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PhD positions in Molecular Immunology
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Job description
Von Willebrand Factor (VWF) plays a pivotal role in blood coagulation, with its secretion from Weibel-Palade bodies (WPBs) being essential for responding to vascular trauma. Dysfunctional WPB biogenesis and exocytosis are characteristic of bleeding disorders such as Von Willebrand disease. In this project, we aim to identify the organelle trafficking routes responsible for WPB formation and secretion.
This project is a collaboration between the research groups of Dr. Ruben Bierings (Department of Hematology, Erasmus MC, Rotterdam) and Dr. Geert van den Bogaart (Department of Molecular Immunology, University of Groningen (UG)).
Two PhD positions are available, one at each institute.
The UG candidate will utilize newly developed microscopy methods, including Förster resonance energy transfer-fluorescence lifetime imaging (FRET-FLIM), to map SNARE protein trafficking to WPBs. Techniques include FRET-FLIM microscopy, mammalian cell culturing, CRISPR, and molecular cloning.
The Erasmus MC candidate will conduct biochemical assays of WPB cargo secretion and optical assays of WPB exocytosis to determine changes in secretory competence and fusion mode due to altered SNARE sorting. Techniques include high content microscopy, proteomics, total internal reflection fluorescence (TIRF) microscopy, shRNA library screenings, and electron microscopy.
The PhD candidates are expected to also spend research time at the other institute.
Founded in 1614, the University of Groningen enjoys an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Flexible study programmes and academic career opportunities in a wide variety of disciplines encourage the 36,000 students and researchers alike to develop their own individual talents. As one of the best research universities in Europe, the University of Groningen has joined forces with other top universities and networks worldwide to become a truly global center of knowledge.
Qualifications
The successful applicant has:
- a Master degree in one of the following expertise: molecular biology, biochemistry.
- a good command of English (oral and written)
- enthusiastic and a team player.
- willing to spend research time in Rotterdam / Groningen
- experience with mammalian cell biology and advanced microscopy approaches is an advantage.
Organisation
Conditions of employment.
We offer stimulating scientific environment, access of state-of-the-art devices and techniques, and a beautiful and modern working environment. Employment possibilities will also become available at spinout company from the laboratory.
We offer you in accordance with the Collective Labour Agreement for Dutch Universities:
- a salary of € 2,770 gross per month in the first year, up to a maximum of € 3,539 gross per month in the fourth and final year
- a full-time position (1.0 FTE)
- a holiday allowance of 8% of gross annual income
- an 8.3% end-of-the-year allowance
- minimum of 29 holidays and additional 12 holidays in case of full-time employment.
The successful candidate will first be offered a temporary position of one year with the option of renewal for another three years. Prolongation of the contract is contingent on sufficient progress in the first year to indicate that successful completion of the PhD thesis within the next three years is to be expected. A PhD training program is part of the agreement and the successful candidate will be enrolled in the Graduate School of Science and Engineering.
The preferred starting date is as soon as possible.
De Rijksuniversiteit Groningen is een internationaal georiënteerde universiteit, geworteld in Groningen, de City of Talent. Al 400 jaar staat kwaliteit centraal. Met resultaat: op invloedrijke ranglijsten bevindt de RUG zich op een positie rond de top honderd. Deze bedrijfspagina is automatisch gegenereerd en bevat daarom nog weinig informatie. Je vindt meer informatie over Rijksuniversiteit Groningen op hun website: http://rug.nl
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Trevor Carter Ph.D. Degree Thesis Defense
Trevor Carter
Ph.D. Degree Candidate
Dr. Brian Buma's Lab
CU Denver Department of Integrative Biology
When: Friday, April 19th, 2024, 12:00pm Where: Science Building, Room 2001
Carbon dynamics in the pacific coastal temperate rainforest: an ecosystem science approach.
Quantifying forest carbon stocks is crucial for policy decisions and the management of forests in the face of global climate change. Investigation of forest carbon stocks at the regional scale provides insight into the fine-scale variability that is not captured by global models. In my dissertation, I investigated the spatial relationships of forest carbon stocks and plant biodiversity across the perhumid region of the Pacific Coastal Temperate Rainforest of North America – the largest temperate rainforest on the globe. Join me for my dissertation defense to learn about the spatial patterns of forest carbon in this region, its relative contribution to the global carbon budget, and how other management objectives such as managing for biodiversity may interact with forest carbon.
