master thesis molecular biology uni wien

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This repository contains metadata and full text versions of diploma theses, master’s theses and doctoral theses that have been approved at the University of Vienna since 1965.

Since 2008, all graduates have been obliged to archive their academic theses electronically in this repository. The full texts are archived royalty-free (i.e. with maximum protection under copyright) and always following the approval of the relevant authors.

Academic theses that have been approved before 2008 can be uploaded directly to and published on the server, unless this would violate any legal or statutory regulations.

The thesis server provides the opportunity to make your thesis available worldwide. Using structured metadata, the theses uploaded to the server get bibliographic descriptions. They are included in and can, therefore, be found via international library catalogues, search engines and other bibliographic tools. This ensures that the theses are citable through a permanent and stable web address.

Publishing theses is the best protection against plagiarism.

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Master & Research Internships

Unlike the PhD programme, there is no formalised master programme at the IMP. Instead, most labs frequently host master students during the research part of their thesis or for placements and internships. 

If you are highly motivated, academically sound and very interested in the work of one of our research groups, then please contact the relevant group leader and enquire about opportunities to join the lab for the time of your master research or an internship.

Frequently, positions for master students are also advertised on this website under “ open positions ”.  You may also be eligible for the Vienna BioCenter Summer School .

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Master Thesis and Completion of the Programme

In the third and fourth semester, students write a master thesis on a topic developed in the context of their chosen research specialisations. Guidance and feedback is offered in the individual interaction with the thesis supervisor as well as in the context of practice-oriented thesis seminars. A selected number of opportunities to write master thesis in the framework of ongoing research projects also exist.

We recommend to commence with the following procedure as soon as you have completed the following modules:

• BM A: 5 ECTS
• BM B: 13 ECTS
• RS: at least 10 ECTS

The administrative procedure is:

1. selection of supervisor.

These supervisors will be available for new thesis projects:

• Univ.-Prof. Dr. Sarah Davies
• Univ.-Prof. Dr. Ulrike Felt
• Assoc.-Prof. Dr. Maximilian Fochler
• Fredy Mora Gámez, PhD
• Dr. Andrea Schikowitz
• Dr. Nina Klimburg-Witjes

Twice per year, the programme director offers a matchmaking between supervisors and students to assure the ideal allocation of supervisors to student topics. Information about this is sent out via the STS student mailing list.

2. Approval of Supervisor & the Topic

Please hand in the following items at the secretariat of the Department of Science and Technology Studies ( office hours ), or send an electronic version to sec.sts @ univie.ac.at :

the Notification Form, signed by you as well as your supervisor

the Regulations Relating to Good Scientific Practice

the Record of Exams, stating all courses completed so far, signed by yourself (We recommend saving this file on your computer as you will need the complete version later on, in the process of completing the Master.)

your Research Exposé, signed by your supervisor

By email you will be notified about the approval of your thesis' topic within 3 weeks (during the term).

 Download

Notification of Master Thesis Topic and Supervisor

1 Notification of Master Thesis Topic and Supervisor.pdf

Regulations relating to good scientific practice

Regulations relating to good scientific practice.pdf

Guidelines for Writing a Master Thesis Expose

Guidelines for Writing a Master Thesis Expose.pdf

Record of Exams

1 Record of Exams.pdf

3. Submission of the Complete Record of Exams

As soon as you have completed all your courses (at the latest 2 weeks before you upload your thesis on u:space - step 4), please submit the following documents to the secretariat of the Department of Science and Technology Studies (either as hard-copy, or an electronic version by email ).

• a signed copy of the complete record of exams . Please note: All grades must be registered and assigned to the appropriate modules in u:space!
• a copy of your acceptance letter ('Zulassungsbescheid')
• (if applicable) a copy of the official notification of recognition of examinations ('Anerkennungsbescheid')

Also, 1-2 weeks before the date of uploading your thesis, please contact one of the second examiners (please also see item 5. Public Defense / Final Examination ) whether he or she would be ready to serve as such.

4. Submission of the Master Thesis - NEW: on u:space!

Important information on the timeline:.

Steps 2 & 3 are a prerequisite! Then, two weeks AFTER having sent the complete record of exams to [email protected] (contact: Karin Neumann): 1) submit the thesis on u:space , PLUS at the same time contact a second examiner (if not even before updoading), 2) receive the grade, 3) two weeks after grading is the earliest date the defense can take place! For details see Steps A-C:

Upload your thesis on u:space in order to perform a plagiarism check. The uploaded thesis must be the same as the one submitted in binding. The formal requirements for academic theses must be observed; for the formal guidelines summarized in English please also see here . Firstly, you need to review and verify the data in u:space that will be printed on the title page . This information is automatically loaded from university’s database and includes your name and academic degrees, as well as details regarding the supervision of your thesis.  For the title page of the thesis, there are concrete specifications regarding the layout and the data listed. To ensure that your title page is correct in terms of form and content, the system will create it automatically from your data. Please do not use a title page you have created yourself, as this will not be accepted during the formal check! To ensure the protection of your personal data, i.e. in order to guarantee an anonymized plagiarism check, please:

• do not include any personal data (like your name or student ID)
• do not include your CV (or affidavit)
• do not include your name in the header or footer

The thesis must contain a German AND English abstract of at least 500 characters. The abstract is a brief summary of the central points of your thesis. You can choose the option to make the full text available through u:theses , so others can read your work. Further information on the use of publications in academic theses can be found on the website of the office of the Studienpräses . Once you have uploaded the document, you will receive an upload confirmation (“Hochladebestätigung”) .

If any textual similarities are detected between your work and other texts, the study program management will examine whether it constitutes plagiarism . Please DO NOT PRINT your thesis until you have received feedback via email to your u:account, confirming a successful plagiarism check. The printed version must exactly match the electronically submitted version. After a successful plagiarism check , you must submit two hardbound & double-sided printed copies of your thesis to the 'Study Service Unit for Social Sciences' - by post or by depositing them at the 'NIG-Porter' ( Universitätsstraße 7 (NIG), 1010 Wien, porter ), so we can forward them to the university libraries. You will need to present the upload confirmation (“Hochladebestätigung”) for this submission. In case of any questions, please contact the Study Service Unit .

The supervisor has 2 months to evaluate your thesis and send the report to the 'Study Service Unit'/StudienServiceCenter. A couple of days after the supervisor has handed in his/her evaluation, you will receive an email with a scanned copy of the evaluation form containing the grade.

Formalities & Layout Master Thesis

Layout Thesis.pdf

Dateigröße:  161 kB

5. Public Defence

Around the date of uploading your thesis (or even better: 1-2 weeks before), please contact one of the following second examiners whether he or she would be ready to serve as such:

• Ass.-Prof. Dr. Nina Klimburg-Witjes
• Fredy Alberto Mora Gàmez, PhD

If the examiner consents, please agree on the literature for the exam*,

and coordinate a date for the defence/final examination with your supervisor, 2nd examiner, and chair.

The date of the examination must be at least 14 days after the evaluation date of the thesis.

*For students who enrolled in the programme before winter term 2014/2015 the reading list comprises 2 books and 5 articles. For this format, there is a list with recommended literature for all examiners. For students who enrolled in the programme in winter term 2014/2015 or after, the reading list comprises two books. For this format, each examiner has his/her own list of literature.

In both cases, the literature should predominantly be from an STS area other than your master thesis.

Submit the registration for master's examination form and the examination literature form to the institute´s secretariat (by e-mail to sec.sts @ univie.ac.at ).

Please read the information sheet about the defence/examination attentively,and consider that the time span between the moment you have handed in the master thesis at the StudienServiceCenter and your defensio can be up to 2.5 months.

Registration for Master Examination

2 Registration for masters examination.pdf

Dateigröße:  62 kB

Form Examination Literature

Form Examination Literature.pdf

Dateigröße:  311 kB

Information Sheet: Public Defence and Final Examination

Information Sheet Public Defence and Final Examination.pdf

Dateigröße:  37 kB

Literature List for Final Examination

Literature List for Final Examination.pdf

Dateigröße:  60 kB

6. Acquiring your Diploma

To acquire your diploma, you have to fill in a form of the Statistik Austria , that you will receive by email. Once you´ve filled in the form, you'll receive a confirmation of the statistical data acquisition . You need to send the pdf-confirmation of it to ssc.sozialwissenschaften @ univie.ac.at , and will then receive ALL your signed and officially approved diploma-documents by email to your u:account:

“Bescheid über die Verleihung eines akademischen Grades”

“Abschlusszeugnis”

Diploma Supplement (including grade point average)

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Master's thesis

Master's Thesis (25 ECTS)

The Master's Thesis serves as proof of the ability to handle scientific topics independently in terms of content and methodology. Therefore, the subject of the master's thesis is to be selected so that it is possible and feasible for the students to complete it within six months. 

The next deadlines for graduation in 2024: 

03.10.2023  – submission of the final thesis to the SSC if you plan to have the master's exam at the  end of January 2024

21.11.2023  – submission of the final thesis to the SSC if you plan to have the master's exam at the beginning  of March 2024

05.12.2023  – submission of the final thesis to the SSC if you plan to have the master's exam at the  end of March 2024

19.03.2024  – submission of the final thesis to the SSC if you plan to have the master's exam at the  end of June 2024

11.06.2024  – submission of the final thesis to the SSC if you plan to have the master's exam at the  end of September 2024

09.07.2024  – submission of the final thesis to the SSC if you plan to have the master's exam at the  end of October 2024

Registration of the topic of the Master's Thesis

As soon as you receive a grade from the MASE seminar, you can register the title of your master's thesis. 

• Print the form "Bekanntgabe Thema und Betreuung der Masterarbeit" two times and sign both sheets. Your supervisor also has to sign both sheets.
• Please submit both forms, together with the form “ regulations relating to good scientific practice ”, to Dimitra Eisterer Petimeza, B.Ed. MA, at  commscience @ univie.ac.at .

ScholarWorks@UMass Amherst

Home > CNS > BIOCHEM > MCB > MCB_THESES

Molecular and Cellular Biology Masters Theses Collection

Theses from 2024 2024.

