarking Best Practices Break-Even Point Budgeting Cash Flow Analysis and Statements Continuous Improvement Cost Accounting Cost-Volume-Profit Analysis Cycle Time Debt vs. Equity Financing Due Diligence Effectiveness and Efficiency Executive Compensation Financial Issues for Managers Financial Ratios Forecasting Gap Analysis Goals and Goal Setting Management Audit Management Control Management Information Systems Market Share Multiple-Criteria Decision Making Nepotism Order-Winning and Order-Qualifying Criteria Performance Measurement Pricing Policy and Strategy Profit Sharing Simulation Stakeholders Value Analysis Value Chain Management Value Creation Vendor Rating Zero-Based Budgeting Zero Sum Game

PERSONAL GROWTH AND DEVELOPMENT FOR MANAGERS

The Art and Science of Management Brainstorming Coalition Building Communication Consulting Contingency Approach to Management Continuing Education and Lifelong Learning Trends Continuous Improvement Customer Relationship Management Delegation Diversity Employee Assistance Programs Empowerment Entrepreneurship Facilitator Feedback Goals and Goal Setting Group Dynamics Intrapreneurship Knowledge Workers Leadership Styles and Bases of Power Managing Change Mentoring Morale Motivation and Motivation Theory Multimedia Organizing Participative Management Personality and Personality Tests Planning Popular Press Management Books Problem Solving Profit Sharing Safety in the Workplace Sensitivity Training Spirituality in Leadership Strategic Planning Tools Stress Succession Planning SWOT Analysis Teams and Teamwork Time Management Trends in Organizational Change Value Creation

PRODUCTION AND OPERATIONS MANAGEMENT

Activity-Based Costing Aggregate Planning Bar Coding and Radio Frequency Identification Benchmarking Break-Even Point Business Process Reengineering Cellular Manufacturing Computer-Aided Design and Manufacturing Computer-Integrated Manufacturing Concurrent Engineering and Design Continuous Improvement Cost-Volume-Profit Analysis Decision Rules and Decision Analysis Decision Support Systems Distribution and Distribution Requirements Planning Domestic Management Societies and Associations Five S Framework Flexible Manufacturing Forecasting Industrial Relations International Management Societies and Associations Inventory Management Inventory Types Japanese Management Layout Lean Manufacturing and Just-in-Time Production Location Strategy Logistics and Transportation Long Tail Maintenance Make-or-Buy Decisions Management Awards Manufacturing Control via the Internet Manufacturing Resources Planning Market Share New Product Development Operations Management Operations Scheduling Operations Strategy Order-Winning and Order-Qualifying Criteria Outsourcing and Offshoring Participative Management Poka-Yoke Popular Press Management Books Porter’s Five Forces Model Production Planning and Scheduling Productivity Concepts and Measures Product-Process Matrix Project Management Purchasing and Procurement Quality Gurus Quality and Total Quality Management Reverse Supply Chain Logistics Robotics Safety in the Workplace Scalable or JIT Workforce Service Factory Service Industry Service Operations Service Process Matrix Simulation Statistical Process Control and Six Sigma Statistics Strategic Integration Supply Chain Management Synergy Teams and Teamwork Technology Management Technology Transfer Theory of Constraints Time-Based Competition Upselling Warehousing and Warehouse Management World-Class Manufacturer

QUALITY MANAGEMENT AND TOTAL QUALITY MANAGEMENT

Communication Customer Relationship Management Domestic Management Societies and Associations Five S Framework Gap Analysis Goals and Goal Setting Innovation International Management Societies and Associations Japanese Management Management Awards Manufacturing Resources Planning Marketing Research Operations Strategy Opportunity Cost Order-Winning and Order-Qualifying Criteria Outsourcing and Offshoring Participative Management Popular Press Management Books Productivity Concepts and Measures Quality Gurus Quality and Total Quality Management Quality of Work Life Statistical Process Control and Six Sigma Strategic Planning Tools Teams and Teamwork Value Analysis Value Creation Vendor Rating World-Class Manufacturer

