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Essay on Nutrition

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100 Words Essay on Nutrition

What is nutrition.

Nutrition is the science that interprets the nutrients and other substances in food in relation to maintenance, growth, reproduction, health, and disease of an organism.

Nutrients are substances that our bodies require to function. They include proteins, carbohydrates, fats, vitamins, and minerals.

Importance of Nutrition

Good nutrition is crucial for good health. It helps in maintaining a healthy weight, reducing the risk of chronic diseases, and promoting overall health.

Healthy Eating

Healthy eating means having a balanced diet that includes a variety of different foods in the right proportions.

Nutrition and Growth

Proper nutrition is especially important for children as it supports the rapid growth and development that occurs during childhood.

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250 Words Essay on Nutrition

Introduction to nutrition.

Nutrition is a fundamental pillar of human health, affecting every aspect of our physical and mental wellbeing. It involves the study of nutrients and how they are absorbed, metabolized, stored, and utilized by the body.

The Importance of Balanced Nutrition

Balanced nutrition is critical for maintaining health, supporting bodily functions, and preventing diseases. It involves consuming a variety of foods in the right proportions, including carbohydrates, proteins, fats, vitamins, and minerals. Each of these nutrients plays a unique role within the body, contributing to growth, repair, energy provision, and the maintenance of essential bodily functions.

Nutrition and Disease Prevention

Poor nutrition can lead to a host of health problems, including obesity, heart disease, diabetes, and certain types of cancer. Conversely, a healthy diet rich in fruits, vegetables, lean proteins, and whole grains can help protect against these diseases. Nutritional science is increasingly highlighting the role of diet in preventing and managing chronic diseases.

Future of Nutrition

The future of nutrition is likely to be characterized by personalized dietary recommendations based on genetics, gut microbiome composition, and lifestyle factors. This approach, known as precision nutrition, aims to optimize health outcomes by tailoring dietary advice to individual needs and circumstances.

In conclusion, nutrition is a vital aspect of health and wellbeing. It not only fuels our bodies but also has a profound impact on disease prevention and management. As our understanding of nutrition evolves, so too will our approach to promoting health and preventing disease.

500 Words Essay on Nutrition

Nutrition is a fundamental pillar of human life that significantly influences health and well-being. It encompasses the intake of food, absorption, assimilation, biosynthesis, catabolism, and excretion. The study of nutrition provides insights into the intricate relationships between dietary habits, health, and disease.

The Role of Nutrients

Nutrients are the substances obtained from food that are vital for growth, development, and maintaining good health. They are divided into macronutrients and micronutrients. Macronutrients include carbohydrates, proteins, and fats, which are needed in large amounts. They provide energy and are essential for growth and repair. Micronutrients, including vitamins and minerals, are required in smaller quantities but are crucial for proper functioning of the body.

Importance of Balanced Nutrition

A balanced diet is one that provides all the necessary nutrients in the right proportions. It is crucial for a robust immune system, energy production, growth and development, and prevention of diseases. Poor nutrition can lead to malnutrition, obesity, cardiovascular disease, diabetes, and other chronic diseases.

Nutrition and Metabolism

Nutrition plays a pivotal role in metabolism, the biochemical process by which the body converts food into energy. The body’s metabolic rate is influenced by factors such as age, gender, physical activity, and nutritional status. A balanced diet provides the necessary fuel for metabolic functions and helps maintain an optimal metabolic rate.

Impact of Nutrition on Mental Health

Emerging research suggests a strong link between nutrition and mental health. A diet rich in fruits, vegetables, whole grains, and lean protein can contribute to good mental health. Conversely, a diet high in processed foods and sugars is associated with a higher risk of depression and anxiety.

Nutrition in Disease Prevention

Nutrition is a key factor in the prevention and management of various diseases. For instance, a diet high in saturated fats and low in fiber is associated with an increased risk of heart disease. On the other hand, a diet rich in fruits, vegetables, lean proteins, and whole grains can help prevent chronic diseases such as diabetes and cancer.

In conclusion, nutrition is a multidimensional field that intersects with many areas of health and well-being. It is an indispensable part of a healthy lifestyle, and its importance cannot be overstated. To ensure optimal health, it is crucial to understand the role of nutrition and make informed dietary choices.

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The Importance of Nutrition and Its Analysis

Categories: Health Promotion

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Introduction, the importance of nutrition.

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Yale J Biol Med
v.91(2); 2018 Jun

Focus: Nutrition and Food Science

Importance of nutrients and nutrient metabolism on human health, yiheng chen.

a School of Human Nutrition, McGill University, Ste. Anne de Bellevue, QC, Canada

Marek Michalak

b Department of Biochemistry, University of Alberta, Edmonton, AB, Canada

Luis B. Agellon

Nutrition transition, which includes a change from consumption of traditional to modern diets that feature high-energy density and low nutrient diversity, is associated with acquired metabolic syndromes. The human diet is comprised of diverse components which include both nutrients, supplying the raw materials that drive multiple metabolic processes in every cell of the body, and non-nutrients. These components and their metabolites can also regulate gene expression and cellular function via a variety of mechanisms. Some of these components are beneficial while others have toxic effects. Studies have found that persistent disturbance of nutrient metabolism and/or energy homeostasis, caused by either nutrient deficiency or excess, induces cellular stress leading to metabolic dysregulation and tissue damage, and eventually to development of acquired metabolic syndromes. It is now evident that metabolism is influenced by extrinsic factors ( e.g. , food, xenobiotics, environment), intrinsic factors ( e.g. , sex, age, gene variations) as well as host/microbiota interaction, that together modify the risk for developing various acquired metabolic diseases. It is also becoming apparent that intake of diets with low-energy density but high in nutrient diversity may be the key to promoting and maintaining optimal health.

Introduction

Over the last several decades, many jurisdictions around the world have witnessed the increasing prevalence of acquired metabolic syndromes, in particular obesity, diabetes, fatty liver disease and cardiovascular diseases [ 1 - 4 ]. In recent years, the upward trend is especially striking in developing countries where changes in diets and lifestyle accompany modernization [ 1 , 5 ]. To counter the increasing public health complications caused by changing nutrition practices, health organizations have provided dietary recommendations [ 6 ]. Whereas past interventions designed to address cases of single nutrient deficiencies have achieved clear indicators of success [ 7 ], intervention trials that target a single class of nutrients to manage the emergence of metabolic diseases in the general population have not produced definitive results [ 8 , 9 ]. It is increasingly being realized that comprehensive analysis of what is being consumed together with the eating pattern, rather than focusing on single nutrients, may be more informative in formulating effective dietary recommendations.

Recent advances in high-throughput analysis have assisted in a better understanding of metabolism and revealed the active role of nutrients and their metabolites in regulating gene expression and cellular function. Nutrients and their metabolites not only serve as building blocks of cellular structures and as fuel sources, but also serve as direct modifiers of protein function, potent signaling molecules as well as inducers and repressors of gene expression. Many of them participate in regulating gene expression by directly modulating the activities of transcription factors and by moderating the changes in epigenetic markings in the genome. One view that is emerging is that optimal cellular homeostasis is crucial for maintaining health and avoiding diseases caused by nutrient deficiency or excess. In addition, intrinsic factors ( e.g. , sex, age, gene variations), extrinsic factors ( e.g. , food, xenobiotics, environment) as well as host/microbiota interaction can influence the assimilation, transformation, and action of both nutrients and non-nutrient components of food. This review considers the importance of nutrient diversity and energy density on cellular metabolism in health and disease ( Figure 1 ).

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Factors that influence human health . A . Relationship of nutrient diversity (ND) and energy density (ED) in equivalent portion sizes, and their impact on cellular metabolism. B . Extrinsic factors ( e.g. , food, xenobiotics, environment), intrinsic factors ( e.g. , sex, gene variations, age), and host-microbiota interaction work together to modulate gene expression program, biological processes, and nutrient and energy metabolism.

Quality of Nutrition

Single nutrient interventions such as fortification of milk with vitamin D, cereal with iron, and table salt with iodine were effective in treating the corresponding nutrient deficiencies [ 10 ]. However, when applied to acquired metabolic syndromes that prevail in modern societies, the same approach has yielded inconclusive results [ 11 , 12 ]. For example, decreasing dietary intakes of saturated fatty acid or cholesterol, and increasing the intake of omega-3 polyunsaturated fatty acids do not appear to be effective in reducing the risk of cardiovascular diseases [ 9 , 13 , 14 ]. The importance of the entire diet that is consumed as a regular practice is being recognized, and an increasing number of studies are analyzing dietary pattern to identify possible causes of under- and over-nutrition. By definition, dietary pattern characterizes the overall diet by the quantities, the proportion, and the variety of foods and beverage as well as the frequency of consumption [ 15 ]. The Mediterranean pattern and Western-style pattern are two commonly practiced dietary patterns. The Mediterranean diet contains a high proportion of fruits and vegetables, legumes, whole grains, fish, and poultry with an emphasis on monounsaturated fats and antioxidants, whereas the Western-style diet is generally characterized by energy-dense foods like butter, high-fat dairy products, refined grains, as well as processed and red meat, leaving less space for other nutrients especially those coming from fruits and vegetables. Epidemiological studies have found that the Mediterranean dietary pattern has preventive and protective effects against cardiovascular diseases [ 16 , 17 ], whereas the Western-style dietary pattern is positively associated with dyslipidemia, obesity, hypertension, atherosclerosis, and diabetes [ 18 , 19 ].

Nutrition transition refers to the shift of diet from traditional to modern along with an increase in sedentary behavior, that occur in conjunction with modernization. The concept of nutrition transition was initially proposed by Popkin [ 20 , 21 ] to demonstrate how economic, demographic, and epidemiological changes interact with shifts in dietary consumption and energy expenditure. Interestingly, some countries in East Asia have lower prevalence of certain acquired metabolic syndromes compared to other societies at comparable stages of nutrition transition [ 2 , 5 , 22 ]. This might be partially due to retention of traditional dietary patterns, which promote consumption of foods with a wider array of nutrients and lower energy density [ 23 - 25 ]. However, the reasons underlying the discrepancy are complex, and extend beyond the chemical composition of food to include social and economic issues. Nevertheless, there is evidence supporting the idea that calorie restriction is beneficial for longevity [ 26 - 28 ], providing support for the potential benefit of low-energy density diets ( Figure 1 A).

The prevailing global increase in the development of acquired metabolic syndromes is associated with nutrition transition [ 29 , 30 ]. One proposed concept that potentially explains the pathogenesis of these syndromes stems from persistent modification of cellular function in response to stress in the endoplasmic reticulum, mitochondria, and other organelles that make up the cellular reticular network [ 31 ]. Both nutrient deficiency (undernutrition) and nutrient excess (over-nutrition) cause the loss of nutrient/energy homeostasis and thus trigger cellular stress. Coping response mechanisms, such as the unfolded protein response mechanism [ 31 - 33 ], are activated to resolve stress. In the case of a maladaptive response, programmed cell death is activated to remove malfunctioning cells. On the other hand, persistent adjustment of cellular functions enables cells to cope even with continued exposure to stress inducers. Stress coping response mechanisms initially promote adaptive strategies to recover homeostasis in the short term but become pathogenic in the long term due to long-term modification of cellular functions.

Food Components

Food is a complex combination of numerous components which can be classified into nutrients and non-nutrients. Nutrients have been traditionally classified as macronutrients and micronutrients. Plants and animals do not have identical nutrient requirements and produce nutrient metabolites that may not be common to each other. Micronutrients, which include vitamins and minerals, are needed in only small amounts, and are required for the proper function of important proteins and enzymes. Macronutrients, which include carbohydrates, proteins, and fats, are typically needed in large amounts. The benefits of consuming macronutrients are self-evident since their subunits serve as building blocks of cellular structures and as energy substrates in all organisms. Some species are unable to synthesize key metabolites needed for survival, and thus must obtain these from other species. These essential metabolites, along with minerals, make up a class of substances referred to as essential nutrients. Non-nutrient components of food are those that cannot be categorized as either macronutrients or micronutrients. These substances include both natural and synthetic compounds. They can be beneficial ( e.g. fiber, and some polyphenolic compounds produced by plants), non-beneficial ( e.g. many food additives, and preservatives) or even toxic ( e.g. xenobiotics, and antibiotics, also some plant-derived polyphenolic compounds) [ 34 , 35 ]. It has become evident that both nutrients and non-nutrients, as well as their metabolites, have the capacity to modulate gene expression, protein function and epigenome [ 36 - 38 ].