The Impact of a Non-ionic Adjuvant to the Persistence of Pesticides on Produce Surfaces , Daniel Barnes, Molecular & Cellular Biology

Investigating the Role of Got2 in Murine Organogenesis and Placenta Development , Olivia Macrorie, Molecular & Cellular Biology

Chromatin Accessibility Impacts Knockout of Mt-Bell4 Transcription Factor , Thomas Redden, Molecular & Cellular Biology

UNDERSTANDING THE FUNCTIONAL IMPACT OF DISEASE-ASSOCIATED PHOSPHORYLATION SITES ON THE NEURODEGENERATIVE PROTEIN TAU , Navya T. Sebastian, Molecular & Cellular Biology

Theses from 2023 2023

Elucidating the Priming Mechanism of ClpXP Protease by Single-Domain Response Regulator CpdR in Caulobacter crescentus , Kimberly E. Barker, Molecular & Cellular Biology

The Discovery of a Novel Bacteria from a Large Co-assembly of Metagenomes , Matthew Finkelberg, Molecular & Cellular Biology

Investigating Diterpene Biosynthesis in Medicago Truncatula , Sungwoo Hwang, Molecular & Cellular Biology

Combining Simulation and the MspA Nanopore to Study p53 Dynamics and Interactions , Samantha A. Schultz, Molecular & Cellular Biology

Caulobacter ClpXP Adaptor PopA’s Domain Interactions in the Adaptor Hierarchy of CtrA Degradation , Thomas P. Scudder, Molecular & Cellular Biology

Climate Change, Giant Viruses and Their Putative Hosts , Sarah K. Tucker, Molecular & Cellular Biology

Theses from 2022 2022

Changes in Gene Expression From Long-Term Warming Revealed Using Metatranscriptome Mapping to FAC-Sorted Bacteria , Christopher A. Colvin, Molecular & Cellular Biology

Determining CaMKII Variant Activities and Their Roles in Human Disease , Matthew J. Dunn, Molecular & Cellular Biology

Developmental Exposures to PFAS Mixtures Impair Elongation of the Exocrine Pancreas in Zebrafish (Danio rerio) , Emily M. Formato, Molecular & Cellular Biology

A Metatranscriptomic Analysis of the Long-Term Effects of Warming on the Harvard Forest Soil Microbiome , Brooke A. Linnehan, Molecular & Cellular Biology

Characterization of the Poly (ADP-Ribose) Polymerase Family in the Fusarium oxysporum Species Complex , Daniel Norment, Molecular & Cellular Biology

Theses from 2021 2021

Exploring Knockdown Phenotypes and Interactions between ATAD3 Proteins in Arabidopsis thaliana , Eli S. Gordon, Molecular & Cellular Biology

Development of a Site-Specific Labeling Assay to Study the Pseudomonas aeruginosa Type III Secretion Translocon in Native Membranes , Kyle A. Mahan, Molecular & Cellular Biology

Liposomal Nanoparticles Target TLR7/8-SHP2 to Repolarize Macrophages to Aid in Cancer Immunotherapy , Vaishali Malik, Molecular & Cellular Biology

Hsp70 Phosphorylation: A Case Study of Serine Residues 385 and 400 , Sashrika Saini, Molecular & Cellular Biology

Activation of Nrf2 at Critical Windows of Development Alters Protein S-Glutathionylation in the Zebrafish Embryo (Danio rerio) , Emily G. Severance, Molecular & Cellular Biology

Utilizing Fluorescence Microscopy to Characterize the Subcellular Distribution of the Novel Protein Acheron , Varun Sheel, Molecular & Cellular Biology

Theses from 2020 2020

The Association Between Sperm DNA Methylation and Sperm Mitochondrial DNA Copy Number , Emily Houle, Molecular & Cellular Biology

Gene Expression Regulation in the Mouse Liver by Mechanistic Target Of Rapamycin Complexes I and II , Anthony Poluyanoff, Molecular & Cellular Biology

Sperm Mitochondrial DNA Biomarkers as a Measure of Male Fecundity and Overall Sperm Quality , Allyson Rosati, Molecular & Cellular Biology

Exploration of the Association between Muscle Volume and Bone Geometry Reveals Surprising Relationship at the Genetic Level , Prakrit Subba, Molecular & Cellular Biology

Theses from 2019 2019

Studies on the Interaction and Organization of Bacterial Proteins on Membranes , Mariana Brena, Molecular & Cellular Biology

Investigating The Role Of LBH During Early Embryonic Development In Xenopus Laevis , Emma Weir, Molecular & Cellular Biology

Theses from 2018 2018

Exploring the Influence of PKC-theta Phosphorylation on Notch1 Activation and T Helper Cell Differentiation , Grace Trombley, Molecular & Cellular Biology

Theses from 2017 2017

Partial Craniofacial Cartilage Rescue in ace/fgf8 Mutants from Compensatory Signaling From the Ventricle of Danio Rerio , Douglas A. Calenda II, Molecular & Cellular Biology

THE FAR C-TERMINUS OF TPX2 CONTRIBUTES TO SPINDLE MORPHOGENESIS , Brett Estes, Molecular & Cellular Biology

Characterization of Calcium Homeostasis Parameters in TRPV3 and CaV3.2 Double Null Mice , Aujan Mehregan, Molecular & Cellular Biology

Microtransplantation of Rat Brain Neurolemma into Xenopus Laevis Oocytes to Study the Effect of Environmental Toxicants on Endogenous Voltage-Sensitive Ion Channels , Edwin Murenzi, Molecular & Cellular Biology

Regulation of Katanin Activity on Microtubules , Madison A. Tyler, Molecular & Cellular Biology

Theses from 2016 2016

The Role of MicroRNAs in Regulating the Translatability and Stability of Target Messenger RNAs During the Atrophy and Programmed Cell Death of the Intersegmental Muscles of the Tobacco Hawkmoth Manduca sexta. , Elizabeth Chan, Molecular & Cellular Biology

An in Vivo Study of Cortical Dynein Dynamics and its Contribution to Microtubule Sliding in the Midzone , Heather M. Jordan, Molecular & Cellular Biology

A Genetic Analysis of Cichlid Scale Morphology , Kenta C. Kawasaki, Molecular & Cellular Biology

Modulation of Notch in an Animal Model of Multiple Sclerosis , Manit Nikhil Munshi, Molecular & Cellular Biology

One-Carbon Metabolism Related B-Vitamins Alter The Expression Of MicroRNAS And Target Genes Within The Wnt Signaling Pathway In Mouse Colonic Epithelium , Riccardo Racicot, Molecular & Cellular Biology

Characterizing the Inhibition of Katanin Using Tubulin Carboxy-Terminal Tail Constructs , Corey E. Reed, Molecular & Cellular Biology

The Identification of Notch1 Functional Domains Responsible for its Physical Interaction with PKCθ , Wesley D. Rossiter, Molecular & Cellular Biology

Dynamics of Microtubule Networks with Antiparallel Crosslinkers , Kasimira T. Stanhope, Molecular & Cellular Biology

Modifications of Myofilament Structure and Function During Global Myocardial Ischemia , Mike K. Woodward, Molecular & Cellular Biology

Theses from 2015 2015

Regulation of Jak1 and Jak2 Synthesis through Non-Classical Progestin Receptors , Hillary Adams, Molecular & Cellular Biology

Antineoplastic Effects of Rhodiola Crenulata on B16-F10 Melanoma , Maxine Dudek, Molecular & Cellular Biology

RNAi Validation of Resistance Genes and Their Interactions in the Highly DDT-Resistant 91-R Strain of Drosophila Melanogaster , Kyle Gellatly, Molecular & Cellular Biology

Characterization of Protein-Protein Interactions for Therapeutic Drug Design Utilizing Mass Spectrometry , Alex J. Johnson, Molecular & Cellular Biology

Promoting Extracellular Matrix Crosslinking in Synthetic Hydrogels , Marcos M. Manganare, Molecular & Cellular Biology

Characterization of the Reconstituted and Native Pseudomonas aeruginosa Type III Secretion System Translocon , Kathryn R. Monopoli, Molecular & Cellular Biology

Thermocycle-regulated WALL REGULATOR INTERACTING bHLH Encodes a Protein That Interacts with Secondary-Cell-Wall-Associated Transcription Factors , Ian P. Whitney, Molecular & Cellular Biology

Theses from 2014 2014

Engineering Camelina sativa for Biofuel Production via increasing oil yield and tolerance to abiotic stresses , Kenny Ablordeppey, Molecular & Cellular Biology

Designing a Pore-Forming Toxin Cytolysin A (ClyA) Specific to Target Cancer Cells , Alzira Rocheteau Avelino, Molecular & Cellular Biology

The Role of the Novel Lupus Antigen, Acheron, in Moderating Life and Death Decisions , Ankur Sheel, Molecular & Cellular Biology

Expression and Purification of Human Lysosomal β-galactosidase from Pichia Pastoris , Sarah E. Tarullo, Molecular & Cellular Biology

Properties of Potential Substrates of a Cyanobacterial Small Heat Shock Protein , Yichen Zhang, Molecular & Cellular Biology

Theses from 2013 2013

Characterizing the Heavy Metal Chelator, Tpen, as a Ca2+ Tool in the Mammalian Oocyte , Robert A. Agreda Mccaughin, Molecular & Cellular Biology

Sustainable Biofuels Production Through Understanding Fundamental Bacterial Pathways Involved in Biomass Degradation and Sugar Utilization , James CM Hayes, Molecular & Cellular Biology

Stiffness and Modulus and Independent Controllers of Breast Cancer Metastasis , Dannielle Ryman, Molecular & Cellular Biology

Theses from 2012 2012

The Pyrethroid Deltamethrin, Which Causes Choreoathetosis with Salivation (CS-Syndrome), Enhances Calcium Ion Influx via Phosphorylated CaV2.2 expresssed in Xenopus laevis oocytes , Anna-maria Alves, Molecular & Cellular Biology

A Test of the Hypothesis That Environmental Chemicals Interfere With Thyroid Hormone Action in Human Placenta , Katherine Geromini, Molecular & Cellular Biology

Analyzing the Role of Reactive Oxygen Species in Male-Female Interactions in Arabidopsis thaliana. , Eric A. Johnson, Molecular & Cellular Biology

Rhythmic Growth And Vascular Development In Brachypodium Distachyon , Dominick A. Matos, Molecular & Cellular Biology

Polymer Prodrug Conjugation to Tumor Homing Mesenchymal Stem Cells , Nick Panzarino, Molecular & Cellular Biology

Investigation of Differential Vector Competence of Bartonella quintana in Human Head and Body Lice , Domenic j. Previte, Molecular & Cellular Biology

Downregulation of Cinnamyl Alcohol Dehydrogenase or Caffeic Acid O-Methyltransferase Leads to Improved Biological Conversion Efficiency in Brachypodium distachyon , Gina M. Trabucco, Molecular & Cellular Biology

Theses from 2011 2011

Evolutionary Relationship of the ampC Resistance Gene In E. cloacae , Shanika S. Collins, Molecular & Cellular Biology

Sex Difference in Calbindin Cell Number in the Mouse Preoptic Area: Effects of Neonatal Estradiol and Bax Gene Deletion , Richard F. Gilmore III, Molecular & Cellular Biology

In Vivo Investigations of Polymer Conjugates as Therapeutics , Elizabeth M. Henchey, Molecular & Cellular Biology

Examination of Sexually Dimorphic Cell Death in the Pubertal Mouse Brain , Amanda Holley, Molecular & Cellular Biology

Human Niemann-Pick Type C2 Disease Protein Expression, Purification and Crystallization , Yurie T. Kim, Molecular & Cellular Biology

Revealing the Localization of the Class I Formin Family in the Moss Physcomitrella patens Using Gene Targeting Strategies , Kelli Pattavina, Molecular & Cellular Biology

Connecting Motors and Membranes: A Quantitative Investigation of Dynein Pathway Components and in vitro Characterization of the Num1 Coiled Coil Domain , Bryan J. St. Germain, Molecular & Cellular Biology

Theses from 2010 2010

The Protective Effects A Full-term Pregnancy Plays Against Mammary Carcinoma , Matthew p. Carter, Molecular & Cellular Biology

Analysis Of An Actin Binding Guanine Exchange Factor, Gef8, And Actin Depolymerizing Factor In Arabidopsis Thaliana. , Aleksey Chudnovskiy, Molecular & Cellular Biology

The Role of Ykl-40, a Secreted Heparin-Binding Glycoprotein, in Tumor Angiogenesis, Metastasis, and Progression: a Potential Therapeutic Target , Michael Faibish, Molecular & Cellular Biology