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Statistics and Actuarial Science
Congratulations to our phd student, alex liebrecht, for successfully presenting his dissertation.
Congratulations Alex!
The National Weather Service (NWS) of the United States gathers and catalogues precipitation data at many sites across the country. The civilian-run complement for gathering precipitation data is known as the Community Collaborative Rain, Hail & Snow Network (CoCoRaHS). The CoCoRaHS network provides many more locations of precipitation data than the NWS; yet, CoCoRaHS having data come from a different environmental monitoring network may have different bias and variability compared to NWS. The two data sets are similar in the way that they both have zero inflation and atypical correlation structure due to the edge of precipitation storms. Using the data provided by CoCoRaHS and NWS in the mid-west region of the United States, we present a statistical analysis that has several main goals --- we determine the helpfulness of the citizen-based data. We propose a model for estimation and prediction of precipitation including the zero-inflated data in addition to determining the proportion of observed positive values that are necessary in order for model fitting to be effective. Furthermore, we accomplish all of these goals while developing computationally-efficient model fitting-strategies.
The data was analyzed in a Bayesian framework using a Gaussian Markov random field (GMRF) spatial model with a zero-inflated Tobit likelihood. After constructing a spatial model, a spatio-temporal model was created using an intrinsic Gaussian Markov random field (IGMRF). Finally, we conclude with a spatio-temporal model for monthly average rainfall that includes a seasonal precision structure. The metrics we used to assess “best” model was predictive coverage, credible set width, mean squared predictive error, efficient LOO-CV, and WAIC.
Committee: Kate Cowles and Sanvesh Srivastava (co-chairs)
Committee Members: Matt Bognar, Joseph Lang, Brian Smith (Biostatistics)
IMAGES
VIDEO
COMMENTS
Dissertations University of Groningen. The UG's dissertations can be found in the research portal. Thesis research portal; Publish and submitting dissertations; Bachelor's and Master's theses University of Groningen. UG theses at Bachelor's and Master's levels can be found per faculty:
Find Student theses Search by expertise, name or affiliation. Show filters; Advanced search; Search in all content Filters for Student theses Search concepts ... the University of Groningen research portal data protection policy. About web accessibility.
The final version of the PhD thesis, both as a text file (rtf, doc, docx) and a as a pdf file. Relevent metadata: a text file read_me_first.txt containing the description of the thesis and any relevant general information. In a separate folder for each chapter of the thesis: All primary (raw) data underlying the chapter.
This dissertation aims to gain a better understanding of the ongoing digital transformation of organizations, with a specific focus on the following aspects: (1) understand what digital transformation is and how it affects firms, (2) shed light on the business value implications and contingencies in the SME context, and (3) to unravel different ...
In this thesis, we tried to find opportunities for improving anticoagulation care. Both older (VKAs) and newer (DOACs) anticoagulants have been addressed. Several determinants in VKA treatment could identify risk subgroups and predict adverse clinical outcomes. ... PB - University of Groningen. CY - [Groningen] ER - Piersma-Wichers M ...
Further financial support for the publication of this thesis was provided by: University Medical Center Groningen, the Graduate School of Medical Sciences, the University of Groningen, Noord Negentig, Angiocare, 3mensio, Stichting Lijf & Leven, Chipsoft.
PhD thesis to obtain the degree of PhD at the University of Groningen on the authority of the Rector Magnificus prof. C. Wijmenga and in accordance with the decision by the College of Deans. This thesis will be defended in public on Friday 02 October 2020 at 12:45 hours by Peter Cornelis Kroon born on 6 November 1990 in Groningen, the Netherlands
PhD thesis to obtain the degree of PhD at the University of Groningen on the authority of the Rector Magnificus Prof. J.M.A. Scherpen and in accordance with the decision by the College of Deans. This thesis will be defended in public on Tuesday 16 January 2024 at 11.00 hours by Yên Hảo Trần born on 7 November 1984 in Vietnam
PhD Thesis, University of Groningen, 173 pages Montofre, Daniel; Abstract. Radio astronomy represents one of the most useful tools for investigating celestial objects such as sychrontronic emissions from quasar , molecular clouds in the interstellar medium, and a black hole event horizon. All this is possible due to the great sensitivity that ...
Defended on: 10-03-2022. Dittfeld, Hendryk. Faculty of Economics and Business. Contextualizing risk management and resilience: The role of supply chain complexity, sales & operations planning and production system characteristics in managing risks and disruptions. Defended on: 06-07-2023. Dube, Nonhlanhla. Faculty of Economics and Business.