SUPPLY CHAIN MANAGEMENT

Activity-Based Costing Business Process Reengineering Capacity Planning Cellular Manufacturing Coalition Building Communication Competitive Advantage Competitive Intelligence Computer Networks Computer-Integrated Manufacturing Conflict Management and Negotiation Customer Relationship Management Cycle Time Decision Support Systems Distribution and Distribution Requirements Planning Economies of Scale and Economies of Scope Effectiveness and Efficiency Electronic Commerce Electronic Data Interchange and Electronic Funds Transfer Enterprise Resource Planning Expert Systems Fulfillment Group Dynamics Industrial Relations Inventory Management Inventory Types Joint Ventures and Strategic Alliances Lean Manufacturing and Just-in-Time Production Location Strategy Logistics and Transportation Long Tail Make-or-Buy Decisions Manufacturing Resources Planning Market Share Multiple-Criteria Decision Making New Product Development Operations Management Operations Scheduling Operations Strategy Organic Organizations Organizing Poka-Yoke Problem Solving Process Management Product Design Product Life Cycle and Industry Life Cycle Production Planning and Scheduling Productivity Concepts and Measures Product-Process Matrix Purchasing and Procurement Quality and Total Quality Management Reverse Auction Reverse Supply Chain Logistics Risk Management Span of Control Stakeholders Teams and Teamwork Vendor Rating Warehousing and Warehouse Management

TRAINING AND DEVELOPMENT

Artificial Intelligence Assessment Centers Autonomy Concurrent Engineering and Design Conflict Management and Negotiation Consulting Contingency Approach to Management Continuing Education and Lifelong Learning Trends Continuous Improvement Corporate Social Responsibility Delegation Domestic Management Societies and Associations Downsizing and Rightsizing Employee Evaluation and Performance Appraisals Employee Handbook and Orientation Goals and Goal Setting Group Decision Making Human Resource Management Innovation Instant Messaging International Management Societies and Associations Job Analysis Knowledge Management Knowledge Workers Management and Executive Development Management Audit Marketing Communication Mission and Vision Statements Morale Motivation and Motivation Theory Multimedia Multiple-Criteria Decision Making Organizational Culture Organizational Learning Organizing Participative Management Personality and Personality Tests Popular Press Management Books Problem Solving Project Management Safety in the Workplace Sensitivity Training Simulation Stress Succession Planning SWOT Analysis Teams and Teamwork Training Delivery Methods Virtual Organizations Women and Minorities in Management

Management has applications in a wide variety of settings and is not limited to business domains. Management tools, as well as the art and science of management, find applications wherever any effort must be planned, organized, or controlled on a significant scale. This includes applications in government, the cultural arts, sports, the military, medicine, education, scientific research, religion, not-for-profit agencies, and in the wide variety of for-profit pursuits of service and manufacturing. Management takes appropriate advantage of technical developments in all the fields it serves.

Management Research 2

The growth of the discipline of management has also led to specialization or compartmentalization of the field. These specialties of management make learning and study easier, but at the same time make broad understanding of management more difficult. It is particularly challenging to the entrepreneur and the small business owner to master the subject areas, yet this group is compelled to excel at all management functions to further their business’s success. Management specialties have grown to such an extent it is difficult for any single manager to fully know what management is all about. So rapid have been the strides in recent years in such subjects as decision making, technology, the behavioral sciences, management information systems, and the like, to say nothing of proliferating legislative and governmental regulations affecting business, that constant study and education is required of all managers just to keep current on the latest trends and techniques. Thus, managers and executives need a comprehensive management online reference source to keep up-to-date. Having the management essays and research papers in one comprehensive site saves valuable research time in locating the information.

In the growing age of specialists, there is a growing lack of generalists. Typically, a business manager spends a large percentage of their career developing a great familiarity and proficiency in a specialized field, such as sales, production, shipping, or accounting. The manager develops a very specialized knowledge in this area but may develop only a peripheral knowledge of advances in other areas of management. Yet as these individuals are promoted from a specialist-type position up the organizational chart to a more administrative or generalist supervisory or leadership position, the person with newly enlarged responsibilities suddenly finds that their horizon must extend beyond the given specialty. It must now include more than just a once-superficial understanding of all aspects of managing, including purchasing, manufacturing, advertising and selling, international management, quantitative techniques, human resources management, public relations, research and development, strategic planning, and management information systems. The need for broader management understanding and comprehension continues to increase as individuals are promoted.

