genetics of cancer research paper

Cancer genetics is the study in humans and other animals of heritable gene variants that cause or confer altered risk of tumour or hematological malignancy. Individual cancer risk varies and is ...

The aim of Cancer Genetics is to publish high quality scientific papers on the cellular, genetic and molecular aspects of cancer, including cancer predisposition and clinical diagnostic applications. Specific areas of interest include descriptions of new chromosomal, molecular or epigenetic …. View full aims & scope.

Cancer, a leading cause of death worldwide, is a result of complex interplay between genetic and environmental factors. The heritability of cancer has been estimated to be 33% according to a Nordic twin's study ().To date, a large number of genetic loci have been identified as susceptibility markers for certain cancers by genome-wide association studies (GWAS).

A cancer gene can be defined as a genetic variant that increases cancer risk when present in normal cells, or promotes the development of cancer as neoplasia grow. Cancer genes are distinct alleles of normal genes that arise as a result of mutation. From a genetic perspective, there are two types of cells in the human body.

The Biology of Cancer. Cancer is a disease that begins with genetic and epigenetic alterations occurring in specific cells, some of which can spread and migrate to other tissues. 4 Although the biological processes affected in carcinogenesis and the evolution of neoplasms are many and widely different, we will focus on 4 aspects that are particularly relevant in tumor biology: genomic and ...

Challenges and considerations. The application of NGS technologies to the characterization of human tumours has provided unprecedented opportunities to understand the biological basis of different cancer types, develop targeted therapies and interventions, discover genomic biomarkers of drug response and resistance, and to guide clinical decision-making regarding the treatment of patients 1,2.

Clinical researches have the aim of studying the interplay between a multi-omics view of cancer and genomic, exposomic, and metabolomic views, evaluating treatment options, utilizing mechanisms of prevention and diagnosis, screening tools, and patient quality of life evaluation to gain a precision in medicine.

Oncorine (rAd5-H101) It is the first replicative, oncolytic recombinant ad5 (rAd5-H101) approved to treat refractory nasopharyngeal cancer. Loss of p53 gene linked with drug resistance and survival rate reduction in non-small cell cancer patients. 50 Oncorine is an ad5 virus with a deletion in the E1B 55K gene.

Cancer genetics has been a broad and fertile area of research. Over the past several decades a large number of cancer genes have been identified and characterized. This has led to improvements in genetic testing and diagnostics, as well as more accurate prognostic information; advances in cancer genetics are just beginning to impact cancer ...

Genomic research has evolved from seeking to understand the fundamentals of the human genetic code to examining the ways in which this code varies among people, and then applying this knowledge to ...

The Cancer Target Discovery and Development Program is a network of research centers devoted to studying how molecular changes found in cancers affect cancer cells and explore opportunities to target those changes with new therapies. The Epidemiology and Genomics Research Program supports research in human populations to understand genomic determinants of cancer occurrence and cancer outcomes ...

The aim of Cancer Genetics is to publish high quality scientific papers on the cellular, genetic and molecular aspects of cancer, including cancer predisposition and clinical diagnostic applications. Specific areas of interest include descriptions of new chromosomal, molecular or epigenetic alterations in benign and malignant diseases; novel laboratory approaches for identification and ...

This study was led by Adam de Smith, an Assistant Professor of Population and Public Health Sciences at the University of Southern California, Lara Wahlster, a Pediatric Oncologist and Postdoctoral Fellow in Vijay Sankaran's research group at Dana Farber Cancer Center, and Soyoung Jeon, as a PhD student in Cancer Biology and Genomics at the ...

Germline genetic markers that accurately distinguish aggressive from non-aggressive disease could have a significant impact on patient care. In the case of prostate cancer, there does appear to be a genetic component to outcome 111, and several groups have examined whether the prostate cancer risk SNPs discovered to date predict outcome.

"The search for genetic damage in neoplastic cells now occupies a central place in cancer research…. Cancer may be a malady of genes, arising from genetic damage of diverse sorts -- recessive and dominant mutations, large rearrangements of DNA and point mutations, all leading to distortion of either the expression or biochemical function of ...

Tang and Anna Vähärautio, a cancer biologist at the University of Helsinki and coauthor of the study, wanted to develop a method that combined lineage tracing—the process of tracking cell fate and offspring—with the ability to profile gene expression in individual cells. However, measuring gene expression in a cell typically destroys it ...

Research could unlock more precise prognoses and targeted treatments for children with cancer. ScienceDaily . Retrieved April 9, 2024 from www.sciencedaily.com / releases / 2024 / 04 ...

Breast cancer (BC) genetics has become a fundamental aspect of BC management. It influences screening, follow-up, prophylactic and therapeutic recommendations in women harboring a germinal BC susceptibility gene. In addition, it helps to identify patient subgroups with either a different prognosis or different response to treatment.

Huntsman Cancer Institute focuses on delivering a cancer-free frontier to all communities in the area we serve. We have more than 300 open clinical trials and 250 research teams studying cancer at any given time. More genes for inherited cancers have been discovered at Huntsman Cancer Institute than at any other cancer center.

The research team also discovered a novel mutation in the ABCC2 gene, not previously linked to DJS. This newly identified mutation alters the MRP2 protein itself, hindering its ability to function ...

The data showed that only 0.329% of cancer publications globally were on Africa, and only 0.016% were on cancer genetics/genomics from Africa. Although the most prevalent cancers in Africa are cancers of the breast, cervix, uterus, and prostate, publications representing breast, colorectal, liver, and blood cancers were the most frequent in our ...

WASHINGTON (TND) — Recent research shows accelerated biological aging could be the reason why there is a rise in some types of cancer in younger people. A study conducted by researchers from the ...

2. Materials and Methods. In order to carry out the current review, in 2020, our team began to collect information and carry out a comprehensive search from different databases, i.e., Google Scholar, Pubmed, Springer, Elsevier ScienceDirect, and Web of Science, for studies published from 2010 to 2022, and older studies published as early as 2000 were included in this paper due to relevancy.