University of Florida
Pharmacy—Medicinal Chemistry
PHA 6354 Natural Medicinal Products 3 Credits
Grading Scheme: Letter Grade
Chemistry of compounds derived from plants and animals.
Catalog Program Pages Referencing PHA 6354
PHA 6356 Structure Determination of Complex Natural Products 3 Credits
Rigorous structure determination of natural products, using modern spectroscopic methods. Become able to elucidate the structure of any organic small molecule.
Prerequisite: CHM 5235 or consent of instructor.
Catalog Program Pages Referencing PHA 6356
PHA 6357 Herbal & Dietary Supplements 3 Credits
Herbal Dietary supplements are extensively used by consumers. This course provides an overview of commonly used supplements to assist healthcare practitioners in providing patients with adequate counseling to avoid drug interactions and false claims.
Catalog Program Pages Referencing PHA 6357
PHA 6416 Pharmaceutical Analysis I 3 Credits
Theory and applications of relevant analytical techniques for analysis of drugs in biological samples. Offered spring term in odd-numbered years.
Catalog Program Pages Referencing PHA 6416
PHA 6417 Pharmaceutical Analysis II 3 Credits
Absorption, fluorescence, phosphorescence, and spectroanalysis of drugs and related compounds.
Catalog Program Pages Referencing PHA 6417
PHA 6425 Drug Biotrans and Molecular Mechanisms of Toxicity 3 Credits
Enzymology and mechanisms of drug biotransformation pathways. Examples of drugs and other xenobiotics that exhibit toxicity related to biotransformation.
Prerequisite: introductory organic chemistry, biochemistry.
Catalog Program Pages Referencing PHA 6425
PHA 6432 Fundamentals of Pharmaceutical Chemistry 1 Credit
This is a foundation course whose aims are providing an introduction to the principles of Pharmaceutical chemistry, including an understanding of drug structure-activity relationships, prediction of the physico-chemical properties of a drug, basic knowledge of the major pathways of drug metabolism, and factors that can contribute to drug-drug interactions.
Catalog Program Pages Referencing PHA 6432
PHA 6435 Biosynthetic Logic of Medicinal Natural Products 3 Credits
Covers topics of biosynthesis of the major families of medical natural products, structural and biochemical understanding of their biosynthetic logic, gene cluster identification, genome mining, and production of bioactive "unnatural products" for drug discovery and development.
Prerequisite: Students are expected to have the background of Biochemistry, Enzymology, and Bioorganic Chemistry. Or permission of instructors.
Catalog Program Pages Referencing PHA 6435
PHA 6444 Pharmaceutical Chemistry I 3 Credits
Students are shown how to predict the solubilities, structure-activity relationships, basic synthesis routes for selected structures, metabolism and pharmacological activity/potency of various drug classes. In particular, anticoagulants, ACE inhibitors, glucocorticoid steroids, nitrate esters, adrenergics, cholinergics, diuretics, anesthetics, antihyperlipidemics, muscle relaxants, anxiolytics, antidepressants, sedative hypnotics and vitamins are covered.
Catalog Program Pages Referencing PHA 6444
PHA 6447 Drug Design 3 Credits
Relevant disciplines and their effect on new drug development, from discovery of a new active lead compound to final refinement as a commercial product.
Prerequisite: organic chemistry, biochemistry, pharmacology, or consent of instructor.
Catalog Program Pages Referencing PHA 6447
PHA 6452 Metabolic Biochemistry 3 Credits
This course will introduce students to the principles of anabolic and catabolic pathways and cellular energy efficiency. The course also provides an understanding of the biological, physical, and chemical processes for each reaction pathway.
Catalog Program Pages Referencing PHA 6452
PHA 6467C Drug Design II 3 Credits
Outline of how relevant disciplines impact on the development of a new drug product from the discovery of a new active lead compound to its final refinement as a commercial product. Contributions of Organic Chemistry, Biochemistry, Metabolic Chemistry, Physical Chemistry, Analytical Chemistry, and Pharmacological Chemistry are discussed.
Prerequisite: PHA 6447 Drug Design I.
PHA 6468 Biotransformation Considerations in Drug Design 2 Credits
Explores the importance of considering biotransformation in the process of drug design and discovery. Topics include the major pathways of biotransformation of various functional groups present in drugs and the enzymes involved, including their regulation and factors affecting metabolism and enzyme activity. Other topics are the role of metabolism in drug toxicity and examples from the literature of metabolic activation of drugs and naturally occurring toxic chemicals.