This site has as its goal to bridge this gap in understanding and to offer every executive, executive-aspirant, management consultant, and educator and student of management, both comprehensive and authoritative information on all the theories, concepts, and techniques that directly impact the job of management. This reference source strives to make specialists aware of the other functional areas of the management discipline and to give the top manager or administrator who occupies the general manager position new insights into the work of the specialists whom he or she must manage or draw upon in the successful management of others. In addition, this site proposes to make all practitioners aware of the advances in management science and in the behavioral sciences. These disciplines touch upon all areas of specialization because they concern the pervasive problems of decision-making and interpersonal relations.

Every effort has been made to achieve comprehensiveness in choice and coverage of subject matter. The essays provided frequently go far beyond mere definitions and referrals to other sources. They are in-depth treatments, discussing background, subject areas, current applications, and schools of thought. In addition, information may be provided about the kinds of specialists who use the term in a given organization, the degree of current acceptance, and the possibilities for the future as the subject undergoes further development and refinement. Longer essays frequently provide charts, graphs, or examples to aid in understanding the topic.

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  • Frontiers in Drug Delivery
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Novel Advancements in Oral Administration of Insulin

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Oral administration of insulin has been a longstanding goal in the field of diabetes management. Currently, insulin is primarily delivered through subcutaneous injections, which is inconvenient and uncomfortable for patients. The development of an effective oral insulin delivery system could greatly improve patients’ compliance and quality of life. However, there are several challenges associated with oral administration of insulin that need to be addressed. One major challenge is the enzymatic degradation of insulin in the gastrointestinal (GI) tract . The proteolytic enzymes in the stomach and small intestine can break down insulin before it can be absorbed into the bloodstream, leading to poor bioavailability. The intestinal mucus also presents a significant challenge in the oral administration of insulin. Researchers are exploring innovative strategies to address this issue, including the use of permeation enhancers, mucoadhesive formulations, and targeted drug delivery techniques. Developing formulations that can bypass or disrupt the mucus layer while ensuring insulin stability and bioavailability remains a key challenge. Another challenge is the permeability of insulin across the GI epithelium. Insulin is a large molecule that cannot easily pass through the intestinal barrier. Enhancing the absorption and transport of insulin across the gut lining is crucial for its effective oral delivery. In conclusion, oral administration of insulin remains a complex and evolving field. Overcoming the challenges associated with enzymatic degradation, permeability, and variability in absorption is essential for the successful development of an effective and reliable oral insulin delivery system. Continued research and innovation in this area hold the potential to revolutionize diabetes management and improve the lives of millions of individuals worldwide. The aim of this Research Topic is to highlight recent advancements and collect new insights for constructing multifunctional drug delivery systems, achieving effective crossing of multiple gastrointestinal barriers and completing the oral delivery of insulin. We encourage submissions (original research, reviews, mini-reviews) of the following, but not limited to, topics: 1) Fabrication of smart drug delivery systems: the fabrication of nanoparticles, liposomes, micelles, and nanogels with active targeting moieties or external stimuli which can enhance the efficient and stable loading of insulin. 2) Fostering a combination of strategies to realize effective crossing of multiple gastrointestinal barriers: protecting insulin from degradation by enzymes, traversing the mucus layer, and crossing the epithelial cell layer of the gastrointestinal tract. 3) Controlled release of drugs: the use of stimuli-responsive materials for the fabrication of drug delivery systems that can respond to a reasonable dose of external or intracellular inducements such as hyperglycemia, enzymes, light, pH, etc.

Keywords : oral administration, insulin, mucus, bioavailability, oral delivery system

Important Note : All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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    Keywords: oral administration, insulin, mucus, bioavailability, oral delivery system . Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements.Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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