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Biochemistry Department Masters Theses Collection

Theses from 2020 2020.

Assessing Stress Tolerance of Organelle Small Heat Shock Protein Mutants in Arabidopsis Thaliana , Parth Patel, Biochemistry

Investigation of SHOT1-binding ATPases in Arabidopsis thaliana , Sam Zelman, Biochemistry

Theses from 2019 2019

Analyzing the Biochemical and Functional Interactions of the RALF1-FERONIA-LLG1 (a peptide ligand-receptor kinase-GPI-anchored protein complex) Signaling Pathways in Arabidopsis thaliana , Samuel Jordan, Biochemistry

Predicting Successful Chaperoning of Fabry Disease Mutants via Computation , Priyank Patel, Biochemistry

Theses from 2018 2018

In Vitro S-Glutathionylation of S-Nitrosoglutathione Reductase from Arabidopsis Thaliana and Phenotype Determination of Sensitive to Formaldehyde 1 Knockout Strains of Saccharomyces Cerevisiae , Ian Truebridge, Biochemistry

FERONIA-RELATED RECEPTOR KINASE 7 AND FERONIA AND THEIR ROLE IN RECEIVING AND TRANSDUCING SIGNALS , David Vyshedsky, Biochemistry

Theses from 2015 2015

THE EVOLUTION OF THERMOTOLERANCE A CHARACTERIZATION OF A DIRECTIONALLY EVOLVED CYANOBACTERIUM , nathen Emil Bopp, Biochemistry

RNAi Mediated Silencing of Cell Wall Invertase Inhibitors to Increase Sucrose Allocation to Sink Tissues in Transgenic Camelina Sativa Engineered with a Carbon Concentrating Mechanism , Joshua Zuber, Biochemistry

Theses from 2014 2014

Investigation of the Effect of Dimerization on Human α-Galactosidase Activity , Scott R. Dooley, Biochemistry

Theses from 2012 2012

Proteolytic Regulation of CtrA, the Master Regulator of Cell Cycle in Caulobacter crescentus , Amber M. Cantin, Biochemistry

Theses from 2011 2011

Pharmacological Chaperoning in Fabry Disease , Jerome Rogich, Biochemistry

Novel Adaptor-Dependent Domains Promote Processive Degradation by ClpXP , Keith L. Rood, Biochemistry

Theses from 2010 2010

Probing the Activation Mechanism of Transcription-Coupled Repair Factor Mfd , Chih-heng Hsieh, Biochemistry

Theses from 2009 2009

Dopamine Controls Locomotion by Modulating the Activity of the Cholinergic Motor Neurons in C. elegans , Andrew T. Allen, Biochemistry

Theses from 2008 2008

Probing the Peptidyl Transferase Center of Ribosomes Containing Mutant 23s rRNA with Photoreactive tRNA , Nicole C. Caci, Biochemistry

Probing for Conformational Changes in the Repair Enzyme Mfd Using Mutant Protein Constructs , Mary E. Hunnewell, Biochemistry

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Department of Biochemistry and Molecular Biology Theses and Dissertations

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This collection contains theses and dissertations submitted by graduate students under the Department of Biochemistry and Molecular Biology for either a Master of Science degree or a Doctor of Philosophy degree.

Recent Submissions

OPTIMIZED ISOLATION AND QUANTIFICATION OF IN VIVO DISTRIBUTION OF EXOSOMES FOR POTENTIAL TARGETED THERANOSTIC APPLICATION

THE ROLE OF GPR109A IN REGULATION OF RETINAL ANGIOGENESIS AND BLOOD-RETINAL BARRIER AS A POTENTIAL THERAPEUTIC TARGET IN DIABETIC RETINOPATHY

A Molecular Basis of Chemoresistance in Bladder Cancer

Osteopontin as a novel immune checkpoint, gene regulation by the putative campylobacter jejuni diguanylate cyclase cbrr, glycosaminoglycans, chondroitinase, and molecular subtypes in bladder cancer.

HLA-G DIMER PROLONGS KIDNEY ALLOGRAFT SURVIVAL BY INHIBITING CD8+T CELL ACTIVATION AND GRANZYME B EXPRESSION

Investigating the Role of the Hdac3 Co-Repressor Complex in Glucocorticoid Signaling-Mediated Bone Marrow Lipid Storage with Age

CHOLINESTERASE INHIBITOR TOXICITY: MECHANISTIC STUDIES AND THERAPEUTIC STRATEGIES FOCUSED ON AXONAL TRANSPORT

Primary Tumor-Induced Immunity Is Suppressed By Surgery-Induced Inflammation In The Presence Of Residual Tumor Cells

DISCOVERY AND VALIDATION OF A NOVEL NEUTROPHIL ACTIVATION MARKER ASSOCIATED WITH OBESITY

Role of arginase in obesity-induced visceral adipose tissue dysregulation and endothelial dysfunction.

DNA METHYLATION AS A KEY PLAYER IN INFLAMMATION-MEDIATED COLON TUMORIGENESIS

The c-MYC oncogene deregulates global DNA methylation and hydroxymethylation to control genome-wide gene expression for tumor maintenance in leukemia/lymphoma

The Role of GPR109A in NAD+ Metabolism in Aging RPE

Immune regulation of tumor cell plasticity: A promising molecular target in breast cancer metastasis

THE TUMOR SECRETORY FACTOR ZAG PROMOTES WHITE ADIPOSE TISSUE BROWNING AND ENERGY WASTING IN CACHEXIA

Canonical wnt signaling in antigen presenting cells regulates microbiota-induced inflammation and immune cell homeostasis in the colon.

CXCR2 EXPRESSING TUMOR CELLS DRIVE VASCULAR MIMICRY IN ANTI-ANGIOGENIC THERAPY RESISTANT GLIOBLASTOMA

MECHANISM OF 12/15 LIPOXYGENASE-INDUCED RETINAL MICROVASCULAR DYSFUNCTION IN DIABETIC RETINOPATHY

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Home > FACULTIES > Biochemistry > BIOCHEM-ETD

Biochemistry Theses and Dissertations

This collection contains theses and dissertations from the Department of Biochemistry, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

Theses/Dissertations from 2024 2024

Elucidating the temporal regulation of protein kinase CK2 by the peptidyl-prolyl isomerase Pin1 , Scott E. Roffey

Theses/Dissertations from 2023 2023

Genetic Tools Towards A Synthetic Biology Approach For Whole Mitochondrial Genome Engineering , Ryan R. Cochrane

Characterization of DNA Regulatory Elements of the Highly Abundant Secreted Protein 1 (HASP1) Promoter and Analysis of Transcriptomic Responses Under Phosphate Depletion in the Diatom Phaeodactylum tricornutum , Mahsa Farmanbar

Multi-omics analysis of epithelial ovarian cancer metastasis , Mallory I. Frederick

Functionalizing conjugative systems to deliver CRISPR nucleases for targeted bacterial killing , Thomas A. Hamilton

Characterizing SaCas9 and SaCas9[D10E] tolerance to mismatches using Directed Evolution Using Fluorescence Activated Cell Sorting (DEUFACS) , Olha Haydaychuk

Selective Activation of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) Attenuates Metastatic and Angiogenic Capabilities of Melanoma and Lung Carcinoma in vitro , Jacklyn Krizsan

The inner workings of thrombin-activatable fibrinolysis inhibitor: a study of the TM-mediated activation of TAFI and inactivation of TAFIa , Haley D N Marier

Advances in Phaeodactylum tricornutum nuclear engineering , Mark Pampuch

Developing Regulated CRISPR Systems to Control Bacterial Microbiomes , Gregory M. Pellegrino

State-of-the-art Approaches for Sequencing, Assembling and Annotating Naphthenic Acid Degrading Bacterial Metagenomes , Henry H. Say

Mechanism of Permissive Cleavage Activity of TevCas12a , Alexa White

Acetylation regulates Thioredoxin Reductase activity and oligomerization , DAVID E. WRIGHT

Kinetic Analyses of SaCas9[D10E] in vitro , Claire Zhang

Theses/Dissertations from 2022 2022

The development of Sinorhizobium meliloti and Deinococcus radiodurans as chassis for synthetic biology applications , Stephanie L. Brumwell

Applications of nanopore DNA sequencing for improved genome assembly , Daniel Giguere

Dual Functions of Interstrand Crosslink Repair Nuclease SNM1A , Ryan Grainger

Probing the genetic code with Leucine tRNA variants , Peter Anderson Hall

Perseverance of protein homeostasis despite mistranslation , Farah Hasan

Towards more complete metagenomic analyses through circularized genomes and conjugative elements , Benjamin R. Joris

Dissecting the Molecular Basis of NRF2 Activity Modulation in the Oxidative Stress Response , Nadun Karunatilleke

Chromatin regulation by RB-interacting proteins in cellular immune functions , Seung June Kim

Identification and characterization of novel fumonisin-detoxifying enzymes , Michael C. Kovacevic

Kinetic and structural influences of acetylation on ubiquitin processing , Rachel E. Lacoursiere

Illuminating Transfer RNA Variants as Genetic Modifiers in Models of Human Disease , Jeremy T. Lant

RHAMM as a biomarker and therapeutic target in triple-negative breast cancer , Britney Messam

Characterization of disease-causing HARS mutations , Yi Qiu

Global Regulation of miRNA and mRNA Homeostasis by Terminal Uridylyltransferases TENT3A/B , Pengcheng Zhang