Prerequisite: PHA 6447 and PHA 6467C and an additional undergraduate chemistry or biochemistry class with permission of instructor..
Catalog Program Pages Referencing PHA 6468
PHA 6471 Synthetic Medicinal Chemistry 3 Credits
Review of acid and base properties of pharmacologically active molecules. Review of mechanisms of synthetic reactions, and their applications.
Catalog Program Pages Referencing PHA 6471
PHA 6472 Organic Synthesis of Drug Molecules 3 Credits
Covers advanced topics in drug molecule synthesis, including: organic reaction mechanisms, retrosynthetic analysis, asymmetric synthesis, heterocyclic chemistry, natural product synthesis, drug design and synthesis, structure-activity relationships. Secondary topics that will be included in this course include: anticancer/antibacterial agents, screening approaches.
Prerequisite: CHM 5224 or permission of instructor.
Catalog Program Pages Referencing PHA 6472
PHA 6532 Occupational Toxicology 3 Credits
Focuses on the growing field of occupational toxicology, the specific toxicants encountered in various work environments, and how both acute and chronic exposure can impact health. Symptom presentation, differential diagnosis, and treatment are covered as well as preventive measures that can be implemented to reduce or prevent such exposures.
Catalog Program Pages Referencing PHA 6532
PHA 6533 Epidemiology & Biostatistics in Clinical Toxicology 3 Credits
Covers principles and applications of epidemiology and biostatistics as they apply to clinical toxicology. Students will learn to critically evaluate and understand data analyses and results presented in the medical literature. Upon completion of this course, students will have the basic knowledge of epidemiological analysis and biostatistical techniques to aid in the interpretation and treatment of the poisoned or overdosed patient.
Catalog Program Pages Referencing PHA 6533
PHA 6534 Toxicology of Chemical Weapons 3 Credits
Providing healthcare providers, first responders, and others that may be exposed to chemical weapons with an understanding of their toxicology and treatment approaches.
Catalog Program Pages Referencing PHA 6534
PHA 6535 Principles of Nucleotide Activity 2 Credits
This course will be introducing the students to the chemical structure of DNA and RNA; the synthetic processes for DNA and RNA synthesis; biochemical reactions and pathways for nucleotide synthesis; DNA replication, transcription and translation; covalent and reversible interactions of nucleic acids with small molecules and proteins and an overview of techniques for the analysis of nucleic acids.
Catalog Program Pages Referencing PHA 6535
PHA 6543 Pharmaceutical Chemistry II 3 Credits
Showing students how to predict the solubilities, structure-activity relationships, basic synthesis routes for selected structures, metabolism and pharmacological activity/potency of various drug classes. In particular antidiabetics, anticonvulsants, H1 and H2 antagonists, analgetics, nonsteroidal antiinflammatory drugs, hormones, antibiotics, antiviral agents, and antineoplastic agents are covered.
Catalog Program Pages Referencing PHA 6543
PHA 6556 Introduction to Clinical Toxicology 3 Credits
Introducing the basic methods and procedures commonly employed in Clinical Toxicology as well as the concept of Clinical Toxicology as an interdisciplinary science within the field of healthcare.
Catalog Program Pages Referencing PHA 6556
PHA 6557 Clinical Toxicology 1 3 Credits
Providing students with an understanding of the toxic effects and clinical applications of various therapeutic drug classes including cardiovascular, CNS, analgetic, anesthetic, antineoplastic, and antibiotic drugs.
Prerequisite: VME 6602
Catalog Program Pages Referencing PHA 6557
PHA 6840 Medicinal Chemistry of Drugs of Abuse 3 Credits
Pharmacological effects of commonly encountered licit and illicit pharmaceutical compounds.
Catalog Program Pages Referencing PHA 6840
PHA 6850 Principles of Forensic Science 3 Credits
Introducing the basic disciplines of forensic science. The course is composed of twelve modules.
Catalog Program Pages Referencing PHA 6850
PHA 6851 Forensic Analysis of DNA 3 Credits
Techniques for isolation of DNA from cells. Spectroscopic techniques. Hydrodynamic and electrophoretic separation methods. Sequence determination. Statistical analysis and forensic significance.
Catalog Program Pages Referencing PHA 6851
PHA 6852 Mammalian Molecular Biology 3 Credits
Focus on the principles of modern molecular biology and biochemistry and expand on the concepts you may have already encountered in other classes in this program. The content will also include the applications of experimental techniques and procedures routinely used in this field.