Upload your PhD thesis. PhD regulations. Poster Portal UMCG. Anyone working at the UMCG can deposit posters and/or slides into the UMCG Poster Portal. For more information contact: ... LibGuides of the University Library Groningen may be re-used under this Creative Commons license.
TY - BOOK. T1 - Essays on Financial Development and Financial Inclusion. AU - Peng, Yiqing. PY - 2021. Y1 - 2021. N2 - This PhD thesis contributes to our understanding about financial development, focusing on three main topics: (1) the link between financial deepening and financial stability; (2) the determinants of financial inclusion; and (3) the effect of financial inclusion on improving ...
The PhD candidates are expected to also spend research time at the other institute. Founded in 1614, the University of Groningen enjoys an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research.
University of Groningen founded in 1614 - top 100 university. Close. Menu and search; Contact; My University; Student Portal
PhD thesis to obtain the degree of PhD at the University of Groningen on the authority of the Rector Magnificus Prof. C. Wijmenga and in accordance with the decision by the College of Deans. This thesis will be defended in public on Tuesday 28 September 2021 at 11.00 hours by Xiaotian Zhu born on 17 July 1991 in Liaoning Province, China
Office of the Dean 201 Gilmore Hall 319-335-2143 Office of Academic Affairs 205 Gilmore Hall 319-335-2144 Iowa City, IA 52242-1320 Contact Us Website Feedback
The Groningen Graduate Schools offers an excellent program for post-graduate study at the University of Groningen. In addition to performing original academic research within one of the ten Faculty Graduate Schools, PhD candidates are offered a broad PhD Training programme including the Career Perspectives Series which helps PhDs prepare for a ...
Mailing Address: Campus Box 171 P.O. Box 173364 Denver, CO 80217-3364
PhD thesis to obtain the degree of PhD at the University of Groningen on the authority of the Rector Magnificus Prof. J.M.A. Scherpen and in accordance with the decision by the College of Deans. This thesis will be defended in public on Tuesday 28 May 2024 at 9.00 hours by
PhD Dissertation Defense for Doctoral Candidate, Joshua G. Hartzog. Friday, May 3 at 10:00 am to 12:00 pm Virtual Event
The University of Michigan provides many sources of financial assistance to help students meet educational and living expenses. Whether you are a prospective student, a current student, a master's or doctoral student, we want to make sure you know about the funding available for your graduate education.
University of Groningen . The work presented in this thesis was performed in the Nanomaterials Laboratory (Intituto de Ciencias Nucleares-ICN) of the Universidad Nacional Autónoma de México (Mexico) and the Surfaces and Thin Films Group (Zernike Institute for Advanced Materials) of the University of Groningen (the Netherlands).
As of July 10, 2020, the University of Groningen Library (UB) does not assign ISBNs (International Standard Book Numbers) to PhD theses anymore. Article 4.6.2 of the PhD Regulations of the University of Groningen, which obliges PhD students to request two ISBNs for their dissertation, is hereby cancelled.
ALBANY, N.Y. (April 25, 2024) —Alexis Weber has earned many titles during her time at UAlbany. The fifth-year PhD student from Jacksonville, Fla., recently added 3-Minute Thesis winner to her list of accolades, which also includes being selected for the 2024 Chancellor's Award for Student Excellence and earning one of the two $25,000 prizes ...
PhD thesis to obtain the degree of PhD at the University of Groningen on the authority of the Rector Magnificus Prof. C. Wijmenga and in accordance with the decision by the College of Deans. This thesis will be defended in public on Monday 24 April 2023 at 12:45 hours by Yifan Wang born on 23 October 1995 in Xi'an, China
Office of the Dean 201 Gilmore Hall 319-335-2143 Office of Academic Affairs 205 Gilmore Hall 319-335-2144 Iowa City, IA 52242-1320 Contact Us Website Feedback
Congratulations to University of Iowa Department of Statistics and Actuarial Science PhD student Alex Liebrecht for successfully presenting his dissertation.
PhD thesis to obtain the degree of PhD at the University of Groningen on the authority of the Rector Magnificus Prof. E. Sterken and in accordance with the decision by the College of Deans. This thesis will be defended in public on Monday 3 November 2014 at 16.15 hours by Nguyen Huong Thao born on 5 August 1977 in Binh Phuoc, Vietnam