In Vivo Visualization of Hedgehog Signaling in Zebrafish , Christopher J. Ferreira, Molecular & Cellular Biology

An In Vivo Study of the Mammalian Mitotic Kinesin Eg5 , Alyssa D. Gable, Molecular & Cellular Biology

Identification of Dynein Binding Sites in Budding Yeast Pac1/LIS1 , Christopher W. Meaden, Molecular & Cellular Biology

Functional Characterization of Arabidopsis Formin Homologues Afh1, Afh5, Afh6, Afh7 and Afh8 , Shahriar Niroomand, Molecular & Cellular Biology

Regulation of Crbp1 In Mammary Epithelial Cells , Stacy L. Pease, Molecular & Cellular Biology

In Vivo Labeling Of A Model β-Clam Protein With A Fluorescent Amino Acid , Mangayarkarasi Periasamy, Molecular & Cellular Biology

In Vivo Characterization of Interactions Among Dynein Complex Components at Microtubule Plus Ends , Karen M. Plevock, Molecular & Cellular Biology

Anti-Diabetic Potentials of Phenolic Enriched Chilean Potato and Select Herbs of Apiaceae and Lamiaceae Families , Fahad Saleem, Molecular & Cellular Biology

Interconversion of the Specificities of Human Lysosomal Enzymes , Ivan B. Tomasic, Molecular & Cellular Biology

Deletions of Fstl3 and/or Fst Isoforms 303 and 315 Results in Hepatic Steatosis , Nathan A. Ungerleider, Molecular & Cellular Biology

Theses from 2009 2009

A New Laser Pointer Driven Optical Microheater for Precise Local Heat Shock , Mike Placinta, Molecular & Cellular Biology

Theses from 2008 2008

Cysteine Dioxygenase: The Importance of Key Residues and Insight into the Mechanism of the Metal Center , Jonathan H. Leung, Molecular & Cellular Biology

Invertebrate Phenology and Prey Selection of Three Sympatric Species of Salmonids; Implications for Individual Fish Growth , Jeffrey V. Ojala, Wildlife & Fisheries Conservation

Paralemmin Splice Variants and mRNA and Protein Expression in Breast Cancer , Casey M. Turk, Molecular & Cellular Biology

Stability of the frog motor nerve terminal: roles of perisynaptic Schwann cells and muscle fibers , Ling Xin, Molecular & Cellular Biology

Theses from 2007 2007

Antioxidant Response Mechanism in Apples during Post-Harvest Storage and Implications for Human Health Benefits , Ishan Adyanthaya, Molecular & Cellular Biology

Progress Towards A Model Flavoenzyme System , Kevin M. Bardon, Molecular & Cellular Biology

The effect of Rhodiola crenulata on a highly metastatic murine mammary carcinoma , Jessica L. Doerner, Molecular & Cellular Biology

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Master's Degree Program

Molecular biotechnology, at a glance.

The English-language Master's degree program in Molecular Biotechnology is unique in Austria: the emphases of the Master´s degree program are molecular medicine, human genetics, drug discovery and immunology. You will investigate the causes of diseases at the cellular level and learn how to develop new treatments and therapies for them. You will learn about the hot topics of big data, personalized data analysis and data security. The degree program is part of a large national and international network at university level.

English-language degree program with focus in cancer research, immunology, drug discovery, human genetics and stem cells

R&d-projects in cooperation with universities and companies: allergy research, cell-based test systems and cellular signaling pathways.

Master of Science in Natural Sciences (MSc)

Tuition fee per semester

+ ÖH premium + contribution 2

Currently no application possible

1 Tuition fees for students from third countries € 727,- per semester

2 for additional study expenses (currently up to € 83,- depending on degree program and year)

Perspectives

Internship at the renowned massachusetts institute of technology.

Florian Kabinger completed the English Master program Molecular Biotechnology in 2020. Equipped with the Austrian Marshall Plan Scholarship, he went abroad to do his internship at the renowned Massachusetts Institute of Technology (MIT). And he will continue his top-class education.

Before the studies

Your interest in breaking new ground in the development of vaccines and other medicines or in areas such as stem cell research and a desire to take on management responsibilities are excellent prerequisites for studying in this degree program. You want to be at the forefront of developing new technologies. You are not interested in a routine job, but want major challenges in research and development. You are a very curious individual who wants to examine things in fine detail and to this end you have the necessary patience to undertake the required steps in order to reach your goals. You know that you can achieve a lot on your own, but in a team you can achieve everything. English as the language of life sciences is part of your everyday working life.

Why you should study with us

Study place = lab place.

Sharing is good, however, not your lab space, please. You are guaranteed your own.

Highly sought-after knowledge

What you learn here is crucial to solving global problems.

International network

Going abroad for an internship or a job: this is the next logical step when studying with us.

Admission requirements

• In order to assess whether you have the required ECTS credits for the Master’s degree program Molecular Biotechnology, please complete the linked table, also add existing or missing credits as part of the application - please click HERE to fill out the table to open the file (PDF 1,1 MB)
• If the applicant graduated from an education system, which does not use the ECTS credit system, it is the applicant’s responsibility to demonstrate ECTS-equivalence.
• If you meet the admission requirements and if the ECTS credits are only slightly below the required number, it will be decided on a case-by-case basis whether the additional ECTS credits can be compensated by additional examinations in order to allow admission to the degree program.
• Equivalent certificate from abroad - Equivalence is determined by international agreements, validation or in individual cases a decision by the head of the academic section.
• The program is conducted entirely in English
• Students who have obtained their higher education entrance qualification and Bachelor's degree in the EU, EEA or Switzerland do not require proof of their English language skills.
• Students who speak English as their first language must prove their nationality, place of birth and length of stay in a country with English as their official language.
• Test of English for International Communication (IELTS) 7-9
• Cambridge English Advanced (CAE)
• Cambridge English Proficiency (CPE)
• Test of English for International Communication (TOEIC) 880-990
• Test of English as a Foreign Language, internet-based test (TOEFLiBT ) 110-120
• UNICERT (III)

Application

There are 40 places available in the Master’s degree program in Molecular Biotechnology each year. The ratio of places to applicants is currently around 1:4.5.

For organizational reasons, we recommend that applicants from outside the EU, EEA and Switzerland complete their application by end of February 2024 at the latest.

To apply you will require the following documents:

• Letter of motivation
• Curriculum Vitae
• Birth certificate or equivalent
• Passport/proof of citizenship
• Bachelor's certificate/Diploma certificate/equivalent certificate from abroad/proof of matriculation 3 4
• Transcript(s) of records 4
• Written proof of your English skills (for applicants outside the EU, EEA and Switzerland)
• A completed table with the relevant ECTS credits from your previous studies: Biology (30, of which 20 are in biology theory and 10 are in biology labs/practical courses), Chemistry (15), Mathematics (6) - please click HERE to complete the table with relevant ECTS credits to open the file (PDF 1,1 MB)

3 If you have not completed your studies at the time of application, please upload the current proof of matriculation and submit the graduation certificates on time. 4 For applicants with non-Austrian (school) certificates: Please check the info sheet below.

Please note:

It is not possible to save incomplete online applications. You must complete your application in one session. Your online application will be accepted once you have uploaded all required documents. After completing your online application, you will receive an automatically generated reply e-mail with the application form. To consider your application as complete, please return the signed application form to [email protected] .

The following applies to international applicants:

Admission procedure.

If the application documents are fully provided and meet the admission requirements, you will be invited to participate in the first part of the admission procedure. The first part is a written admission test on the computer on site, where your knowledge of biology, molecular biology, cell biology, English, etc. on Life Science Bachelor’s level, as well as cognitive questions are tested.

For the written admission test, which takes place at the main location of the FH Campus Wien, your personal presence in Vienna is required.

After positive completion of the written admission test, you will be invited to the second part of the admission procedure, which is planned as an online interview. You will have the opportunity to present your motivation, your studies and your professional and scientific goals, as well as to answer knowledge questions at Life Science Bachelor’s level. The interview will be conducted with an online meeting tool.

The test and the interview are scored and ranked.

• Written test 60%
• Interview 40%

The committee, consisting of the head of the degree program and representatives of the teaching staff, awards places to the applicants who score highest in the admission procedure. The admission procedure as a whole, including tests and assessment results, are documented in a transparent and verifiable manner.

• Waiting list If you are not offered a place in the degree program but your score is considered good in comparison to others, you will be placed on the waiting list. This means that if another person declines their offer of a study place for the upcoming winter semester, applicants from the waiting list will be contacted. This can happen at short notice and no deadline can be determined in advance. You will be informed immediately if you are offered a spot in the degree program.  
• Rejection by the degree program If you receive a rejection after the admission process, you can reapply for the next winter semester as soon as the application window is open again. You will then have to reapply online, submit all the necessary documents and go through the entire admission procedure again.
• Acceptance of the study place You will be informed via e-mail about the opportunity of receiving a place in the degree program. Attached to that you will find your training contract and a number of regulations. You need to return the signed contract in time (clearly stated in the e-mail) to secure and accept your place in the degree program. The accounting department will forward you the invoice for the tuition fee separately. This may take a few days. The timetable for the respective degree program is expected to be online one to two weeks BEFORE the beginning of each semester. All other study-relevant information will either be sent to you via e-mail, or you will receive it at the beginning of the academic year.
• Cancellation from the applicant’s side If you are unable or unwilling to accept your place in the degree program, please inform the Secretary's Office at [email protected] as soon as possible. Your place will then be allocated to the next person on the waiting list. Cancellations or withdrawal from the training contract will only be accepted in writing.

Written admission test: expectedly calendar week 17, 2024 Interviews: expectedly calendar weeks 20/21, 2024

Start of the winter semester 2024/25: 9th September 2024

Have you missed the Online-Infosessions?

Do not worry, for those interested in studying, the videos are available to watch on YouTube.

During the studies

You will be able to study and conduct research in state of the art lecture halls and laboratories. In addition, your education and research benefit from our close partnerships with the University of Vienna and the Medical University of Vienna. We have built a strong international network that provides you with the opportunity to study or conduct research at prestigious universities such as the King's College in London or the Stockholm University in Sweden. Numerous R&D projects in the degree program’s labs offer you the opportunity to participate in application-oriented practical research and to make valuable contacts for your future career.

The Molecular Biotechnology Section is active in medical and pharmaceutical research. Your education benefits from the results of our already established research priorities cellular signaling pathways and immunology. In allergy research, we focus on food allergies as well as the pathological mechanisms of inhalational allergies, such as pollen allergies, with the help of epithelial cell culture systems. Thus, the degree program is not only a strong foundation for medical and pharmaceutical research, but also for a doctoral program at a university.

What you will learn in this program

• This English language Master’s degree program, which is unique in Austria, offers you a balanced mix of molecular-biological subjects as well as key transversal skills.
• You will acquire knowledge und practical skills in the fields of molecular medicine and drug discovery.
• You will follow the main steps of modern drug development, from the first screening until the drug is approved.
• The degree program focuses on the following subjects: immunology, neurobiology, stem cells, pathology, as well as signaling pathways, pharmacology, and data analysis.
• You will improve your employment prospects with practical vocational auxiliary qualifications. You will learn more about innovation and the clinical development of drugs  and will be able to move among the different cultures in the biotech industry. You will learn about bioethics as well as entrepreneurship and strategic business management.
• During your studies, you will refine your English, the international language of applied life sciences. In addition, you will learn interdisciplinary skills that are required in research and in management.
• The entire 4th semester of your studies is reserved for the research project, which you can undertake nationally or internationally. The studies will culminate in the Master’s thesis, comprising the results of the research project.