The potential of macronutrients and their metabolites to regulate metabolic function is typically taken for granted. For example, the monosaccharide fructose is commonly used as a sweetener in commercially prepared foods and is present in these foods at exceedingly high amounts compared to natural foods [ 39 ]. Fructose is known to stimulate de novo lipid synthesis in the liver and to induce endoplasmic reticulum stress in many cell types [ 40 , 41 ]. In general, excess glucose and fructose induce cellular stress which leads to the development of insulin resistance and fatty liver disease [ 40 , 42 , 43 ]. Certain amino acids have been shown to act as signaling molecules to regulate cellular growth and proliferation via mTOR (mechanistic target of rapamycin) [ 44 , 45 ], whose function has been implicated in many human diseases [ 46 ]. Some fatty acids from fats and oils serve as ligands for G protein-coupled receptors as well as for transcription factors belonging to the nuclear receptor family of transcription factors [ 47 , 48 ], and therefore regulate cellular processes and gene expression [ 49 ]. Saturated fatty acids have long been the focus of investigation as high intake of saturated fats was considered to be a risk factor for cardiovascular diseases [ 50 ], however subsequent studies have not provided strong evidence for causality [ 9 ]. This may be partly attributable to the wide range of biological activities associated with different fatty acids species [ 51 ]. Palmitic acid, a fatty acid species that is enriched in the Western-style diet, is a potent inducer of endoplasmic reticulum stress whereas oleic acid, a fatty acid prominent in the Mediterranean diet, has been shown to inhibit endoplasmic reticulum stress [ 52 , 53 ]. Importantly, the surplus of nutrients and energy induce endoplasmic reticulum stress and inflammatory responses that lead to systemic metabolic dysregulation [ 31 , 32 ].

Many metabolic diseases caused by micronutrient deficiencies can be corrected by restoring the missing micronutrients in the diet [ 54 , 55 ]. One critical aspect of micronutrient supplementation applied to the general population is overdose. Some of these compounds are potent modulators of nuclear receptors and have serious impacts on the activities of multiple metabolic pathways. For example, deficiency of vitamin A can lead to blindness while its excess is teratogenic. Vitamin D also modulates the expression of many genes that participate in many pathways [ 56 ], and its deficiency causes rickets. However, it is not yet known if it is possible to overdose with this micronutrient. Excessive dietary intake of minerals can be equally deleterious, as exemplified by diet-induced hypertension due to high intake of sodium [ 57 ].

Other metabolites produced by the mammalian metabolic machinery also play critical roles in metabolism. For example, cholesterol serves as a membrane component, signaling molecule, and precursor for the synthesis of steroid hormones and bile acids [ 58 ]. Bile acids aid in the absorption of dietary fats and lipid-soluble compounds, and also act as signaling molecules modulating macronutrient and energy metabolism, inflammatory responses, and detoxification through intracellular ligand-activated nuclear receptors [ 59 ]. Gut bacteria are capable of metabolizing bile acids and one of the products is a secondary bile acid referred to as ursodeoxycholic acid. It is of interest to note that this bile acid and its taurine-conjugated derivative can alleviate endoplasmic reticulum stress by promoting proteostasis [ 60 ], and has been shown to be effective in preventing cardiac fibrosis [ 61 , 62 ].

The non-nutrient components of food can be beneficial or non-beneficial. Beneficial ones include fiber and certain types of plant polyphenolic compounds. Dietary fiber, derived from plant-based foods, is not an effective nutrient for humans, but serves as a nutrient for gut microflora. Some of the products generated from dietary fiber include short chain fatty acids ( e.g. , butyric and propionic acids) that are absorbed in the lower gut and serve as both energy substrates and regulators of host metabolism [ 63 , 64 ]. Plant polyphenolic compounds have been popularized as anti-oxidants. However, there are numerous polyphenolic compounds present in plants, and these compounds likely have a wide range of biological activities and effects on human metabolism [ 65 , 66 ]. A polyphenolic-rich extract prepared from potatoes exhibits beneficial activity by attenuating weight gain in mice fed with obesity-inducing high fat diet [ 67 ]. There is also emerging evidence for the modulating effect of polyphenols on the composition and metabolic activity of gut microbiota that provides potential benefits to the host [ 68 ]. Not all polyphenolic compounds are beneficial, as some compounds such as caffeic acid and genistein may be carcinogenic or genotoxic at high dosage [ 34 , 69 , 70 ]. It is commonly assumed that synthetic food additives (colorants, preservatives, sweeteners) do not have effects on metabolism, but this assumption should be tested regularly to ensure food safety. Other xenobiotics ( e.g. pollutants, drugs, and agricultural chemicals) that find their way into the food supply can influence human health directly, by disrupting normal metabolic processes, or indirectly, by influencing the composition of the gut microbiota [ 71 ]. All food components likely work together to drive metabolic processes in every cell of the body.

Factors that Influence Human Nutrition

It is now evident that both extrinsic factors (such as food, xenobiotics, environment) and intrinsic factors (such as sex, age, gene variations), separately and cooperatively, influence nutrient metabolism and the risk for developing various metabolic diseases ( Figure 1 B). Extrinsic factors are important in dictating the efficiency of nutrient metabolism and health outcomes, including physical cues such as photoperiod and temperature. For example, the alternating light/dark photoperiod of the day-night cycles is important in setting endogenous circadian rhythms, which in turn are intimately linked to the regulation of metabolic activity [ 72 ]. Detrimental environments, which include situations that induce the release of stress hormones, can impair the ability of the body to sense and respond to metabolic challenges [ 73 - 75 ]. Extrinsic factors also promote alterations of the epigenome which can have long-lasting impacts on nutrient and energy metabolism and contribute to the development of metabolic disorders in organs like the heart ( e.g. coronary heart disease) and the brain ( e.g. , Alzheimer’s disease) [ 76 - 78 ].

Similarly, intrinsic factors such as gene variations, sex, and age, influence the efficiency of nutrient metabolism ( Figure 1 B). Genetic variations impact on the efficacy of metabolic pathways by affecting the function and specific activities of membrane transporters, receptors, signaling proteins, enzymes, carrier proteins, transcription factors, and other proteins involved in the transport, sensing and processing of specific nutrients [ 79 ]. For example, single nucleotide polymorphisms in genes encoding taste receptors influence food preferences [ 80 ]. Variations in NPC1L1 cholesterol transporter influence dietary cholesterol absorption [ 81 , 82 ]. Sex and aging determine the biological context and represent important modifiers of metabolic efficiency. Males and females have distinct features in terms of metabolic profiles, gene expression programs, and susceptibility to diseases [ 83 - 87 ]. Aging is associated with the loss of metabolic efficiency caused by deterioration of cellular and genetic components resulting from chemical damage accumulated through life stages. At the cellular level, aging is associated with gradual changes in cellular processes designed to maintain homeostasis. However, these adaptive changes that alter cellular metabolism may contribute towards the loss of metabolic efficiency at the organismal level [ 31 ]. Remodeling of the epigenome through life stages may also influence disease susceptibility in elderly individuals [ 37 ].

The gut microbiota represents an important interaction nexus for extrinsic and intrinsic factors that influence the metabolism of nutrients ( Figure 1 ). This enormous ecosystem has gained increased attention in recent years for its role in health and disease. Due to its location, the gut microbiota is exposed not only to the same extrinsic factors experienced by the host but also the metabolites and products produced by the host, such as bile acids, digestive enzymes, and other substances excreted into the gut. Males and females have distinct microbiomes, as do young and old individuals [ 62 , 88 , 89 ]. Recent studies show that the composition of the gut microbiota can have dramatic effects on the phenotype of the host. For example, transplantation of fecal microbiota from a twin pair discordant for obesity into germ-free mice reproduces the obese/lean phenotypes of the donors in their respective recipients [ 90 ]. Gut microbiota taken from children suffering from kwashiorkor can induce significant weight loss when transplanted into germ-free recipient mice [ 91 ]. Moreover, the gut microbiota may be capable of altering the susceptibility of its host to metabolic diseases, by transforming non-nutrient components of food into useful nutrients for the host. Short-chain fatty acids produced from breakdown of dietary fibers can influence the expression of genes involved in proliferation and differentiation of mammalian colonic epithelial cells. They also serve as energy substrate elsewhere in the host [ 63 , 92 ]. Other non-nutrient components of food, such as artificial sweeteners which are deemed safe for human consumption, have been shown to induce dysbiosis in gut microbiota, transforming it into a pathogenic profile [ 35 ]. It was recently suggested that even the use of natural substances, such as trehalose, as routine food additives could have deadly consequences for public health [ 93 ]. The emergence of a highly infectious strain of Clostridium difficile is coincident with the introduction of trehalose into prepared foods, and it is suggested that this compound had permitted the selection and expansion of pathogenic strains by providing a carbon source and energy substrate not normally used by the non-pathogenic strain of this bacterium [ 35 ]. These examples illustrate the importance and interaction of extrinsic and intrinsic factors in modulating and integrating nutrient metabolism, and in determining the nutritional status of the organism.

Technologies Used in the Study of Metabolism and Nutrition

Over the last few decades, the study of metabolism and nutrition has gradually increased in scope in its mission to find ways of alleviating hunger and improving nutrition and health status. With better understanding of cellular and whole-body metabolism, it has become apparent that optimal nutrition is not simply a case of energy adequacy but also that of nutrient diversity ( Figure 1 A). To address the complicated metabolic disorders that stem from over-nutrition and sub-optimal nutrition, it is necessary to apply multipronged approaches using a variety of experimental systems targeted at various levels of biological organization ( Figure 2 ).

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Modern approaches used in the study of nutrition . Descriptive data obtained by Omics technologies from both human studies and animal models to guide mechanistic studies in in vitro and cell models. These approaches collectively provide information for the design of interventions for promoting optimal nutrition.

Animals and humans do not share identical nutrient requirements, but animal models have nonetheless been indispensable in elucidating the processes involved in the metabolism of nutrients. Transgenic and targeted gene disruption technologies applied to mice have greatly contributed to understanding the role of specific genes and their associated polymorphisms in dictating the efficiency of nutrient metabolism. It has been possible to recapitulate human metabolic diseases in these models, as well as to allow the study of human genes in vivo [ 94 - 97 ]. The recent advent of CRISPR/Cas9-mediated gene editing will further simplify the creation of new animal models [ 98 ]. With better awareness of the impact of sex differences [ 85 ], future studies can be designed to collect information from both sexes in regard to responses to specific nutritional interventions. Cell culture models have served as useful platforms for elucidating the molecular mechanisms that underlie nutrient metabolism. The use of cells from both experimental animals and human donors can also highlight species-specific differences that impact on nutrition. These models can help to provide insights into descriptive data generated by human intervention trials. It will be important to rigorously design these intervention trials so that these studies generate high quality data that are needed for reliable interpretations.

Omics technologies (genomics, transcriptomics, proteomics, and metabolomics) provide a diverse and rich source of descriptive information needed for the detailed surveillance of nutrient metabolism in humans and experimental models [ 99 ]. Fortunately, suites of mature bioinformatics tools and the necessary computing power are now available to decipher these data and infer relationships among genomes, metabolic processes, and cellular functions that are relevant to health and disease [ 88 , 100 - 102 ]. A coordinated strategy may be useful in integrating the mechanistic and descriptive information drawn from various sources to generate the knowledge that can ultimately be used to formulate useful recommendations for optimal human nutrition and health.

Nutrients have been commonly regarded as nourishment, providing raw materials needed for cells growth and proliferation, and fuel for powering cellular metabolism. However, in addition to these roles, it is evident that nutrients and their metabolites are also active in the facilitation, regulation, and coordination of the vast number of cellular processes that operate to maintain cellular homeostasis. Effective cellular function depends on context, such as sex and age, as well as ideal supply of necessary nutrients. The processed foods that are prominent in the Western-style dietary pattern may be the important factor responsible for the rise of acquired metabolic syndromes as seen in developed societies. The long-term consumption of these foods, which typically have poor nutrient diversity and excessive energy content, lead to deficiencies in key nutrients and excess fuel substrates that likely trigger the loss of cellular nutrient/energy homeostasis. Due to the continued exposure of cells to stressors, the metabolic changes at the cellular level intended initially as adaptive strategies, persist and ultimately become the driver of metabolic dysfunction at the organismal level. Recent advances in high-throughput analyses, creation of animal models of human metabolic diseases and bioinformatic tools hold promise for accelerating the process of formulating more effective nutritional recommendations. In the meantime, consumption of foods with low-energy density and high nutrient diversity seems to be a prudent approach for minimizing cellular stress and the promotion of optimal cellular function and health.