Catalog Program Pages Referencing PHA 6852
PHA 6853 Biological Evidence and Serology 3 Credits
Overview of crime scene investigation as it pertains to biological evidence. Crime scene safety. Collecting and preserving evidence. Identifying, analyzing, and interpreting biological stains.
Catalog Program Pages Referencing PHA 6853
PHA 6854 Forensic Immunology 3 Credits
Antibody formation, antigen structure. Complement mediated reactions. Hypersensitivity. Immunoelectrophoretic techniques in forensic science.
Catalog Program Pages Referencing PHA 6854
PHA 6855 Forensic Genetics 3 Credits
Principles of inheritance. Genetic polymorphisms and forensic implications, population genetics and paternity testing.
Catalog Program Pages Referencing PHA 6855
PHA 6856 Bloodstain Pattern Analysis 3 Credits
Blood spatter creation and interpretation. Recording, collection, and processing of bloodstains and blood spatter evidence.
Catalog Program Pages Referencing PHA 6856
PHA 6857 Forensic Analysis of DNA 2 3 Credits
This course covers how to interpret DNA data to include mixture deconvolution and the statistics that apply to DNA matches/inclusions. Modules guide the student through the basis of Y-STR and Kinship testing statistical applications. Students will learn the report writing, review and testimony skills required of a DNA analyst.
Prerequisite: PHA6851 - Forensic Analysis of DNA
Catalog Program Pages Referencing PHA 6857
PHA 6861 Intro to Forensic Medicine 2 4 Credits
Forensic medicine is the application of medical knowledge to the investigation of crime. This course gives knowledge and understanding of the application of scientific knowledge to medico-legal problems and legal proceedings, specifically as related to investigating medical crimes as well as the causes of sudden and unexpected deaths.
Prerequisite: VME 6582 .
Catalog Program Pages Referencing PHA 6861
PHA 6905C Research Procedures in Pharmaceutical Sciences 1-4 Credits
Research Procedures in Medicinal Chemistry
PHA 6910 Supervised Research 1-5 Credits, Max 5 Credits
Grading Scheme: S/U
Supervised Research
Catalog Program Pages Referencing PHA 6910
PHA 6934 Seminar in Medicinal Chemistry 1 Credit, Max 3 Credits
Weekly presentation and discussion of research reports based on college programs or literature.
Catalog Program Pages Referencing PHA 6934
PHA 6935 Selected Topics in Pharmacy 1-4 Credits, Max 12 Credits
Open to all departments in the College of Pharmacy.
Catalog Program Pages Referencing PHA 6935
PHA 6936 Advanced Topics in Pharmaceutical Sciences 1-2 Credits, Max 4 Credits
Written and oral presentation of research designs, protocols, papers, and critical appraisals with discussion and critical review of such topics.
Catalog Program Pages Referencing PHA 6936
PHA 6938 Research Seminar 1 Credit, Max 3 Credits
Seminar required of graduate students in the College of Pharmacy.
Catalog Program Pages Referencing PHA 6938
PHA 6940 Supervised Teaching 1-5 Credits, Max 5 Credits
Supervised Teaching
Catalog Program Pages Referencing PHA 6940
PHA 6971 Research for Master's Thesis 1-15 Credits
Research for Master's Thesis
Catalog Program Pages Referencing PHA 6971
PHA 7979 Advanced Research 1-12 Credits
Research for doctoral students before admission to candidacy. Designed for students with a master's degree in the field of study or for students who have been accepted for a doctoral program. Not appropriate for students who have been admitted to candidacy.
Catalog Program Pages Referencing PHA 7979
PHA 7980 Research for Doctoral Dissertation 1-15 Credits
Research for Doctoral Dissertation
Catalog Program Pages Referencing PHA 7980
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The graduate program in Pharmaceutical Sciences spans the entire life cycle of a drug, from bench to bedside. The Medicinal Chemistry concentration focuses on drug discovery and development, part of the pre-clinical studies phase of the cycle. Pharmaceutical Sciences Ph.D. Programs Distinction through five interrelated training opportunities involving the entire life cycle of a drug.…
Lina Cui, Ph.D. Dr. Cui's lab in the University of Florida College of Pharmacy explores the biochemical activities of glycan processing enzymes and develops therapeutic and diagnostic molecules or tools for various types of cancer and age-related diseases (e.g. diabetes, neurodegeneration, etc). Watch Video.