Student voices

“Having completed your Master's degree, you have a wide range of options: you can continue with a doctoral degree or work in industry, for example, in quality management or other areas.”

Florian Kabinger studied Molecular Biotechnology.

1. Semester

Module communication & culture, communication & culture - modul.

1 SWS   1 ECTS

Current (bio-)ethical topics relevant for the life sciences/pharmaceutical/biotech industry (see Learning Outcomes) 

Teaching method

Student-centred methods: presentations, discussions, written group tasks, blended learning. 

Examination

Continuous assessment: Continuous assessment

> Druml (2018): Managing Ethics in Europe and Austria, Meeting of the National Ethics Councils

(NEC) Forum and the European Group on Ethics in Science and New Technologies (EGE)

> Druml (2016): Further Bioethics internationally and in Austria: A sense of solidarity, Wien Klin. Wochenschr., 128:229–233, DOI 10.1007/s00508-016-1000-2

> Solinis (2015) Global Bioethics: What for? Twentieth anniversary of UNESCO’s Bioethics

Programme UNESCO, http//creative commons.org/license/by-sa/3.0/igo/

> The Austrian Bioethics Commision: www.federal-chancellery.gv.at/bioethics-commission

> Council of Europe: www.coe.int/en/web/portal

> World Commission on the Ethics of Scientific Knowledge and Technology (COMEST): www.unesco.org/new/en/social-and-human-sciences/themes/comest/

> World Medical Association: www.wma.net

Teaching language

The content of this integrated course, which is specially designed as the Kick-Off of the Master degree programme prepares the students from different countries, cultural backgrounds, universities, disciplines, and with individual life experiences to work together optimally in interdisciplinary, intercultural and international study and working environments. See the ‘Learning Outcomes’ for further details.

Student-centred methods: presentations, discussions, individual and group tasks

> None / keine

2 SWS   3 ECTS

The scientific and ethical content (see the ‘Learning Outcomes’ for specific details) of this course aligns with the aims of the Master degree programme, and by working closely with other lecturers compliments the content of the other courses. 

Student-centred methods: presentations, discussions, written individual and group tasks, blended l earning. 

> McCarthy & O’Dell (2016): Academic Vocabulary in Use, Cambridge University Press, ISBN-13: 978-1-107-59166-0

> Skern (2011): Scientific Writing: A Workbook, Facultas WUV UTB, ISBN-13: 978-3-8252-3619-9

> Current scientific literature / aktuelle wissenschaftliche Literatur

Module Human Pathology

Human pathology - modul.

Students know and can explain the principles of general pathology, causes and development of pathological processes and diseases at the level of cells, tissues and the whole organism in detail. Students know and are able to describe the courses of illness and symptoms based on morphological alterations and clinicopathological correlations from the systemic/special pathology. In addition, students are familiar with and can explain the systematics and nomenclature of diseases as well as applied diagnostic and therapeutic strategies.

Lecture (Powerpoint presentations, manuscript, glossary, mind maps) / Vorlesung (VL-Unterlagen als Powerpoint-Folien mit Schemata und Bildmaterial, VL-Manuskript, Glossar, Mind-Maps)

Final exam: Written multiple choice test

> Kumar, Abbas & Aster (2017): Robbins Basic Pathology, Elsevier, 978-0323353175

> Damjanov (2011): Pathology for the Health Professions, Saunders, 978-1437716764

In this lecture course, initially the knowledge about the human genome is deepened. Building on that it is pointed out how genetic alterations can lead to disease. Further, methods to the identification of genetic diseases as well as methods for gene therapy are presented.

In a further part, we deal with the malignant transformation of cells leading to cancer. We discuss how neoplastic cells move out from the primary tumor and how the duality of cancer cell signaling essentially contributes to metastatic colonization in distal organs. Experimental models will be introduced which are used to examine cell motility and cancer cell spreading.  

Another part of the lecture illustrates female reproductive diseases and the underlying molecular changes. We will focus on the development and function of maternal breast, uterus and placenta, their respective pathologies, molecular diagnostics, therapy, as well as state-of-the-art cell culture models including stem cells and organoids. Topics such as pregnancy pathologies with altered cell invasion, genetic trophoblast diseases, implantations defects, endometriosis and breast cancer will be discussed.

The final part is concerned with the topics of tissue printing and cell engineering. This is complemented by presenting novel developments in stem cell biology in normal as well as tumor tissues. Accompanying, in all parts important methods like flow cytometry, migration assays, fluorescence microscopy and blood cell analysis are addressed.

Mainly PowerPoint slides pointing out additional weblinks to literature sources, web-based texts and video content. The PowerPoint presentations are available online as lecture notes.

Final exam: Written exam at the end of the course with open questions. No multiple choice.

The Biology of Cancer (R.A. Weinberg, 2nd Edition); ausgewählte Übersichtsartikel wie angegeben (e.g. Nat. Rev. Cancer)

 > Strachan & Read (2010): Human Molecular Genetics, Garland Science, 978-0815341499 > Weinberg (2013): The Biology of Cancer, Garland Science, 978-0815342205

> Strachan & Read (2010): Human Molecular Genetics, Garland Science, 978-0815341499

> Weinberg (2013): The Biology of Cancer, Garland Science, 978-0815342205

Module Immunology

Immunology - modul.

- Case studies: Clinical development of selected drugs (biopharmaceuticals and small-molecule drugs) - Classes of Pharmaceuticals - Clinical and epidemiological study designs - Outcomes and inclusion/exclusion criteria, special populations - Randomized Controlled Trials (RCTs): Randomization, Blinding and Placebos - Conduct of clinical trials - Data analysis and interpretation - Ethical aspects - The origins and principles of Good Clinical Practice (GCP) - International regulations (EMEA, FDA, ICH) - Interfaces: Regulatory Affairs and Pharmacovigilance, Marketing and Product Life Cycle Management - Special chapters: Generic drugs and biosimilars, orphan drugs and Advanced Therapy Medicinal Products

Lectures, small group discussions and in-class exercises 

Continuous assessment: Grading of participation and in-class exercises. Written exam at the end of the lecture course. Exam includes multiple choice questions as well as open questions.

> Hill, R.G., and Rang, H.P..: Drug discovery and development: technology in transition (2021, 3rd ed.). Churchill Livingstone/Elsevier

> Schulz K.; Grimes D.A.: The Lancet Handbook of Essential Concepts in Clinical Research (2019, 2nd ed.). Elsevier

> Hulley, S. B., Cummings S.R., Browner W.S., Grady D.G., and Newman T.B.: Designing Clinical Research. (2013, 4th ed.). Lippencott, Williams and Wilkins

> Hackshaw, A.K.: A concise guide to clinical trials (2009). Wiley Blackwell/BMJ Books

Fundamental concepts of immunity, immunologic tolerance and autoimmunity, immunity to microbes, transplantation immunology, immunity to tumors, hypersensitivity disorders, allergy, congenital and acquired immunodeficiencies, immunotherapy and immunological methods.

Lectures, interactive discussions between students and lecturer. 

Final exam: Written exam at the end of the lecture course. Exam includes multiple choice questions as well as open questions.

> Abbas, Lichtman, Pillai (2017): Cellular and Molecular Immunology, Elsevier LTD, Oxford, ISBN-13: 978-0323479783

Module Medical Genetics

Medical genetics - modul.

2 SWS   2 ECTS

The course will be divided in several parts:

• summary of basic principles
• discussion of molecular biological techniques including their limitations
• discussion of several examples for genetic diseases, also in the context of useful and suitable methods (monogenetic, polygenetic, acquired).

Students are encouraged to take the lead to preside over debates and scientific discussions on current scientific and/or ethical topics. At the end of the course, students undertake a quiz where they are encouraged to try to identify the cause of a disease.

Use of Power Point presentation, regular discussions, use of quiz. 

Final exam: Preparation of a written manuscript to a specific topic, evaluation of the participation in discussions. (Seminar paper)

> Mannhalter C. (2017 May 10) New developments in molecularbiological diagnostic. Hamostaseologie;37(2):138-151. doi: 10.5482/HAMO-17-01-0001

> For this broad field with high publication numbers the suitable and new literature will be mentioned in context with the respective topic. / Da das Gebiet sehr breit ist und regelmäßig neue Publikationen erscheinen, werden zu den jeweiligen Themen die möglichst neuesten wissenschaftliche Arbeiten referenziert.

Various methods used in genetic analysis are explained and carried out practically. These include the reverse transcriptase polymerase chain reaction for the detection of leukemia associated fusion transcripts, gene amplification and hybridization to immobilized, allele specific oligonucleotides for the detection of mutations in the cystic fibrosis gene, and real-time polymerase chain reaction for the detection of mutations in BRAF and KRAS in various cancer cells defining a subpopulation of patients with a poorer prognosis.

- The theoretical basis of each of the analyses conducted in the laboratory is explained in a preceding seminar.

- Students conduct genetic analyses according to detailed reports provided by the lecturers.

- Laboratory results are discussed with lecturers at the end of each unit, and are summarized in a report whose structure corresponds to that of a scientific paper.

Continuous assessment: Immanent assessment of student's understanding of the subject, written laboratory report.

Lynn B. Jorde, John C. Carey, Michael J. Bamshad (2019): Medical Genetics. Elsevier; 6. Edition; Paperback ISBN: 9780323597371; eBook ISBN: 9780323596534

Korf, Bruce R., Pyeritz, Reed E., Grody, Wayne W. (2019): Emery and Rimoin's Principles and practice of medical genetics and genomics: foundations. Academic Press,

ISBN 9780128125373

1 SWS   2 ECTS

Students are able to decribe  the three main areas: hematology, vascular biology and vascular pathology.

Hematology deals with the following topics:

1. erythrocytes (structure, cytoskeleton, hemoglobin, gas exchange, erythrocyte breakdown, iron metabolism, blood groups)

2. leukocytes (morphological leukocyte differentiation)

3. Platelets (structure, activation, adhesion, aggregation, interaction with cells or with the extracellular matrix)

4. Hemostasis (plasmatic coagulation, cell-based model of coagulation, fibrinolytic system, inhibitor systems, blood coagulation tests)

5. Laboratory diagnosis of blood (sample collection, plasma/serum, sample composition/sources of error, clinical chemistry, red/white blood count, blood group serology)

6. Hematological diseases (reactive changes of the erythrocytes/leucocytes/platelets, disorders of hemostasis)

Vascular biology deals with:

1. an overview of the vascular system (terms, structure, blood vessel system / lymphatic system)

2. development of the blood vessels (vasculogenesis, angiogenesis, significance and function of specific angiogenic growth factors)

3. the endothelium (biology of the endothelial cell, structure of endothelia, endothelial species)

4. the functions of the endothelium (regulation of vascular tone, endothelium and cell adhesion, endothelial dysfunction)

Vascular pathology describes:

1. the role of the endothelium in the acute inflammatory response (systemically explained by the example of sepsis and locally using the example of "acute lung injury" and

2. atherosclerosis described as a chronic inflammatory vascular disease (risk factors, lipid metabolism, atherogenesis, pathophysiology of unstable plaque / plaque rupture, animal models in atherosclerosis research).

Reading of primary literature, lectures with power point and flip chart, self-study. 

Final exam: Exam; single-choice questions and essay about a topic.