Acknowledgments

Research in our laboratories is funded by grants from the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada.

Author Contributions

Yiheng Chen, BSc, prepared a draft of the manuscript; Marek Michalak, PhD, and Luis Agellon, PhD, provided guidance on topic selection, manuscript outline construction, discussions during the writing process, and editing of the manuscript.

GBD 2016 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 . Lancet . 2017; 390 ( 10100 ):1345–422. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data . Lancet . 2005; 365 ( 9455 ):217–23. [ PubMed ] [ Google Scholar ]
Kelly T, Yang W, Chen CS, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030 . Int J Obes . 2008; 32 ( 9 ):1431–7. [ PubMed ] [ Google Scholar ]
Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030 . Diabetes Res Clin Pract . 2010; 87 ( 1 ):4–14. [ PubMed ] [ Google Scholar ]
Misra A, Khurana L. Obesity and the metabolic syndrome in developing countries . J Clin Endocrinol Metab . 2008; 93 ( 11 Suppl 1):S9–30. [ PubMed ] [ Google Scholar ]
World Health Organization Healthy diet 2015. [cited 2018 30 Jan]. Available from: http://www.who.int/mediacentre/factsheets/fs394/en/
Boy E, Mannar V, Pandav C, de Benoist B, Viteri F, Fontaine O, et al. Achievements, challenges, and promising new approaches in vitamin and mineral deficiency control . Nutr Rev . 2009; 67 Suppl 1 :S24–30. [ PubMed ] [ Google Scholar ]
Fortmann SP, Burda BU, Senger CA, Lin JS, Whitlock EP. Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: an updated systematic evidence review for the U.S. Preventive Services Task Force . Ann Intern Med . 2013; 159 ( 12 ):824–34. [ PubMed ] [ Google Scholar ]
Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease . Am J Clin Nutr . 2010; 91 ( 3 ):535–46. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Miller DD, Welch RM. Food system strategies for preventing micronutrient malnutrition . Food Policy . 2013; 42 :115–28. [ Google Scholar ]
Desai CK, Huang J, Lokhandwala A, Fernandez A, Riaz IB, Alpert JS. The role of vitamin supplementation in the prevention of cardiovascular disease events . Clin Cardiol . 2014; 37 ( 9 ):576–81. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Martini LA, Catania AS, Ferreira SR. Role of vitamins and minerals in prevention and management of type 2 diabetes mellitus . Nutr Rev . 2010; 68 ( 6 ):341–54. [ PubMed ] [ Google Scholar ]
Berger S, Raman G, Vishwanathan R, Jacques PF, Johnson EJ. Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis . Am J Clin Nutr . 2015; 102 ( 2 ):276–94. [ PubMed ] [ Google Scholar ]
Siscovick DS, Barringer TA, Fretts AM, Wu JH, Lichtenstein AH, Costello RB, et al. Omega-3 Polyunsaturated Fatty Acid (Fish Oil) Supplementation and the Prevention of Clinical Cardiovascular Disease: A Science Advisory From the American Heart Association . Circulation . 2017; 135 ( 15 ):e867–84. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Hu FB. Dietary pattern analysis: a new direction in nutritional epidemiology . Curr Opin Lipidol . 2002; 13 ( 1 ):3–9. [ PubMed ] [ Google Scholar ]
de Lorgeril M, Renaud S, Mamelle N, Salen P, Martin JL, Monjaud I, et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease . Lancet . 1994; 343 ( 8911 ):1454–9. [ PubMed ] [ Google Scholar ]
Shen J, Wilmot KA, Ghasemzadeh N, Molloy DL, Burkman G, Mekonnen G, et al. Mediterranean Dietary Patterns and Cardiovascular Health . Annu Rev Nutr . 2015; 35 :425–49. [ PubMed ] [ Google Scholar ]
Lutsey PL, Steffen LM, Stevens J. Dietary intake and the development of the metabolic syndrome: the Atherosclerosis Risk in Communities study . Circulation . 2008; 117 ( 6 ):754–61. [ PubMed ] [ Google Scholar ]
McEvoy CT, Cardwell CR, Woodside JV, Young IS, Hunter SJ, McKinley MC. A posteriori dietary patterns are related to risk of type 2 diabetes: findings from a systematic review and meta-analysis . J Acad Nutr Diet . 2014; 114 ( 11 ):1759-75 e4. [ PubMed ] [ Google Scholar ]
Popkin BM. Nutritional patterns and transitions . Popul Dev Rev . 1993:138–57. [ Google Scholar ]
Popkin BM. The nutrition transition and obesity in the developing world . J Nutr . 2001; 131 ( 3 ):871S–3S. [ PubMed ] [ Google Scholar ]
Grundy SM. Metabolic syndrome pandemic . Arterioscler Thromb Vasc Biol . 2008; 28 ( 4 ):629–36. [ PubMed ] [ Google Scholar ]
Niu K, Momma H, Kobayashi Y, Guan L, Chujo M, Otomo A, et al. The traditional Japanese dietary pattern and longitudinal changes in cardiovascular disease risk factors in apparently healthy Japanese adults . Eur J Nutr . 2016; 55 ( 1 ):267–79. [ PubMed ] [ Google Scholar ]
Song Y, Joung H. A traditional Korean dietary pattern and metabolic syndrome abnormalities . Nutr Metab Cardiovasc Dis . 2012; 22 ( 5 ):456–62. [ PubMed ] [ Google Scholar ]
Tada N, Maruyama C, Koba S, Tanaka H, Birou S, Teramoto T, et al. Japanese dietary lifestyle and cardiovascular disease . J Atheroscler Thromb . 2011; 18 ( 9 ):723–34. [ PubMed ] [ Google Scholar ]
Bishop NA, Guarente L. Genetic links between diet and lifespan: shared mechanisms from yeast to humans . Nat Rev Genet . 2007; 8 ( 11 ):835–44. [ PubMed ] [ Google Scholar ]
Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase . Science . 2004; 305 ( 5682 ):390–2. [ PubMed ] [ Google Scholar ]
Rogina B, Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction . Proc Natl Acad Sci USA . 2004; 101 ( 45 ):15998–6003. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Astrup A, Dyerberg J, Selleck M, Stender S. Nutrition transition and its relationship to the development of obesity and related chronic diseases . Obes Rev . 2008; 9 Suppl 1 :48–52. [ PubMed ] [ Google Scholar ]
Reddy KS, Yusuf S. Emerging epidemic of cardiovascular disease in developing countries . Circulation . 1998; 97 ( 6 ):596–601. [ PubMed ] [ Google Scholar ]
Groenendyk J, Agellon LB, Michalak M. Coping with endoplasmic reticulum stress in the cardiovascular system . Annu Rev Physiol . 2013; 75 :49–67. [ PubMed ] [ Google Scholar ]
Cao SS, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease . Antioxid Redox Signal . 2014; 21 ( 3 ):396–413. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Hotamisligil GS, Davis RJ. Cell Signaling and Stress Responses . Cold Spring Harb Perspect Biol . 2016; 8 ( 10 ). [ PMC free article ] [ PubMed ] [ Google Scholar ]
Mennen LI, Walker R, Bennetau-Pelissero C, Scalbert A. Risks and safety of polyphenol consumption . Am J Clin Nutr . 2005; 81 ( 1 Suppl):326S–9S. [ PubMed ] [ Google Scholar ]
Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota . Nature . 2014; 514 ( 7521 ):181–6. [ PubMed ] [ Google Scholar ]
Choi SW, Friso S. Epigenetics: A New Bridge between Nutrition and Health . Adv Nutr . 2010; 1 ( 1 ):8–16. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Daniel M, Tollefsbol TO. Epigenetic linkage of aging, cancer and nutrition . J Exp Biol . 2015; 218 ( Pt 1 ):59–70. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Hardy TM, Tollefsbol TO. Epigenetic diet: impact on the epigenome and cancer . Epigenomics . 2011; 3 ( 4 ):503–18. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Duffey KJ, Popkin BM. High-fructose corn syrup: is this what’s for dinner? Am J Clin Nutr . 2008; 88 ( 6 ):1722S–32S. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Lee AH, Scapa EF, Cohen DE, Glimcher LH. Regulation of hepatic lipogenesis by the transcription factor XBP1 . Science . 2008; 320 ( 5882 ):1492–6. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Softic S, Cohen DE, Kahn CR. Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease . Dig Dis Sci . 2016; 61 ( 5 ):1282–93. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Robertson RP. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes . J Biol Chem . 2004; 279 ( 41 ):42351–4. [ PubMed ] [ Google Scholar ]
Stanhope KL. Role of fructose-containing sugars in the epidemics of obesity and metabolic syndrome . Annu Rev Med . 2012; 63 :329–43. [ PubMed ] [ Google Scholar ]
Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, et al. Bidirectional transport of amino acids regulates mTOR and autophagy . Cell . 2009; 136 ( 3 ):521–34. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, et al. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 . Science . 2015; 347 ( 6218 ):188–94. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Sabatini DM. Twenty-five years of mTOR: uncovering the link from nutrients to growth . Proc Natl Acad Sci USA . 2017; 114 ( 45 ):11818–25. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Huang P, Chandra V, Rastinejad F. Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics . Annu Rev Physiol . 2010; 72 :247–72. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Husted AS, Trauelsen M, Rudenko O, Hjorth SA, Schwartz TW. GPCR-Mediated Signaling of Metabolites . Cell Metab . 2017; 25 ( 4 ):777–96. [ PubMed ] [ Google Scholar ]
Georgiadi A, Kersten S. Mechanisms of gene regulation by fatty acids . Adv Nutr . 2012; 3 ( 2 ):127–34. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Posner BM, Cobb JL, Belanger AJ, Cupples LA, D’Agostino RB, Stokes J., 3rd Dietary lipid predictors of coronary heart disease in men. The Framingham Study . Arch Intern Med . 1991; 151 ( 6 ):1181–7. [ PubMed ] [ Google Scholar ]
Calder PC. Functional Roles of Fatty Acids and Their Effects on Human Health . JPEN J Parenter Enteral Nutr . 2015; 39 ( 1 Suppl):18S–32S. [ PubMed ] [ Google Scholar ]
Pardo V, Gonzalez-Rodriguez A, Muntane J, Kozma SC, Valverde AM. Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection . Food Chem Toxicol . 2015; 80 :298–309. [ PubMed ] [ Google Scholar ]
Ricchi M, Odoardi MR, Carulli L, Anzivino C, Ballestri S, Pinetti A, et al. Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes . J Gastroenterol Hepatol . 2009; 24 ( 5 ):830–40. [ PubMed ] [ Google Scholar ]
Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications . Endocr Rev . 2001; 22 ( 4 ):477–501. [ PubMed ] [ Google Scholar ]
Stoltzfus RJ, Dreyfuss ML. Guidelines for the use of iron supplements to prevent and treat iron deficiency anemia : Ilsi Press; Washington, DC; 1998. [ Google Scholar ]
Berridge MJ. Vitamin D cell signalling in health and disease . Biochem Biophys Res Commun . 2015; 460 ( 1 ):53–71. [ PubMed ] [ Google Scholar ]
Karppanen H, Mervaala E. Sodium intake and hypertension . Prog Cardiovasc Dis . 2006; 49 ( 2 ):59–75. [ PubMed ] [ Google Scholar ]
Lecerf JM, de Lorgeril M. Dietary cholesterol: from physiology to cardiovascular risk . Br J Nutr . 2011; 106 ( 1 ):6–14. [ PubMed ] [ Google Scholar ]
Zwicker BL, Agellon LB. Transport and biological activities of bile acids . Int J Biochem Cell Biol . 2013; 45 ( 7 ):1389–98. [ PubMed ] [ Google Scholar ]
Vega H, Agellon LB, Michalak M. The rise of proteostasis promoters . IUBMB Life . 2016; 68 ( 12 ):943–54. [ PubMed ] [ Google Scholar ]
Groenendyk J, Lee D, Jung J, Dyck JR, Lopaschuk GD, Agellon LB, et al. Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis . PLoS One . 2016; 11 ( 7 ):e0159682. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Rani S, Sreenivasaiah PK, Kim JO, Lee MY, Kang WS, Kim YS, et al. Tauroursodeoxycholic acid (TUDCA) attenuates pressure overload-induced cardiac remodeling by reducing endoplasmic reticulum stress . PLoS One . 2017; 12 ( 4 ):e0176071. [ PMC free article ] [ PubMed ] [ Google Scholar ]
den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud DJ, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism . J Lipid Res . 2013; 54 ( 9 ):2325–40. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Samuel BS, Shaito A, Motoike T, Rey FE, Backhed F, Manchester JK, et al. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41 . Proc Natl Acad Sci USA . 2008; 105 ( 43 ):16767–72. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships . J Nutr Biochem . 2002; 13 ( 10 ):572–84. [ PubMed ] [ Google Scholar ]
Shay J, Elbaz HA, Lee I, Zielske SP, Malek MH, Huttemann M. Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration . Oxid Med Cell Longev . 2015; 2015 :181260. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Kubow S, Hobson L, Iskandar MM, Sabally K, Donnelly DJ, Agellon LB. Extract of Irish potatoes (Solanum tuberosum L.) decreases body weight gain and adiposity and improves glucose control in the mouse model of diet-induced obesity . Mol Nutr Food Res . 2014; 58 ( 11 ):2235–8. [ PubMed ] [ Google Scholar ]
Cardona F, Andres-Lacueva C, Tulipani S, Tinahones FJ, Queipo-Ortuno MI. Benefits of polyphenols on gut microbiota and implications in human health . J Nutr Biochem . 2013; 24 ( 8 ):1415–22. [ PubMed ] [ Google Scholar ]
Klein CB, King AA. Genistein genotoxicity: critical considerations of in vitro exposure dose . Toxicol Appl Pharmacol . 2007; 224 ( 1 ):1–11. [ PubMed ] [ Google Scholar ]
Rietjens IM, Boersma MG, Haan L, Spenkelink B, Awad HM, Cnubben NH, et al. The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids . Environ Toxicol Pharmacol . 2002; 11 ( 3-4 ):321–33. [ PubMed ] [ Google Scholar ]
Taguer M, Maurice CF. The complex interplay of diet, xenobiotics, and microbial metabolism in the gut: implications for clinical outcomes . Clin Pharmacol Ther . 2016; 99 ( 6 ):588–99. [ PubMed ] [ Google Scholar ]
Johnston JD, Ordovas JM, Scheer FA, Turek FW. Circadian Rhythms, Metabolism, and Chrononutrition in Rodents and Humans . Adv Nutr . 2016; 7 ( 2 ):399–406. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Dallman MF. Stress-induced obesity and the emotional nervous system . Trends Endocrinol Metab . 2010; 21 ( 3 ):159–65. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Feil R, Fraga MF. Epigenetics and the environment: emerging patterns and implications . Nat Rev Genet . 2012; 13 ( 2 ):97–109. [ PubMed ] [ Google Scholar ]
Kyrou I, Tsigos C. Stress hormones: physiological stress and regulation of metabolism . Curr Opin Pharmacol . 2009; 9 ( 6 ):787–93. [ PubMed ] [ Google Scholar ]
Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals . Nat Genet . 2003; 33 Suppl :245–54. [ PubMed ] [ Google Scholar ]
Nicolia V, Lucarelli M, Fuso A. Environment, epigenetics and neurodegeneration: focus on nutrition in Alzheimer’s disease . Exp Gerontol . 2015; 68 :8–12. [ PubMed ] [ Google Scholar ]
Ordovas JM, Smith CE. Epigenetics and cardiovascular disease . Nat Rev Cardiol . 2010; 7 ( 9 ):510–9. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, et al. Biological, clinical and population relevance of 95 loci for blood lipids . Nature . 2010; 466 ( 7307 ):707–13. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Chamoun E, Mutch DM, Allen-Vercoe E, Buchholz AC, Duncan AM, Spriet LL, et al. A review of the associations between single nucleotide polymorphisms in taste receptors, eating behaviors, and health . Crit Rev Food Sci Nutr . 2018; 58 ( 2 ):194–207. [ PubMed ] [ Google Scholar ]
Wang LJ, Wang J, Li N, Ge L, Li BL, Song BL. Molecular characterization of the NPC1L1 variants identified from cholesterol low absorbers . J Biol Chem . 2011; 286 ( 9 ):7397–408. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Muendlein A, Leiherer A, Saely CH, Rein P, Zanolin D, Kinz E, et al. Common single nucleotide polymorphisms at the NPC1L1 gene locus significantly predict cardiovascular risk in coronary patients . Atherosclerosis . 2015; 242 ( 1 ):340–5. [ PubMed ] [ Google Scholar ]
Link JC, Reue K. Genetic Basis for Sex Differences in Obesity and Lipid Metabolism . Annu Rev Nutr . 2017; 37 :225–45. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Regitz-Zagrosek V, Kararigas G. Mechanistic Pathways of Sex Differences in Cardiovascular Disease . Physiol Rev . 2017; 97 ( 1 ):1–37. [ PubMed ] [ Google Scholar ]
Sugiyama MG, Agellon LB. Sex differences in lipid metabolism and metabolic disease risk . Biochem Cell Biol . 2012; 90 ( 2 ):124–41. [ PubMed ] [ Google Scholar ]
Varlamov O, Bethea CL, Roberts CT., Jr Sex-specific differences in lipid and glucose metabolism . Front Endocrinol (Lausanne) . 2014; 5 :241. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Freire AC, Basit AW, Choudhary R, Piong CW, Merchant HA. Does sex matter? The influence of gender on gastrointestinal physiology and drug delivery . Int J Pharm . 2011; 415 ( 1-2 ):15–28. [ PubMed ] [ Google Scholar ]
Dhariwal A, Chong J, Habib S, King IL, Agellon LB, Xia J. MicrobiomeAnalyst: a web-based tool for comprehensive statistical, visual and meta-analysis of microbiome data. Nucleic Acids Res . 2017;45 W1:W180–8. [ PMC free article ] [ PubMed ] [ Google Scholar ]
O’Toole PW, Jeffery IB. Gut microbiota and aging . Science . 2015; 350 ( 6265 ):1214–5. [ PubMed ] [ Google Scholar ]
Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice . Science . 2013; 341 ( 6150 ):1241214. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Smith MI, Yatsunenko T, Manary MJ, Trehan I, Mkakosya R, Cheng J, et al. Gut microbiomes of Malawian twin pairs discordant for kwashiorkor . Science . 2013; 339 ( 6119 ):548–54. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Davie JR. Inhibition of histone deacetylase activity by butyrate . J Nutr . 2003; 133 ( 7 Suppl):2485S–93S. [ PubMed ] [ Google Scholar ]
Collins J, Robinson C, Danhof H, Knetsch CW, van Leeuwen HC, Lawley TD, et al. Dietary trehalose enhances virulence of epidemic Clostridium difficile . Nature . 2018; 553 ( 7688 ):291–4. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Drover VA, Agellon LB. Regulation of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) by thyroid hormone in transgenic mice . Endocrinology . 2004; 145 ( 2 ):574–81. [ PubMed ] [ Google Scholar ]
Agellon LB, Drover VA, Cheema SK, Gbaguidi GF, Walsh A. Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice . J Biol Chem . 2002; 277 ( 23 ):20131–4. [ PubMed ] [ Google Scholar ]
Jiang XC, Agellon LB, Walsh A, Breslow JL, Tall A. Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences . J Clin Invest . 1992; 90 ( 4 ):1290–5. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Walsh A, Azrolan N, Wang K, Marcigliano A, O’Connell A, Breslow JL. Intestinal expression of the human apoA-I gene in transgenic mice is controlled by a DNA region 3′ to the gene in the promoter of the adjacent convergently transcribed apoC-III gene . J Lipid Res . 1993; 34 ( 4 ):617–23. [ PubMed ] [ Google Scholar ]
Hsu PD, Lander ES, Zhang F. Development and applications of CRISPR-Cas9 for genome engineering . Cell . 2014; 157 ( 6 ):1262–78. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Piening BD, Zhou W, Contrepois K, Rost H, Gu Urban GJ, Mishra T, et al. Integrative Personal Omics Profiles during Periods of Weight Gain and Loss. Cell Syst . 2018; 6 ( 2 ):157-70 e8. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Huang da W. Sherman BT Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists . Nucleic Acids Res . 2009; 37 ( 1 ):1–13. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Kanehisa M, Araki M, Goto S, Hattori M, Hirakawa M, Itoh M, et al. KEGG for linking genomes to life and the environment . Nucleic Acids Res . 2008; 36 ( Database issue ):D480–4. [ PMC free article ] [ PubMed ] [ Google Scholar ]
Xia J, Benner MJ, Hancock RE. NetworkAnalyst--integrative approaches for protein-protein interaction network analysis and visual exploration . Nucleic Acids Res . 2014; 42 (Web Server issue):W167-74. [ PMC free article ] [ PubMed ] [ Google Scholar ]