e-Learning. 1225 Center Drive. Gainesville, FL 32610. Guangrong Zheng, Ph.D., is an associate professor in the department of medicinal chemistry at the University of Florida College of Pharmacy. He received his B.S. in medicinal chemistry from Fudan University and his Ph.D. in synthetic organic chemistry from Shanghai Institute of Materia Medica.
discovery, to teach these principles in the professional and graduate programs, and to provide service to the scientific community. The Department of Medicinal Chemistry is located in the College of Pharmacy, and is an integral part of the University of Florida's Health Science Center. Medicinal Chemistry is a unique blend of the physical ...
Important Information for Applicants Steps to Apply To complete your application to the Pharmaceutical Sciences graduate program, follow the instructions below. If you have questions about the application process or graduate program, please contact [email protected]. Step 1: Review the COP Graduate Admissions Guidelines We strongly ...
Guangrong Zheng, PhD - PI Guangrong Zheng, PhD, is an associate professor in the Department of Medicinal Chemistry at the University of Florida (UF), College of Pharmacy. Dr. Zheng received his BS in medicinal chemistry from Fudan University and his PhD in synthetic organic chemistry from Shanghai Institute of Materia Medica. He then completed his…
Education. The mission of the department of Medicinal Chemistry is to conduct basic and translational research in chemistry and biochemistry as it relates to drug discovery, to teach these principles in the professional and graduate programs and provide service to the scientific community and public. The department focuses on all aspects of ...
Jane V. Aldrich, Ph.D., joined the University of Florida as professor of medicinal chemistry in 2015 under UF's preeminence initiative in drug discovery and development. Dr. Aldrich's research on analogs of opioid peptides has been continuously funded by the National Institute on Drug Abuse for over 25 years, and she has been the principal investigator of over $14 million in research grants.
University of Florida Office of Graduate Admissions PO Box 114000 201 Criser Hall Gainesville, FL 32611-4000 (352) 392-1365. ... Examples include motivations for attending graduate school, what type of chemistry you are interested in pursuing during your graduate career, if there are particular faculty members that you would like to work with ...
Candidate compounds are investigated for further development through interactive chemistry and pharmacology efforts. The center embraces all aspects of natural products research from discovery, biosynthesis and chemical synthesis, assay development, screening and target identification to drug development.
welcome to the laboratory of synthetic medicinal chemistry and drug discovery. Principal Investigator - Guangrong Zheng, PhD.
The Department of Medicinal Chemistry has excellent facilities for research in these major areas of medicinal chemistry. Faculty have been highly successful in attracting extramural research support for the past several years. Faculty and Research Areas Department Equipment & Facilities State-of-the-art equipment are available in individual research faculty laboratories. Additional training ...
The Department of Chemistry granted its first master's degree in 1909 and the first Ph.D. in 1930. Since then, we have awarded over 2000 graduate degrees. The faculty are engaged in research in all areas of modern chemistry. Specializations include chemical biology, organic, physical, inorganic and analytical chemistry with extensive interdisciplinary research opportunities (e.g., catalysis ...
The College of Pharmacy at University of Florida offers the Doctor of Philosophy degree in Pharmaceutical Sciences with a concentration in Medicinal Chemistry. University of Florida. Gainesville , Florida , United States. Top 1% worldwide. Studyportals University Meta Ranking.
PHA 6452 Metabolic Biochemistry 3 Credits. Grading Scheme: Letter Grade. This course will introduce students to the principles of anabolic and catabolic pathways and cellular energy efficiency. The course also provides an understanding of the biological, physical, and chemical processes for each reaction pathway.
Christopher R McCurdy Ph.D., F.A.A.P.S. Professor And The Frank A. Duckworth Eminent Scholar Chair; Associate Dean For Faculty Development; Director Of The UF Translational Drug Development Core. (352) 294-8691. [email protected].
Oliver GRUNDMANN, Professor (Full) | Cited by 3,647 | of University of Florida, FL (UF) | Read 144 publications | Contact Oliver GRUNDMANN
Drug Discovery and Development Departmental faculty have been highly successful in attracting extramural research support for drug discovery and development and co-founded startup companies based on UF intellectual property generated in their academic labs. Other preclinical and clinical candidates have been licensed to pharmaceutical and biotech companies. Learn more about our faculty and ...