> Current scientific literature / Aktuelle wissenschaftliche Literatur.

Module Molecular Biotechnology

Molecular biotechnology - modul.

Commands in Linux  Individual topics will be taken up and discussed in more detail, e.g: - biological sequences, sequence comparison  - bioinformatic output formats/files

Lectures, Powerpoint presentation, hands-on exercises and independent work 

Continuous assessment: Continuous assessment including assessment of final project

> None/Keine

1.5 SWS   2 ECTS

- Fundamental features of genetics and genetic engineering - Different levels of regulation of gene expression in pro- and eukaryotes - Transcriptional regulation (transcription in eukaryotes, transcriptional activation, properties of transcription factors) - Posttranscriptional regulation (splicing, transport, stability of mRNA, translational control) - Effects of chromatin (composition, histone modifications, regulation, epigenetics) - Examples from signalling pathways

Lectures with Powerpoint presentations 

Final exam: Written exams

> Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter (2014): Molecular Biology of the Cell. Garland Science, ISBN-13: 978-0815344643 > David Latchman (2010): Gene Control. Garland Science, ISBN-13: 978-0815365136

Module RNA Biology

Rna biology - modul.

RNA fundamentals, RNA structure, catalytic RNAs, RNA processing, RNA splicing, RNA editing, riboswitches, RNA applications, non-coding RNAs, RNAi, RNA world, SELEX

Lecture 

Final exam: Written exam at the end of the course.

> D. Elliott and M. Ladomery (2011): Molecular Biology of RNA. Oxford University Press, ISBN-13: 978-0199671397 

3 SWS   3 ECTS

RNA methods:

- Northern blot (glucose/galactose metabolism in yeast, RNA extraction from yeast, denaturing RNA agarose gel, RNA transfer, specific oligonucleotide hybridization, band detection, quantitative PCR)

- EMSA ( in vitro transcription with T7 RNA polymerase, RNA purification, RNA folding, native polyacrylamide gel electrophoresis, RNA staining using methylene blue, detection of RNP complexes)

- RNA stability (temperature dependence, pH dependence, RNAses)

Laboratory 

Continuous assessment: Continuous assessment - presence, motivation, participation, practical skills (results), written report.

> Donald C. Rio, Manuel Ares, Jr., Gregory J. Hannon, Timothy W. Nilsen (2011): RNA: A laboratory manual. Cold Spring Harbor Laboratory Press, ISBN 978-0-879698-91-1

2. Semester

Module drug development, drug development - modul.

The lecture course "Biologicals" gives an overview over the most important aspects of biotherapeutics (= biologics) which is the fastest growing type of drug gaining more and more importance.  The focus of the course is the discovery research of therapeutic concepts enabled by engineering of biologics, bioprocess development of biologicals, and manufacturing aspects. Major differences and therapeutic aspects differing between small molecule drugs and biologics are discussed; examples of major classes of biologics are presented as case studies. Discovery and engineering of therapeutic monoclonal antibodies are discussed in more detail as this class of therapeutics reflects the biggest class amongst many other biologicals. Approaches and technologies for biopharmaceutical manufacturing and purification will be discussed; major aspects and challenges of protein analytics and physicochemical characterization of biologics will be highlighted.

Final exam: Written exam in the last lecture

> Edward A. Greenfield (editor, 2014) Antibodies: A Laboratory Manual, Dana-Farber Cancer Institute, ISBN: 978-1-936113-81-1 > Gary Walsh (2013) Biopharmaceuticals: Biochemistry and Biotechnology, Wiley-Blackwell, ISBN: 978-1-118-68738-3 > Stefan Dubel & Janice M. Reichert (editors, 2014): Handbook of Therapeutic Antibodies, Wiley-Blackwell, ISBN: 978-3-527-32937-3

Students learn how to isolate natural drugs (small molecules) from plants or how to produce biologics. Course content also includes different in vitro screening methods, HCS, HTS (including target-and phenotype-based drug discovery).

Final exam: Final written exam (100%)

> The latest publications will be included in the lecture course. / Die neuesten Publikationen werden in die Vorlesung aufgenommen.

Important signalling pathways of the cell (e.g. MAP kinase-, GPCR-, Nuclear Hormone Receptor-, NF-kB-, Jak/Stat-, Wnt-, Hedgehog-, Tgfß-, Apoptosis-, PI3K/Akt- and stress pathways) are presented together with their effects on gene expression and other functions of the cell. In addition the crosslinks with other pathways are discussed. Techniques for the analysis of signalling pathways are also presented.

Lectures with Powerpoint presentations, Discussion of selected chapters 

Final exam: Written Exam

> Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter (2014): Molecular Biology of the Cell. Garland Science, ISBN-13: 978-0815344643 > Martin Beckerman (2009): Cellular Signaling in Health and Disease. Springer, ISBN-13: 978-0387981727

Methods for the manipulation and the analysis of signalling pathways in cell culture are applied, broadening the knowledge on specific pathways. The applied methods are transient transfection in cell culture, reporter constructs with gfp and luciferase, overexpression of activators/repressors (including RNAi), Western analysis of cellular extracts, analysis of phosphorylation, fluorescence microscopy of labelled proteins and pharmacologic manipulation of the pathways.

Laboratory work 

Final exam: Assessment of the work in the laboratory, written exams at the beginning of the laboratory course, discussion of the results after the laboratory course and a written report of the experiments. (Seminar paper)

> Lewis Wolpert, Cheryll Tickle, Alfonso Martinez Arias (2015), Principles of Development. Oxford University Press, ISBN-13: 978-0198709886 > Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter (2014): Molecular Biology of the Cell. Garland Science, ISBN-13: 978-0815344643 > Martin Beckerman (2009): Cellular Signaling in Health and Disease. Springer, ISBN-13: 978-0387981727

Module Entrepreneurship

Entrepreneurship - modul.

Definitions and meaning of Knowledge and the management of knowledge in a knowledge-driven society in general and in the field of Biotechnology in particular with heavy focus on phases of Research and Development (R&D). What is it? Definitions? Perspectives: The human and the data, principles, types, processes, concepts, tools and practice. From Invention (Research/Technology) to Innovation: The Management of Innovation. Definitions and basics, the process of Innovation Management, the strategic dimension of innovation. Innovation analyses/assessment and organisational aspects of implementation.  From a business idea to a business plan: The story of a business plan and its elements (externally and internally). The business idea, the vision/mission statement and it’s reflection in a certain product/service, the targeted market with its characteristics (such as customers, competitors, partners, etc.), the financials, the legal environment, the organisation needed to drive business implementation, the plan for implementation. The four phases for business-plan development and its implementation: Build hypotheses derived from a business idea, feedback, maturing it through “friendly customers”, incorporate results and show business plan to real customers, to real investors (or funding organisations), if successful, go through foundation process, business start and ongoing improvements. Useful Tools: Porter Model – 5 Forces, SWOT Analyses; Life-Cycle Analyses; Canvas Business Model Concept, BP-Calculation templates, BP templates; Risk Analyses.

Student-centred methods: project work in fixed groups, presentations, partly: flipped class-room approach, debates, discussions, written tasks. 

Final exam: Evaluation of group results (a complete business-plan plus a BP presentation). In addition, individual interviews with students about their results facilitates quality assurance respectively control at an individual level. (Group work)

> Nonaka, I., Takeuchi, H. (1995): The Knowledge Creating Company - How Japanese Companies Create the Dynamics of Innovation, Oxford University Press, ISBN: 9780195092691

> Ideas To Business: www.i2b.at

> Innovation Into Business: www.inits.at

• Which forms of protection of intellectual property are available? – trademark, industrial design, copyright, utility model, complementary protection certificate, patent • History of patent rights • What is a patent? – effects of a patent – what can be patented and what is excluded from patent protection? – what are the prerequisites for patent application/protection?  – How to define an inventor? Rights and obligations of employee inventors • From application to patent grant – structure of a patent application – application and granting processes - protective reach and duration – legal measures – fees and costs – where to apply for a patent • Rights of patent owners and legal measures • International agreements (EP, PCT), important national differences • Biopatents – legal framework, important decisions • Freedom to Operate  • Espacenet and how to use it for patent research • Patent lawyer - the profession • Fundamentals in copyright • Fundamentals in industrial design • Fundamentals in trademark • Strategies and decision making • Important agreements– MTAs, CDAs, licensing contracts • Licensing contracts - fundamental principles, important clauses – Franchise

Lectures with interactive elements and discussions, actual cases will be discussed in more detail. 

Continuous assessment: Written exam at the end of the course.

> World Intellectual Property Organization (WIPO): www.wipo.int and www.wipo.int/romarin

> Austrian Patent Office: www.patentamt.at and see-ip.patentamt.at

Student-centred methods: presentations, debates, discussions, written individual and group tasks, blended learning. 

> McCarthy & O’Dell (2016): Academic Vocabulary in Use, Cambridge University Press, ISBN-13: 978-1-107-59166-0 > Skern (2011): Scientific Writing: A Workbook, Facultas WUV UTB, ISBN-13: 978-3-8252-3619-9 > Current scientific literature / aktuelle wissenschaftliche Literatur

Bioinformatics topics will be addressed and the practical solution of biological problems with bioinformatics tools will be discussed. The topics include: - the Human Genome (Genome analysis: SNPs, Variant Discovery) - biological batabases - data formats - protein domains, regulatory patterns - non-coding RNA prediction - gene set analysis

Lectures, Powerpoint presentation, discussion and independent hands-on exercises with bioinformatics tools 

Final exam: Written test on the theoretical part (50%), report (50%)

> Hütt, Marc-Thorsten & Dehnert, Manuel (2016): Methoden der Bioinformatik. Eine Einführung zur Anwendung in Biologie und Medizin. Springer, 978-3-662-46149-5 > Arthur M. Lesk (2014): Introduction to Bioinformatics (Fourth edition). Oxford, ISBN 978-0-19-965156-6 

Module Molecular Pathology

Molecular pathology - modul.

In this lecture course the complex interactions between pathogens and the human host are presented and the molecular, cellular and immunological aspects of this interaction are explained. Strategies developed by bacteria, viruses, fungi and parasites to colonize, invade, survive, reproduce and spread are discussed. The cellular and systemic effects on the host, the host's defence mechanisms and the clinical manifestations of the infectious diseases are shown. Furthermore, diagnostic tests and antimicrobial and antiviral treatment possibilities are explained and the concepts behind the development of novel diagnostic tools, drugs and vaccines for future prevention and therapy of infectious diseases are introduced.

Final exam: Written exam in the end of the lecture course

> Madigan MT, Martinko JM, Bender KS, Buckley DH, Stahl DA (2015): Brock Biology of Microorganisms, Pearson, 978-0321897398 > Abbas AK, Lichtman AH, Pillai S (2017): Cellular and Molecular Immunology, Elsevier Saunders, 978-0323479783 > Murphy K, Weaver C (2016): Janeway's Immunobiology, Garland Science, 978-0815345053 > Flint SJ, Racaniello VR, Rall GF, Skalka AM, Enquist LW (2015): Principles of Virology, ASM Press, 978-1555819514

Tissue staining using different techniques (hematoxylin/eosin, immunofluorescence), preparation of normal and methotrexate (MTX, tumor therapy) -treated placental tissues for immunostaining, immune-detection of different placental types, apoptosis, proliferation and cell fusion; photographical evaluation and analyses, patho-histological evaluation of tumor tissue; characterization of different blood cell types in blood smears; determination of leucocytes; Cultivation of choriocarcinoma cells with MTX, EdU labelling, detection of in situ proliferation and cell fusion using immunofluorescence.