Open access
Published: 07 February 2015

The challenges of nutrition policymaking

Joanne L Slavin 1

Nutrition Journal volume 14 , Article number: 15 ( 2015 ) Cite this article

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In my over three decades of work in the field of food and nutrition, I have participated in many efforts that seek new policy initiatives in the hopes that these programs can curb rates of obesity and chronic disease and help consumers make healthier dietary choices. Because of the profound effect that many of these policies have on consumers, the food environment, federal nutrition assistance programs and subsequent policy and regulatory recommendations, it is imperative that only the strongest, best available evidence is used to set policy. This review evaluates methods by which current nutrition policies use scientific research as well as provides recommendations for how best to ensure future nutrition policies are truly science-based and likely to have a meaningful impact on public health. Specifically, this review will:

Describe the current food and nutrition policy environment in the US

Examine how science is used in federal food and nutrition policymaking efforts, using the Dietary Guidelines for Americans (DGA) as an example

Describe strong versus weak science as well as what types of studies are most appropriate for use in policymaking

Discuss the potential effects and consequences of making policy recommendations in the absence of scientific consensus or agreement

Make recommendations to support the present and ongoing development of science-based policy likely to positively impact public health

Peer Review reports

Introduction

The US food and nutrition policy and regulatory environment is highly active. The current administration, federal agencies and regulators are increasingly looking to policy and systems-change interventions to improve public health in America. For example, within the last five years, federal and state/local governments have instituted significant changes to the school food environment [ 1 ], proposed state and local initiatives to tax and/or ban certain foods and beverages [ 2 ], and published proposed rules to significantly change nutrition labeling regulations [ 3 ]. Additionally, the 2015 Dietary Guidelines Advisory Committee (DGAC) [ 4 ] is presently meeting and will issue the 2015 DGAC report in the coming year.

The process by which federal agencies and policymakers consult scientific research in developing proposed regulations and policies varies, and greatly impacts the nature of the ultimate recommendations. An investigation into this process would yield important understanding about how science is used to set policy and what impact this process is likely to have on consumers.

How science is used in policymaking

Science is used by all agencies to set nutrition policy. Yet, guidelines for how to identify, evaluate, and translate scientific research into policy recommendations vary among agencies. Policymakers generally rely on published research and consensus reports by scientific authorities and government bodies; however the manner in which research findings and report conclusions are interpreted and applied can differ from one initiative to the next. Government agencies have outlined their approach for evaluation of scientific studies to be used in decision-making. For example, NIH uses the AHRQ system [ 5 ] and FDA has an accepted system of systematic review for health claims [ 6 ]. Because there is not a universally accepted evidence-grading scheme, conclusions are based on research studies with varying degrees of methodological strength and applicability. The fact that nutrition research produces constantly evolving scientific findings further complicates the development of objective, evidence-based policy recommendations.