Theses/Dissertations from 2021 2021

Mapping Ku70 Protein Interactions Using Proximity-Dependent Biotin Identification , Sanna Abbasi

Applications of Genetic Testing for Endocrine and Metabolic Disorders , Amanda Berberich

Implications and Applications of Transfer RNA Variants that Mistranslate the Genetic Code , Matthew D. Berg

Biochemical and biophysical characterization of a novel fumonisin detoxifying enzyme from Aspergillus niger , Shane G. Butler

Elucidating the Structural and Dynamical Properties of the Intrinsically Disordered Protein Nrf2 Using Molecular Dynamics Simulations , Megan Nicole Chang

Investigating The Role Of PKC And Its Mechanisms In Regulation Of IGF-I Bioavailability In Fetal Growth Restriction , Allan W. Chen

The Genetic Landscape of Neurodegenerative and Cerebrovascular Disease Phenotypes. , Allison A. Dilliott

New Perspectives on Phosphorylation State in the Parkin Ubiquitination Cascade , Karen Dunkerley

The study of the structure and dynamics of parkin activation , Elaine Aisha Freeman

Development of 3D Bioartificial Human Tissue Models of Periprosthetic Shoulder Joint Infection , Tony B. Huang

tRNA Regulation in Humans: The cellular effect of a pathological HARS Y454S mutation , Rosan Kenana

Genetic Approaches for the Study of Complex Human Diseases , Julieta Lazarte

Uncovering the ubiquitin ligase activity and substrates of the human C-terminal to LisH (CTLH) complex , Matthew E.R. Maitland

Characterizing the Role of TDG in FXR-dependent Signaling , Oladapo A. Onabote

Functional Role of DREAM and DYRK1A in High-Grade Serous Ovarian Cancer Cell Dormancy , Pirunthan Perampalam

Disruption of Insertion Sequence 200 (IS200) leads to a premature induction of the Cysteine regulon in Salmonella Typhimurium , Naomi-Jean Q. Scherba

A Characterization of RGNEF Biophysical Properties and Interactome , Brooke E. Wile

Theses/Dissertations from 2020 2020

Nutrient Sensing Pathways Mediating IGFBP1 Phosphorylation in FGR , Shapnil Bhuiyan

The Genetic Determinants of Complex Lipid and Lipoprotein Phenotypes , Jacqueline S. Dron

Development of a Thermosensitive Endonuclease to Act as a Plasmid Kill-Switch , Christopher D. Leichthammer

AWT1 is Constantly Expressed in Palmar Fascia Fibrosis and Promotes a Pro-Inflammatory Milieu , Johnny Luo

Practical Applications and Future Directions of Genetic Code Expansion: Validation of Novel Akt1 Substrates and the Design of a Synthetic Auxotroph Strain of B. subtilis , McShane M. McKenna

Deciphering the CK2-dependent phosphoproteome and its integration with regulatory PTM networks , Teresa Nunez de Villavicencio Diaz

Generation of Conditional Ku70 Knockouts in Human Cell Lines Using CRISPR/Cas9 and Dual-Nuclease CRISPR/TevCas9 , Gursimran Parmar

Thyroxine-Dependent and -Independent Effects on Premature Aging and Myelination in ATRX Mutant Mice , Megan E. Rowland

Development of the Model Marine Diatom Phaeodactylum tricornutum for Synthetic Biology Applications , Samuel S. Slattery

The role of Heat Shock Protein 90 in the Keap1/Nrf2 Mediated Oxidative-Stress Response , Zheng Song

Structural Study of the Complex Between DNA Polymerase Iota and Ub-PCNA , Harrison Taylor

Quinone Reductase 2 Roles in Proteomic Regulation and Response to Treatment with Clinical Drugs , Matthew D. Walker

Calcium signaling and pathogenesis of dysferlin C2 domains , Yuning Wang

Determining Whether the Nature of the Amino Acid Substitution or the Extent of Mistranslation Affects the Impact of Mistranslating tRNAs in Saccharomyces cerevisiae. , Yanrui Zhu

Theses/Dissertations from 2019 2019

Placental MicroRNA Expression in Pregnancies Complicated with Preeclampsia and Intrauterine Growth Restriction , Zain Awamleh

Differentially activating the oncogenic kinase Akt1 , Nileeka Balasuriya

Regulation of RNA stability by terminal nucleotidyltransferases , Christina Z. Chung

The Characterization of the Rat Bone Sialoprotein Knockout Phenotype , Benjamin Harvey

Improving the genetic diagnosis of familial hypercholesterolemia , Michael Iacocca

High Molecular-Weight Hyaluronan Prevents Basal Cell Carcinoma Via Promoting Apoptosis In Cancer-Initiating Adult Stem Cells , Violet Liu

Applications of Phosphotyrosine Superbinding SH2 Domain Variants , Xuguang Liu

Functional investigation of the role of the retinoblastoma protein in genome stability , Aren E. Marshall

Structure and Function of Stomatin-like Protein 2 , Safee Mian

Nobiletin Corrects Intestinal Insulin Resistance and Lipid Metabolism in Ldlr-/- Mice Fed a High-fat Diet , Nadya Morrow

Systematic identification of the lysine methylome using methyllysine binding domains , Wen Qin

Investigating the Role of ATRX in Glutamatergic Hippocampal Neurons , Renee Tamming

Structural and Functional Characterization of Deinococcal DNA Damage Response A (DdrA) , Filip Todorovic

Parkin Structural Perturbations in Oxidative Stress , An Tran

Mass Spectrometry-Based Proteomics Analysis Of Bioactive Proteins In EMD That Modulate Adhesion Of Gingival Fibroblast To Improve Bio-Integration Of Dental Implants , David Zuanazzi Machado Jr

Theses/Dissertations from 2018 2018

Attenuation of Obesity, Hepatic Steatosis and Reversal of Atherosclerosis by the Flavonoids Naringenin and Nobiletin , Amy C. Burke

Regulation of Beta-Catenin by the CTLH Complex , Christopher Chiasson

Conformational Arrangements of UbcH7-Ubiquitin with OspG and Parkin , Tara E. C. Condos

Chromatin organizer CTCF in brain development and behaviour , Adrienne Elbert

Characterizing the Role of Thymine DNA Glycosylase in Transcriptional Regulation and Cancer In Vivo , Mohammad Haider Hassan

Genetic determinants underlying rare diseases identified using next-generation sequencing technologies , Rosettia Ho

The Role of Thymine-DNA Glycosylase In Transcriptional Regulation , Bart Kolendowski

Metabolic and Expression Changes Associated with a Mouse Model of Intrauterine Growth Restriction (IUGR) , Bethany N. Radford

The Functional Characterization of the N-terminal Domains of TUT4 , Lauren E. Seidl

Theses/Dissertations from 2017 2017

Autoinhibition and Activation of Parkin , Jacob D. Aguirre

Characterizing the Cofactor Specificity of NQO2 , Shahed Al Massri

Role of High Molecular Weight Hyaluronan in Ultraviolet B Light-Induced Transformation , Katelyn Cousteils

An Investigation of the CK2-dependent Phosphoproteome using Inhibitor Refractory CK2-alpha , Edward Cruise

Identification of novel binding partners and substrates of histone H3K4 specific demethylase KDM5B/JARID1B , Qi Fang

Effect on Pellicle Proteome upon Adsorption of Salivary Peptide on Hydroxyapatite and their effects on Enamel Demineralization , Rajesh Kr. Gupta

Tti2 in PIKK Biosynthesis and Its Use in Identifying Missense Suppressor tRNAs , Kyle S. Hoffman

The CDK-resistant pRB-E2F1 complex recruits chromatin-organizing proteins to repetitive DNA sequences , Charles A. Ishak

Proteomic Characterization of Human Multipotent Stromal Cells Secreted Proteins with Therapeutic Potential for β-cell Regeneration , Miljan Kuljanin

Coevolving Residues and the Expansion of Substrate Permissibility in LAGLIDADG Homing Endonucleases , Thomas A. McMurrough

Regulation of C-RAF stability by the RanBPM/CTLH complex , Christina J. McTavish

Quantitative Proteomic Characterization of CX-4945, a Clinical Stage Inhibitor of Protein Kinase CK2 , Adam J. Rabalski

Investigating E2F independent cell cycle control and tumor suppression by pRB , Michael J. Thwaites

An invasive tumor cell subpopulation as a therapeutic target in breast cancer , Tahereh Vakili

Assessing the role of Ku70 vWA domain phosphorylation in the inhibition of Aurora B and activation of the DNA damage response , Elizabeth A. Walden

Structural and Functional Characterization of Non-Homologous End Joining Factors , Huasheng Wang

Nicotinamide Phosphoribosyltransferase In Smooth Muscle Cells And Aortic Integrity , Alanna R. Watson

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• v.31(1); 2010 Feb

The Hitchhiker’s Guide to Research in Clinical Biochemistry

Introduction.

Research within Clinical Biochemistry is at a crossroads. There is currently a degree of navel gazing about what the future academic direction for our profession should be. However, our speciality is distinctive in many ways: it occupies a unique position in medicine at the interface between laboratory testing and clinical diagnosis; we have a closer understanding of the concepts and limitations of diagnostic testing than most others in medicine; we have a history of being at the forefront of using information technology within healthcare; we are also probably a self-selected group whose abilities include being able to rigorously evaluate complex sets of data and then to draw conclusions.

Taken together, these talents mean our discipline should be integral to the development of ‘evidence-based’ medicine and be central in converting research findings into clinical practice, as is now called ‘translational research’. With some lateral thinking we can also help answer some of the fundamental questions related to Clinical Biochemistry and within the many specialities with whom we liaise.

This article gives a personal view of how anyone, whether in an academic centre or not, can make valuable research contributions to Clinical Biochemistry without having to assume they need large funding beforehand. Rather, they just need an inquisitive mind and an enjoyment of the speciality. A number of examples are given of my own experience, but the intention is just to be illustrative rather than to bolster my ego or my number of citations.

Why Do Research?

We are often told that research is a central part of our jobs, as it is for any healthcare professional, without usually understanding why or how it can possibly be achieved. The author of this article has certainly not always been enamoured with the thought of doing research. As a medical student, I could not understand why someone would wish to devote so much time to get, at best, a single line in a textbook written about their work.

But I was missing the point. To be thefirsthuman to have thought of an idea, no matter how unimportant, and have found a way of answering a research question is very satisfying personally. Indeed the satisfaction is often completely disproportionate to the achievement made. In addition, any employing institution is also likely to be pleased by the profile given to the organisation. However, beyond self-satisfaction, we need to remember that the main purpose of the research is that we may actually report on something which will help - either directly or indirectly - the patients that we look after.

When applying for my first medical student scepticism, why research seemed to be such an important part of a curriculum vitae. Should doing your current job, and doing it well, I thought, not be sufficient on its own? Having sat on the other side of the interview table several times I have finally been able to answer my own question. A research record is one way of marking someone out as being able to develop ideas, to formulate these ideas into plans and to be able to express their thoughts clearly. It means they are likely to be a good communicator (in writing, at least), a finisher of tasks and probably a good teamworker. Also, since research can seldom be done solely during working hours, and assuming they are not deficient in their day job, it also distinguishes them as someone who probably works harder than most. Lastly, as we would all wish to have colleagues we know we can work with, a research record just might indicate that the candidate is a likeminded person.

Of course, all these qualities can be demonstrated in ways other than through research, but I think I now understand why achievement in this area was as valued as it was.

Rules of Research

If research can be satisfying, important and probably only of help in career progression then it follows that there should be equal exposure to it. However, not everyone works in a centre of academic excellence where there is a culture of research, so it is not always obvious how to even start to be involved. In this case I would recommend following what I’ve modestly called ‘Kilpatrick’s Seven Rules of Research’ ( Table ). The following gives some examples of how some of these ‘rules’ can be put into practice.

Kilpatrick’s Seven Rules of Research.

Don’t be Afraid of Asking Daft Questions

Simply because they are probably not daft after all. ‘Daft’ questions are also often the ones that vex people who are even specialists in that area of the laboratory. When I first started to develop an interest in diabetes, the glucose test strip market was beginning to burgeon with glucose oxidase-based meters. I asked the simple question ‘where does the oxygen come from?’, by which I meant, did the enzyme use oxygen from the atmosphere or from the blood sample itself? Trying to think laterally, there then followed plenty of tinkering with rubber tubing to connect a Boyle’s anaesthetic machine to a tonometer in order to be able to dial up a desired pO 2 and pCO 2 in a blood sample. We established that some contemporary tests strips obviously used sample rather than atmospheric oxygen and so could give inaccurate results in hypoxic patients or in those on oxygen treatment. 1

Don’t Assume Someone has Already Studied It

When training, it is easy to assume that all the research questions worth answering have already been done so, or that solving the difficult ones will be impossible without large grants. The further along the career you travel, the more obvious it becomes that many of the fundamental issues in a medical subspeciality have still to be addressed. A simple example of my own followed on from the glucose meter experiments. I asked how we knew whether a whole blood sample for point-of-care-testing instruments was haemolysed or not. As it transpired, no one had ever looked at this, even though in retrospect it should probably have been one of the first questions asked of these systems. So by deliberately haemolysing blood to various extents with a sonicator, we showed that this could be a significant source of error for some glucose meter systems. 2

Jump on Unusual Findings

Many a discovery and career has been made either because of sheer luck or because the potential of an observation has been realised by someone but not others. Such events are unpredictable and infrequent, but when they do happen it is important not to let a busy routine job mean that they are never followed up. Such a moment happened when assessing the renal function of patients with hypo- and hyperthyroidism before and after treatment. Creatinine concentrations were high in hypothyroidism, low in hyperthyroidism and both normalised on treatment. There was still a lingering doubt that the creatinine may not be giving an accurate indication of glomerular filtration rate (GFR), so the samples were sent to another laboratory to measure cystatin C which, at that time, was a marker of GFR with apparently few, if any, limitations. 3 The results suggested the samples had been transposed as the cystatin C was, in fact, high in hyperthyroidism and low in hypothyroidism. Tempting though it was to just accept the transposition and not ask the laboratory to rerun the samples - especially as they had been done as a favour - there was the realisation that hyperthyroidism was possibly leading to an overproduction of cystatin C and vice versa with hypothyroidism. This ultimately proved to be the case and was reported as the first major limitation of cystatin C to be found. 4

Armchair Research

This expression was coined by a colleague to describe my appetite for interrogating large databases to try to answer some basic questions related to Clinical Biochemistry, and to perhaps debunk conventional wisdom along the way. We have, at our disposal, a wealth of data recorded in our laboratory computers just waiting to be examined. Take the simple question of whether hypothyroidism is associated with hyponatraemia. Of course it is, because we have often been told so, 5 but on closer inspection the evidence for this strays little from simple case reports. Some data had disputed the relationship, but also had its limitations. 6 From our laboratory database, we were able to identify 999 patients who were newly diagnosed with hypothyroidism by their family doctors (so presumably were not also acutely unwell) and found that the concurrently measured serum sodium distribution was virtually identical to the distribution in euthyroid patients. 7 It seems, therefore, that any association is unlikely to be causal.

If our laboratory data can be somehow linked with other databases then they can become even more powerful tools. We already know that as estimated GFR (eGFR) falls from normal values, mortality increases. 8 By linking to the register of deaths in our population, we were able to determine that patients with high eGFR (>90 mL/min/1.73m 2 ) are also at higher risk than the ‘sweet-spot’ of 60–89 mL/min/1.73m 2 , such that the distribution is actually ‘U’ shaped. 9 Sticking with eGFR, an ongoing debate in the UK is whether urea measurement is of any value now that we report this calculation. Most people assume that urea gives additional evidence of hydration, but there is little data to support this. However, we were able to link admission urea and creatinine measurements with the urine specific gravity of patients recorded by automated urine analysers in our Accident and Emergency (A&E). It showed that urea measurement did add to creatinine in predicting this urine marker of hydration, albeit not especially strongly. 10

Medical Freakonomics

‘Freakonomics’ is the title of a book written by the US economist Steven Levitt. He too has asked unusual questions of large datasets, but has also examined how human nature can impact on the business economy. 11 As a laboratory speciality, we are in a strong position to be able to determine how human nature can impact on our health economy.

When we moved to having ward terminals to access results in wards, we stopped telephoning abnormal results to those clinical areas in the knowledge they would have them available to look at. Human nature said to me that if I worked on these wards and had the choice of having a coffee or looking at laboratory results, I would be tempted by the coffee. Sure enough, we found that not only was there a delay between the time results became available and being accessed, but nearly half of A&E results were never viewed, including a significant number which were likely to have led to an immediate change in patient management. 12 We now telephone very abnormal results again.

It is already known that women have a poorer outcome than men post myocardial infarction (MI), and this is at least partly due to the fact that they appear to be less aggressively treated with lipid lowering or other drugs and fewer undergo cardiac rehabilitation. We linked our troponin measurements to the discharge diagnosis database for our hospital and found, not surprisingly, that as troponin concentrations increased the chances of being discharged with a myocardial infarction diagnosis increased as well. What was less predictable was that, on average, a man was 50% more likely to go home with that diagnosis than a women with the same troponin level. 13 Human nature seemed to be making the clinician act differently depending on gender, and so in addition to being managed less well post MI, women seemed to be at less chance of being diagnosed with an MI in the first place.

Other Databases

If your own laboratory system does not satisfy your wishes there may be another database that does. The Diabetes Control and Complications Trial was the seminal study in type 1 diabetes that showed for the first time that improving glycaemic control could reduce the risk of developing the microvascular complications of the disease. This database was made public in 2003 and has since allowed independent investigators, such as ourselves, to help address questions which the original study never envisaged answering. These have ranged from showing that increased glucose variability does not seem to influence the risk of developing microvascular complications, 14 to more eccentric observations demonstrating that tall patients develop neuropathy before small ones. Many other datasets have been made publicly available and could well prove to be relevant to Clinical Biochemistry, such as those of the National Institute of Diabetes and Digestive and Kidney Diseases. 15

Get It Published

Standing by your first poster presentation at a national meeting is a proud moment for every researcher. However, for the work to get its widest (and usually deserved) dissemination, it is important that every effort is put towards publishing the article. Despite this, only a minority of abstracts at meetings make it to full publication. 16

Guaranteeing a larger audience is not the only reason for writing up an article for publication. A salutary lesson involved the cystatin C study already described above. This serendipitous finding, 17 years after the initial paper proposing its use as a marker of GFR, 17 was presented as a poster at the Association for Clinical Biochemistry meeting in the UK in 2002 and published in April of the following year. 4 Within six months, three further groups independently reported the same finding. 18 – 20 Needless to say, it would have been disheartening if their publications had been the first to break the news. Moreover, being the fourth, rather than the first, would have meant it was far more difficult for the paper to be accepted for publication at all.