In another part, we deal with lung cancer cells and (i) investigate the impact of a chemotherapeutic agent on the proliferation, metabolism and clonogenic growth behavior of immortalized cells and malignant tumor cells, and (ii) analyze the migratory and invasive potential as well as the impact of targeted therapy on the chemosensitivity of cancer cells after conversion to a metastatic phenotype.

Practical laboratory course accompanied by introductory seminars.

Continuous assessment: Continuous assessment of practical participation and personal involvement. Evaluation of the quality of data assessment and documentation in written protocol.

Scripts written by the presenters and web-based tutorials will be provided. Histology and anatomy textbooks will be provided in the lab during the course.

Von den Vortragenden verfasste Skripten und web-basierte Anleitungen werden zur Verfügung gestellt. Histologie und Anatomie Lehrbücher werden während des Kurses im Labor bereitgestellt.

Replication cycle of important virus families, pathogenetic mechanisms of important viruses, anti-viral strategies, and importance of viruses in molecular biology and medicine. 

Interactive Lecture 

Final exam: Written examination

> Wagner, Hewlett, Bloom & Camerini (2007): Basic Virology, Wiley-Blackwell, ISBN-13: 978-1405147156

Module Stem Cells

Stem cells - modul.

Reports about stem cells and their usage in biomedical research has raised several important key questions about their capacity to use for stem cell-based therapies to cure diseases. Our course starts with an overview about stem cell biology, where to find stem cell and might there be a different o stem cells isolated from various organisms, such as axolotl. We start to understand how an organsims is developing and where to find stem cells in a human body. For a deeper knowledge in stem cell biology we learn about induced pluripotent stem cells and the development of mini organs/organoids. We discuss the potential usage of stem cells in clinical applications, the importance for society and relevant ethical aspects. Finally, we present latest key news and views about recently published stem cell research breakthroughs.

Interactive lectures with discussions using Power point presentation and the blackboard 

Final exam: Written exam

> Lanza, Robert P. et al. (2013) : Handbook of Stem Cells, Vol 1, Elsevier Amsterdam, 978-0123859426 > Lanza, Robert P. et al. (2013) : Handbook of Stem Cells, Vol 2, Elsevier Amsterdam, 978-0123859426

2.5 SWS   3 ECTS

The course teaches the fundamentals of the culture of murine embryonic stem cells (ESC) and induced stem cells and practical applications. Different cultivation possibilities for ESC and the control of the stability of the cultures in the undifferentiated state will be learned (morphological analysis, proliferation analysis, alkaline phosphatase assay). Targeted differentiation using the embryoid body (EB) model will be learnt accomplished and in addition, experimental investigations will be carried out on how different inhibitors or activators influence differentiation. The formation of EBs is analyzed by light microscopy. PCR and Kkaryotyping will be used to further characterize the ESCs used in this course.Using an example, the use of CRISPR/Cas in stem cells will be practiced. Furthermore indirect immunofluorescence microscopy will be employed to investigate the stemness characteristics of the cells.

Practical laboratory course 

Continuous assessment: Continuous assessment. The grade is comprised of the following sections: attendance, motivation, cooperation, written report

> Lanza, Robert P. et al. (2013): Handbook of Stem Cells, Vol 1, Elsevier Amsterdam, 978-012385942 > Elling, U. et al. Forward and Reverse Genetics through Derivation of Haploid Mouse Embryonic Stem Cells. Cell Stem Cell, 2011 Dec 2;9(6):563-74.

Electives 1 (1 ECTS of your choice)

Module electives 1, electives 1 - modul.

In this course research papers from internationally respected high-quality journals from the field of Drug Discovery are distributed to the students who read them on their own. The seminar itself then takes the format of a peer-group discussion, where students present the background, the most important findings and the conclusion of the publications. Furthermore, they discuss the strengths and the weaknesses of the publications and make suggestions for improvements.

Final exam: Participation in discussion (Seminar paper)

> Recent, important publications from scientific journals / > Neueste/Wichtige Publikationen aus Fachzeitschriften

In this course research papers from internationally respected high-quality journals from the field of Molecular Immunology are distributed to the students who read them on their own. The seminar itself then takes the format of a peer-group discussion, where students present the background, the most important findings and the conclusion of the publications. Furthermore, they discuss the strengths and the weaknesses of the publications and make suggestions for improvements.

Continuous assessment: Participation in discussion (Seminar paper)

> Recent, important publications from scientific journals / Neueste/Wichtige Publikationen aus Fachzeitschriften

In this course research papers from internationally respected high-quality journals from the field of RNA research are distributed to the students who read them on their own. The seminar itself then takes the format of a peer-group discussion, where students present the background, the most important findings and the conclusion of the publications. Furthermore, they discuss the strengths and the weaknesses of the publications and make suggestions for improvements. 

Continuous assessment: Participation in discussion

Electives 2 (2 ECTS of your choice)

Module electives 2, electives 2 - modul.

Therapeutic strategies based on signal transduction pathways in health and disease provides a detailed view of the underlying molecular biology of selected diseases and novel treatment modalities with a particular focus on oncology. Clinical failures and validity of targets, Extracellular signaling (endocrine – paracrine – autocrine; Multitype) - Mechanisms of signal transduction and the determination of the fate of a cell - Intracellular signal-transduction (signaling by phosphorylation and GTP-binding) - PD-1/PD-L1 and CTLA-4 signaling in immune cells - Molecular mechanisms of EMT - Ligand-binding and effector specificity of receptor proteins - Acetylcholine: Same signal can lead to different effects in cells of different tissues - Hormones: Small lipophilic molecules and their intracellular receptors; hydrophilic and lipophilic hormones and their cell-surface receptors - Hormone receptors (retinoid-x-receptor; PR, GR, AR and ER receptors) - Hashimoto's thyroiditis, Graves' disease - Nuclear receptors - Prostaglandin (PG) Biosynthesis (COX1, 2; COX inhibitors) - Prostaglandin signal-transduction pathways - Insect and snake venom (PLA2) - Prostaglandins in breast cancer and endometriosis (autocrine and paracrine actions of PEG2 and PEF2a - Biphasic activation of FGF-9 by PGE2 - Phagocytic ability of macrophages and PEG2 - StAR aromatase and aromatase inhibitors - G protein-coupled receptors - Ion-channel receptors - Tyrosine kinase-linked receptors - Receptors with intrinsic enzymatic activity - EGFR (mechanisms of EGFR dysregulation - Therapeutic concepts, types of biomarkers - Molecular mechanisms of oncogene addiction and clinical resistance - Compensatory pathways in oncogenic kinase signaling and resistance to targeted therapies (EGFR, BRAF, SMO) - Dual-specificity phosphatases: Critical regulators with diverse cellular targets - The hedgehog and Hippo pathway in development and disease - Fusion proteins of ALK and their contribution to tumorigenesis - Tyrosine kinase-linked receptors - Mechanisms to die: Immunogenic cell death (ICD).

Oral presentations with PowerPoint slides, printed handouts will be provided (if requested), short presentations by students on selected topics (FlipChart); see also Assessment Methods. 

Final exam: Written exam and a short oral presentation (5 minutes, FlipChart) + feedback

> R.A. Weinberg (2007): The Biology of Cancer, Garland Science - Taylor & Francis Group, ISBN: 0-8153-4078-8 > H.P. Rang et al. (2012): RANG and DALE´S Pharmacology, Elsevier, ISBN: 13-978-1-4377-1933-8 > T. M. Devlin et al. (2010): Textbook of Biochemistry with Clinical Correlations, ISBN: 978-0-470-28173-4 > L.H. Butterfield et al. (2017): Cancer Immunotherapy Principles and Practice, Demos Medical Publishing, ISBN: 978-1-620-70097-6

Students know and can explain the currently used vaccines and the approaches to the development of vaccines against known and emerging infectious diseases. Furthermore, students can describe how the vaccines are being developed from an ‘industrial perspective’ and can appreciate the complexities involved in development of vaccines all the way to licensure of the vaccines. Post licensure effectiveness of the vaccines are also discussed. Students gain a deeper understanding of the development and production of vaccines from the laboratory to the clinical trials by carrying out independent literature research and communicating their findings with supporting media (peer teaching), using current globally significant vaccines as examples.

Interactive lectures with Powerpoint slides and active participation 

Continuous assessment: Continuous assessment, assignment and presentation

> Stanley Plotkin, Walter Orenstein, Paul Offit & Kathryn M. Edwards (2017): Plotkin's Vaccines, Elsevier, ISBN: 9780323357616 

3. Semester

Module biodata analysis, biodata analysis - modul.

1) Acquire knowledge on selected bioinformatics chapters (Next Generation Sequencing, ChIP-Seq, RNA-Seq), and 2) Application of relevant bioinformatics tools to analyse the associated data.

Introductions and explanations (lecture), Exercises using the computer 

Final exam: 100 % Report in which students have to analyse RNA-Seq Data/ChIP-Seq Data

> Goodwin et al. (2016) Coming of age: ten years of next generation sequencing technologies. Nature Reviews Genetics 17, 333–351 > Eija Korpelainen et al. (2015) RNA-seq Data Analysis: A Practical Approach. Chapman & Hall/CRC, ISBN 9781466595002 > Conesa et al. (2016) A survey of best practices for RNA-Seq data analysis. Genome Biology 17:13

During the "hands on" laboratory every student excises a band containg a protein out of a 4-20% SDS-PAGE (Tris/Glycine) gradient gel. Purification, reduction and alkylation of Cysteines, o/n digestion with Trypsin, next day spotting onto a MALDI target, and generation of a PMF mass spectrum with MALDI-TOF and MSMS spectra of the most intense peptides. Subsequently identification of the protein with database search algorithms. The theoretical part provides an introduction into the basic principles of proteomics: sample preparation & fractionation (1D and 2D GE, HPLC, CE, SCX RP and affinity chromatography, difficulty of contamination e.g. keratins, SDS, salts). Explanation of the principles of mass spectrometry: ion sources (MALDI, ESI), types of mass spectrometers (TOF, quadrupole, ion trap, FT ICR) and the respective combinations e.g. MALDI-TOF/TOF etc. Resolution R and mass accuracy dm/m (ppm). Improvement of the latter by delayed extraction & reflectron for MALDI-TOF. Isotopic distribution, single and multiple charged ions (ESI). PMF (peptide mass fingerprinting), principles of data base analysis of mass spectra. Collision induced dissociation CID, MS/MS analysis and de novo sequencing. In addition, an introduction into the methods of quantitative proteomics as well as the analysis of post-translational modifications will be included, as well as an introduction into the application of mass spectrometry (and other technologies) to further analytical questions in addition to proteomics, e.g. metabolomics, lipidomics, drug development and environmental research. Finally, students present an exposé with their own concepts how to tackle a specific analytical question, using the methodology discussed in the course.

Wet laboratory work, tutorial on all theoretical contents, video material, data analysis on computer, critical evaluation of data.