One example of a US scientific authority with significant influence is the Institute of Medicine (IOM). The IOM is one of the premier authoritative bodies that conducts health-related research and promulgates health and nutrition recommendations for policymaking purposes. IOM reports are frequently commissioned by government agencies for topics where policy and/or regulatory interest exists but research gaps remain. Some recent examples include sodium [ 7 ] and front-of-package labeling [ 8 ]. Once IOM recommendations are published, they are often used as scientific basis for proposed regulations and nutrition guidance. IOM recommendations aim to reflect our most current scientific understanding and usually precede the actual setting of policy to ensure any action is evidence-based. However, the IOM is challenged to keep pace with advances in our understanding of nutrition.

For example, the IOM completes the Dietary Reference Intake (DRI) reports, which are considered the most reliable sources of nutrient recommendations – they inform the very basis of our current nutrition understanding. The DRIs are summarized in the 2006 volume [ 9 ] and are an update to the Dietary Recommended Allowances (RDA) that have been published since 1941. While DRI reports for certain nutrients have been updated recently (vitamin D and calcium were updated in 2011), other DRI reports have not been updated since 1997–1998. This means that the body of research that has been completed for a number of nutrients within the last 15-plus years is not accounted for in our current IOM DRI report conclusions.

Researchers and policymakers also rely heavily on the National Health and Nutrition Examination Survey (NHANES), an ongoing group of studies designed to assess the health and nutritional status of adults and children in the United States. These studies are based on self-reporting; they consist of 24-hour dietary recalls completed through individual surveys. NHANES also collects biological data and anthropometrical data with mobile units. NHANES information is a valuable resource on changes in nutrient intake and health status of a cross-sectional group of US consumers.

Critics suggest the data are flawed because of biases that accompany self-reporting measures [ 10 ]. As one might expect, survey respondents have a tendency to under-report their caloric intake or over-report the amount of more nutritious foods they consume and under-report the amount of less nutritious foods they consume. Archer et al. [ 11 ] reported that 67% of women and 59% of men who participated in NHANES provided caloric intake responses that were not physiologically plausible. They calculated physiologically credible energy intake values as the ratio of reported energy intake to estimated basal metabolic rate and subtracted estimated total energy expenditure to create disparity values. The greatest mean disparity values were – 716 kcal/day and −856 kcal/day for obese men and women, respectively. The limitations of our nutritional data are generally not acknowledged in scientific reports or consensus statements. And yet, NHANES is cited by virtually every government agency involved in health and nutrition as an accurate representation of Americans’ eating habits.

These examples raise important questions about the data that US nutrition policymakers have available to them. How confident can we be that federal dietary guidance is evidence-based when our foundational measures are outdated and significantly limited? What controls can be put in place to ensure that policies and regulations are likely to have demonstrated, positive public health impact?

The dietary guidelines advisory committee

Another highly influential scientific authority is the Dietary Guidelines Advisory Committee (DGAC), the appointed review committee responsible for formulating and publishing (in the form of a comprehensive report) an evidence-based review that provides scientific support for the Dietary Guidelines for Americans (DGA) policy document. The DGA are statutorily mandated (Section 301 of Public Law 101–445 (7 U.S.C. 5341, the National Nutrition Monitoring and Related Research Act of 1990, Title III)) and are a collaborative effort between the Department of Health and Human Services (HHS) and Department of Agriculture (USDA); the DGA have been published every five years since 1980. The DGA aim to provide “sound advice for making food and physical activity choices that promote good health, a healthy weight, and help prevent disease for Americans ages 2 years and over, including Americans at increased risk of chronic disease” [ 12 ]. DGA recommendations serve as the cornerstone for all Federal nutrition education and program activities, including but not limited to nutrition labeling campaigns by the Food and Drug Administration (FDA) and USDA Food Safety and Inspection Service (FSIS), the Office of Disease Prevention and Health Promotion (ODPHP) Healthy People objectives, and USDA Food and Nutrition Service nutrition assistance programs including the Supplemental Nutrition Assistance Program (SNAP) and the National School Lunch Program (NSLP). As a result, DGA reach and impact are extensive.

The 2015 DGA process is underway, with the current DGAC holding meetings to share their evidence review process and findings with the general public. According to the 2015 DGAC charter, the Committee’s official responsibilities are to “examine the current Dietary Guidelines for Americans , take into consideration new scientific evidence and current resource documents, and then develop a report to be submitted to the Secretaries that outlines its science-based recommendations and rationale which will serve as a basis for developing the eighth edition of Dietary Guidelines for Americans ” [ 12 ].

The DGAC is governed by Federal Advisory Committee Act (FACA) guidelines and an official charter and charge [ 13 ]. While the freedom exists to explore food and nutrition topics that the DGAC deems important and scientifically relevant, the charge explicitly states that “DGAC responsibilities include providing authorship for this report; however, responsibilities do not include translating the recommendations into policy or into communication and outreach documents or programs” [ 13 ]. In other words, DGAC recommendations should be scientific in nature and not indicative of policy direction.

The DGAC evidence review process

The DGAC process to identify, review, and evaluate available nutrition research for a variety of topics is complex and time-intensive. Typically, DGAC members are divided into subcommittees to address specific research areas based on topic importance and DGAC member expertise. In 2010, the DGAC consisted of thirteen scientists with expertise in nutrition, physical activity, food behavior and nutrition through the lifecycle. There were eight subcommittees focusing on the following dietary issues: 1) alcohol; 2) carbohydrate; 3) energy balance and weight maintenance; 4) fatty acids and cholesterol; 5) food safety and technology; 6) nutrient adequacy; 7) protein; and, 8) sodium, potassium and water. As a member of the 2010 DGAC, the author of this paper served as chair of the carbohydrate and protein subcommittees and also as a member of the energy balance and the nutrient adequacy subcommittees.

The 2015 DGAC is organized somewhat differently, with fourteen scientists serving on five subcommittees: 1) Food and Nutrient Intakes, and Health: 2) Current Status and Trends; Dietary Patterns, Foods and Nutrients, and Health Outcomes; 3) Diet and Physical Activity Behavior Change; 4) Food and Physical Activity Environments; and 5) Food Sustainability and Safety. There are separate working groups for sodium, added sugar, saturated fat and physical activity. The 2015 Committee is also using expert consultants to inform its evidence reviews.

One of the first steps in the DGAC evidence review process is to develop research questions regarding the relationship between diet and health outcomes, including disease risk or health benefits (e.g., what is the relationship between dietary fiber intake and specific health outcomes). These questions should reflect the research gaps identified by the previous DGAC, as well as areas of nutrition where there is new, influential evidence since the previous edition of the DGA. Once the research questions have been agreed upon, the DGAC, in concert with USDA Nutrition Evidence Library (NEL) staff, gathers the relevant available studies.

The research studies are then closely examined and evaluated based on strength of study design as well as relevance of outcomes. In past years, the DGAC used the NEL evidence-based review process [ 14 ], a strict hierarchy of evidence and rigorous grading process. For each question addressed in the 2010 evidence-based report, the DGAC developed precise search criteria, inclusion and exclusion criteria for all of the studies, including the range of dates searched, and made this information available on the USDA DGA portal [ 14 ]. Such detailed process and transparency in the NEL evidence-based approach minimizes bias and therefore adds credibility to the findings. However, the scientific review method ultimately used by the DGAC is at the Committee’s discretion – for example, at the time of this paper’s completion, the 2015 DGAC has decided to use the NEL process to answer some research questions, but not others. This permitted subjectivity and variability increases the potential for less rigorous studies to be used to inform DGAC recommendations.

Once the DGAC has determined which studies to examine for each research question, evidence conclusion statements are written. Within the NEL system, the conclusions drawn can be deemed as strong, moderate, limited, or lacking data to support them. There may also be strong evidence of no relationship. For example, strong evidence was found of no relationship between glycemic index and disease outcomes in the 2010 DGAC review [ 15 ]. Agreeing on the strength of the relationship is always difficult, as for each question, different types of studies with a variety of outcomes have been published. A closer examination of study methodology will help further illustrate this point.

The DGAC process is transparent and open to input from scientists and consumers. The 2015 DGAC will hold 7 public meetings with public comments accepted throughout the process. Although the final DGAC report is not released, the committee regularly updates their progress on reviewing scientific questions at the public meetings.

Research methodology: what makes a strong vs. weak study

The evidence-based medicine (EBM) hierarchy ranks research design in the following order of strength (from highest to lowest): systematic reviews of randomized-controlled trials (RCT), RCT, prospective cohort studies, case control studies, cross-sectional studies, case series/case reports and editorials/expert opinions. RCT are the strongest study designs for determining cause and effect between a dietary exposure and a health outcome [ 16 ]. Following RCT are prospective cohort studies, where a group or cohort of subjects is studied over time. Food frequency instruments are often used to collect dietary information before any diagnosis of disease, making these studies more reliable than cross-sectional studies where diet and outcome measures are assessed simultaneously. Historically, in the case of DGAC reviews, no case–control studies, animal research, or in vitro studies have been considered due to their relative weakness and because their findings cannot prove cause and effect in humans. Typically cross-sectional studies are only included in DGAC reviews if no stronger prospective studies are available.

Following this reasoning, food and nutrition policies would be best served if only the strongest types of evidence – perhaps RCT alone – informed their development. However, this is an unrealistic ideal as not all diet and health outcome relationships can be practically or ethically evaluated using RCT. For example, it is difficult to carry out blind food treatments in dietary studies (subjects know they are consuming an apple versus apple juice). However, such trials can work with nutrients, as nutrients can be added to food or drinks without the knowledge of the participants or investigators (the double-blind mechanism).

Further, all RCT data are not created equal. RCT generally use biomarkers as outcome measures rather than disease incidence due to the length of time it takes healthy people to manifest disease symptoms. Biomarker data can be extrapolated to infer relationships regarding population health without adequately accounting for weaknesses in the relationship between the biomarker and the disease state. Ultimately, this can result in a strong study methodology being misapplied and used to make assumptions that are not actually supported by the research. For example, RCT are clear that sodium intake or excretion is directly related to blood pressure, yet prospective cohort studies show that too low sodium intakes actually increase risk of cardiovascular disease (CVD). Thus, at low levels of sodium consumption, blood pressure does not account for all of the CVD risks. Biomarker data fail to tell the complete story.

In reality, many dietary recommendations are supported by evidence primarily from observational data, particularly those from prospective, cohort studies. Nutrition scientists and policymakers often underappreciate limitations of such data. Some of the limitations of observational evidence for diet-disease relationships include imprecise exposure measures, collinearity among dietary exposures, displacement/substitution effects, healthy/unhealthy consumer bias, and residual confounding. Maki et al. [ 16 ] recommend greater caution in making dietary recommendations for which RCT evidence of clinical event reduction after dietary intervention is not available.

For these reasons and because nutrition science is complex and changeable, it is critical that study methodology is carefully considered and applied to our interpretation of nutrition science. Ideally, observational data would be validated by stronger research methods before being used to inform policy. While observational research may be valuable to our understanding of nutrition and health, its limitations must be acknowledged. Consider the 2015 DGAC investigation into sustainable dietary patterns. This field of research is arguably in its infancy – in fact, there is no scientific consensus for even a definition of sustainability [ 17 ]. Any sustainability-related recommendations in the 2015 DGAC report should be preliminary at best, recognizing the need for additional, rigorous research to validate initial findings. Without these underlying studies in place, it would be premature for HHS and USDA to use sustainability recommendations to inform nutrition guidance in the 2015 DGA policy document.

Consequences of non-evidence-based policy

We don’t have to travel very far back in time to witness examples of dietary guidance recommendations that were made prematurely and are now challenged as more research is introduced. Our understanding of fats has evolved considerably, with dietary recommendations now emphasizing healthy consumption of monounsaturated and polyunsaturated fats, proving that healthier dietary patterns include, rather than exclude, foods higher in fat content.

More recently, it could be argued that the 2010 DGA sodium intake recommendation was made in the absence of scientific consensus. The policy document recommends that individuals over 51 years old, African Americans or those with hypertension, diabetes, or chronic kidney disease reduce their daily sodium intake to 1,500 milligrams. This applies to about half the US population, including children and the majority of adults.

Since then, the IOM published its Sodium Intake in Populations: Assessment of Evidence report. Findings stated that recent studies “support current efforts to reduce excessive sodium intake in order to lower risk of heart disease and stroke. However, the evidence on health outcomes is not consistent with efforts that encourage lowering of dietary sodium in the general population to 1,500 mg/day. Further research may shed more light on the association between lower—1,500 to 2,300 mg—levels of sodium and health outcomes [ 7 ].

The 2010 DGA recommendations are now inconsistent with our most recent scientific understanding of sodium and health. As noted, this conflict could have been avoided if the DGA policy document had withheld such extreme guidance until more rigorous studies were fielded, reviewed, and published. Recent papers in the New England Journal of Medicine cast further doubt on our low sodium recommendations for the general public [ 18 ].

The sodium example is important because of the aforementioned impact of DGA recommendations on other food and nutrition policies. The Final Rule for the Nutrition Standards in the National School Lunch and School Breakfast Programs [ 1 ] states that schools must “reduce the sodium content of meals gradually over a 10-year period through two intermediate sodium targets of two and four years post implementation”. Now that schools have begun to implement the new regulations, these severe sodium reductions are proving difficult, costly, and may reduce student participation rates [ 19 ]. These consequences are especially concerning considering the underlying recommendation may not accurately reflect the current evidence base.

Inaccurate and conflicting dietary guidance messages are also detrimental to consumers’ understanding of nutrition and their ability to build healthy diets. At a time when consumers are already subjected to an overabundance of nutrition and health information, government agencies should be held accountable for developing policies and regulations that are rooted in strong science, and are realistic and achievable for the majority of the population. In the case of sodium, not only is there insufficient evidence to link highly restrictive sodium intakes to improved health outcomes, but encouraging the general public to reduce intakes from the estimated current average of 3,400 mg/day to 1,500 mg/day is self-defeating and unachievable [ 20 ].

Another example can be seen in the use of the 2010 DGAC review to support the FDA proposal to mandate added sugars labeling on the Nutrition Facts panel [ 3 ]. Added sugars have become the current nutrition “watch out”, believed by some to uniquely contribute to obesity and other adverse health outcomes. However, the majority of scientific evidence shows that all sugars (added or intrinsic) provide 4 kcalories/gram just like any other digestible carbohydrate and are no more likely to cause weight gain or negative health outcomes than other calorie sources [ 21 ]. In fact, even the proposed rule acknowledges this fact:

“U.S. consensus reports have determined that inadequate evidence exists to support the direct contribution of added sugars to obesity or heart disease. Specifically, although it is recognized that sugar-sweetened beverages increase adiposity (body fat) in children (Ref. 30), neither the 2010 DGA nor the IOM macronutrient report concluded that added sugars consumption from all dietary sources, in itself, increases obesity. In fact, the 2010 DGA states that added sugars do not contribute to weight gain more than any other source of calories…” [ 3 ].

FDA states that the basis for this proposed labeling requirement is the 2010 DGA recommendation to reduce intakes of added sugars to assist consumers in maintaining healthy dietary practices. The DGA rationale is that lower intakes of added sugars will result in decreased calorie intakes and increased nutrient density of individual diets, not reduced risk of adverse health outcomes. Specifically, the 2010 DGAC energy balance subcommittee investigated sugar-sweetened beverage intakes and found that “strong evidence shows that children who consume more sugar-sweetened beverages have greater adiposity (body fat) compared to those with a lower intake” [ 15 ]. However, a closer look at the evidence review shows that only 12 of the 19 studies (which included cross-sectional studies) found a positive association between sugar-sweetened beverage intakes and adiposity in all or a subsample of population studies. It is difficult to see how the subcommittee concluded this to be “strong” evidence.

Furthermore, it is unclear why FDA proposed mandatory added sugars labeling in the absence of consumer research to demonstrate whether the change will in fact influence consumer understanding and purchasing behavior. The proposed rules even preceded the agency’s own study. Existing consumer research suggests that consumers already find aspects of the current nutrition label confusing [ 22 ]. In addition, public misunderstanding about added sugars abounds. Some consumers believe added sugars do cause unique adverse health outcomes compared to other sugars and even contain more calories that intrinsic sugars [ 22 ]. Even if the intention behind the proposed rule is to steer consumers away from purchasing non-nutrient dense foods and beverages that contain added sugars, current available research suggests they will do this for the wrong reasons. This proposal stands to perpetuate misleading beliefs about nutrition and lead to more consumer confusion.

It is extremely difficult to reverse or change public policy, once enacted, without causing consumer confusion. There are few mechanisms available to regulators and policymakers to make adjustments that reflect new science and understanding. Furthermore, nutrition policy recommendations, once adopted, appear frequently in the media and online. Reversing consumer misunderstanding about nutrition is an incredibly difficult task; providing the public with accurate, realistic and achievable information first would go a long way in improving our understanding of nutrition and health, and ultimately contributing to improved public health outcomes.

Conclusions

It is imperative that food and nutrition policies reflect, and do not get ahead of the strongest available scientific evidence. It is unlikely we will ever have RCT data available to answer most nutrition questions, but we should rely on our strongest designs, including prospective cohort studies. We should not accept cross-sectional studies as influential drivers of policy development. We must demand stronger scientific standards from our appointed committee members who serve on advisory IOM and DGAC panels.

A transparent system that grades evidence quality would help achieve consistency in science interpretation and use across nutrition policies and regulations. Grading schemes should be vetted and discussed by experts across the wide expertise needed in dietary guidance, including nutritionists, dietitians, food scientists, physicians, applied economists, and food processors so that findings and recommendations could be supported across a wide array of credible groups. This would also help ensure that the dietary guidance messages consumers are receiving are factual and consistent.

When policy recommendations are developed by committees, such as the DGAC, those committees should be comprised of a balanced and well-rounded set of perspectives and expertise. Ideally a scientific nutrition committee would not only include experts in nutrition, biochemistry, physiology, epidemiology and statistics, but also food science, food production and processing, food policy and behavior. This combination of skills would ensure that the ultimate recommendations adequately reflect our entire food system and food environment.

Scientists who understand how we “learn” about nutrition must be included, even if they have worked on research supported by commodity groups or food companies. The IOM process considers bias of individual committee members and whether they have taken such strong public stands on issues that it is not possible for them to move to another position based on the deliberations of the committee. Any linkages to the food industry are criticized, yet there seems to be little concern about committee members who are closely linked to professional groups, such as American Heart Association or other advocacy groups. Improvements to our food system and public health can only be realized if we work together, respecting the strengths of all parties. Nutrition advice that is produced in such a collaborative system will more likely be translatable and realistic for the general public.

Policies should reflect what is practical and likely to have the most impact on the general population. Simple, flexible and straightforward messages that are rooted in the best available evidence are likely to be most effective. For example, the majority of Americans are unlikely to be interested in or able to prioritize building sustainable diets, shop at farmers markets, or avoid processed foods, which provide nutrition and convenience for individuals with less access to full-service grocery stores and fresh produce.

I would finally suggest that the US government consider elongating the DGA publication schedule. The DRI reports and nutrition labeling regulations are not updated every 5 years; instead they are reexamined when there is a sufficient level of new research to warrant a change. Without new science to review, the DGAC may choose to focus on fads and trends instead of updating the scientific data for the core areas of dietary guidance. As every DGAC wants to be bold and set new direction, nutrition science would support that first we must do no harm with our dietary guidance. Moderation and variety must be kept front and center, as well as an appreciation that a teenage active boy may need 2 or 3 times more calories than an elderly man or young child. A suggestion that all Americans should reduce sodium intakes is not sound and is potentially dangerous. Targeting certain foods and beverages, including chocolate milk, processed meats, added sugars, and even the noble potato as villains in the nutrition wars is not a science-based strategy and may need to be countered on the political front if appointed scientific review committees continue to take this approach.

As described by Schneeman [ 6 ], science is necessary for developing effective food regulation and policy, but it is not sufficient. The interface between nutrition and public health must include food science and agriculture. Food technology can help all consumers, including those of lower socioeconomic status, have access to safe, nutritious foods that science has found to be linked to improved health outcomes.

Abbreviations

Department of Health and Human Services

Department of Agriculture

Dietary Guidelines Advisory Committee

Dietary Guidelines for Americans

Dietary reference intakes

Evidence-based medicine

Federal Advisory Committee Act

Food and Drug Administration

Institute of Medicine

Low-density lipoprotein

National Health and Nutrition Examination Survey

National School Lunch Program

Office of Disease Prevention and Health Promotion

Randomized-controlled trials

Supplemental Nutrition Assistance Program

USDA Food Safety and Inspection Service

USDA Nutrition Evidence Library

Nutrition Standards in the National School Lunch and School Breakfast Program, Food and Nutrition Service (FNS), USDA. Final Rule. Federal Register Vol 77, No 17, January 26, 2012.

Taber DR, Chriqui JF, Vuillaume R, Chaloupka FJ. How state taxes and policies targeting soda consumption modify the association between school vending machines and student dietary behaviours: A cross-sectional analysis. PLoS ONE 9(8):e98249. doi:10.1371/journal.pone.0098249.

Food Labeling: Revision of the Nutrition and Supplement Facts Labels; Proposed Rule.” 21 CFR 101 (3 March 2014), pp. 11904–11905. Available online: http://www.gpo.gov/fdsys/pkg/FR-2014-03-03/pdf/2014-04387.pdf

“Establishment of the 2015 Dietary Guidelines Advisory Committee; Notice;” 78 Federal Register 24 (5 February 2013), pp. 8147–8148. Available online: http://health.gov/dietaryguidelines/2015.asp#resources

Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov .

Schneeman B. Linking science and policy. Nutr Today. 2014;49:167–73.

Article Google Scholar

Institute of Medicine. Sodium intake in populations: assessment of evidence. Washington DC: National Academies Press; 2013.

Google Scholar

Front-of-Package Nutrition Rating Systems and Symbols. Promoting Healthier Choices. Committee on Examination of Front-of-Package Nutrition Rating Systems and Symbols (Phase II), Food and Nutrition Board, Wartella EA, Lichtenstein AH, Yaktine A, Nathan R, eds. Institute of Medicine, The National Academies Press, Washington, DC.

National Research Council. Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Washington DC: The National Academies Press; 2006.

Schoeller DA, Thomas D, Archer E, Heymsfield SB, Blair SN, Goran MJ, Hill JO, Atkinson RL, Corley BE, Foreyt J, Dhurandhar NV, Krol JG, Hall KD, Hansen BC, Heitmann BL, Ravussin E, Allison DB. Self-report-based estimates of energy intake offer an inadequate basis for scientific conclusions. Am J Clin Nutr. doi:10.3945/ajcn.113.062125.

Archer E, Hand GA, Blair SN. Validity of US nutritional surveillance: National Health and Nutrition Examination survey caloric energy intake data: 1971–2010. PLoS One. 2013;8(10):e75532.

Dietary Guidelines for Americans, 2010. Available online: http://www.health.gov/dietaryguidelines/dga2010/DietaryGuidelines2010.pdf

Charter of the 2015 Dietary Guidelines Advisory Committee. Approved January 9, 2013. Available online: http://www.health.gov/dietaryguidelines/dgac2015-charter-final.pdf

USDA Nutrition Evidence Library, 2010 Dietary Guidelines process. http://www.nel.gov/category.cfm?cid=21

Dietary Guidelines Advisory Committee. Report of the Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans, 2010. To the Secretary of Agriculture and the Secretary of Health and Human Services, U.S. Department of Agriculture. Washington, DC: Agricultural Research Service; 2010.

Maki KC, Slavin JL, Rains TM, Kris-Etherton PM. Limitations of observational evidence: implications for evidence-based dietary recommendations. Adv Nutr. 2014;5:7–15.

Article CAS PubMed PubMed Central Google Scholar

Johnston JL, Fanzo JC, Cogill B. Understanding sustainable diets: a descriptive analysis of the determinants and processes that influence diets and their impact on health, food security, and environmental sustainability. Adv Nutr. 2014;5:418–29.

Oparil S. Low sodium intake – Cardiovascular health benefit or risk? New Eng J Med. 2014;371:677–9.

Article CAS PubMed Google Scholar

Protect School Meal Programs. School Nutrition Association Policy Resources, July 2014. Available online: https://schoolnutrition.org/uploadedFiles/Legislation_and_Policy/SNA_Policy_Resources/July2014-Protect%20School%20Meal%20Programs.pdf

Maillot M, Monsivais P, Drewnowski A. Food pattern modeling shows that the 2010 Dietary Guidelines for sodium and potassium cannot be met simultaneously. Nutr Res. 2013;33:188–94.