Issues Presenting Barriers to Research

Fear of the unknown.

There is now a plethora of regulations related to research governance, and knowing how to comply with these is no easy task for inexperienced non-academics. It may be, in the UK at least, that the project does not need to undergo a full Research Ethics Committee submission if it is being done as part of a clinical audit. This is defined as an analysis where care is being assessed against clearly defined standards. Since, for example, it is recommended that patients with raised cardiac troponin concentrations be diagnosed as having had a myocardial infarction, it was appropriate that the troponin study mentioned earlier be an audit of local practice, even though it ultimately unearthed the differences between genders. Approval for a clinical audit can usually be obtained from the local hospital in a manner that is much less involved than that required for a full research study.

For other projects, ethical approval will undoubtedly be required. Having someone to help with this who has previously gone through the process is invaluable. There is no particular need for them to be laboratory-based and they may well be employed within the Research and Development infrastructure of the hospital. As might be expected, having done the submission once, subsequent applications are much more straightforward. Indeed, that person should be expected (or even compelled) to help others with their own proposals. My own experience is that the types of studies I am recommending, by not involving drugs or patient intervention, seldom give rise to ethical committee concerns beyond maintaining patient confidentiality. However, the submission can lead to a delay of 2–3 months in starting the study.

Time and Other Resources

These seem to be in increasingly short supply in clinical laboratories throughout the world and this is especially true when it comes to prioritising research. However, it is not a coincidence that the words ‘Research’ and ‘Development’ are often used together since the laboratories at the forefront of the former tend also to those at the forefront of implementing new technologies, reconfiguring services and being respected (and therefore supported) by clinical colleagues. Having a research ethic in a department may make further financial sense as the interest it engenders often promotes the recruitment and retention of the most talented staff. Having mentors to help direct and advise junior staff is also important in order to make sure the culture is not the sole preserve of senior staff members.

Conclusions

Being able to conduct research is one reason why many of us chose Clinical Biochemistry as a career, but in recent years, for various reasons, it has become more difficult for this source of job satisfaction to be accommodated. I hope this article has shown that large grant application success is not always required to perform meaningful research in our speciality. Although the approach described could be accused of being simplistic and naïve, I feel that this is still one way in which our discipline can continue to make a unique and relevant contribution to healthcare research.

Competing Interests : None declared.

DigitalCommons@University of Nebraska - Lincoln

Home > Biochemistry > Dissertations, Theses, and Student Research

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Department of biochemistry: dissertations, theses, and student research.

Mitochondrial Metal Homeostasis: A look into iron and copper mobilization within mitochondria , Jonathan Dietz

Characterization of the Multifunctional Enzyme Proline Utilization A , YiZi Mao

Development of High Value oil traits using the model oilseed crop Camelina sativa , Evan Updike

Characterization of Sphingolipid Biosynthesis and Modification in Plants , Dongdong Zhang

The Role of Liver Sinusoidal Endothelial Cells in Liver Malady Homeostasis , Fatima Cabral

THE ROLE OF CONFORMATIONAL DYNAMICS IN ISOCYANIDE HYDRATASE CATALYSIS , Medhanjali Dasgupta

Dissecting the Regulatory Network of Sphingolipid Biosynthesis in Plants , Ariadna Gonzalez-Solis

Characterization of Human Pyrroline-5-Carboxylate Reductase Enzymes Responsible for L-Proline Biosynthesis , Sagar Patel

Protease OMA1 Modulates Mitochondrial Bioenergetics and Ultrastructure through Dynamic Association with MICOS Complex , Martonio P. Viana

TRANSCRIPTOMIC ANALYSES AND COMPUTATIONAL MODELING REVEAL THAT FATTY ACID TRANSPORT PROTEIN 2 (FATP2) IMPACTS THE TRANSCRIPTIONAL ACTIVITY OF PPARα THUS ALTERING THE LIPID METABOLIC LANDSCAPE , Vincent M. Perez

Xenobiotic Exposure Requires Mitochondrial Metabolism for REDOX Homeostasis and Survival in Astrocytes , Jordan Rose

Defining the Roles of Serine Palmitoyltransferase-Interacting Proteins in the Regulation of Sphingolipid Homeostasis , Athen N. Kimberlin

Investigation of Pathways for Complex Sphingolipid Biosynthesis in Arabidopsis thaliana (L.) Heynh , Kyle Luttgeharm

Functional Genomic Analyses of Switchgrass Developmental Processes , Nathan Palmer

Characterization of Inhibitors of Fatty Acid Transport Protein-2 in Cell and Animal Models , Nipun Saini

Reactive Oxygen Species Homeostasis and Proline Catabolism , Lu Zhang

Single Tube, Multiple Enzyme Reaction for Detection of UV and Oxidative Damage in Forensic Physiological Stains , Nicholas J. Eurek

REDOX REGULATION OF PROTEIN TRANSLATION IN EUKARYOTES , Maxim Gerashchenko

ER-associated Degradation and Cadmium Dependent Rescue of PCA1 , Nathan Smith

Investigation of Proline Utilization A: Kinetic Analysis of Substrate Channel-blocking Mutants and Creation of a Trifunctional Chimera Enzyme , Benjamin W. Arentson

Transcriptomic Analyses of the CO 2 -Concentrating Mechanisms and Development of Molecular Tools for Chlamydomonas reinhardtii , Andrew J. Brueggeman

MAKING CHLAMYDOMONAS REINHARDTII A BETTER MODEL ORGANISM: TACKLING THE INEFFICIENCY OF NUCLEAR TRANSGENE EXPRESSION AND IMPROVING METHODS FOR THE GENERATION AND CHARACTERIZATION OF INSERTIONAL MUTANT LIBRARIES , Thomas M. Plucinak

Investigations of Substrate Channeling in the Proline Oxidative Pathway , Nikhilesh Sanyal

Sinusoidal Endothelial Dysfunction in Non-Alcoholic Fatty Liver Disease. , Sandhya Lakshmi Gopalakrishnan

Studies on the Small Ubiquitin-Like Modifier (SUMO) E2 Conjugases of the SUMOylation System in Chlamydomonas reinhardtii and their Role in Stress Physiology , Amy R. Knobbe

Developing a High Throughput Protocol for Using Soil Molecular Biology as Trace Evidence , Sabreena A. Larson

Phylogenetic Engineering of the Ribulose-1,5-bisphosphate Carboxylase/Oxygenase Large Subunit in Chlamydomonas Reinhardtii , Boon Hoe Lim

UNDERSTANDING OF FUNCTIONS OF SELENOPROTEINS AND DIETARY SELENIUM BY USING ANIMAL MODELS , Marina V. Kasaikina

Functional Studies of Human Cellular Detoxification Enzymes , Melanie Neely Willis

The crosstalk between human fatty acid transport protein 1 and fatty acid transport protein 4 , Zhe Yuan

METHIONINE-R-SULFOXIDE REDUCTASES AND BIOLOGICAL IMPORTANCE OF FREE METHIONINE SULFOXIDE REDUCTION , Byung Cheon Lee

The In Situ Function of a Microbial Community Profiled by FT-IR: A Snapshot in Time , Ryan Roberts

Consequences of Hyaluronan Metabolism on Cell Cycle Progression in Prostate Tumor Growth and Metastasis , Alamelu G. Bharadwaj

Identification and Characterization of a Cadmium-Transporting P-Type ATPase in Yeast Saccharomyces cerevisiae , David J. Adle

Structural Basis of Allosteric and Intrasteric Regulation in Human Cystathionine β-Synthase and its Regulation by a CXXC Motif , Suvajit Sen

Studies on Nutritional Muscular Dystrophy. I. Dietary Factors, II. Fibrosis and Lipomatosis of Tissues , Violet Myrtle Wilder

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Dissertations / Theses on the topic 'Medical Biochemistry and Clinical Chemistry'

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Stemp, Melissa. "Biomarkers of disease : concentrations in the serum of women during natural and stimulated ovarian cycles and during early pregnancy." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2013. https://ro.ecu.edu.au/theses/865.

Woods, Nicole Natasha Brooks Lee R. "The role of biomedical knowledge in medical diagnosis by learners." *McMaster only, 2005.

Meiklejohn, Barbara A. "Ektachem evaluation /." Online version of thesis, 1985. http://hdl.handle.net/1850/9634.

Wabomba, Mukire John. "Signal and Image Processing Techniques for Environmental and Clinical Applications of Infrared Spectroscopy." Ohio University / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1040131767.

Carberry, Helen. "Semiotic analysis of clinical chemistry: for "knowledge work" in the medical sciences." Thesis, Queensland University of Technology, 2003. https://eprints.qut.edu.au/15809/1/Helen_Carberry_Thesis.pdf.

Carberry, Helen. "Semiotic analysis of clinical chemistry: for " knowledge work " in the medical sciences." Queensland University of Technology, 2003. http://eprints.qut.edu.au/15809/.

Bani, Rashaid Ayat H. "Clinical and Forensic Biomarkers in Human Hair." Ohio University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1407256298.

Wang, Yin 1951. "Influences of membrane biophysical properties on the Metarhodopsin I to Metarhodopsin II transition in visual excitation." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282520.

Persson, Johanna. "Hälsoundervisning : Elevers syn på hälsa inom ämnet Idrott och hälsa." Thesis, University of Kalmar, School of Human Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-2478.

Fler unga människor än någonsin är idag överviktiga och stress och stressrelaterade symptom drabbar idag allt fler unga. Därför är det viktigt att unga människor får kunskaper om hur de på bästa sätt kan ta hand om sig själva.

 Syftet med detta arbete är att undersöka hur elever som läser gymnasiets kurs Idrott och hälsa A ser på den hälsoundervisning de får.

Detta är relevant för alla som arbetar som idrott och hälsa lärare för att kunna hitta en jämkning mellan kursplan och elevernas tankar och förkunskaper.

 Genom intervjuer och fokusintervjuer kom jag fram till att eleverna vill lära sig mer om stress och hur man hanterar stress samt om kost. Eleverna tycker däremot att idrottsläraren inte är rätt person att lära ut kunskaper om tobak.

Tang, Yuanyuan. "Nitric Oxide/Peroxynitrite Imbalance Induces Adhesion of Cancer Cells to Lymphatic Endothelium - Clinical Implications for Cancer Metastasis." Ohio University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1439563414.

Ozinsky, Adrian. "Post-translational processing of the low density lipoprotein receptor." Doctoral thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/26672.

Lu, Liang. "CLINICAL AND ANIMAL STUDIES OF LIPID-DERIVED PROTEIN MODIFICATIONS IN AUTISM, KIDNEY DIALYSIS, KERATITIS AND AGE-RELATED MACULAR DEGENERATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1180231149.

Barnard, Sandra H. "Amalgamation of Nucleosides and Amino Acids in Antibiotic Biosynthesis." UKnowledge, 2013. http://uknowledge.uky.edu/pharmacy_etds/20.

Borg, Mathias. "Study of the insulin-like peptide 3 in human platelets." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-21016.

The insulin-like 3 peptide is autocrine/paracrine insulin-related hormone with a size of approximately 6kDa [1]. It mediates through a leucine richG-coupled receptor named LGR8. INSL3 is mainly expressed in human Leydig cells and is directly responsible for migration of the testis during the pre-natal period in maledevelopment. [2]

INSL3 mRNA has recently been verified in human platelets whereas no mRNA has been detected for LGR8 (by Sanofi-Aventis GmbH in Frankfurt,Germany), indicating that INSL3 might be released through paracrine functions at sites of platelet adhesion and aggregation upon a vascular injury.Furthermore, has activated platelets been shown to translate essential proteins upon activation, in a term called “signal-dependent protein synthesis”.The B-Cell lymphoma-3 protein (BCL-3) is an example of such a protein [3], and there is a possibility that INSL3 might be also.

In this thesis we wanted to detect the relaxin- like peptide 3 hormone (INSL3). (Its function, location and the timeframe of its release, when/if it issecreated in stimulated platelets).The source of platelet-derived INSL3 can be found with Western blotting and Enzyme immunoassay.

Detection of the insulin-like 3 peptide in human platelets turned out to be a difficult challenge due to the small amount of INSL3 secretion uponplatelet activation; hence the total amount of INSL3 produced might be below detection limit.

Rafael, Venson. "Hollow-fibre liquid-phase microextraction : investigation into the potential use in clinical and forensic toxicology." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8697/.

Shah, Ketan. "Development of clinical biomarkers of DNA double strand breaks for cancer care." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:2e6b2595-fbbc-4fff-80e2-bec8a4d9d15e.

Alabdulwaheed, Abdulhameed. "3D-Printed Fluidic Devices and Incorporated Graphite Electrodes for Electrochemical Immunoassay of Biomarker Proteins." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etd/3477.

English, Suzanne Elizabeth. "Within-host evolution of HIV-1 and the analysis of transmissible diversity." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:df24b49c-fb27-49a3-bd2e-3e38008e9da4.

Tian, Lei. "BIOCHEMICAL CHARACTERIZATION OF HUMAN MISMATCH RECOGNITION PROTEINS MUTSα AND MUTSβ." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/43.

Paripelly, Rammohan. "Molecular Level Interaction of Human Fibroblast Growth Factor-1 (hFGF-1) With Phloridzin." TopSCHOLAR®, 2013. http://digitalcommons.wku.edu/theses/1314.

Wallin, Olof. "Preanalytical errors in hospitals : implications for quality improvement of blood sample collection." Doctoral thesis, Umeå universitet, Institutionen för medicinsk biovetenskap, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1672.

Sayce, Andrew Cameron. "Iminosugars as dengue virus therapeutics : molecular mechanisms of action of a drug entering clinical trials." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:8d4da0ce-bfa6-447d-a280-630479f898af.

Wright, Sam Mathew. "Structural and biophysical studies of RNA-dependent RNA polymerases." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:d5c2a16d-e1e2-4c22-aca5-70f72aa96853.

Beer, Nicola L. "The role of genetic variation in glucokinase and glucokinase regulatory protein in diabetes and related traits." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:87f8ea0d-9528-49fd-8f01-5f976cf9f210.

Klinac, Dragana. "The evaluation of midazolam on head injured patients in the prehospital setting." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2008. https://ro.ecu.edu.au/theses/195.

Zhou, Gang. "PURIFICATION AND CHARACTERIZATION OF BLOOD ASPIRIN HYDROLASES." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1338916020.

Källebring, Tina. "THE EXPRESSION OF THROMBOMODULIN, TISSUE FACTOR, TISSUE FACTOR PATHWAY INHIBITOR AND ENDOTHELIAL PROTEIN C RECEPTOR IN NORMAL AND IUGR PLACENTA." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6156.

The aim of this study was to examine the expression of Thrombomodulin, Tissue Factor, Tissue Factor Pathway Inhibitor and Endothelial Protein C Receptor in placenta throughout the three phases of the third trimester in the normal placenta and in IUGR placenta from full term.

Twenty-five normal placenta samples and twenty-five IUGR placenta samples were obtained and each sample was stained by immunohistochemistry using monoclonal antibodies. Each antibody was optimised for antigen retrieval method and for optimal dilution, before been applied to the test tissue.

The results showed that each of the antibodies mentioned was expressed in normal placenta and in IUGR placenta.

No significant difference could be established concerning the expression of each antibody mentioned between normal and IUGR placenta.

Sukthankar, Pinakin Ramchandra. "Biophysical characterization of branched amphiphilic peptide capsules and their potential applications in radiotherapy." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/18174.

Gaentzsch, Ricarda E. G. "Establishment and maintenance of the DNA methylation pattern in the human alpha-globin cluster." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:fecf70d2-4845-4f42-b890-c163a1020eec.

Mai, Yvonne M. "Use of various health care providers and the associated clinical and humanistic outcomes in an ambulatory Medicare population." Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/265.

Pang, Chunyan. "REGULATION OF L-TYPE VOLTAGE-DEPENDNET CALCIUM CHANNELS BY THE REM GTPASE." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/656.

Lundin, Desiré. "Do the new signal transduction modulators have activity in vitro in tumor cells from ovarian carcinoma and lymphoma?" Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6158.

During the last decades, chemotherapy with cytotoxic drugs has played a significant role in cancer therapy. It’s important to develop new anticancer drugs, and drug sensitivity testing in vitro can be used to find the right diagnosis for the newly developed substances.

The aim of this study was to investigate the cytotoxic activity of the new signal transduction modulators bortezomib, gefitinib and PKC412. The well-established substances cisplatin, cytarabine, doxorubicin and vincristin were investigated for comparison.

The activity of the cytotoxic drugs was analysed in human tumor samples from patients with ovarian carcinoma (n=16) and lymphoma (n=15) by using the Fluorometric Microculture Cytotoxicity Assay (FMCA). The testing of cellular drug resistance by FMCA was accomplished successfully in 33 out of the 34 samples (97%).

The results of this study indicated that the activity of cytotoxic drugs in tumor cells obtained from patients with ovarian carcinoma and lymphoma may be detected by the FMCA. It also suggested that bortezomib and gefitinib could represent promising agents for treatment of ovarian carcinoma and that PKC412 might be of less use for patients with this diagnose.

He, Qinghao. "The Degradation of Pharmaceutical Pollutants in Wastewater Catalyzed by Chloroperoxidase and the Construction of Chloroperoxidase H105R Mutant." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2540.

Borg, Johanna. "Jämförelse av kemiinstrument och validering av referensintervall hos hund och katt." Thesis, Högskolan Kristianstad, Fakulteten för naturvetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-22058.

Sanvitale, Caroline E. "Investigation of kinase activation in fibrodysplasia ossificans progressiva." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:3ac802e9-a864-4a0d-8e13-f21bcffc957d.

Lee, Hyosung. "DEVELOPMENT OF NOVEL AHR ANTAGONISTS." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/103.

Whalen, Daniel M. "Structural and functional studies of the hedgehog signalling pathway." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:ce0e765c-04f1-4a64-a67b-89204ecaa155.

Cisek, Katryna. "Rational Optimization of Small Molecules for Alzheimer’s Disease Premortem Diagnosis." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338325484.

Chitranshi, Priyanka. "Interactions of small molecules with duplex DNA and lesion containing G-quadruplex DNA." Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/145.

Fierer, J. O. "Development of spontaneous isopeptide bond formation for ligation of peptide tags." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:833289ee-87cf-42f0-a66f-ca9ef9dd6420.

Lucca, Julie Ann. "ASSOCIATIONS BETWEEN ALCOHOL CONSUMPTION AND FASTING BLOOD GLUCOSE IN YOUNG ADULTS." DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/1057.

Buen, Zachary. "Establishment of gas-phase thermochemical values of various small organic compounds and oligopeptides." Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/262.

Mindemark, Mirja. "The Use of Laboratory Analyses in Sweden : Quality and Cost-Effectiveness in Test Utilization." Doctoral thesis, Uppsala universitet, Klinisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120554.

Williams, Jennifer Nicole. "Metal Containing Nucleosides that Function as Therapeutic and Diagnostic Agents Against Brain Cancer." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1409238775.

Lopez, Aguilar Aime. "Peptides as therapeutics." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:d893e962-5cb9-4d50-bbe1-c5183418295c.

O'Hara, Connor P. "Inhibition of Cancer Stem Cells by Glycosaminoglycan Mimetics." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5989.

Soler, Lecha Anna. "Desenvolupament de la gestió del risc al laboratori clínic. Aplicació al procés analític del Programa de Cribratge Neonatal de Catalunya." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/670019.

Söderberg, Johan. "Sources of preanalytical error in primary health care : implications for patient safety." Doctoral thesis, Umeå universitet, Klinisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-21256.

Fu, Josephine K. Y. "Functional characterization of the teleost multiple tissue (tmt) opsin family and their role in light detection." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:39bc18bb-16cb-4549-94cd-5f872daafe7e.

Chen, Bety. "Estudo dos polimorfismos das regiões hipervariáveis HV1 e HV2 do DNA mitocondrial da população brasileira aplicado à identificação humana." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-19032015-095415/.

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This is a research-based course. Students receive training in scientific laboratory skills and methods appropriate to the PhD project. 

Students undertake a specific research project of three to four years' duration and submit a thesis which is examined for the PhD. In principle, the research project can be in any area of interest to principal investigators based in the IMS-MRL. View the Principal Investigators page  on the IMS-MRL website for details. Between them, groups encompass skills in genetics, cell biology, cell signalling, neuroendocrinology, bioenergetics, human and animal physiology, as well as experimental medicine and clinical trials. 

Postgraduate students at the IMS-MRL are expected to attend regular weekly Hot Topics and Technical sessions, seminars by local, national and international speakers and are encouraged to attend appropriate training courses provided by the University Postgraduate School of Life Sciences to widen their experience further.

Our students receive expert training in state-of-the-art technologies, through our core research facilities and also have diverse opportunities to communicate their research findings and develop collaborative networks at, for example, the IMS-MRL research retreat and the Cambridge Metabolic Network .

Students also arrange a student symposium each year, which gives valuable experience in all aspects of organising a scientific meeting, including managing budgets, arranging catering, scheduling the day and marketing the event.

Students wishing to apply for a PhD in Clinical Biochemistry at the Cambridge Institute for Medical Research (CIMR), should investigate opportunities via the Study at CIMR page on the CIMR website.  

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By the end of the programme, candidates will have acquired excellent skills, experience and knowledge to undertake postdoctoral work (research and teaching) or another related profession.

Those who wish to progress to a PhD after completing an MPhil will be required to satisfy their potential supervisor, Head of Department and the Faculty Degree Committee that they have the skills and ability to achieve the higher degree.

The Postgraduate Virtual Open Day usually takes place at the end of October. It’s a great opportunity to ask questions to admissions staff and academics, explore the Colleges virtually, and to find out more about courses, the application process and funding opportunities. Visit the  Postgraduate Open Day  page for more details.

See further the  Postgraduate Admissions Events  pages for other events relating to Postgraduate study, including study fairs, visits and international events.

Key Information

3-4 years full-time, 4-7 years part-time, study mode : research, doctor of philosophy, department of clinical biochemistry, course - related enquiries, application - related enquiries, course on department website, dates and deadlines:, lent 2024 (closed).

Some courses can close early. See the Deadlines page for guidance on when to apply.

Easter 2024 (Closed)

Michaelmas 2024 (closed), easter 2025, funding deadlines.

These deadlines apply to applications for courses starting in Michaelmas 2024, Lent 2025 and Easter 2025.

Similar Courses

• Medical Science (Clinical Biochemistry) MPhil
• Basic and Translational Neuroscience MPhil
• Medical Genetics PhD
• Network of Life (Leverhulme Doctoral Scholarship Programme) PhD
• Medical Science (Medical Genetics) MPhil

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Home > Dissertations, Theses & Capstones Projects by Program > Biochemistry Dissertations

Biochemistry Dissertations

Dissertations from 2024 2024.

Comparative Animal Mucomics , Antonio R. Cerullo

Protein-Protein Interactions in Cell Cycle Proteins: An In silico Investigation of Two Important Players , Andriele Eichner

Development of Platinum(IV)-Gold(I)-Based Anticancer Agents , Javier E. Lopez-Hernandez

Evaluating the Reliability and Accuracy of Alchemical Binding Free Energy Methods and Calculations , Fnu Sheenam

Dissertations from 2023 2023

Structural Basis of Signal Transduction within Environmental Sensing PAS Regulated Ser/Thr Kinases , Roksana Azad

Establishing a Mouse Model of Glioblastoma (GBM) And Developing Strategies to Eliminate Cancer Cells. , Juliet N.E. Baidoo-Kanneh

Changes in the Epigenetic Landscape of Oligodendrocyte Progenitor Cells with Time , David K. Dansu

Characterization of the Conformational Binding of N-methyl Mesoporphyrin IX with DNA Model Telomeric G-Quadruplex Forming Sequences , Jessica Desamero

Improving Collagen-Mimetic Fibrils to Study Fibrillogenesis and Effects of Disease-Causing Mutations on Fibrillogenesis , Faizunnahar Dewan

Metabolic Reprogramming in KRAS-driven Cancer Cells , Ahmet Hatipoglu

Magnetically-driven Therapeutic Agents Delivery System using Iron Oxide Nanocages and Enhancement of Exosome Secretion, a Potential Biological Drug Delivery Carrier , Min A Kang

Leveraging Bio-Inspired Molecules for Cancer Theranostics , Douglas S. MacPherson

Engineered PLGA Nanofibers for Drug Delivery , Andrew Mancuso

Characterization of Pathological Tau Mutants , Charles J. McDonald

Leveraging Local Perturbations to Map Allosteric Networks of Phosphatases , Tamar (Skaist) Mehlman

The Development of Novel Radioimmunoconjugates for the PET Imaging and Radioimmunotherapy of Cancer , Samantha M. Sarrett

Singlet Oxygen-Mediated Conformational Flexibility, Antioxidant, and Isomerization Studies in Chemistry and Biochemistry , Oliver Turque

Characterization and Modulation of the Emergent Material Properties of Biomolecular Condensates , Alfredo Vidal Ceballos

Targeting HIF/Coregulator Complexes in Cancer: Characterizing Fragile Fold and Inhibitor Binding Sites of ARNT , Xingjian Xu

Dissertations from 2022 2022

Role of Metals in Human Immune System: Study of Metal-Dependent Structural Changes of S100A12 Protein , Aleksey Aleshintsev

Determining the Roles of the Oligomerization and C-terminal Domains in Mutant p53 Gain-of-Function Activities , George K. Annor

Histone Post-translational Modification Dysregulation Contributes to Toxicity in Amyotrophic Lateral Sclerosis Proteinopathy Models , Seth A. Bennett

Molecular Mechanism of Rapamycin Resistance in Cancer Cells , Sohag Chakraborty

Structural and Biochemical Investigations of the Initiation of DNA Replication in Bacteriophage Lambda and Escherichia coli , Jillian D. Chase

Biochemical and Biophysical Characterization of Replicative Helicase Loading by Vibrio cholerae DciA, Crystal Structure of a Monoclonal Antibody Bound to a C-Terminal Fragment of EBNA-1 from Epstein Barr Virus , Nicholas Gao

Mechanism of Activation and Regulation of BY-Kinases, a Unique Family of P-Loop Enzymes , Fatlum Hajredini

Paddling Along the Voltage Gated Sodium Channel Galaxy with Sea Anemone Toxins: Structural Studies of the Interaction between the Paddle Motif from Nav1.5DIV and Sea Anemone Toxin , Adel K. Hussein

Prenatal Choline Supplementation During Maternal Obesity Alters Offspring Response to Western Diets , Hunter W. Korsmo

Novel Therapeutic Strategies for Alzheimer’s Disease: Targeting Toll-Like Receptor Signaling and a Multi-Target Approach , Giovanni Oliveros

Water-based Lead Generation , Brian Olson

Cdc6 is Sequentially Regulated by PP2A-Cdc55, Cdc14, and Sic1 for Origin Licensing in S. cerevisiae , Jasmin Philip

An in silico Approach to Investigate the Structural and Biochemical Basis of the RNA Binding Functions of Nucleolin , Avdar San

Novel Therapeutic Strategies for Alzheimer’s Disease: Prostaglandin D2 Signaling and Its Human Polymorphisms as Well as a Polypharmacological Approach , Charles H. Wallace

Role of Nuclear Lamins in Oligodendrocyte Lineage Cells , Camila Yattah

Dissertations from 2021 2021

Using the Marcus Inverted Region and Artificial Cofactors to Create a Charge Separated State in De Novo Designed Proteins , Eskil ME Andersen

Mechanism of Action of Dihydropteridine Reductase , Gabriela Arias De la Rosa

Development and Maintenance of the Thymic Epithelial Microenvironment , Shami Chakrabarti

Machine Learning and Solvation Theory for Drug Discovery , Lieyang Chen

The C. neoformans Cell Wall: A Scaffold for Virulence , Christine Chrissian

Design, Synthesis and Evaluation of Molecules with Selective and Poly-Pharmacological Actions at D1R, D3R and Sigma Receptors , Pierpaolo Cordone

Don't Sell Them Short, There's More to Bacterial Natural Products Than Antibiotics , Alison Clare Domzalski

Dual Control of One Component Signaling: Mechanistic and Structural Insights Into EL222 Active States , Uthama Phani R. Edupuganti

Direct Recruitment of eIF4GI and/DAP5 to the 5' UTR of a Subset of Human mRNA Drives Their Cap-independent Translation , Solomon A. Haizel

The Structural and Functional Role of Photosensing in RGS-LOV Proteins , Zaynab Jaber

Oxydifficidin-Producing Bacillus Presents Novel Antimicrobial Activity Against Neisseria gonorrhoeae Involving the Deda Protein , Jingbo Kan

Synthesis and Evaluation of C-10 Nitrogenated Aporphine Alkaloids at Serotonin and Dopamine Receptors , Anupam Karki

Development of High-Throughput Methods for Screening Venom Peptides , Tanya Napolitano

Synthesis, characterization and applications of peptide-coated nanoparticles , Mina Sadat Poursharifi

Molecular Dynamics Simulations of Self-Assemblies in Nature and Nanotechnology , Phu Khanh Tang

Dissertations from 2020 2020

HuR Ubiquitination by BRCA1/BARD1 and Its Role in Controlling Gene Expression During DNA Damage Response , Gamage M. Aruggoda

Pointing the Zinc Finger on Protein Folding: Energetic Investigation into the Role of the Metal-Ion in the Metal-Induced Protein Folding of Zinc Finger Motifs , Inna Bakman-Sanchez

Transcription Initiation and Termination of Chemically Synthesized Small RNA Expression Vectors , Jose Cobo

Structural and Dynamic Features of a Transiently Assembled Complex between a Bacterial Tyrosine Kinase and Its Cognate Phosphatase , Imane Djemil

Oxytocin Receptor and MicroRNA-198/c-MET Signaling as Mechanisms of Chemoresistance in Pancreatic Cancer , Trisheena Harricharran

DNA Damage Recognition and UvrB Loading by UvrA within the Nucleotide Excision Repair Pathway , Silas Hartley

PARP1-Targeted Radiotherapies , Stephen Jannetti

Machine Learning Applications for Drug Repurposing , Hansaim Lim

Advanced Computational Methodologies to Study Binding Free Energies of Biomolecular Complexes , Rajat Kumar Pal

Mutational Analysis and Domain Characterization of the Apolipoprotein L-1 Ion Channel , Charles M. Schaub

Structural Studies of Peptide Toxins and Their Binding Properties Towards the Voltage Sensing Domain of Nav1.7 , Ryan Schroder

Development of Ligand Guided Selection (LIGS) to Identify Specific DNA Aptamers Against Cell Surface Proteins , Hasan Ekrem Zumrut

Dissertations from 2019 2019

CK2 Negatively Regulates 5-HT4 Receptor Signaling in the Prefrontal Cortex and Mediates Depression-like Behaviors , Julia Castello Saval

The Determining Factors of the Self-Assembly of Collagen Mimetic Peptide , Fangfang Chen

Characterization of Immunomodulatory Microbial Factors in Medicinal Plants , Kriti Kalpana

Developing a Dissociative Nanocontainer for Peptide Drug Delivery , Michael Patrick Kelly

Minimalistic Peptide-Based Supramolecular Systems Relevant to the Chemical Origin of Life , Daniela Kroiss

Structural Studies on Calcium/calmodulin-dependent Activation of Eukaryotic Elongation Factor 2 Kinase , Kwangwoon Lee

Molecular Dynamics Simulations of Supramolecular Assemblies in Biology and Bionanotechnology , Anjela Manandhar

Green Tea Extract, Epigallocatechin Gallate, Protect Against Methamphetamine-Induced Striatal Neurotoxicity in Mice , Allen L. Pan

Solvation Thermodynamic Mapping in Computer Aided Drug Design , Steven Ramsey

Renal Specific RNAi Delivery by Fibrillar Nanoparticle Excipients , Sam Wong

Dissertations from 2018 2018

Functional Interactions of tau, Pin1, p53 and mRNA 3′ Processing Factors in Non-Neuronal Cells , Jorge E. Baquero

Phospholipase D-Dependent mTORC1 Activation by Glutamine , Elyssa Bernfeld

Information Content, Charge Transport Properties, and Computational Capacities of Proteins , Joseph Murphy Brisendine Jr.

Mechanisms Adopted by Dengue-2 Viruses to Induce Autophagy in Mammalian Cells , Sounak Ghosh Roy

Evidence for Organelle-Like Extracellular Vesicles from a Parasite of Drosophila and Their Function in Suppressing Host Immunity , Mary Heavner

Binding of Maize Necrotic Streak Virus (MNeSV) 3’ I-Shaped Structure (3’ ISS) to Eukaryotic Translation Factors (eIFs) and Implication in eIF4F Mediated Translation Initiation , Qiao Liu

Bacterial LPS at the Immune Modulating Component in Juzen-taiho-to , Diego Montenegro

Strategies Involving the Food-Derived Agent Curcumin to Eliminate Brain Cancer , Sumit Mukherjee

Mechanisms for Survival and Drug Resistance in Cancer Cells , Matthew B. Utter

Towards an Atomic Level Model of the Structure and Calmodulin Mediated Activation of eEF-2K , Nathan E. Will

Dissertations from 2017 2017

Chloride and Proton Binding in the E. coli 2Cl¯:1H+ CLC Exchanger , Catherine Chenal

Regulation of the Amyloid Precursor Protein by Prostaglandin J2, A Mediator of Inflammation: Relevance to Alzheimer’s Disease , Teneka L. Jean-Louis

Potential Modifications to Enzyme Replacement Therapy in Anderson-Fabry Disease , Mariam Meghdari

Lipid Sensing by Mammalian Target of Rapamycin , Deepak Menon

Pharmacological Antagonism and the Olfactory Code , Mihwa Na

Structural and Biochemical Studies of the DNA Replication Initiation Mechanism of the Second Chromosome of Vibrio cholerae , Natalia Orlova

Therapeutic Exploitation of Metabolic Checkpoints In Cancer Cells , Deven S. Patel

Mutagenesis of Human Alpha-Galactosidase A for the Treatment of Fabry Disease , Erin Stokes

Insight into the Interaction Between the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Adipocyte Fatty Acid-Binding Protein (A-FABP) , Qian Wang

Dissertations from 2016 2016

Role of BEC-1/Beclin 1 and Autophagy Genes in C.elegans Germline Cell Proliferation , Kristina Ames

Tuning into Toxins and Channels: The Characterizations of Tv1 and a Human Cardiac Sodium Channel Voltage-Sensor Domain , Mohammed H. Bhuiyan

Metabolic Profiling of Genetically Modified Potato Periderm Tissues , Liqing Jin

Therapeutic Targets for Alzheimer's Disease: Insights from In Vitro and In Vivo Models of Inflammation , Magdalena J. Kiprowska

Circular Oligodeoxynucleotides (Coligos) as Chemically Synthesized, Promoter-Independent Small RNA Expression Vectors , Lodoe Lama

Role of hnRNP A1 in the Regulation of HDM2 Gene Expression , Heriberto Moran

The Interaction Between Eukaryotic Translation Initiation Factor eIF4G and 3’ Cap Independent Translation Element of Barley Yellow Dwarf Virus Is Affected by Multiple Initiation Factors , Pei Zhao

Messenger RNA Transport and Translation Regulated by the 3' UTRs of Dendritic mRNAs and Abnormal Alternative Splicing of Neuroligin1 in the Fmr1 KO Mouse Hippocampus , Tianhui Zhu

Dissertations from 2015 2015

The Role of ATP and Cleavage Factor Phosphorylation in pre-mRNA 3' Cleavage Reaction , Asya Khleborodova

Characterizing Migratory Signaling Pathways Of Transplantable Retinal Progenitor Cells And Photoreceptor Precursor Cells Toward Restoration Of Degenerative Retina ' A Systems Biology Approach , Uchenna John Unachukwu

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Biochemistry & Molecular Biology Department Theses and Dissertations

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clinical biochemistry

The book deals with analytical biochemical tests and consequences for these topics,it deals with all analytical methods and cklinical as[pects,procedures and stastical analysis

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Ph.D. Thesis Proposal

Procedures and policy guidelines, a. procedures.

The Graduate Advisory Committee (GAC) evaluates all Ph.D. Thesis Proposals. The GAC consists of at least seven (7) faculty members of the Department, and of one graduate student representative. Current GAC faculty members can be found online*.

• Graduate students must present their Thesis Proposals in the 5th or the 6th semester of their graduate studies.
• The Graduate Advisory Committee convenes twice a year to evaluate proposals (Fall and Spring).
• Proposals are usually scheduled near the end of semesters (December, May).

Before the Examination

• Graduate students must have passed (overall satisfactory) their yearly presentation in front of a Research Advisory Committee (RAC), with the more recent RAC no more than 6 months.
• Permission to present a Ph.D. Thesis Proposal is required and should be clearly stated in the most recent RAC report.
• The title of the Ph.D. Thesis Proposal must be submitted at least five (5) weeks in advance of the examination to Christine Laberge ( Christine.laberge [at] mcgill.ca ).
• The complete written Ph.D. Thesis Proposal must be submitted at least three (3) weeks in advance to Christine Laberge.
• The written proposal must be prepared and formatted as described in Appendix A  below.
• The student must prepare a twenty (20) minute oral presentation of their Ph.D. The presentation should not be longer than 20 minutes. Thesis Proposal (PowerPoint or the like) as instructed in Appendix B below.

Thesis Proposal Examination

• Examinations are done in person and should take no more than 1 hour. This is usually conducted in room 908 of the Biochemistry Department.
• Before the start of the examination, the GAC will meet without the student to review the student’s progress (RAC reports, course performances, Junior Seminar evaluation), flag any areas of concern, and discuss the written Ph.D. Thesis Proposal.
• The student will deliver a 20-minute oral presentation of their Ph.D. Thesis Proposal. The overall question period should last no longer than approximately 40 minutes.
• The meeting outcome (satisfactory, conditional, or unsatisfactory)
• Identify any areas of concern and corrective actions
• Determine any other advice to be provided to the students
• Based on the outcome, set the date of the next meeting if necessary
• The GAC Chair will summarize the examination outcome in a letter to be submitted to the graduate student and supervisor.
• Graduate students must register to the BIOC702 (Ph.D. Thesis Proposal) course.

B.  Policy on Ph.D. Thesis Proposal Procedure and Outcome

The Ph.D. Thesis Proposal examination consists of the following three (3) components:

• The written Thesis Proposal . The written proposal must be prepared and formatted as per Appendix A. Incomplete or poorly written proposals will impact the GAC’s decision and examination outcome. Failure to submit the written proposal in due time may also impact the student’s status in the program.
• The oral presentation . The oral presentation should summarize the content of the written document and be prepared as outlined in Appendix B. The student should be able to defend their Thesis Proposal based on the presentation. Presentations that are poorly prepared or that last longer than 20 minutes will impact the GAC’s decision and examination outcome.
• Answers during the question period . General competence will be assessed in the question period. Students must be able to discuss and explain presented experiments and provide details as needed. They must be able to elaborate beyond what is shown in the presentation (e.g. provide alternative questions, experiments, analyses, interpretations). They must demonstrate some general knowledge outside of their immediate research by answering connected and general questions in their research fields. Failure to demonstrate competence could impact the GAC’s decision and examination outcome.

Each component of the exam will be rated as Satisfactory , Conditional , or Unsatisfactory . The overall outcome of the Ph.D. Thesis Proposal is determined as follows:

Satisfactory

When all 3 components are rated as Satisfactory, the student will be deemed to have completed all three components and will receive a “PASS” grade on the BIOC702 course (Ph.D. thesis Proposal). The next meeting will be with a RAC at their yearly presentation.

Conditional

If one or more of the components is rated as less than Satisfactory and no more than one component is Unsatisfactory , the student will be graded as “CONDITIONAL”. In the letter submitted to the student and supervisor following the examination, the GAC will impose one or more condition and a timeline for the student to fulfill them (normally no more than 3 months). If the student fulfills the conditions set by the GAC, the student will be awarded a “ Satisfactory ”, be given a “PASS” for BIOC702, and be granted permission to continue in the program. If not, the meeting outcome will be deemed “ Unsatisfactory ”, and the procedures outlined in the following section will be followed.

Unsatisfactory

When two (2) or more components of the exam are rated as Unsatisfactory, the overall meeting outcome will be graded as “UNSATISFACTORY”. In keeping with GPS regulations**, the following consequences will result:

In the case where a student is unsuccessful at the first attempt of the exam:

• A grade of “HH – to be continued” will be recorded for BIOC702
• The student will be required to repeat the entire exam at a time determined by the GAC. As per GPS regulations, this meeting must occur not sooner than 4 months and not later than 6 months after the first meeting.
• A student who is successful in the second attempt will be deemed to have passed the exam, and will be given a “PASS” for BIOC702.

In the case where a student is unsuccessful at the second attempt of the exam:

• The student will be deemed to have failed the Ph.D. Thesis Proposal.
• A grade of “FAIL” will be entered for BIOC702 replacing the previously recorded HH. The student will be required to withdraw from the program.

Preparing and formatting the written Ph.D. Thesis Proposal

The written Ph.D. Thesis Proposal should be prepared with the oral presentation in mind. This document should properly introduce the project, justify its importance, describe your research progress to date, and propose future experiments that will overall represent an important contribution to research. The Ph.D. Thesis Proposal should feature substantial preliminary experimental work and propose future experiments . The proposed experiments should be well thought of and feasible.

• Approximately and not more than 5 pages single spaced including figures.
• Figures should be inserted in line with the text, be legible, and not exceed 1 page of total space.
• References are not included in the document’s 5 page maximum.
• The main text should provide the following:
• Central hypothesis
• Specific Aims: these could represent your proposed thesis chapters. Three (3) proposed results Chapters is common but not required. In each of your Aims, specify the short and long term objectives.
• Significance
• You can include extra pages reporting additional work that does not fit in the main Thesis Proposal. This is optional and should be clearly marked as an Appendix.
• Document must be letter size (21.25 x 27.5 cm / 8.5 x 11 inches).
• In the header on the left, indicate your name (the lab you are in).
• In the header on the right, indicate the section title (Ph.D. Thesis Proposal)
• In the footer, include the page number (center) and date (right)
• A minimum margin of 2 cm all around the page is mandatory.
• Use a font size of 12 point. Single line spacing. No condensed type or spacing.
• Each section of your document should be properly separated (e.g. skip a line between sections, use bold font for section titles, etc.)
• Figures must have legends.

As per GPS ruling:

“The work submitted for this assessment is expected to be your own. The use of technologies such as ChatGPT are prohibited and will be considered a violation of the Code of Student Conduct.”

Preparing the Ph.D. Thesis Proposal presentation

The Ph.D. Thesis Proposal presentation should summarize the written proposal. It should contain everything needed to explain and defend the project and proposed experiments. With the presentation, you should be able to convince the Examiners that the Proposal is Satisfactory . Importantly , the Ph.D. Thesis Proposal is not merely a progress report: it should also clearly propose future experiments.

Your oral presentation should last approximately 20 minutes and not more. You can choose to have questions during your presentation or only after. The question period should last no more than 40 minutes.

The presentation should:

• Properly introduce the research question and project .
• Clearly state the main hypothesis, Aims and proposed experiments.
• Include substantial preliminary experimental work. You must clearly specify who did the presented experiments. Acknowledge the contribution of others where relevant. This includes figures or data published elsewhere, which must be accompanied by a citation.
• Clearly outline future directions and propose new experiments.

Evaluation criteria

• Quality and clarity of the presentation and it’s delivery.
• Quality of responses to questions about the design, background, and potential of the project. This includes experiments already performed and those suggested as future directions.
• Quality of responses to general background questions about biochemistry and molecular biology.
• Response to criticism raised during the Research Seminar 1 (Junior) examination.
• Feasibility of the proposed experiments.

Important note

• It is the responsibility of the student to inform themselves of the Ph.D. Thesis Proposal Procedures, Policy and deadlines. Failure to comply can lead to expulsion from the program, unless strong justification is provided and confirmed in writing by the Supervisor.
• The methods adopted for examination and evaluation are specified by Departmental regulations and are in agreement with the Graduate Studies guidelines approved by the Dean of Graduate and Postdoctoral Studies, McGill University.

Quick Guidelines

Before the examination:.

• Title of the proposal submitted five weeks in advance to Christine Laberge
• Complete written proposal submitted three weeks in advance to Christine Laberge
• Up to five pages single spaced
• Describe research progress to date, and proposed (future) research for the Ph.D. thesis
• Optional extra page indicating additional work not in the main proposal may be added and must be clearly marked
• Present the background, rationale, central hypothesis, specific aims and significance
• Include short and long term objectives
• Three proposed results chapters is common but not required
• Must include substantial preliminary experimental work

Thesis Proposal Examination:

• 20 minute presentation to GAC, 40 minute discussion
• Presentation summarizes the written proposal
• Questions about the design, background and potential of the project
• Questions about general background knowledge of biochemistry and molecular biology

Evaluation Criteria:

• Presentation, background knowledge and insight into the proposed research
• Knowledge in related areas of biochemistry
• Response to criticisms raised during the Research Seminar 1
• Feasibility of the proposed experiments

Revised: April 2023

*    Graduate Advisory Committee Members (GAC)

**  Graduate Student Supervision

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