Continuous assessment: Active course participation, results of written test and/or oral examination, evaluation of laboratory report and exposé on potential research project using mass spectrometry

> Friedrich Lottspeich, Joachim W. Engels, Solodkoff Zettlmeier Lay (2012): Bioanalytik, Spektrum Akademischer Verlag, ISBN-13: 978-3827429421 > Friedrich Lottspeich, Joachim W. Engels, Solodkoff Zettlmeier Lay (2018): Bioanalytics: Analytical Methods and Concepts in Biochemistry and Molecular Biology, Wiley, ISBN-13: 978-3527339198 > Jürgen Gross (2017): Mass Spectrometry: A Textbook, Springer, ISBN-13: 978-3319543970 > Mike S. Lee (2012): Mass Spectrometry Handbook, Wiley, ISBN-13: 978-0470536735 

Module Gene Therapy & Immunology

Gene therapy & immunology - modul.

In this lecture course the molecular and cellular mechanisms of allergies and other hypersensitivity reactions are explained and the symptoms, causes and risk factors of allergic diseases are described. Furthermore, advantages and disadvantages of current diagnostic tests and therapeutic possibilities are discussed and strategies for improvement of diagnosis and therapies of allergies are introduced. This lecture course also explains the pathomechanisms underlying autoimmune disorders and describes determinants (such as genetic predisposition or environmental factors) that influence the development autoimmunity. In addition, the pathogenesis, clinical manifestation and the treatment possibilities of a few selected autoimmune diseases (e.g., Rheumatoid Arthritis, Multiple Sclerosis) are discussed. Furthermore, this lecture course also highlights similarities and differences between allergies and autoimmune disorders.

Final exam: Written exam after the last lecture

> Abbas AK, Lichtman AH, Pillai S (2017): Cellular and Molecular Immunology, Elsevier Saunders, 978-0323479783 > Murphy K, Weaver C (2016): Janeway's Immunobiology, Garland Science, 978-0815345053 > Holgate ST, Church MK, Broide MH, Martinez FD (2012): Allergy, Elsevier Saunders, 978-0702057823 > Male D, Brostoff J, Roth DB, Roitt I (2013): Immunology, Elsevier Mosby, 978-0323080583

Principles of gene therapy, overview on applications of gene therapy, gene transfer methods, methods for gene transfer estimation, characteristics of different viral vector systems, non-viral vector systems, lenti-/retroviral vectors, adenoviral vectors, adeno-associated viral vectors, applications of gene therapy for different diseases, problems and perspectives.

Interactive lecture

In the Molecular Immunology laboratory the theoretical immunological knowledge is deepened and practically applied to research problems from the field of allergy research. Students work in small groups of 2 to 3 people on a scientific research question. As a team they have to find the best way to answer the research question, they have to design and perform the experiments using state-of-the-art immunological and molecular biological methods such as ELISAs, SDS-PAGE, immunoblotting, PCR, microscopy and flow cytometry. Finally, each student writes a laboratory report in the format of a scientific publication, in which the background of the research topic is summarized and the experimental work, the results and the conclusion are described. 

Continuous assessment: Continuous assessment, active participation, report

Module Pharmacology & Toxicology

Pharmacology & toxicology - modul.

At the center of this course is the drug and its interaction with target proteins. Methods for determination of protein structures and characterization and quantification of protein ligand interactions are presented. In addition strategies and methods for the optimization of these interactions are discussed (lead optimization, rational design). Furthermore, aspects of pharmacokinetics (ADME, prodrugs) are presented. The underlying principles are demonstrated by selected examples.

Lectures (Powerpoint presentations and downloads) 

> G. Patrick, (2017): An Introduction to Medicinal Chemistry, Oxford University Press, ISBN: 9780198749691

Structure and function of drug targets on the molecular level as well as their role as regulators of cell function, the prodrug strategy, and most frequently prescribed drugs for the treatment of human diseases (e.g. background of a disease, mechanism of action, important side effects).

Each topic is introduced and necessary information is provided through didactic lectures and e-learning methods. Subsequent lectures focus on the use of this information (e.g. discussion of research papers or research problems, student/poster presentations). 

Final exam: Written examination at the end of the course, evaluation of the tasks provided during the course

> Rang, Ritter, Flower, Henderson (2016): Rang & Dale’s Pharmacology. Elsevier Ltd, 978-0-7020-5362-7 > G. Patrick, (2017): An Introduction to Medicinal Chemistry, Oxford University Press, ISBN: 9780198749691 > Scientific papers provided during the course

The toxicological and therapeutic potential of a small molecule drug will be estimated with a variety of cell based test systems. On the one hand the activating potential of the small molecule on a specific pathway (heat shock response pathway) is analysed and on the other hand possible cytotoxic effects are estimated in a concentration-dependent manner. A broad variety of assays is provided for the students including luciferase reporter assays, Western blot, qPCR, flow cytometry, ELISA and general viability assays. The students themselves select suitable methods.

Practical course with independent performance of the experiments. 

Continuous assessment: Assessment of the work in the laboratory, written exams at the beginning of the laboratory course, discussion of the results after the laboratory course and a written report of the experiments

> Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter (2014): Molecular Biology of the Cell. Garland Science, ISBN-13: 978-0815344643 > Gerhard Klebe (2009): Wirkstoffdesign (in German). Spektrum Akademischer Verlag, ISBN-13: 978-3827420466  > Salvatore J. Enna (2007): Short Protocols in Pharmacology and Drug Discovery. Current Protocols, ISBN-13: 978-0470095263

Module Research & Development

Research & development - modul.

During this course, the students independently - with the support of the Master's Thesis Coordinator - seek a research project in an inter/national life science research institution or research company, whose content, quality and duration is suitable to write a high-quality master's thesis. Together with the direct supervisor of the research project, the students prepare a project plan for the course of the research project. The plan contains the project goals, the problem definition and the method spectrum to be used. In small groups, the students present the elaborated plans of their planned research projects to their peer group as well as their motivation to carry out this research project. The group discusses and reflects on the presented problems, strategies and methods and gives their feedback.

Activating Methods: e.g. presentations, discussions … 

Continuous assessment

> Allen & Baker (2001): Biology: Scientific Process and Social Issues, Fitzgerald Science Press Inc., ISBN-13: 9781891786099 > Holmes, Moody & Dine (2011): Research Methods for the Biosciences, Oxford University Press, ISBN-13: 9780199545766 > Marder (2011): Research Methods for Science, Cambridge University Press, ISBN-13: 9781139035118 > Ruxton & Colegrave (2011): Experimental Design for the Life Sciences, Oxford University Press, ISBN-13: 9780199569120 > Sesinik (2010): Einführung in das wissenschaftliche Arbeiten: mit Internet, Textverarbeitung, Präsentation, E-Learning, Web2.0, Oldenbourg Wissenschaftsverlag, ISBN-13: 9783486713305

The Strategic Business Management course is built on four pillars.  I) Leadership and Management of enterprises/projects for Industry and/or Academia The major drivers for modern business management are addressed (innovation, globalisation, market dynamic, etc.). From there, the difference of management and leadership will be explained. Build on fundamentals of systemic thinking, reflected for the background of complexity, innovation and change, the differences of working “on a system” (leadership) and working “in a system” (management) will be explained and discussed. Pros/Cons will be elaborated for different environments. The different traditional management styles will be enhanced by leadership approaches and mapped to leading people (individuals) and organisations (teams) in a dynamic branch. II) Strategic Thinking – Strategy Development (Strategic Concepts – from Vision/Mission to Strategy) and its Elements in a Holistic Approach  A company’s identity through vision, mission and corporate culture as framework for its strategy is the baseline of this chapter. A vision and its important function for organisations and its individuals as initial impulse for orientation and order, as success driving function for alignment and motivation will be explored. The effectiveness of visions in the sense of positioning, top down implementation, targets and continuous communication is analysed. The Porter Model is explained and used to show different strategy types (e.g. product market Strategies (Ansoff), competitive strategies, development strategies). III) The Operational Perspective of Business Management – Strategy Implementation (Management-system, Framework and Indicators) The importance, characteristics and elements of management systems are explained and elaborated by analysing different models such as Balanced Scorecard, EFQM Model and/or ISO 9001:2015. It is shown, how a set of policies, processes and its alignment to the organization is targeted to achieve company´s objectives. IV) Adopted Company – A capstone project, where students apply the learning outcomes by analysing all elements learned in I-III The strategic analysis of a selected, “adopted” company builds the final capstone of the lecture course. Students analyse all relevant elements of a company (vision, mission, values/culture, strategic approach and goals related research, product portfolio, human resources, market, sales, etc.) and derive strategic recommendations for the company to successfully mature its market position. The entire course content will be critically addressed by future requirements as well as trends and developments in biotechnology business areas.

Student-centered methods: project work in fixed groups, presentations, partly: flipped class-room approach, debates, discussions, written tasks 

Continuous assessment: Evaluation of group results (results of “adopted company” analyses and suggestions). In addition, individual interviews with students about their results facilitates quality assurance respectively control at an individual level.

> R.S. Kaplan & D.P. Norton (2004): Strategy Maps: Converting Intangible Assets into Tangible Outcomes, Harvard Business Review Press, 978-1591391340 > Richard M. Steers, Luciara Nardon, Carlos J. Sanchez-Runde (2013): Management Across Cultures: Developing Global Competencies, Cambridge University Press, 978-1107030121 > John J. Campbell (2008): Understanding Pharma: The Professional´s Guide to How Pharmaceutical and Biotech Companies Really Work, Pharmaceutical Institute, 978-0976309635 > Frederic Laloux (2014): Reinventing Organizations, Nelson Parker, 978-2960133509 > Michael E. Porter (2004): Competitive Strategy: Techniques for Analyzing Industries and Competitors. Free Press, 978-0743260886

Module Systems Pathology

Systems pathology - modul.

Students  are able to explain membrane physiology, the development of action potentials, electrotonic and saltatoric conduction, synapses, important transmitters and the resulting pharmacological modulation, temporal and spatial integration, pre- and postsynaptic inhibition, as well as, motor functions of the spinal cord, basal ganglia, cerebellum, and cortex including disorders caused by lesions in these regions, the structure and function of the autonomic nervous system including effects on important organs, and the function of the sensory systems.

> MF Baer, BW Connors, MA Paradiso (2015): Neuroscience: Exploring the Brain, Wolters Kluwer, 978-0781778176 > R Carpenter & B Reddi (2012): Neurophysiology: A Conceptual Approach, Hodder Arnold, 978-1444135176

Cancer is a devastating disease representing the second most leading cause of death worldwide. Despite major improvements in diagnosis and therapy, cancer represents a major health burden and affects every second man and every third women during their lifetime. The lecture focuses on the most relevant aspects of cancer development and particularly deals with (i) risk factors and cancer prevention, (ii) genomic stability and DNA repair, (iii) oncogenes and tumor suppressors, (iv) tumor viruses and cancer models, (v) evolution of tumor cells, (vi) cancer cell signaling, (vii) tumor angiogenesis and tumor immunology, (viii) dissemination of cancer cells, and (ix) the resistance to cancer cells against therapy. Importantly, we aim at discussing the molecular mechanisms in each aspect and their translation into clinical applications.

The lecture is supported by PowerPoint. The lecture is accompanied by an open discussion of current issues. The PowerPoint presentations are available online as lecture notes.

Final exam: Written examination at the end of the lecture with open questions. No multiple choice.