Hess J, Latuilippe ME, Ayoob K, Slavin J. The confusing world of dietary sugars: definitions, intakes, food sources and international dietary recommendations. Food Funct. 2012;3:477–86.

Consumer Investigation into Nutrition Facts Panels and Sugars Labeling: Topline Report of Findings. Consumer research conducted by Turner Research Network and supported by the IFIC Foundation. Available online: http://www.foodinsight.org/sugars-labeling-nutrition-panels

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Acknowledgements

The author thanks Sarah Levy, MPH, RD, for her support in the development of this paper, which includes assistance with outline development and revision of drafts. Ms. Levy is a Vice President with FoodMinds LLC, a food and nutrition affairs company that represents a range of food, nutrition, and wellness organizations. During this paper’s development, she worked for FleishmanHillard, a global communications agency that represents the Corn Refiners Association.

This paper was funded by an unrestricted grant from the following organizations: Corn Refiners Association, Grocery Manufacturers Association, International Dairy Foods Association, American Beverage Association, National Confectioners Association, and American Meat Institute.

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Competing interests.

In the past 5 years Dr. Slavin has received research grants from Minnesota Beef Council, Minnesota Cultivated Wild Rice Council, Novartis Consumer Health, USA Rice, Nestle Nutrition, Tate and Lyle, General Mills, Inc., USA Pears and American Pulse Association. In the past 5 years Dr. Slavin has received speaking fees from food companies and commodity groups with interests in processed foods, dairy products, meat, pulses, fruits, vegetables, fiber, grains, and carbohydrates. Dr. Slavin has participated in scientific panels and advisory boards that are funded by food companies, ingredient companies, commodity groups, scientific societies, and trade groups. She holds a third interest in the Slavin Sisters LLC, a 119-acre farm in Southern Wisconsin.

Joanne Slavin, PhD, RD, is a Professor in the Department of Food Science and Nutrition, University of Minnesota, St. Paul. She is a Science Communicator for the Institute of Food Technologists and served as a member of the 2010 Dietary Guidelines Advisory Committee (DGAC).

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Slavin, J.L. The challenges of nutrition policymaking. Nutr J 14 , 15 (2015). https://doi.org/10.1186/s12937-015-0001-8

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Received : 13 September 2014

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DOI : https://doi.org/10.1186/s12937-015-0001-8

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200 Unique Nutrition Research Topics for Students of All Levels

Nutrition research holds immense importance in advancing our understanding of the link between food and health. A well-chosen research topic plays a pivotal role in this process, as it fosters curiosity, drives critical thinking, and contributes to the body of knowledge in the field. A compelling topic enables students to apply their knowledge, develop research skills, and contribute significantly to nutrition science, ultimately driving positive change in dietary practices and informing public health policies.

Table of Contents

Comprehensive Lists of Impressive Nutrition Research Topics

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Interesting Nutrition and Exercise Research Topics

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An application of metabolomics to epidemiology can be found here.
Providing nutritional care and disease management with particular emphasis on enteral and parental nutrition
Nutrition as a means of preventing cancer
The challenges that food companies face in terms of regulatory standards and competitiveness
Studies on the therapeutic Role of diet in the treatment of chronic diseases
A review of nutritional factors based on physical activity levels, socioeconomic factors, and demographic characteristics
The importance of healthy eating habits to your physical and mental well-being and how they can help you
Sleep and height growth in children: Is there a causal relationship between the two?
Consumption of alcohol and tobacco may be linked to breast cancer and other types of cancer.
Work and breastfeeding are a mother’s responsibility.
Development of innovative solutions to meet the challenges of sustainable food resource development
The sustainability of food production in the world today
A healthy diet and high quality of life
What is the most effective way to adapt healthy habits to your lifestyle?
Healthy eating habits can prevent chronic diseases from occurring.
Maximizing the nutritional, sensory, functional, and safety characteristics of the food that we consume
Menopause age and cardiovascular risk during the aging process
The longitudinal relationship between cognitive and motor Performance and how nutrition can influence it to perform at its peak can be explored.
An accelerometer and a questionnaire were used to measure physical activity levels.
A study on the early determinants of whether children prefer protein from animals or protein from vegetables
Identifying and assessing the causes of early childhood food allergies in children
The problem of malnutrition in children
Infectious diseases and various other conditions can be treated with nutritional support.

Trendy Nutrition Topics to Research

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An analysis of the determinants and states of health based on a typology
After the age of 50, several factors contribute to frailty
Health effects of outdoor air pollution on humans: a study of associations
Oxidative stress plays an imperative role in the function of biological markers
Cleaning and disinfecting products in the workplace can result in occupational exposure
Depending on your social group, how often you use food, and how it affects your general eating habits
Role of a healthy diet in a brilliant mental health
Treating infertility through medical means
Young adults using electronic cigarettes and the factors associated with their use are discussed in this article
The environments in which we live have an effect on our stress levels in everyday life
Identifying nutritional exposures and assessing their impact
Biobanking of nutritional exposures; estimation of nutritional exposures
Nutritional markers with a high level of stability
A revolutionary method of analyzing nutritional problems based on innovative statistical methods and big data
How can eating well improve our lives?
Researching public health and nutrition issues using experimental and epidemiological approaches
An assessment of the impact of public health nutrition strategies can be done using theoretical systems
Public health nutritional strategies that may have a positive impact on public health
Public health epidemiology and evaluation are critical aspects of public health
There are several mechanisms involved in the relationship between nutrition and health
Nutrition and health are interconnected through the mechanism of nutrient absorption
A novel approach to determining dietary habits based on innovative determinants
Nutrient exposures and behaviors in emerging and underexplored populations

New Research Topics in Nutrition

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Eating disorders are caused by a variety of factors
Families play a critical role in the treatment of eating disorders
Role of the family as the reason for eating disorders
Eating disorders associated with sociocultural values
Eating disorders caused by difficulties with physical health and fatigue
Several psychological factors influence eating disorders
An overview of the methodology for measuring eating disorders with measuring instruments.
A brief description of anorexia nervosa and its characteristics.
An overview of the definitions and characteristics of eating disorders.
Eating disorders being reported by the patient
The results of a survey conducted between three different colleges concerning eating disorders
A study of food disorders and their relation to the environment is presented below
The definition and characteristics of bulimia can be found in the following document

Fitness and Nutrition Research Topics

Pick a topic from this list to get a chance to research the world of fitness and nutrition. Here you go with the list:

Overview of the History of Fitness and Nutrition
After childbirth, what Role does fitness play in a woman’s life?
Relationships between the fitness industry and the nutritional industry
The Role of Fitness in the Health of the Public as a Whole
What is the ideal number of fitness centers per 100 square kilometers, and where should they be located?
How can nutrition influence hormones in college students and prevent unhealthy eating habits?
Where to get guidance regarding fitness and precision nutrition?
An overview of the technological developments occurring in the fitness industry as well as their relation to nutrition
Weightlifters’ relationships with their bodies and their interaction with each other
The practice of fitness is of interest to women: The rising trend of women’s gyms
Taking part in fitness activities and meeting other people: A great source to socialize and release mental pressure
Chronic diseases in college students accumulated with disordered eating habits
Exercise as a means of combating stress and anxiety
What are the reasons for practicing fitness exercises?
The importance of exercise and proper nutrition in slowing down premature aging
Pregnant women can benefit from fitness and nutrition during their pregnancy
Number of exercises that can be used to combat metabolic diseases
Exercises that are beneficial to the health of the lungs
Heart disease prevention exercises that you can do at home
An exercise program that will help you overcome physical inactivity and paralysis

Nutrition Research Topics Related to Sports

Student-athletes are always curious to learn how what they eat affects their Performance. These topics can be just as helpful to them as they are to medical students. Here’s your chance to write excellent nutritional research articles.

Nutritional requirements for the provision of micronutrients and nutrients to the athlete of the body
Essential polyunsaturated fatty acids for sportsmen
Trans fatty acids and conjugated fatty acids for sportsmen
Estimation of daily energy expenditure by athletes
Estimation of the basal metabolic rate
Calculation of the recommended daily energy intake
Nutritional Needs of the General Population Compared to Athletes
Evolution of carbohydrate recommendations
Dietary Supplements to enhance athletic Performance
The Role of Glycogen in Performance
Interaction and synergy of metabolic pathways
Energy and carbohydrates metabolism
Comparison of sporting disciplines in terms of diet
Consumption of food products intended for athletes
Consumption of food supplements
A healthy controlled diet and health benefits of sports nutrition
Dietary supplements to improve circulation and health benefits
Muscular development and fat mass loss
Proteins, amino acids, and derivatives: Athletic support requirements
Dietary supplements used by Athletes and their risks
An athlete’s fight against fatigue.
Athletes need vitamins
Risks of post-exercise products

Food and Nutrition Research Topics

Understanding how different foods affect your health is a great reason to watch what you eat. The following topics can help you narrow your focus on the important aspects of food and nutrition that everyone should know about.

The foods that contribute to negative thinking
Chemical analysis of foods leads to negative thinking and fatigue.
An economic analysis of food systems
Health benefits of organic food vs. staple food
The food security situation in the northern Saharan region
An analysis of strategies that can be used to build resilience to food insecurity
A food security perspective on the vegetable sector
Evaluation of the food security situation in the country
Insufficient nutrition among children is a significant problem.
Urban Malnutrition and its Determinants in the developing world
How public stock of food products Significantly impacts public health and safety.
Households vulnerable to successive food shocks show a high level of resilience.
Gardening for market income and ensuring the security of food and nutrition
The profile and integrated management of severe acute malnutrition at the San Jose Hospital: a case study
Unique health benefits of food additives for college students
Nutritional contributions of keto diets
Role of administrative authorities to assure food safety
The nutritional and dietary behaviors of specific populations, as well as patients with specific conditions
The determinants of eating innovative behavior
Nutrition and health are interconnected through the mechanism of nutrient absorption.

Health and Nutrition Research Topics

We feel what we eat impacts our daily health and happiness. Some people want to change their diet but don’t know where to begin or how to avoid eating disorders. This list of hot topics will let you explore that.

In terms of climate change and food security, what is the extent of the problem?
Monitoring the nutritional status of the population utilizing various methods
The promotion of nutrition research in the human population
Importance of food safety in society
The process of training teachers, trainers, and relay personnel.
Training in the fields of medicine and paramedicine.
Public health measures and actions that have been taken to improve public health
Media and personality involvement in food and health issues at the level of artistic, cultural, and sports media and personalities
How poor eating habits lead to food addiction and too many vitamins
Establishing a system for evaluating the food provided to hospital patients
An overview of nutrition-related illnesses and their diagnosis and treatment
Initiatives aimed at educating patients on the importance of diet and health
Tool to assess nutritional status as part of a clinical assessment
How unbalanced diets and poor eating habits lead to poor nutrition
Different food groups contribute to the immune system as healthier alternatives to poor feeding habits.
Different food groups ensure healthy eating effects and prevent eating disorders.
Ensure food safety with dietary guidelines with the help of food science.

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Global food systems: A research paper on the subject
The women’s perspective on breastfeeding and returning to work after maternity leave
The effects of a balanced diet on the weight gain of pregnant women
Health benefits of proper nutrition in women
Consultation about diet during pregnancy and the delivery of twins.
The importance of diet monitoring during pregnancy for women with gestational diabetes
Managing diabetes in pregnant women and following up with them after delivery
The impact of nutrition and micro-nutrition on the development of autoimmune diseases
Analyzing the Effectiveness of artificial nutrition prescription practices in Adults
The impact of a vegetarian diet on the development of a child
Health benefits of nutrition education and promoting healthy food choices
A guide for vegetarian pregnant women on how to take care of themselves
The relationship between micronutrients and immunity
Proper nutrition to overcome food additions and lose weight with homemade food
The effect of lifestyle and dietary measures on patients with heart failure
An examination of the relationship between oral health and nutrition in a population
A study on the marketing of fruits and vegetables and healthy eating: characterization of the marketing channels involved
How food science contributes to endorsing and promoting proper nutrition with the help of healthy organic foods
A review of the association between orthostatic hypertension and geriatric syndromes
The self-esteem of patients with liver transplants in terms of their physical appearance
A report on the state of undernutrition in several hospitals on the island of Reunion
Non-drug therapies in the management of pain in women: an overview of their use
Insomnia management is based on a multidisciplinary approach.
The Role of Communication in preventive actions in Pharmacies

For centuries, people have been fascinated with understanding how our bodies work and respond. That’s why there are so many interesting research topics on nutrition and nursing for today’s students to pick from. Speaking of which, we have put together 200 of the best nutrition topics for your research paper in this exciting blog post.

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Nutrition Education: Its Importance and Promotion Essay

Nutrition education is one of the most complex and complicated areas of health care. the most difficult task is to motivate and persuade the target audience to follow dietary patterns and change their lifestyles. Best practices are based on motivation and emotional appeal aimed to influence the mind and feelings of listeners and students. The increasing complexity of modern society develops a wide range of pressures and stressors that challenges dietary patterns. Best practices in nutrition education are aimed to teach a student the main principles and norms of a healthy diet and show the simplest way how to follow them. The best practice is to involve a student/trainee in the process of change: new dietary patterns and new identity, excellent health, and no illnesses. A trainee should tackle the challenge of attempting to differentiate health styles and wellness. The teacher should discuss the possible outcomes and potential problems of unhealthy behavior patterns and their impact on a person. Whatever program is established, it is important to create and communicate a healthy lifestyle approach that meets the needs of both the trainee and his family.

The difficult task is to develop nutrition programs for poor countries. Thus, the main difficulty is to persuade people that a healthy diet is not expensive and can be successfully introduced by any family. It takes time but it brings healthy lifestyles and the absence of illnesses. A controversy that has surfaced repeatedly is whether health promotion programs reflect health care cost-containment strategies. It is crucial for nutrition educators to motivate and involve the poor in a healthy diet. In very poor countries, it is important to change negative stereotypes concerning dietary patterns and health. Because health promotion programs are relatively new for these countries, their administrative locations are not consistent across poor states. This lack of consistency brings with it a clear difference in philosophical goals. The main strategies should involve healthy cooking and a simple diet including milk products and grain, meat, fruits, and vegetables. The conclusions seem to be that nutrition education programs should be integrated into poor societies and their culture.

Mass media (TV, radio, and press) can be effective tools to promote nutrition education and diet in poor countries. It is possible to promote healthy lifestyles and a balanced diet through TV shows and press releases. Many people in less developed countries are unaware of how much, what, or where they eat. Much of the food they eat can be considered forgotten food, this is particularly so with snacks, food is eaten whilst watching TV or food tasted during cooking. Helping poor states increase their awareness of current eating habits is an essential first step in the management process.

Only when they begin to recognize the eating practices which are contributing to their excess energy intake can they move towards considering where and how to make appropriate changes. Food diaries are a very useful self-monitoring tool, encourage patients to be actively involved in treatment, and may give an indication of motivation. Special attention should be given to costs spend on healthcare and problems caused by current dietary patterns and ineffective dietary balance. It is possible to use a slogan like: health is cheaper than illness: eating and healthy diet is the best approach to save money”. Involving partners and families in the attempts to make healthier choices is important in increasing compliance to dietary changes and as a cost-effective means of extending health messages. Rather than the goal is to eat less fatty food, which is very general, it would be preferable for the patients to set specific goals such as to eat less fatty foods by changing from butter to a low-fat spread and to use fat-free salad dressings rather than mayonnaise in salads and sandwiches.

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130 Nutrition Research Topics For Exceptional Paper

When it comes to the world of nutrition, navigating it should be as precise as possible, and that means keeping tabs on current nutrition topics and hot nutrition topics, as well as integrated health and nutrition topics. For anyone willing to seek homework help for their nutrition topic needs, there are cheap, trusted quality experts you can get on board to help you. These experts can be trusted to provide quality work, and they can help you meet up with whatever deadline has been set for you to work on your research paper topics for nutrition class. The best part is that these professional services are offered to university students at affordable rates. We understand how tasking it can be for students to juggle their entire college life while trying to meet social expectations and end up with top grades, so we’ve put together some nutrition hot topics and popular nutrition topics for college students and anyone willing to make further research into these topics. Whether you’re looking for some nutrition topics for presentation, below are some areas and topics that constitute the latest research topics in nutrition. If you’ve already chosen a topic, but have difficulties with paper writing, then check out our college paper writing services .

Nutrition Topics for Research

The science of nutrition is important in understanding and contributing to one’s own healthy lifestyle. Below are some research topics you can explore to fully grasp and express the importance of nutrition and nutritional health in growth and development.

Differences in the responses of different people to certain foods.
How responses to diet can vary from person to person.
How proper nutrition supports healthy growth and development.
The influence of certain diets on reproductive health.
How proper nutrition helps in the management and promotion of health.
The impact of a controlled healthy diet on diabetes.
How certain foods precipitate an individual’s pre-existing medical condition.
The psychology and biological factors surrounding eating disorders.
How healthy diets and an active lifestyle help to maintain health.
Effects of malnutrition on the immune system.
How malnutrition affects mother and child.
How poor eating habits lead to physical ailments and conditions.
How behavior relates to a person’s nutritional habits.
Differences in the contribution of minerals and vitamins to a person’s health.
Diets and nutritional influencers of cardio metabolism.

Sports Nutrition Topics

Whether it’s light exercise or athletics, the right diet is needed in order for one to be able to keep up with the demands of the body to replenish the energy that has been lost. When exploring sports nutrition, the following topics will prove useful to you in your research. Carefully examine each research topic.

Animal-based and plant-based protein foods.
The place of variety in an athlete’s diet.
How fruits and vegetables help in managing energy for sporting activities.
The roles played by protein and carbohydrates in the healthy mental development of athletes.
The cycle of water in an athlete’s diet.
Special diets that help build stamina and endurance.
Diets that help replenish energy and depleted stamina.
How diets and supplements interact in the maintenance of weight.
The place of supplements in diets.
How much is too much food before and after training?
Overdependence on exclusive diets.
How nutrition helps in the development of target muscles and organs.
Calcium: a highly underrated integral portion of an athlete’s diet.
How saturated and trans fat affects the performance of an athlete.
The role of diets and supplements in the prevention and healing of injuries.

Nutrition Education Topics

When it comes to educating other people on how their nutritional choices affect their overall health, one will see that they need a hand. Not to worry, as the following topics will help point you in the right direction in your research.

Vegetarian vegan diets
Maintaining a healthy diet in the midst of a pandemic.
How water aids digestion and circulation of nutrients.
The place of diets in preexisting conditions like HIV/ AIDS.
Rationale behind the specialized dietary requirements for people with chronic illnesses.
Dietary supplements: mythical or factual.
The safety of herbal remedies as nutritional supplements.
Mitigating malnutrition with a healthy diet.
Consequences of poor feeding habits.
How nutrition enhances the immune system of women and children.
Factors that contribute to food safety.
Dietary requirements for children.
Nutritional contribution to weight gain and management.

Food and Nutrition Essay Topics

Understanding how different types of food interplay to affect one’s health is more than enough reason to maintain a healthy diet. The following food and nutrition essay topics will help hone your focus on the important aspects of food and nutrition that everyone needs to know about.

Organic foods.
How good nutrition influences the productivity of physical activity.
How genetics contribute to a person’s susceptibility to obesity.
How a healthy diet helps in the repair of cardiovascular impairments.
The impacts of psychological, biological, and nutritional elements on a person’s eating habits.
The impacts of psychology on a person’s feeding habits.
How unhealthy eating habits have progressed among teenage children to become trendy.
Stimulants: dependency, overdependence, and healthy methods of getting weaned off of them.
Diets that help facilitate weight loss in patients with obesity.
Brain foods: foods that boost mental and cognitive health.
The impact of a healthy, wholesome diet on the mental health of a person.
Maintaining a healthy diet even in the face of economic hardship.
Food security and availability, and how they propagate malnutrition.
How unbalanced diets can result in psychotic and psychological disorders.
The place of calories in nutrition.

Sports Nutrition Topics for Research

For further research into the impact of food choices on sports, the topics below would make great research topics. Having a clear focus will aid in this aspect of your research, and the topics below are ideal for new discoveries and techniques in promoting good nutrition.

Metabolism of carbohydrates
Special energy requirements of athletes
Managing or maintaining body weight
Tailoring food and exercise for specific sports
Food supplements
Proper hydration
Steroids and their impact on sports
The sports nutrition principles
Foods to stay away from
Foods that boost sports performance
The best kind of foods for different athletes
Can athletes be vegans?
Effects of energy drinks on athletes
The place of food in recovery
How does food affect the way we sleep?

Nutrition Research Paper Topics

Without doing too much, this list of topics will help refine your research skills and help you discover uncharted territories in nutrition, food, and health.

Balanced diet
Vitamins: what really are they?
The relationship between food and hormones
Are food additives safe?
Different kinds of eating disorders
Fighting eating disorders
The best kinds of foods to maintain weight
Foods to help you gain weight
Foods that help you lose weight
Curbing food addictions
Is being vegan worth it?
Balanced diets for vegans
The prevalence of malnutrition
Foods appropriate for children
Foods children need to avoid

Interesting Nutrition Topics for Research Paper

Teaching children about nutrition and nutritional health benefits.
How proteins help produce energy.
Synthesis of proteins and carbohydrates.
The unhealthy supplementation of healthy proteins and carbohydrates in diets today.
Managing malnutrition as a sustainable development goal.
Zero hunger: the quest to ensure food security and mother and infant nutrition.
Commercialization of foods rich in antioxidants: a governmental strategy to boost health.
The role of nutrition and heredity in allergies.
Exclusive breastfeeding for infants.
Viability of the supplementation of colostrum found in breastmilk.
Breastmilk: an infant’s first supply of antioxidants.
How folate helps prevent spina bifida before conception.
Myths surrounding nutrition in pregnancy.
What cravings say about nutrient deficiency.

Research Topics In Nutrition and Dietetics

Health risks associated with abdominal obesity.
Childhood obesity: causative factors and remedial actions.
The role of dieting in gerontology.
Free radicals: are they good or bad?
The underrated potentials of vitamin c.
Proper nutritional habits in toddlers and young children.
Nutritional requirements in adolescents and teenagers.
How nutritional habits and requirements vary across genders.
Duets to help control and eliminate abdominal fat.
Alcohol, alcohol dependency, and its effect on a person’s nutrition.
Oils that help in the development of mental abilities.
Omega 3 Fatty acids.
Keto diets: should you be so dependent on them?
The place of supplementation in nutrition.

Research Topics In Clinical Nutrition

How chronic illnesses affect nutritional health.
Chronic diseases and healthy food choices.
Ideal sources of calcium.
Good and bad cholesterol.
Pocket-friendly alternatives to healthy organic foods.
Eating disorders.
Pharmacological interaction between enzymes and drugs.
Disorders of the digestive system.
Cardiovascular diseases and heart health.
Fiber, fish, and folic acids: three important “F’s” to adhere to during pregnancy.
Myths and misconceptions about food and nutrition.
The role of micronutrients in overall health.
The role of macronutrients in overall health.
Physical activity vs sedentary lifestyle: effects of both on general health.

Food is a constant part of the life of every living thing, so any knowledge that can be gotten on the topic is valuable. The place and role of knowledge on food and nutrition cannot be overemphasized. Having the right knowledge of the different kinds and classes of foods as well as their uses will go a long way to ensuring their proper use. More so, a healthy population is one of the greatest assets of any nation. This can be achieved through proper nutrition and detailed research. No person, group, or economy can grow without having substantial knowledge of food, hence the need to know more about this staple. You can find some topic inspiration for your essay or assignment. Be sure to research thoroughly to determine if you have enough information to work with before starting.

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Focus: Nutrition and Food Science

Marek Michalak

Luis B. Agellon

Introduction

Quality of Nutrition

Food Components

Factors that Influence Human Nutrition

Technologies Used in the Study of Metabolism and Nutrition

Acknowledgments

Author Contributions

The challenges of nutrition policymaking

Introduction

How science is used in policymaking

The dietary guidelines advisory committee

The DGAC evidence review process

Research methodology: what makes a strong vs. weak study

Consequences of non-evidence-based policy

Conclusions

Abbreviations

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