The Biology of Cancer (R.A. Weinberg, 2nd Edition); Molecular Biology of the Cell (B. Alberts et al, 7th Edition); selected Review articles as indicated (e.g. Nat. Rev. Cancer)

The Biology of Cancer (R.A. Weinberg, 2nd Edition); Molecular Biology of the Cell (B. Alberts et al, 7th Edition); ausgewählte Übersichtsartikel wie angegeben (e.g. Nat. Rev. Cancer)

Electives 3 (1 ECTS of your choice)

Module electives 3, electives 3 - modul.

Introduction to the fundamentals of validation and operation of computerised systems in the pharmaceutical industry and regulative environment as required to be compliant with the current EU regulations

• GxP requirements to be considered 

• Quality risk management

• Qualification / validation of systems ...

• Management of deviations and changes

• Corrective and preventive actions

• Appropriate documentation

• Navigation in a multivalent working environment

• Typical systems as examples, introduced from the systemic point of view (ERP, MES, diverse databases, LIMS, cloud systems, data storage and retention systems and procedures like electronic archiving and backup procedures)

• Practical examples as the core of explanations applied to the legislative demands

Lectures combined with discussion, based on practical examples 

Final exam: Presentation and discussion of the developed strategy

> publicly available literature on validation of computerised systems and data integrity in the preclinical / clinical environment and pharmaceutical industry > EudraLex - EU Legislation, Volume 4 - Guidelines for good manufacturing practices for medicinal products for human and veterinary use, Annex 11: Computerised Systems > OECD Advisory Documents of the Working Group on GLP, No 17: Application of GLP Principles to Computerised Systems (will be updated contemporarily) / > öffentlich verfügbare Literatur über die Validierung computergestützter Systeme und Datenintegrität im präklinischen / klinischen Umfeld und in der pharmazeutischen Industrie > EudraLex, Band 4 – Leitfaden für die gute Herstellungspraxis, Humanarzneimittel und Tierarzneimittel der Europäischen Kommission (EU-Leitfaden der Guten Herstellungspraxis), Anhang 11: computergestützte Systeme > OECD Beratungsdokument der Arbeitsgruppe Gute Laborpraxis, Nr. 17: Anwendung von Grundsätzen der Guten Laborpraxis auf computergestützte Systeme (wird zeitnah ergänzt)

Regulatory affairs, the main contact point to health authorities and, pharmacovigilance, patient safety post clinical development, see Learning Outcomes for specific details.

Interactive lectures with discussions 

> Waller & Harrsion-Woolrych (2017): An Introduction to Pharmacovigilance. Wiley-Blackwell, ISBN 978-1119289746

Electives 4 (1 ECTS of your choice)

Module electives 4, electives 4 - modul.

In this course the students learn strategies of scientific research. In a small group they develop a strategy for a given topic (in Drug Discovery), by designing experiments and work packages which they evaluate according to different criteria like costs, effort, efficiency, Finally each group presents its research project.

> No general literature / keine allgemeine Literatur 

In this course the students learn strategies of scientific research. In a small group they develop a strategy for a given topic (in Immunology), by designing experiments and work packages which they evaluate according to different criteria like costs, effort, efficiency. Finally each group presents its research project.

> No general literature / keine allgemeine Literatur

4. Semester

0 SWS   2 ECTS

The Master's examination represents the final examination of the Master's program before an examination committee of experts. The students present their Master's thesis in the form of a lecture. The students are questioned about their presentation and they defend the contents and conclusions of their Master’s thesis. They are asked to cross-connect the topic of their Master's thesis to relevant subjects of the degree program. The students reflect and discuss current research topics from the main fields of the Master's program with the examination committee of experts.

Activating Methods: presentations and oral exam 

Final exam: For the presentation of the Master's thesis up to 40 points are awarded by the examination committee. Up to 30 points are awarded for the subsequent discussion on the presentation. Up to 30 points are also awarded for the discussion of current research topics from the main areas of the Master's program. The sum of these points gives the overall grade for the Master's examination.

> None/keine.

0 SWS   28 ECTS

Writing an English language Master‘s thesis.

Laboratory and literature research

Final exam: Assessment by experts.

> Current research literature / aktuelle Forschungsliteratur.

Semester dates

Summer semester 2024: 12 th February 2024 to 26 th July 2024 Winter semester 2024/25: 9 th September 2024 to 31 st January 2025

Number of teaching weeks 18 per semester

Choosing Electives Electives can only take place when enough students register for them. An admission procedure may take place if the number of interested students exceed the course limit.

Times Mon. to Fri. all day; some vocational subjects also held on Sat .

Curriculum until 2019 Expiring Curriculum

After graduation

As a graduate of this program, a wide range of occupational fields and career opportunities are open to you. Find out here where your path can take you.

Career opportunities

As a graduate, you will mainly be engaged in research and development in your future employment. You can undertake a life science PhD at an Austrian or international university. You are qualified to lead lab or research groups. In addition, you have the entrepreneurial expertise to set up your own start-up. You will work in the following industries and sectors:

Industry (Pharma, Biotech, Medtech, Food industry, etc.)

Medical research (e.g. tumor biology, vaccine development, degenerative diseases), research and development departments of established pharmaceutical (life science) companies as well as biotech start-ups, universities, non-university research establishments (e.g.: the austrian academy of sciences, austrian institute of technology, etc.) and universities of applied sciences, analytical laboratories in the industry and clinics, veterinary research and development, government agencies, studying made easy.

Funding & Scholarships

More information here

Time abroad

Expertise, language skills, broadening horizons

Open Lectures

Find out more, in German

Center for academic writing

Intensive german course, accessibility, queer @ fh campus wien, networking with graduates and organizations.

We work closely with numerous biotech companies, universities, such as the University of Vienna, and research institutes and have a strong international network. This guarantees you strong contacts for a semester abroad, participation in research and development activities or your professional career. You can find information about our cooperation activities and much more at Campusnetzwerk. It's well worth visiting the site as it may direct you to a new job or interesting event held by our cooperation partners!

Welcome to our Campusnetzwerk

Find job offers, build valuable mentoring relationships and expand your professional network - become part of our community!

Head of Degree Program

FH-Prof. Mag. Dr. Beatrix Kuen-Krismer

Head of Department Applied Life Sciences; Head of Degree Programs Molecular Biotechnology +43 1 606 68 77-3501 [email protected]

Secretary's office

Favoritenstraße 222, F.3. 23 1100 Vienna +43 1 606 68 77-3500 +43 1 606 68 77-3509 [email protected]

Main campus Favoriten (Google Maps)

Office hours Mon. to Thurs., 9.00 a.m. to 1.00 p.m. and 4.00 p.m. to 5.00 p.m. Fri., 9.00 a.m. to 1.00 p.m.

Information on application and admission [email protected]

Information: Application and Admission

Mag. a Janina Agis-Blei Assistance Favoritenstraße 222, F.3. 21 1100 Wien +43 1 606 68 77-3505 +43 1 606 68 77-3509 [email protected]

Teaching staff and research staff

Fh-prof. dr. thomas czerny.

Academic Staff

FH-Prof. Univ. Doz. Dr. Ines Swoboda

Head of Competence Center Molecular Biotechnology; Academic Staff

FH-Prof. Dr. Paul Watson

Deputy Head of Degree Programs Molecular Biotechnology; Academic Staff

FH-Prof. Mag. Dr. Marianne Raith

Dr. mary grace wallis, fh-prof. dr. herbert wank, you want to know more we will help you., have you found all the information you are looking for.

• Master Thesis
• Studium & Weiterbildung
• Universitäre Weiterbildung
• Alle Lehrgänge und Kurse
• Clinical Research
• Studienaufbau & Curriculum

The Master Thesis is comprised of the following parts:

• Written composition of a study protocol including patient information sheet
• Oral presentation of the study protocol
• Written appraisal of the study protocol by a colleagues

1. Written composition of a study protocol including patient information sheet:

• Approval to undertake the written Master Thesis is conditional upon the successful completion of the examinations set for Modules l to VI.
• The Master Thesis must be completed individually by each course participant. Partner and group work submissions are not permitted.
• The subject of the Master Thesis comprises the written composition of a protocol for clinical study, which is realistically implementable within the participant's field of research, together with the associated patient information sheet. The paper should contain details of the scientific background, the chosen study design, the selected methodology and the statistical analysis plan to the same extent as would be expected of a study protocol.
• The completion of the written Master Thesis will be supervised by a thesis supervisor who will conduct an initial appraisal. The course participants have a right of nomination in accordance with the available thesis supervisors. The thesis supervisors will be appointed by the course director.
• The final paper (incl. bibliography) should be at least 50 A4 pages in length (Arial 12-point, double line spacing) excluding any Appendixes. The time of submission is to be documented.
• The thesis supervisor is required to prepare a written report on the written composition of the study protocol. The course director is responsible for the awarding of grades.

2. Oral presentation of the study protocol:

The students will present their protocols and patient information sheets to the  teaching staff in a setting of a simulated ethics commission meeting. The presentations will then be discussed from the perspective of applicants and committee members. The evaluation criteria are the relevance of the study, the methodological composition, concise presentation of content, presentation technique and the discussion of the written report.

3. Written appraisal of the study protocol by a colleague:

Each student is required to critically appraise the finished study protocol and accompanying patient information sheet prepare by another fellow student. This will be done on an anonymous basis. The quality of the course participant's appraisal will be included in the assessor's final overall assessment of the Master Thesis.

If the Master Thesis is negatively assessed by the course director the provisions contained in Section 17a para. 12 of the 2nd Section of the Constitution of MedUni Vienna will be applied.

Master Thesis - formal requirements:

Master Thesis step by step

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Cumulative thesis or monograph?

Special regulations apply for cumulative theses . They must contain at least 2 publications. At least one of them must be published or in press, while the other(s) may be included at the stage of submission. Publications on preprint servers are eligible for cumulative theses, as well. The confirmations of acceptance/submission must be included in the thesis. The student must be the main contributor (first or co-first author) on at least one of these papers. Also, it must be clearly specified what the student's contribution to the paper was. Blockage of thesis must be requested for 2 years (see chapter "Submission of thesis & registration for defense).

Guidelindes for cumulative thesis 

Papers that do not show the correct affiliation to the Vienna Biocenter PhD Program will not be considered for cumulative theses.

If you have only one published paper, your thesis will be a monograph with an introduction, methods, discussion and a conclusion that refers to all parts of your thesis. Feel free to include the pdf of your paper in your thesis. A contribution statement must be included, similar to cumulative thesis.

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Molecular Precision Medicine (Master)

Of the university of vienna & the medical university of vienna.

The aim of the master's degree in Molecular Precision Medicine at the Medical University of Vienna and the University of Vienna is to train highly motivated and talented students in the scientific basis of human diseases, the development and clinical evaluation of therapeutics and modern clinical practices in connection with precision medicine.

Students learn the pathogenesis of human diseases on a molecular and mechanistic level. You will learn how this information can be used to develop precision therapeutics that target the underlying causes of the disease; how these therapeutics are evaluated for efficacy and toxicity and what future challenges precision medicine will face. Fundamental scientific and therapeutic concepts are illustrated in detail using appropriate diseases and case studies so that students can understand the disease from the molecular basis to clinical treatment.

Students acquire the skills to use bioinformatics to analyze large sets of genomic information, including programming and applied statistics. Students will be exposed to ethical and health economic issues related to the practice of precision medicine so that they can critically assess future socio-economic challenges.

Master of Science

Degree Programme Code: 066 329

4 semesters / 120 ECTS credits

Language: English

Special Admission Procedure at the Medical University of Vienna

Joint Programme with: