pharmacology phd programs

Pharmacology, PhD

School of medicine.

The Department of Pharmacology and Molecular Sciences hosts the Pharmacology Graduate Program, which offers a program of study and research leading to the Ph.D. degree. Research training opportunities within the program cover a broad spectrum of biomedical sciences including chemical biology, immunology, virology, cancer, and neuroscience. The mission of departmental research is to understand the molecular processes underlying physiology and pathology, and to apply this knowledge to discovering new drug targets and developing novel therapeutics. Within the program, students may choose to focus their efforts in any of a large number of specific research areas including signal transduction, structural biology and drug design, NMR spectroscopy, molecular genetics, cancer chemoprevention, viral immunosuppression, cancer immunology, cell-mediated immunity, mechanisms of HIV infection, vaccine development, glycobiology, biomedical mass spectrometry, clinical pharmacology, drug delivery, anti-parasite drug development, histone acetylation and gene regulation, melatonin and circadian rhythm, drug metabolism, Vitamin D pharmacology, natural product biosynthesis, telomerase and chromosome stability, T cell activation and tolerance, DNA repair, DNA topoisomerases, molecular imaging, and the clinical pharmacology of cardiovascular agents. The department is also pleased to host students and award doctoral degrees to M.D./Ph.D. degree candidates and students in other Ph.D. graduate programs in which Pharmacology faculty participate (Biochemistry, Cellular and Molecular Biology, Cellular and Molecular Medicine, Immunology, Neuroscience, and Pathobiology).

Financial Support

Financial support covering normal living costs, individual medical insurance, and tuition is provided.

Admission Requirements

Applicants should have a B.A. or B.S. degree with a major in any of the biological or physical sciences. Entering students are expected to have completed college-level courses in chemistry (inorganic, organic, and physical), calculus, and physics; a strong background in biochemistry is particularly desirable. A completed application form, at least three letters of recommendation, undergraduate transcripts, and a statement of interest must be received by December 8th.

Program Requirements

Students in the Pharmacology program must successfully complete the following courses:

Students must also take two advanced elective courses selected from those offered by this or other departments. Students are able to select a course of studies uniquely suited to their own career goals.

During their first year of study, students will complete ~10-week research rotations in addition to their coursework. They will initiate dissertation research by the end of their first year and complete elective courses relevant to their developing interests in subsequent years of training.

During the second year of study, students will be required to pass a qualifying examination conducted as prescribed by the Doctor of Philosophy Board of the University. This examination will probe the depth and breadth of the student’s knowledge of the biomedical subjects taught in the core courses.

The candidate is required to present a written dissertation based on original research undertaken while in residence as a graduate student and to present a departmental seminar describing the thesis research.

Combined M.D.-Ph.D. Degrees

Students seeking admission to or who are already participating in the M.D. program in the School of Medicine may participate in a program leading to both the M.D. and the Ph.D. degrees.

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Pharmacology, PhD

Pharmacological sciences represent an extremely large field of modern science, intertwined with many other biomedical disciplines: cancer and cardiovascular pharmacology, cell signaling, neuropharmacology, pharmacogenetics, pharmacological chemistry, environmental health sciences, and targeted therapeutics. Core courses include Cell Biology, Fundamentals in Pharmacology, Human Physiology, and Medical Pharmacology. Electives are chosen by the student to suit their interests. Pharmacology students may rotate in labs doing very different types of research, to enrich their background and allow unrushed, instructed selection of direction of their future thesis research.

For more information: https://www.med.upenn.edu/ggps/index.shtml

View the University’s Academic Rules for PhD Programs .

Required Courses 

Or other statistics course with approval of the Graduate Group.

The degree and major requirements displayed are intended as a guide for students entering in the Fall of 2023 and later. Students should consult with their academic program regarding final certifications and requirements for graduation.

Sample Plan of Study

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Pharmacology

Pharmacology is the science of drugs, their chemical and biochemical properties, and their interactions with live cells, tissues and organisms. In the past 60 years, pharmacology has changed biology and medicine dramatically. Diseases are cured, pain is relieved and formerly fatal illnesses are arrested due to the discoveries made in pharmacology laboratories. Important questions have been answered by basic science, but many remain unsolved.

The scientific foundation of the Pharmacology PhD program at Weill Cornell Graduate School trains students in areas of  medical sciences, biochemistry, chemical biology, signal pathways and more! The program's mission, facilitated by the broad scope of research conducted by the its faculty, is to provide students with the foundation necessary for pursuing research activities in cancer pharmacology, the neurosciences, cardiovascular pharmacology, toxicology, clinical pharmacology, proteomics, metabolomics, drug design and synthesis, and translational research.

The research activities of the program's faculty are broad and include cancer pharmacology, neurobiology, cardiovascular pharmacology, drug metabolism, toxicology, proteomics, receptors and signal transduction, drug and alcohol addiction research, and drug design and synthesis. Some of the research focuses on developing and evaluating novel therapies for a variety of diseases, and several faculty members have clinical involvements at Weill Cornell Medical College (WCMC) or Memorial Sloan-Kettering Cancer Center (MSKCC). This allows students in the Pharmacology Program to perform research that will result in better or new therapies for serious medical conditions such as cancer, epilepsy, neurodegenerative disorders, addictive and mental health disorders, infectious diseases, pain, and heart disease.

Pharmacology students have ample opportunities to improve their scientific communication skills, both by writing research papers and presenting their research data at laboratory meetings, the program's annual retreat and national scientific meetings. The program provides supportive, spirited colleagues along with a collegiality that helps prepare students for productive research careers in academia, government or industry.

Additional information is available at the Pharmacology graduate program web site.

Related Links

• Department of Pharmacology, Weill Cornell Medical College

Pharmacology | Weill Cornell Medicine

Program Requirements

A baccalaureate degree with a strong background in the natural sciences and/or health sciences is required for acceptance into the Pharmacology program. For applicants to the Pharmacology program, GRE scores are optional.  If you have GRE scores, please list your GRE scores in the application. Additionally, official scores must be sent directly to the Weill Cornell Graduate School of Medical Sciences by the Educational Testing Service. The Institution Code Number is 2119. Please visit http://www.ets.org/gre for more information and to register for the test if you would like to add your GRE scores to your application. Applicants whose native language is not English are required to take the TOEFL examination. See Apply Online for application procedures.

Becoming a Doctoral Candidate

In the first year, students complete the core academic curriculum; in their second year, they complete elective courses. More information about Pharmacology program courses is available at Courses .

In addition to coursework, students participate in bi-weekly student-run Pharmacology Journal Clubs, the annual program retreat, and the annual Vincent du Vigneaud Research Day. Students are also required to attend all Pharmacology program seminars and must pass the Pharmacology Seminar Course throughout their tenure as graduate students.

Three laboratory rotations are required of each student. The rotations provide the opportunity to participate in the diverse research activities available within the program. This experience is designed to assist the student in selecting major and minor sponsors for his/her thesis research.

Each student typically selects a thesis lab and major sponsor (thesis advisor) by the end of the first quarter of the second year. After choosing a thesis lab, the student selects a Special Committee, consisting of the major sponsor and two minor sponsors, chosen from among members of the Graduate School faculty with expertise in the student's thesis research area.

The Special Committee meets at least once a year to discuss research progress and future research directions with the student. The Special Committee also serves as the core group of examiners for the student's Admission to Candidacy Exam (ACE) and, typically, their thesis defense examination.

The ACE consists of two parts: a uniform written exam and an oral exam, which includes discussion of a written research proposal. A student typically takes this exam by April 1st of his/her second year. The ACE provides an opportunity for the student to demonstrate that he/she has attained the breadth of knowledge required to continue in the PhD program and is prepared to undertake full-time thesis research. When the student passes the ACE, he/she is considered a PhD candidate.

PhD Research and Degree

After completing the ACE, the student's annual (or more frequent) meetings with the Special Committee provide the forum to review progress and agree upon future research directions. The Special Committee (Thesis Advisory Committee) also oversees development of the thesis.

Thesis research is typically completed in the fifth year in the program. While working full-time in the thesis laboratory and developing the thesis, the student continues to participate in Pharmacology Program activities.

The culmination of the student's successful progression through the program is the final examination (the "defense") and certification by the Special Committee that the thesis represents an official piece of research that satisfies Graduate School requirements for a PhD degree.

Student Stories

Through the institutional collaboration between Weill Cornell and Memorial Sloan Kettering, I’m able to conduct my research at MSK surrounded by brilliant scientists. The opportunities are unmatched and the support systems I’ve built has helped me to take advantage of them.

Research Topics

• Cancer Pharmacology
• Cardiovascular Pharmacology
• Cell Signaling and Signal Transduction
• Chemical Biology
• Clinical Pharmacology
• Drug Metabolism
• Drug Discovery and Development
• Molecular Imaging/Cancer Diagnostics
• Immunopharmacology
• Molecular Pharmacology
• Molecular Toxicology
• Neuropharmacology and Neuronal Signaling
• Renal Pharmacology
• Radiobiology
• Stem Cell Pharmacology
• Abdel-Wahab, Omar
• An, Heeseon
• Bachovchin, Daniel
• Blenis, John
• Brentjens, Renier
• Buck, Jochen
• Chiosis, Gabriela
• DiLorenzo, Annarita
• Ganesh, Karuna
• Geri, Jacob
• Giannakakou, Paraskevi
• Gross, Steven
• Gudas, Lorraine
• Guzman, Monica
• Hemmings, Hugh
• Inturrisi, Charles
• Jaffrey, Samie
• Kharas, Michael
• Kolesnick, Richard
• Lee, Francis
• Levi, Roberto
• Levin, Lonny
• Lewis, Jason
• Li, Yueming
• Luo, Minkui
• Mellinghoff, Ingo
• Melnick, Ari
• Merghoub, Taha
• Nowak, Dawid
• Pitt, Geoffrey
• Pleil, Kristen
• Rosen, Neal
• Rudin, Charles
• Scheinberg, David
• Toth, Miklos
• Zhou, Pengbo
• Zippin, Jonathan

Courses and Required Curricular Components

• Accelerating Bio Venture Innovation (ABI)
• Critical Analysis of the Scientific Literature in Pharmacology
• Drug Development: From Molecule to Prescription
• Essential Principles of Pharmacology
• Neuropharmacology I: Genes, Drugs and Behavior
• Neuropharmacology II: Neuropeptides, Pain and Drugs of Abuse
• Next-Gen Methods For Neuroscience and Pharmacology
• Pharmacology Seminar Series
• Principles of Clinical Pharmacology
• Principles of Pharmacology I: Chemical Biology
• Principles of Pharmacology II: Signal Transduction
• Principles of Pharmacology III: Principles and Systems Pharmacology
• Principles of Pharmacology IV: Cancer Pharmacology
• Responsible Conduct of Research

Program Co-Chairs

• Gudas, Lorraine J.

Program Director

Program coordinator.

• Rosales, Aileen

Student Handbook

To view the Pharmacology Student Handbook, click here .

Weill Cornell Medicine Graduate School of Medical Sciences 1300 York Ave. Box 65 New York, NY 10065 Phone: (212) 746-6565 Fax: (212) 746-8906

• Weill Cornell Medicine

Toth, M. The Other Side of the Coin, Hypersociability.    Genes, Brain, and Behavior  2019

Program in Pharmacology

Related links.

A strength of the Pharmacology Program at Cornell is that the research of many of the faculty is focused on therapies for a variety of diseases, and several faculty have clinical responsibilities or close association with clinical faculty at Weill Cornell Medical College and/or Memorial Sloan-Kettering Cancer Institute. This allows students and fellows in the Pharmacology Program to perform research which will result in better or new therapies for diseases such as cancer, epilepsy, Alzheimer's disease, diabetes, mental illness and heart disease. 

The goal of the Pharmacology Program is to produce scientists who possess knowledge of pharmacology, as well as a foundation of understanding of biochemistry, molecular biology, chemical biology, and cell and organ physiology. Students and postdoctoral fellows also have ample opportunities to improve their scientific communication skills, both by writing research papers and by presenting their research data at laboratory meetings, at the Pharmacology Program Retreat, and at national scientific meetings. Ph.D. students and postdoctoral fellows have the option of teaching, but this in not a required part of the program. We want our students and fellows to be prepared for productive research careers in academia, government and industry. Lectures about various career paths are presented regularly to assist students and fellows in planning for their futures. Finally, the program provides students and fellows with a group of supportive, helpful and spirited colleagues who enjoy their work and each other. The Weill Cornell Pharmacology Graduate Program was rated 4th in the USA in New York City by the prestigious National Research Council. The National Research Council (NRC) of the USA is the working arm of the National Academies of the United States. To find out more about the Weill Cornell Pharmacology PhD Program, view our rating . This rating was done in 2010 by the National Research Council, part of the USA National Academy of Sciences, #4 Cornell University is the Weill Cornell Pharmacology Graduate Program (located in New York City) of Cornell University.  (Weill Cornell Medical College is rated 9th in the USA among medical schools (2019 rating)

Weill Cornell Medicine Pharmacology 1300 York Avenue, Room E-409 New York, NY 10021 Phone: (212) 746-6250 Fax: (212) 746-8835

Ph.D. in Pharmacology

General info.

• Faculty working with students: 47
• Students: 40
• Students receiving Financial Aid: 100%
• Part time study available: No
• Application terms: Fall
• Application deadline: November 30

David MacAlpine Director of Graduate Studies Department of Pharmacology Duke University Medical Center Box 3813 Durham, NC 27710

Phone: (919) 613-8600

Email: [email protected] , [email protected]

Website:  https://pcb.duke.edu/

Program Description

Pharmacology utilizes the basic concepts of biology and chemistry to determine how drugs affect organisms. It encompasses the study of the biological targets of drug action, the mechanism by which drugs act, the therapeutic and toxic effects of drugs as well as the development of new therapeutic agents. As the study of pharmacology is interdisciplinary, graduate programs in pharmacology are diverse and flexible. Students take a small core of courses in pharmacology, and complete their didactic instruction with courses in areas related to their research including molecular biology, biochemistry, genetics, and cell biology. The Department of Pharmacology and Cancer Biology at Duke University has particular strengths in the areas of receptor function and cellular signaling mechanisms as targets of drug action, neuropharmacology, metabolism, and the pharmacology of normal and abnormal cell growth. Current research emphasis of the faculty includes the ontogeny of signaling pathways in nervous and cardiovascular tissue, cellular signaling mechanisms including the actions of calcium and cyclic nucleotides and protein phosphorylation/dephosphorylation, receptor function and cell signaling mechanisms regulating cell growth, and the molecular basis of rational drug design.

• Pharmacology: PhD Admissions and Enrollment Statistics
• Pharmacology: PhD Completion Rate Statistics
• Pharmacology: PhD Time to Degree Statistics
• Pharmacology: PhD Career Outcomes Statistics

Application Information

Application Terms Available:  Fall

Application Deadline:  November 30

Graduate School Application Requirements See the Application Instructions page for important details about each Graduate School requirement.

• Transcripts: Unofficial transcripts required with application submission; official transcripts required upon admission
• Letters of Recommendation: 3 Required
• Statement of Purpose: Required
• Résumé: Required
• GRE Scores – GRE General: Optional This program does not require applicants to provide GRE (Graduate Record Examination) or other graduate entrance exam scores, but does allow you to upload scores if you feel they enhance your application. If you choose to submit test scores, you may enter them on the Test Scores page. If you choose to enter self-reported test scores, official test scores will become a required component of your application.
• English Language Exam: TOEFL, IELTS, or Duolingo English Test required* for applicants whose first language is not English *test waiver may apply for some applicants
• GPA: Undergraduate GPA calculated on 4.0 scale required

Department-Specific Application Requirements (submitted through online application)

Writing Sample None required

Additional Components Optional Video Essay: How would a Duke PhD training experience help you achieve your academic and professional goals? Max video length 2 minutes; record externally and provide URL in application.

We strongly encourage you to review additional department-specific application guidance from the program to which you are applying: Departmental Application Guidance

List of Graduate School Programs and Degrees

Georgetown University Medical Center

PhD in Pharmacology & Physiology

Our department offers a comprehensive and rigorous PhD program. Pharmacology, the study of the effects of drugs and chemicals on living organisms, is inherently interdisciplinary and builds on the strengths of physiology, biochemistry, cell biology, neuroscience, and molecular biology. Our faculty and students, using drugs and chemicals as tools, probe the molecular machinery of living systems in order to understand how cellular and organ systems function and how they are regulated.

Although the research areas covered by the participating faculty are broad, the most concentrated areas of research strength are in neuropharmacology and signal transduction. Because of our strong focus on neuropharmacology, students interested in clinical pharmacology or cancer pharmacology may wish to apply elsewhere. In particular, the  Tumor Biology Program  at Georgetown is very strong.

There is a strong didactic component to the Ph.D. program, however it is inherently a research degree and the first year of study is divided between research in various laboratories (rotations) and course work. The following years are devoted, almost exclusively, to a novel research project culminating in publications in international journals and an original Ph.D. dissertation. On average, our students complete the program in approximately 5 years.

Applicants selected for interview living in the contiguous 48 US states will be flown to Washington DC for in-person interview; most travel expenses, including airfare and hotel, will be reimbursed by our department. Applicants selected for interview who live outside the contiguous 48 US states will be interviewed by Zoom.

Accepted students receive financial support from the university including full tuition scholarship, health insurance, and an annual stipend of $35,500, unless supplanted by external funding (ie, foreign government scholarship, NIH fellowship, Gates Millennium Scholars, and others).

Learn about the application process and requirements. Our application deadline is December 1st every year.

Find the degree requirements here. On average, our students complete the program in approximately 5 years.

Meet our PhD Thesis Mentors

Meet our current students & alumni, healy fellowship.

The Ph.D. Program in Pharmacology is deeply committed to diversity within our community. We particularly encourage applications from individuals from historically under-represented groups in science (including but not limited to individuals from under-represented racial/ethnic groups, individuals with disabilities, and individuals from disadvantaged backgrounds). A diverse scientific community produces stronger science . Students from diverse backgrounds may be considered for the Patrick Healy Graduate Fellowship :

Named in honor of Georgetown’s 28th President, Patrick Healy, the first African-American to earn a doctorate degree, and the first African-American President of Georgetown University (1874–1882), the Healy Fellowship is intended to further Georgetown’s commitment to creating a diverse community composed of the most qualified students. The Program is designed to help recruit and retain graduate students who are talented individuals of the highest caliber and who might otherwise find it difficult or impossible to successfully pursue a doctoral degree.

Healy Fellowships will be awarded to students whose background or experience, when evaluated holistically, suggests they are uniquely able to contribute to the diversity of the Georgetown community and to the academic profession as a whole. Support will be provided to Patrick Healy Fellows for twelve months per year for up to five years, assuming satisfactory progress toward the Ph.D.

• PhD in Pharmacology & Physiology
• Course Schedule
• Research Rotations
• Comprehensive Exam
• Thesis Research
• Completion of Degree
• Our Students & Alumni
• Student Resources
• Grant Opportunities
• Teaching Opportunities
• PhD Student Handbook

• Student/Faculty Portal
• Learning Hub (Brightspace)
• Continuous Professional Development

Molecular Pharmacology and Experimental Therapeutics

Molecular pharmacology and experimental therapeutics track.

average number of publications by each program graduate

High faculty-to-student ratio

Guaranteed 5-year internal fellowship.

including full tuition, stipend, and benefits

Imagine a career that melds the unparalleled thrill of discovering basic biological mechanisms with the excitement of translating those findings into novel therapies for human diseases.

In other words, "basic science on steroids" ... an environment in which you not only perform cutting-edge basic research that leads to new insights in biology, but you also see how your discoveries can make a difference and you often help to make that possible.

The Molecular Pharmacology and Experimental Therapeutics (MPET) Track of the Ph.D. Program at Mayo Clinic Graduate School of Biomedical Science is a unique and innovative Ph.D. training opportunity for graduate students looking to contribute to the frontiers of 21st-century discovery and medicine.

Our success in training students is demonstrated by the:

• Tremendous productivity during student training, including publications in high-impact journals
• Excellent postdoctoral opportunities
• Fulfilling careers, as leaders in both academia and industry, that former students have pursued
• Extra funding provided by a competitive, peer-reviewed NIH predoctoral pharmacology training grant

Extraordinary mentors

MPET faculty members actively mentor you by guiding your research project, fostering your intellectual development as a scientist, developing your communication skills, and providing you with career advice, all with the goal of helping you to become an independent investigator in academia or industry. They also are world-class scientists whose multidisciplinary research programs integrate across the fields of pharmacology, biochemistry, molecular biology, cell biology, systems biology, organic chemistry, structural biology, genetics, and computational disciplines of artificial intelligence and machine learning.

Most importantly, your independent graduate student research project will be a key component of these research programs, which include the areas of:

• Cancer biology and therapeutics. Discover the molecular underpinnings that drive cancer and new approaches to curing cancer.
• Regenerative medicine. Investigate how to program, or reprogram, human cells to regenerate organs and treat disease.
• Pharmacogenetics and pharmacogenomics. Use cutting-edge genetic technologies to discover, at the molecular and cellular levels, why humans have vastly different responses to drugs.
• Drug discovery. Use supercomputing and chemistry to discover and develop mechanism-based drugs.
• Biology and genetics of addiction. Have you ever wondered how genetics affect addictive behavior, or whether gene therapy can be used to combat addiction? Mayo has several innovative studies underway.
• Cardiovascular biology and therapeutics. Identify the molecular mechanisms and genetic defects that contribute to heart disease and develop improved therapies.
• Therapy for neurodegenerative diseases.  Explore pathways that are disrupted in neurodegenerative conditions such as Alzheimer's disease, and strategies to intercede.
• Systems pharmacology.  Apply artificial intelligence, machine learning, and other computational tools to the study of biological systems and their response to various therapeutics.
• Computational pharmacology.  Our faculty have embraced the most advanced computational approaches including machine learning and artificial intelligence as applied biomedical science.

This visionary didactic program can be tailored specifically to your needs and is designed to train you to:

• Integrate across scientific disciplines
• Perform cutting-edge, discovery-oriented research and to apply modern computation to help perform that research
• Further your understanding of human biology
• Enhance patient care through the development of novel disease therapies

The first- and second-year core curriculum courses provide the broad foundation of knowledge needed to interpret cutting-edge research findings and successfully perform laboratory research. Additional classes focus on the basic principles of drug action and metabolism and the rapidly evolving concepts of receptor and signal transduction mechanisms relevant to pharmacology and to all of biology.

As a student, you’ll also select from a menu of small-group tutorials that provide in-depth learning experiences covering:

• Systems and computational pharmacology
• Pharmacogenomics and pharmacogenetics
• Drug discovery
• Cell signaling
• DNA damage signaling and repair
• Cardiovascular biology
• Neurodegeneration
• Psychiatric pharmacology

In your first year, you’ll have the opportunity to rotate with three research mentors. By the end of the first year, you’ll select a mentor who best matches your scientific interests and goals.

You have the option of taking the written qualifying exam, followed by the oral qualifying exam, at the end of your first year or second year.

The third, fourth and fifth years of the MPET program focus on thesis research. After completing class work and passing the written and oral qualifying exams, you’ll work full-time on your thesis project.

Presentation opportunities

Throughout graduate training, you’ll gain effective communication skills by participating in weekly student seminars, lab meetings, journal clubs, and class tutorials. In addition, virtually all MPET students present their work at national scientific meetings.

Additional learning opportunities

MPET students have excellent opportunities to learn from national and international experts inside and outside of Mayo Clinic. Active seminar programs in each department bring many distinguished scientists to the Mayo Clinic campus. MPET investigators host seminar speakers who are engaged in therapy development in a variety of settings, including academia, the pharmaceutical and biotechnology industries, and government laboratories.

As a student, you’ll have ample opportunity to interact with these distinguished visitors in formal and informal settings and are encouraged to attend seminars sponsored by any of the graduate school departments and programs.

Our faculty are on the cutting edge of science in numerous fields. Even though they come from many different fields and perspectives, the faculty are united in their investment in our success as students and they provide us with a supportive environment that fosters critical thinking and innovative approaches to our research.

Rebecca Kelly Ph.D. student, Molecular Pharmacology and Experimental Therapeutics Track

The most exciting part about being at Mayo Clinic for Ph.D. training is that I don’t need to restrict myself to any particular field or track. The curriculum is designed to encompass the basics of every field, and the opportunity to pick labs from outside my own track means I can develop my own personal skill set theoretically and in terms of lab experience.

Glancis Luzeena Raja Arul Ph.D. student, Molecular Pharmacology and Experimental Therapeutics Track

The nice thing about smaller class sizes is that students do not overload the resources we have here. As such, we have full access to core facilities, student services and faculty. This has allowed me to pursue my education as I see best. The only limiting factor is me, not the environment.

Christopher Paradise Ph.D. student, Molecular Pharmacology and Experimental Therapeutics Track

Being part of an extremely productive, yet incredibly social and fun-loving lab has provided an incredible work environment that makes every day an absolute joy to be in the lab working toward better understanding of the diseases we study.

Steven Dotzler M.D.-Ph.D. student, Molecular Pharmacology and Experimental Therapeutics Track

Recent thesis topics

• “Keto Acids and Cancer Metabolism,” Katie Minter Dykhouse, Ph.D. (Mentor: Taro Hitosugi, Ph.D.)
• “Pathobiology of Cluster in in Alzheimer's Disease,” Christopher Paradise, Ph.D. (Mentor: John D. Fryer, Ph.D.)
• “Microglial Responses to Citrullinated Myelin and the Consequences of Demyelination,” Elizabeth Wiese, Ph.D. (Mentor: Charles L. Howe, Ph.D.)
• “Neural Basis of Chronic and Binge Alcohol Exposure and Impulsive Behaviors,” Rachel Hurley, M.D., Ph.D. (Mentor: Doo-Sup Choi, Ph.D.)
• “Nectin-elicited Cytoplasm Transfer Characterization and its Exploitation by Measles Virus,” Somaira Nowsheen, M.D., Ph.D. (Mentor: Roberto Cattaneo, Ph.D.)
• “Evaluation and Modulation of Cardiomyocyte Subtype Development from Human Induced Pluripotent Stem Cells,” Yujin Kim, Ph.D. (Mentor: Timothy J. Nelson, M.D., Ph.D.)
• “Elucidation of MRAS-Mediated Noonan Syndrome,” Sherri Biendarra-Tiegs, Ph.D. (Mentor: Michael J. Ackerman, M.D., Ph.D.)
• “Investigating Seeding and Aggregation of Microtubule-Associated Protein Tau,” Erin Higgins, Ph.D. (Mentor: Leonard Petrucelli, Ph.D.)
• “The Genetics of Aromatase Inhibitor-related Phenotypes in Postmenopausal Women with ER+ Breast Cancer,” Tanda Dudenkov, M.D., Ph.D. (Mentor: Richard Weinshilboum, M.D.)
• “Metformin Pharmacogenomics: Functional Genomics of CDC25B and TPD54 Regulation of Metformin Anticancer Response in Breast Cancer,” Reynold C. Ly, Ph.D. (Mentor: Liewei Wang, M.D., Ph.D.)
• “GLI1 Gene Expression Regulation in Cancer,” Stephanie L. Safgren, Ph.D. (Mentor: Martin E. Fernandez-Zapico, M.D.)
• “Regulation of DNA Double Strand Break Repair,” Somaira Nowsheen, Ph.D. (Mentor: Zhenkun Lou, Ph.D.)
• “Linking Oncogenic Signal to Mitochondrial Metabolism,” Kiran Kurmi, Ph.D. (Mentor: Taro Hitosugi, Ph.D.)
• “Individualization of 5-Fluorouracil (5-FU) Chemotherapy,” Shikshya Shrestha, Ph.D. (Mentor: Robert B. Diasio, M.D.)
• “Impacting the Clinical Course of Epithelial Ovarian Cancer Through Novel Therapeutic Advances,” Rachel M. Hurley, Ph.D. (Mentor: Scott H. Kaufmann, M.D., Ph.D.)
• “Developing Inhibitors of Mesotrypsin Utilizing Protein Engineering and Computational Modeling," Olumide Kayode, Ph.D. (Mentor: Evette S. Radisky, Ph.D.)
• "Elucidating the Tumor Suppressive Effects of Estrogen Receptor Beta in Breast Cancer," Jordan M. Reese, Ph.D. (Mentor: John R. Hawse, Ph.D.)
• "Adenosine Signaling and Hippocampal-Cortico-Limbic Circuitry: Implications for the Regulation of Reward Seeking Behavior," Alfredo Oliveros, Ph.D. (Mentor: Doo-Sup Choi, Ph.D.)
• "Novel Therapeutic Approaches for Acute Myelogenous Leukemia and Other Myeloid Disorders," Katherine Knorr, M.D., Ph.D. (Mentor: Scott H. Kaufmann, M.D., Ph.D.)
• “Discovering Molecular Genetic Defects Underlying Pediatric Dilated Cardiomyopathy," Pamela A. Long, Ph.D. (Mentor: Timothy M. Olson, M.D.)
• "Assessing the Mechanisms of Chk1 Inhibitor-Induced Cell Death and Resistance in Acute Myelogenous Leukemia," Nicole D. Vincelette, Ph.D. (Mentor: Scott H. Kaufmann, M.D., Ph.D.)
• "Development of an Early Drug Discovery Campaign Targeting Fungal Rtt109 Histone Acetyltransferases," Jameson L. Dahlin, M.D., Ph.D. (Mentor: Zhiguo H. Zhang, Ph.D.)
• "CDK12: A Kinase at the Intersection of Homologous Recombination and mRNA Processing in Ovarian Cancer," Poorval M. Joshi, Ph.D. (Mentor: Larry M. Karnitz, Ph.D.)
• "New Mechanism of Liver Fibrosis: A Novel Role of Exosome," Ruisi Wang, Ph.D. (Mentor: Vijay Shah, M.D.)
• "Regulation of Base Excision Repair by GSK-3 Mediated Phosphorylation of UNG2," Carly A. Baehr, Ph.D. (Mentor: Larry M. Karnitz, Ph.D.)

Your future

Graduates of Mayo's MPET Track have a long history of advancing to top-notch residency and postdoctoral positions at the most prestigious research institutions in the country. These include Stanford, Baylor, University of Virginia, Johns Hopkins, Harvard, the National Cancer Institute and Memorial Sloan Kettering. Many former students are now principal investigators in academia or industry, including at Emory, Louisiana State, Mayo Clinic, University of Minnesota, Amgen, Abbott, and AstraZeneca.

Meet the director

The most successful biomedical scientists integrate across various disciplines to devise and answer important questions that enhance our understanding of biology and impact the treatment of disease.

Our program provides exactly that integration by training students to use pharmacology, biochemistry, molecular biology, genetics, cell biology, and genomics to develop new therapeutic approaches to treat human diseases.

Martin Fernandez-Zapico, M.D. Molecular Pharmacology and Experimental Therapeutics Track Director Professor of Medicine and Pharmacology Phone: 507-225-0285 Email: [email protected]   See research interests

Browse a list of Molecular Pharmacology and Experimental Therapeutics Track faculty members

The Pharmacology program at Duke is consistently ranked among the top pharmacology graduate programs in the nation. Its focus is to prepare qualified individuals for a career in independent research. Pharmacology is the science of drug action on biological systems. It encompasses the study of targets of drug action, the mechanisms by which drugs act, the therapeutic and toxic effects of drugs, as well as the development of new therapeutic agents. As the study of pharmacology is interdisciplinary, the graduate program in pharmacology is diverse and flexible. Graduate positions in the program are fully funded providing for payment of tuition, fees, and an annual stipend for the first two years. After the first two years, students are supported by the faculty member with whom they are doing their thesis research. The average time to completion of a Ph.D. is 5.5 years.

Pharmacology Alumni

We are very proud of the alumni from our department who have successfully completed their training in Pharmacology. Please follow this link to learn more about our alumni for   pharmacology .

David MacAlpine, PhD

Jamie Baize-Smith

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Message From Dr. Cory Abate-Shen

Read a message from the Chair of the Department of Molecular Pharmacology and Therapeutics.

Featured Lab: Concepcion Lab

The Concepcion lab studies how chromatin deregulation impacts tumor evolution with a focus on lung cancer.

Graduate Program

Learn how to apply.

Get all the details on how to apply to The Molecular Pharmacology & Therapeutics Graduate Program.

Welcome to our new Graduate Program!

Pharmacology – the study of how drugs or other agents affect cells and living organisms - is a foundational science that intersects with many disciplines in basic science and human disease. Our graduate program emulates the breadth of pharmacology by providing our students with a solid foundation and broad training in cellular and organismal mechanisms, as well as translational science.  The scientific focus of the program is to merge basic science research with emergent research in developing new avenues for therapeutic interventions. Faculty in the program can be focused on developing a basic biological understanding of mammalian organ systems, developing conceptually new avenues/technologies for therapeutics, or combining both of these approaches in an interdisciplinary manner.

Our graduate program has recently been re-vamped to create a modern, vibrant program that is well-aligned with both the historical foundations and new strategic vision of the department. To realize this vision, we have new leadership, co-directors Dr. Nikhil Sharma and Dr. Yonghao Yu, whose research is focused in areas that are vital to pharmacology.  

Our program is ideal for students who are interested in studying basic cellular mechanisms with an emphasis on their application to human disease.  The research interests of our program faculty encompass all areas of modern pharmacology, including cancer pharmacology, cardiovascular pharmacology, and neuropharmacology. The incorporation of novel interdisciplinary approaches (e.g., chemical biology) towards the development of therapeutic strategies is also emphasized. Our graduate program faculty draw from several basic science and clinical departments at Columbia University Irving Medical Center, as well as Columbia University, which enables seamless collaborative and interdisciplinary interactions for our students.

Although rigorous, our program is individualized to each student, allowing students to gain a strong foundation in pharmacology, while adapting the specific educational components to the specific research interests of each student. Training in the first year consists of courses aligned with the integrated program in cellular, molecular, and biomedical studies (CMBS), as well as research rotations in the laboratories of approved program faculty.  In the second year, students begin their thesis research and continue to take their remaining core courses as well as elective courses relevant to their thesis work. At the end of the second year, students take their qualifying exam, for which they prepare and defend a research proposal that is related to their intended thesis research. Subsequent years are devoted to the research, writing and defense of their PhD thesis. As they advance in their degree, students benefit from the advice of their faculty mentor, an advisory committee of expert faculty with whom they meet regularly, and our outstanding and dedicated program co-directors, Dr. Nikhil Sharma and Dr. Yonghao Yu.

Students benefit from the rewarding environment at Columbia University, which is rich in diversity and has unparalleled faculty. Students also benefit from the cultural environment of New York City, with its many museums, theaters, and historical venues.

Nikhil Sharma, PhD

• Assistant Professor of Molecular Pharmacology and Therapeutics
• [email protected]

Yonghao Yu, PhD

• Professor in the Department of Molecular Pharmacology and Therapeutics
• [email protected]

Participating Faculty

Graduate program requirements.

Get more information on applying or answers to questions about the Molecular Pharmacology & Therapeutics Graduate Program.

PhD in Pharmacological Sciences

Fall 2025 Admission Deadline: TBD

UC Irvine’s PhD in Pharmacological Sciences program provides a unique opportunity for those interested in any scientific discipline represented by the Pharmaceutical Sciences faculty to have a year of broad, interdisciplinary training and self-selected lab rotations followed by focused doctoral research in the Pharmaceutical Sciences research group of their choice.

Students can choose from one of three tracks within the program: Pharmaceutical Sciences, Pharmacology or Medicinal Chemistry.

The current areas of study in the Pharmaceutical Sciences Department include:

• Structural and chemical biology
• Medicinal chemistry
• Structure-based drug design
• Molecular neuropharmacology
• Pharmacology of aging
• Molecular evolution
• Synthetic biology
• Natural product biosynthesis and synthase engineering
• Cancer prevention and therapy
• Gene regulation and intercellular signaling
• Computational biology and bioinformatics
• Nanomedicine for targeted drug and gene delivery

“The school has rotations that are longer than most departments – lasting a full quarter as opposed to a few weeks – which allows you to get a taste for what research is like in the industry and to really figure out what environments are best suitable for you.” David Wych, PhD ’21

About Our PhD Program

The Pharmacological Sciences PhD program is flexible and tailored to the needs of each individual student. Students are actively engaged in research throughout their training: In the first year, laboratory rotations ensure exposure to a variety of techniques and research problems. By the end of their first year students have worked with several faculty members and selected a lab to join. During their third year, students are considered for advancement to PhD candidacy on the basis of academic standing, laboratory performance, and a qualifying examination. After advancement to candidacy, students devote their time to completion of an original research dissertation.

CLICK HERE  to view the sample curriculum for the Pharmaceutical Sciences Track.

CLICK HERE  to view the sample curriculum for the Pharmacology Track.

CLICK HERE  to view the sample curriculum for the Medicinal Chemistry Track.

For more details regarding the required course work, please visit our program’s section in the  UCI General Catalogue .

Application Instructions

Complete the  Online Application  which is submitted to the UCI Graduate Division. When completing the “Degree Program” section of the online application for admission, please make the following selections:

• School/Department: Pharmaceutical Sciences
• Major/Degree: Pharmacological Sciences-PhD

Students are admitted to the Pharmacological Sciences PhD program on an annual basis in the fall quarter only. The admissions committee screens applications immediately after the application deadline. First round applicants selected to interview will be notified by early January. Admitted applicants can expect to receive an offer of admission in late January through mid-March.

Submit applications by December 1 for full consideration

The online application and supporting materials should be received by December 1, 2023.

Applicants are required to submit:

• An official  online application  including the application fee ($135 for domestic applicants, i.e. US citizens and permanent residents and $155 for international applicants)
• For application review purposes only, scan and upload copies of transcripts for all institutions attended since high school. In the online application, you will be prompted to upload your scanned documents. Please upload both the front and back sides of the transcript. Uploaded transcripts should be recent and include the following: your name, dates of attendance, grades/marks received, credits and grading legend. Official transcripts will be requested by the Graduate Division if and when you are admitted and decide to attend UCI. Do not send official transcripts until this time.
• A Statement of Purpose – must include your specific research interest and three possible research advisors you would be interested in working with. You can describe your research interests, career goals, and other related information.
• A Personal History Statement – this can discuss how your personal background– including any relevant educational, familial, cultural, economic, or social experiences, challenges or opportunities– informs your decision to pursue a Ph.D. in Pharmacological Sciences. If you have overcome socioeconomic or educational challenges, please indicate that you are a diversity candidate and describe your experience in detail. 
• Three letters of recommendation – uploaded to the online application by your recommender.
• UCI no longer requires the GRE.
• International students are also required to submit TOEFL scores (Code: 4859)

Applicants are encouraged to upload the following in their application:

• Current curriculum vitae or resume
• List of publications

For additional details about applying to the PhD in Pharmacological Sciences program, view our information sheet here .

Prerequisites

• An MS degree is  not  required for consideration. However, research experience (laboratory or fieldwork) is  a primary criterion  for acceptance into our graduate programs.
• Some biology and chemistry courses are required. However, because we are an interdisciplinary program, we admit students from various academic backgrounds, so there are no specific course requirements. Applicants recently admitted to our program have undergraduate degrees in a wide range of disciplines, including molecular biology, psychology, and chemical engineering, as well as chemistry and biology.
• Minimum cumulative undergraduate GPA of 3.0.

Admission Statistics

The acceptance rate for the Pharmacological Sciences program is approximately 23%, and admitted applicants from previous cycles had the below characteristics:

• Average undergraduate GPA: 3.32

Student Funding

Admitted applicants receive funding for tuition, health insurance, and a monthly stipend/salary through a combination departmental or university fellowships and/or teaching assistant (TA) and graduate student researcher (GSR) positions in their first year. In years two through five, students are generally funding by their faculty advisor as GSRs, as well as through a combination of university fellowships, extramural grants/fellowships, and/or TA positions.

Diversity Fellowships

UCI is committed to the recruitment, admission, and retention of a high quality and diverse graduate student population and has several  diversity fellowships  for new and returning students who qualify.  If you have overcome socioeconomic or educational challenges, please indicate that you are a diversity candidate and describe your experience in detail within the Personal History section of the application.

English Language Proficiency Requirements

TOEFL or IELTS

All graduate applicants are required to demonstrate English proficiency for admissions consideration. Applicants are waived from the English Language Proficiency requirement if they have earned an undergraduate degree from an institution at which English was the sole language of instruction according to the  World Higher Education Database (WHED) .  Please see  WHED’s instructions  on how to search for your institution. If English is not the sole language of instruction listed or if no language is listed at all, the waiver does not apply and the applicant is required to take and pass an approved English proficiency test.  Approved tests and minimum scores are outlined in the next section.  

Please note: Test results that are two years old or older are not acceptable.

IMPORTANT NOTE: If a student will be supported as a Teaching Assistant (TA), please read the  English proficiency summary chart for teaching assistants . Students who have not earned an undergraduate degree from an institution at which English was the sole language of instruction according to WHED are required to demonstrate English language proficiency to serve as a TA when they apply to the program. 

The TOEFL is administered by the Educational Testing Service (ETS).

• Please select institution code  4859  to have your official score sent to UCI. No department code is needed.
• We only accept scores submitted electronically by ETS.
• Test results that are two years old or older are  not acceptable .
• We do not accept  MyBest  scores; you must submit all individual test scores.
• Results of institutional (non-ETS) administrations of the TOEFL are  not acceptable .
• We will accept the TOEFL iBT Special Home Edition test.  The same minimum score applies.
• We do  NOT  accept the TOEFL ITP Plus test for China or the TOEFL Essentials test.
• For more information, please visit their website at  www.ets.org/toefl

TOEFL Score Requirements for Admission Consideration:

• An overall minimum score of  80 
• A minimum score of 26 on the speaking section to be eligible for a Teaching Assistant position

As an alternative to the TOEFL, you may submit scores from the Academic Modules of the International English Language Testing System (IELTS).

• We only accept scores submitted electronically by the IELTS test center. No paper Test Report Forms will be accepted.
• We will accept the IELTS Indicator test.  The same minimum score applies.
• An institutional code is NOT required. Please contact the test center directly where you took the IELTS test and request that your test scores be sent electronically using the IELTS system. All IELTS test centers worldwide are able to send scores electronically to our institution. 
• For more information, please visit their website at  www.ielts.org

IELTS Score Requirements for Admission Consideration:

• An overall minimum score of 7 for admission, with a score of no less than 6 on any individual module.
• A Minimum score of 8 on the speaking module to be eligible for a Teaching Assistant position.

Pharmacology PhD

Looking for the best Pharmacology PhD program? Emory University's top-ranked Molecular and Systems Pharmacology (MSP) graduate program prepares students for jobs and careers in pharmacology, pharmaceutical research, toxicology and biotechnology. The program is a unique opportunity for PhD candidates interested in learning how the drugs of today work and how the novel therapeutics of tomorrow can be developed.

Emory University was recently rated by The Scientist magazine as the #1 university in terms of impact in pharmacology and toxicology research. Particular strengths within the MSP graduate school program at Emory include neuropharmacology, cancer biology, AIDS research, cardiovascular pharmacology, toxicology, and chemical biology. Ph.D. training in the Emory MSP program provides students with an ideal preparation for successful careers in the biotechnology and pharmaceutical industries as well as in academic research, teaching, government research, patent law and other disciplines that depend upon knowledge of fundamental pharmacological principles.

We live in a golden age of pharmaceutical research. Each passing year brings the development of exciting new therapeutics in the treatment of cancer, heart disease, AIDS, diabetes, psychiatric disorders, and other diseases. Pharmacology PhD. Continued success in this quest to improve human health depends upon fresh ideas, adventurous basic research, and the cutting-edge training of future scientists.

Pharmacology PhD Program: Curriculum

In the first year of the MSP program, PhD candidates get research experience through laboratory rotations and attend classes focused on the fundamental principles of pharmacology, toxicology, biochemistry and cell biology.

What is Pharmacology?

Pharmacology is the science of drugs, and is perhaps the original interdisciplinary science. It has the goals of understanding how drugs work, how drugs are processed in the body, and of using that information to develop new drugs and new drug targets to treat human disease. Knowledge, concepts and experimental approaches are drawn from each of the traditional basic biomedical science disciplines to achieve these goals. Knowledge about drugs interacting with known target molecules and the identification of novel target molecules (Molecular Pharmacology) is combined with information about how effects of drugs on different organs and tissues are integrated to produce a therapeutic or toxic effect (Systems Pharmacology). Therefore, Pharmacology is an appropriate and exciting field of study for students with diverse undergraduate science backgrounds including Chemistry, Biology, Biochemistry, Molecular and Cellular Biology, Physiology, Neuroscience or Psychology.

A Diversity of Careers

The MSP graduate program prepares students for a diversity of careers . A graduate of the MSP program emerges with a broad training in the basic biomedical sciences, encompassing such disciplines as biochemistry, molecular biology, physiology and neuroscience, but also has training and expertise in the specialized principles and approaches of Pharmacology, This is a combination that is increasingly sought after by the pharmaceutical, biotechnology and government sectors, as well as being excellent preparation for an academic career. The Program also offers a specialization in  Toxicology , which focuses on the adverse effects of drugs and chemicals. The Program additionally participates in a Chemistry-Biology Interface program, providing select MSP students the opportunity to obtain concomitant training and expertise in aspects of Chemistry that are particularly relevant to Pharmacology and drug development. Students choose their dissertation mentors from more than 40 internationally-recognized MSP faculty in 15 different academic departments.

Research Foci

• Drug Development and Molecular Therapeutics
• Cell Growth Control. Cancer Biology and Cancer Pharmacology
• Cell Surface Receptors and Intracellular Signaling
• Cardiovascular Pharmacology
• Substance Abuse and Behavioral Pharmacology
• Cell and Developmental Biology
• Metabolism and Molecular Toxicology
• Neuroscience and Neuropharmacology
• Regulation of Gene Expression

• Administration
• Department Resources
• D423 Schedule
• K550 Schedule

GRADUATE PROGRAM

Here you'll find a year-by-year breakdown of the requirements for the PhD degree from the University of Washington Pharmacology Department, and well as information about your general exams, and selecting a Doctoral Supervisory Committee.

• PHARMACOLOGY COURSE OFFERINGS
• FIRST YEAR PhD REQUIREMENTS
• SECOND YEAR PhD REQUIREMENTS
• THIRD YEAR PhD REQUIREMENTS
• FOURTH YEAR AND BEYOND
• SUPERVISORY COMMITTEE
• GENERAL EXAM
• FINAL EXAMINATION

Pharmacology Graduate Program Overview Pharmacology explores the nature of interactions between drugs and biological systems, and their applications to the treatment of disease. Courses in this field are offered to graduate, medical, dental, pharmacy, nursing, and other interested UW students.

The Department of Pharmacology offers the Doctor of Philosophy (PhD) degree.

Admissions Requirement GRE Scores are not required. 

A baccalaureate degree with a major in any of the sciences, such as biochemistry, chemistry, pharmacy, physics, physiology, psychology, or zoology, is strongly advised. Students are selected from the applicant pool based on several criteria, including academic performance, letters of recommendation, and previous research experience.

Graduation Requirements Minimum of 90 credits, to include:

• Pharmacology 501-506 course series with a minimum grade of 2.7 for each course.
• Pharmacology 507 throughout graduate school (must attend 5 seminars).
• Pharmacology 514 in the first and second years of graduate study.
• Pharmacology 519 (laboratory rotations) during the first year of graduate study.
• Four advanced courses in Pharmacology.
• CONJ 531 (Signaling Mechanisms in Excitable Cells)
• One Quantitative Analysis course.
• Creditable passage of the General Examination. Thesis research beginning the second and subsequent years of study.
• Completion of an approved PhD dissertation and creditable passage of the Final Examination, which is the defense of the dissertation.

Time to Doctoral Degree The Graduate Program in the Pharmacology Department is designed to provide the guidance and mentoring necessary for graduate students to finish all course requirements and complete and defend their thesis research within a period of 6 years from matriculation. In the Winter quarter (Year 2) after entering their thesis lab, students will form and convene their Doctoral Thesis Supervisory Committee to review their progress in preparation for the general exam.

Following completion of the general exam, students are required to meet with their Doctoral Thesis Supervisory Committee at least once every 12 months. The committee and the student develop a definite plan of action for achieving specific goals, which will be summarized in the annual thesis committee report. Stipend and tuition support extending beyond year 6 are dependent on Thesis Committee approval and the advisor’s research funding or appropriate training grant support.

Financial Support Financial support is offered to students who maintain satisfactory academic progress. Tuition and stipends are provided by National Institutes of Health training grants, University of Washington teaching assistantships, individual research grants, and fellowships from private sources.

Contact Debbie Bale Box 357750 (206) 543-7485 [email protected]

Pharmacology Course Offerings

PHCOL 501 Drug Discovery and Emerging Therapeutics (2) Zheng Consideration of the general principles and current approaches involved in modern drug discovery and development, with an emphasis on basic concepts in drug action, delivery, and metabolism. Discussion of novel drug discovery techniques and emerging non-standard therapeutics. Lectures and student presentations. Prerequisite: basic knowledge of organic chemistry and biochemistry. Offered: A (first five weeks of the quarter).

PHCOL 502/CONJ 532 Signal Transduction from the Cell Membrane to the Nucleus (2) Scott, Ong Intracellular signaling pathways leading from cell membrane receptors to the nucleus. Pathways activated by seven transmembrane receptors and G-proteins, insulin/PI3 kinase, nitric oxide and WNTs and mechanisms of signal termination. Cytokine/Jak/Stat signaling and role of subcellular localization in signal transduction. Prerequisite: basic knowledge of biochemistry. Offered: Jointly with CONJ 532; A (second five weeks of the quarter).

PHCOL 503 Autonomic/Cardiovascular Pharmacology (2) Nathanson Consideration of the pharmacology of the cardiovascular and autonomic nervous systems. Emphasizes the mechanisms of neurotransmitter, hormone, drug action at autonomic synapses, and the molecular basis for physiology and pathophysiology of the cardiovascular system. Lectures, group discussion, and analysis of recent research. Prerequisite: organic chemistry, biochemistry, and introductory anatomy and physiology. Offered: W (first five weeks of the quarter).

PHCOL 504 Neuropharmacology (2) Bajjalieh, Yadav Consideration of the neurobiological basis of drug action on the central nervous system, including mechanism of action and therapeutic use in psychiatric disorders; neurodegeneration/neuroinflammation; control of neuronal excitability and pain; drug abuse and addiction. Lectures, group discussion, and analysis of recent research. Offered: W (second five weeks of the quarter).

PHCOL 505 Endocrine Pharmacology (2) McKnight, Sancak Consideration of the pharmacology of endocrine systems including the actions of hypothalamic/pituitary regulatory peptides, glycoprotein hormones/growth factors, peptide and steroid hormones. Lectures, group discussion, and analysis of recent research. Prerequisites: organic chemistry, biochemistry, and introductory anatomy and physiology. Offered: Sp (first five weeks of the quarter).

PHCOL 506 Immunopharmacology and Chemotherapeutics (2) McKnight, Shechner Basic principles of immunology as applied to immunopharmacology. Current overview of cancer chemotherapy and antimicrobial chemotherapy. Lectures, group discussions, student presentations, and analysis of recent research. Prerequisite: coursework in biochemistry and physiology. Offered: Sp (second five weeks of the quarter).

PHCOL 507 Pharmacology Seminar (1) Scott Presentation of comprehensive reports on recent medical and scientific literature in fields of current importance. Research progress reports and reports on results of completed research. Prerequisite: permission of instructor. Offered: AWSp.

PHCOL 514 Current Topics in Pharmacology (1) Faculty Requirement for first and second-year students.  Offered: AWSp.

PHCOL 519 Introduction to Laboratory Research in Pharmacology (4) Wang On a rotation basis, students carry out individual research projects in the laboratories of different faculty members with appointments in the Pharmacology department. At the end of each rotation, students make formal presentations of their work. For first-year graduate students in the Pharmacology program. Offered: A,W,Sp

PHCOL 550 Introduction to the Pharmacology Department (1) Wang Overview of the Pharmacology graduate program; presentation of program requirements including required courses and teaching opportunities.  Prerequisite: first-year graduate student in the Pharmacology program. Offered: A.

PHCOL 600 Independent Study or Research (*) AWSpS Faculty

PHCOL 800 Doctoral Dissertation (*) AWSpS Faculty

ADVANCED COURSES PHCOL 529 Ion Channel Pharmacology (2) Catterall, Sancak Recent work has shown that ion channels are often the targets of mutations which cause disease in humans and mice. Inherited diseases are known which affect voltage-gated sodium, calcium, potassium, and chloride channels, epithelial sodium channels, ATP-gated potassium channels, glycine receptors, and CFTR. We will use the inherited diseases and the naturally occurring mutations in these channel proteins as starting points to consider the structure, function, physiology, genetics, and pharmacology of these ion channels. The class will be in seminar format, with most presentations given by student participants. Prerequisites: Conj 531 and students are requested to review the lectures by Dr. Zagotta before the first class meeting. Offered: odd years; A.

PHCOL 531 Genetic Analysis of Signaling Systems (3) McKnight Current topics involving signal transduction will be discussed with an emphasis on genetic analysis of multicellular systems and creative experimental design. Prerequisites: permission of instructor. Offered: odd years; Sp.

PHCOL 534 Molecular Basis of Drug Addiction (2) Chavkin Advanced consideration of the effects of drugs on neurotransmission and higher order neural systems including current topics in receptor pharmacology, hormonal modulation of neuro signaling, effects of disease on neural circuits, regulation of synaptic plasticity, and mechanisms underlying neurodegeneration. Prerequisites: PHCOL 504 or permission of instructor. Offered: even years; A.

PHCOL 537 Molecular Neurobiology of the Cell Membrane (2) Nathanson Advanced consideration of the structure and function of cell membranes, membrane trafficking, exocytosis, endocytosis, membrane proteins, and lipid-mediated signal transduction. Processes important to nervous system functioning will be emphasized. Prerequisites: Neuro 501, 502, 503 or permission of instructor. Offered: odd years; W.

MEDCH 528 Biophysical Enzymology and Biopharmaceuticals (2) Atkins Covers in-depth treatment of chemical catalysis and transition state theory as related to enzyme mechanisms; thermodynamics and kinetics of protein-ligand interactions, protein-protein-interactions and protein-lipid interactions, and methods for their study. Discusses therapeutically relevant examples, including viruses, therapeutic antibodies, and drug targets. Offered: even years; W.

MEDCH 541 Biological Mass Spectrometry (3) Whittington Covers the basics of modern ionization methods and mass analyzers; small molecule structure assignment, quantitative assay development by LC-MS and metabolomics; quantitative discovery-based proteomics and validation methods; and peptide sequence determination, post-translational modification mapping, and protein structure determination methods. Prerequisite: permission of instructor. Offered: Sp.

PhD Requirements and Curriculum: First Year

Students engage in three different laboratory rotations and take classes in different aspects of pharmacology. The rotations provide students the opportunity to examine different biological problems and work in different lab environments, one of which will ultimately become their dissertation laboratory.

Fall Quarter: PHCOL 501 – Drug Discovery and Emerging Therapeutics (2 credits) PHCOL 502/CONJ 532 – Signal Transduction from the Cell Membrane to the Nucleus (2 credits) PHCOL 507 – Pharmacology Seminar (1 credit) PHCOL 514 – Current Topics in Pharmacology  (1 credit) PHCOL 519 – Introduction to Laboratory Research in Pharmacology (4 credits) PHCOL 550 – Introduction to the Department (1 credit) CONJ 531 – Signaling Mechanisms in Excitable Cells (1.5 credits)

Additional Courses: Students can take one Advanced Pharmacology course and/or additional graded approved courses selected from the list of approved courses. Students should not register for more than 18 total credits.

Winter Quarter: PHCOL 503- Autonomic/Cardiovascular Pharmacology (2 credits) PHCOL 504 – Neuropharmacology (2 credits) PHCOL 507 – Pharmacology Seminar (1 credit) PHCOL 514 – Current Topics in Pharmacology (1 credit) PHCOL 519 – Introduction to Laboratory Research in Pharmacology (4 credits)

Spring Quarter: PHCOL 505 – Endocrine Pharmacology (2 credits) PHCOL 506 – Immunopharmacology and Chemotherapy (2 credits) PHCOL 507 – Pharmacology Seminar (1 credit) PHCOL 514 – Current Topics in Pharmacology (1 credit) PHCOL 519 – Introduction to Laboratory Research in Pharmacology (4 credits)

Summer Quarter:  Register for UCONJ 510 (2 credits)   OR  PHCOL 600 – Research (2 credits) (UCONJ 510 space is limited, register early!)

Students should register for 2 credits MAX.

Biomedical Research Integrity Lecture Series : Students attend a minimum of 2 lectures and 2 discussion sessions.

Student Advising and Evaluation Dr. Edith Wang advises first-year graduate students and is responsible for overseeing the activities of individual students including course registration, laboratory rotation selection, and selection of their thesis advisor and Doctoral Thesis Supervisory Committee members.

The progress of Pharmacology students is reported quarterly to the Pharmacology Faculty. This report is based on the student’s performance during lab rotations and coursework.

At the end of the Spring Quarter of the first year, students select a thesis advisor (with the approval of the Department Chair) who will be the Chair of their Doctoral Thesis Supervisory Committee.

Laboratory Rotations Laboratory rotations are designed to provide first-year students with an opportunity to gain hands-on experience with the theoretical and technical approaches to research that are practiced in different laboratories. This experience helps students to select a permanent lab in which to conduct their thesis research. Students complete three 10-week rotations in the labs of their choice during the Autumn, Winter, and Spring quarters of their first year.

At the completion of each laboratory rotation, students provide a title and abstract describing the objectives, results, and conclusions of their research project and present a short research talk to fellow students and faculty in the Pharmacology Department. The rotation advisor provides a numerical grade and written evaluation of the student’s performance in the lab and the rotation talk. The student receives a copy of the evaluation, which becomes a part of the student’s academic file.

Students with a Master’s degree and significant research experience may petition the Pharmacology Graduate Program Committee to reduce the number of laboratory rotations required before selecting a thesis advisor.

Selection of Dissertation Advisor By the end of the eighth week of Spring quarter (mid-May), each student must notify Dr. John Scott (Pharmacology’s Chair) of their first and second choices for a thesis advisor. Finding a mentor who agrees to accept the student into his/her lab is a qualifying step for continuation in the Pharmacology graduate program and a successful graduate career.

With the approval of the Department Chair and completion of their Spring Quarter rotation, the student moves to their thesis advisor laboratory for the remainder of their graduate studies.

Biomedical Research Integrity The summer series on Biomedical Research Integrity (BRI) was developed by the UW School of Medicine in response to a directive from the National Institutes of Health (NIH) requiring that all graduate students supported by NIH training grants be provided with training in the ethics of research. Additionally, the Medical School Executive Committee recommends that all trainees, regardless of funding source, participate in the BRI Series during their training.

The Department of Pharmacology requires all Pharmacology graduate students to complete the course in research ethics during their study in the department. It is a requirement for graduation, whether or not you may be supported on a NIH training grant. The Department office will receive an attendance sheet; the fulfillment of the requirement is documented.

It is required that first-year students take a minimum of two lectures and two discussion groups from the Biomedical Research Integrity Series. When you are on a training grant, it is essential to check with the administrators of the training grant every year to ensure compliance with specific requirements for your training grant.

PhD Requirements and Curriculum: Second Year

Students begin work on their dissertation research project, select their Doctoral Supervisory Committee, and prepare for the written portion of the General Exam.

Fall Quarter: PHCOL 507 – Pharmacology Seminar (1 credit) PHCOL 514 – Current Topics in Pharmacology (1 credit) PHCOL 560-577 (1 credit) Register for your Thesis Advisor’s laboratory meeting course. PHCOL 600 – Research (Variable credits) The number of credits to register for will vary. Student must register for at least 10 total credits and no more than 18 total credits during any given Quarter, except Summer Quarter.

Additional Courses: Students can take one Advanced Pharmacology course and/or additional graded approved course.

Winter Quarter: PHCOL 507 – Pharmacology Seminar (1 credit) PHCOL 514 – Current Topics in Pharmacology (1 credit) PHCOL 560-577 (1 credit) Register for your Thesis Advisor’s lab meeting course. PHCOL 600 – Research (Variable credits) See Autumn Quarter for explanation.

Spring Quarter: PHCOL507 – Pharmacology Seminar (1 credit) PHCOL 514 – Current Topics in Pharmacology (1 credit) PHCOL 560-577 (1 credit) Register for your Thesis Advisor’s laboratory meeting course. PHCOL 600 – Research (Variable credits) See Autumn Quarter for explanation.

Summer Quarter: PHCOL 600 – Research (1 credit) PHCOL 560-577 (1 credit) Students register for their Thesis Advisor’s laboratory meeting course. Students should not register for more than 2 total credits during Summer quarter.

Teaching Requirement Teaching experience is considered an important aspect of training in the Pharmacology graduate program.  Students serve as Teaching Assistants for one quarter of the Pharmacology 500 series during their second year or may choose to participate in a community outreach teaching experience. The TA experience begins with participation in the TA workshop on Teaching & Learning offered by UW in September. TA responsibilities for courses include attending all sessions, supporting 1st year graduate students, preparing and delivering lectures, management of class discussion and grading of student presentations. If you prefer to participate in a community outreach TA experience, please contact Dr. Stan McKnight ( [email protected] ) for more details.

University of Washington Resources for Teaching: http://www.washington.edu/teaching  

Choosing Your Doctoral Supervisory Committee  During the Autumn Quarter of the second year, students (with the advice of the Thesis Advisor and the Graduate Program Committee) select faculty members to serve on their Doctoral Thesis Supervisory committee. The Doctoral Thesis Supervisory Committee consists of the thesis advisor, Graduate School Representative (GSR), and Pharmacology faculty and faculty members from other departments most familiar with the student’s dissertation research area.

At least five, but no more than seven faculty members are recommended on the Doctoral Thesis Supervisory Committee. The majority of the Committee members should have a primary appointment in the Department of Pharmacology. At least one, but no more than three (including the Graduate School Representative), should hold primary appointments outside of the Department of Pharmacology. Only one committee member may be a faculty member who is not a member of the Graduate Faculty. The chair of the Doctoral Thesis Supervisory Committee (Thesis Advisor) and the Graduate School Representative (GSR) must be in attendance at the General Examination and at the Final Examination.

Criteria for selecting the Graduate School Representative (GSR)

• The GSR cannot have an appointment within the Pharmacology department
• The GSR has no conflict of interest with the committee chair(s)/student (i.e., budgetary, familial, romantic).
• The GSR must be a Graduate Faculty member with an endorsement to chair doctoral committees.
• The GSR cannot have an affiliate or adjunct appointment with the Pharmacology department.

The names of Committee members must be submitted to Debbie Bale, who submits the information to the Graduate School with the authority of the Graduate Program Director.

Individual Development Plan (IDP) Preliminary Review Pharmacology graduate students in their second year of graduate school are required to create an IDP and schedule a preliminary review that will prepare them for a successful future career. Please see the following guidelines for details about “ Creating an IDP “.

Preliminary Review For the preliminary review, you should plan to present the general area/ideas of your thesis project. The primary purpose is to allow committee members to provide feedback on your potential thesis project and to help you formulate the actual specific aims of your future General Exam research proposal. This meeting also will allow you to get to know your committee members before your General Exam.

Students are required to convene a preliminary review meeting with their committee members before the end of Winter quarter of their second year.

Written Component of General Examination  The written portion of the General Examination is scheduled by Dr. Wang during the month of June or July for graduate students to take at the end of their second year. The purpose of this examination is to evaluate the student’s knowledge and understanding of basic pharmacology and the medical sciences (e.g., biochemistry, physiology, molecular/cellular biology, etc.) and their ability to apply this knowledge. The exam is take-home and consists of questions written by members of the Pharmacology faculty.

Questions will be graded by the authoring faculty members and an evaluation of overall performance on the exam will be provided to each student. Areas of perceived weakness will be noted and may be reexamined during the oral portion of the General Examination. Results of the Written General Examination will be included as a permanent part of the student’s record.

PhD Requirements and Curriculum: Third Year

The student continues on dissertation work and takes the oral General Examination.

Third Year Courses

Fall Quarter: PHCOL 507 – Pharmacology Seminar (1 credit) PHCOL 560-577 (1 credit) Students register for your Thesis Advisor’s laboratory meeting course. PHCOL 600 – Research (Variable credits)

Students can take one Advanced Pharmacology course and/or additional graded approved course. Students should not register for more than 18 total credits.

  Winter Quarter: PHCOL 507 – Pharmacology Seminar (1 credit) PHCOL 560-577 (1 credit) Students register for their Thesis Advisor’s laboratory meeting course. PHCOL 800 – Research (Variable credits) For students who have passed the Pharmacology written and oral General Examinations. The number of credits to register for will vary. Students must be registered for a minimum of 10 total credits and no more than 18 total credits each Quarter (except Summer Quarter).

Spring Quarter: PHCOL 507 – Pharmacology Seminar (1 credit) PHCOL 560-577 (1 credit) – Students register for Thesis Advisor’s laboratory meeting course. PHCOL 800 – Research (Variable credits)

Summer Quarter: PHCOL 560-577 (1 credit) – Students register for their Thesis Advisor’s laboratory meeting course. PHCOL 800 – Doctoral Dissertation (1 credit)

*Students supported by a training grant may need to attend required Biomedical Research Integrity Lecture Series lectures and discussions. Check with your training grant administrator for specific details.

Oral Component of General Examination Students schedule the oral General Examination, which is administered by the Doctoral Thesis Supervisory Committee, during the Fall Quarter of their third year of graduate studies. The oral General Examination is chaired by a departmental faculty member who is not the Thesis Advisor. The chairing faculty member will be designated by the Thesis Advisor prior to the exam with the concurrence of the Graduate Program Committee. The examination is based, in part, on an evaluation of the student’s proposed research for the dissertation and on his or her knowledge of the disciplines important to the research.

A short thesis research proposal (in the style of an NIH F31 NRSA proposal) will be provided by the student to his/her/their Doctoral Thesis Supervisory Committee members at least one week prior to the oral General Examination. During the oral examination,  the student will present the background for the proposed research, thesis proposal, and dissertation research progress. This will be followed by questions from the Doctoral Thesis Supervisory Committee on issues related to the background and thesis proposal.

• 20-minute uninterrupted talk on background
• 20-minute faculty questions on foundational knowledge of their fields
• 20-minute uninterrupted talk on proposed research
• Up to 60 minutes faculty questions the proposed research, general knowledge of pharmacology and related disciplines

The duration may be influenced by the student’s previous performance on the written general examination and in-class work. Each Committee member will be invited to ask a series of questions on general knowledge.

On the basis of an evaluation of student performance on all portions of the general examination (written general examination, oral presentation, and defense of the thesis proposal), the committee recommends one of the following: 1) approval of candidacy towards the Ph.D. degree, 2) further work and subsequent reexamination (over specific areas or in total), or 3) termination from the program.

After successful completion of the oral General Examination, graduate students enroll in PHCOL 800 rather than PHCOL 600. This reflects the change in status from a pre-candidate to a candidate for the doctoral degree.

Steps To Your Oral General Examination Contact your Thesis Advisor and committee members to find a suitable date. Your Graduate School Representative (GSR), Thesis Advisor, and two other committee members must be in attendance. When you have confirmed the date and time with your committee, notify Debbie Bale – ( [email protected] ) and a suitable location will be scheduled.

After you have a room reservation, date, and time for your oral General Examination, you will need to submit your request for a General Examination online through MyGrad: https://grad.uw.edu/mygrad-program/ at least three weeks in advance of the exam date. Notify Debbie after you have submitted your request so that she can approve the date and time of your exam.

At least two weeks before the oral General Examination, a written description of your thesis proposal must be circulated to your supervisory committee for them to review. A copy should be given to Debbie for your file. Specific guidelines for the written thesis research proposal will be provided to students at the beginning of the Fall quarter in their 3rd year.

Prior to the oral General Examination, Debbie will provide the necessary warrant that will be given to your Advisor. Each member of your supervisory committee who is present must sign the document.

If it is not possible to schedule your oral General Examination by the stated deadline, please contact Dr. Edith Wang ( [email protected] ).

PhD Requirements and Curriculum: Fourth and Subsequent Years

The student continues with their dissertation research and prepares for their dissertation defense.

Fall/Winter/Spring Quarter: PHCOL 507 – Pharmacology Seminar (1 credit) PHCOL 560-577 (1 credit) Students register for your Thesis Advisor’s laboratory meeting course. PHCOL 800 – Doctoral Dissertation (Variable credits)

Summer Quarter: PHCOL 560-577 (1 credit) Students register for their Thesis Advisor’s laboratory meeting course. PHCOL 800 – Doctoral Dissertation (1 credit)

Annual Review of Dissertation Progress In Winter quarter of your fourth year and each subsequent years until the doctoral defense, the student will be reviewed annually by their Doctoral Thesis Supervisory Committee regarding their dissertation progress. The student prepares a two-page status report, which is circulated to the Doctoral Thesis Supervisory Committee and meets with the Committee for a discussion of their dissertation research progress and future plans. The annual review must be completed by the end of the Winter Quarter each year.

Laura Sheard Graduate Lecture Fourth year students will select the lecture speaker and will consult with the department’s seminar co-chairs prior to inviting the speaker. Student will also host a lunch and dinner with the speaker. Full details will be shared before the beginning of your fourth year. To learn more about the lecture, please visit: https://pharmacology.uw.edu/seminars/laura-sheard-lecture/

Final Examination When you and your supervisory committee have agreed you are ready to graduate, you will select a Reading Committee, a subgroup of at least three members of your Supervisory Committee, who will be appointed to read and approve your dissertation. It is the responsibility of a Reading Committee to (a) ensure that the dissertation is a significant contribution to knowledge and is an acceptable piece of scholarly writing; (b) determine the appropriateness of a candidate’s dissertation as a basis for issuing a warrant for a Final Examination and; (c) approve a candidate’s dissertation.

Once you have selected the Reading Committee, contact Debbie Bale ( [email protected] ) with the names of your choice, Debbie will enter the Reading Committee member names into MyGrad to inform the Dean of the Graduate School. Your Reading Committee will approve your dissertation online through the MyGrad Committee View portal. Instructions will be given to them by email from the Graduate School.

Next, you will need to select a date for the thesis defense that is acceptable to your Supervisory Committee members and you. After a date has been selected, contact Debbie to reserve a room for your defense. After a room has been reserved, log In to  MyGrad: https://grad.uw.edu/mygrad-program/ to schedule your doctoral final exam. Contact Debbie after you have entered the information in MyGrad for approval.

The other formalities regarding the final submission of your dissertation are all detailed very nicely, with each step delineated, at the following website:  https://grad.uw.edu/current-students/enrollment-through-graduation/graduation-requirements/

If you have any questions, please contact Debbie.

Choosing the Doctoral Supervisory Committee

During the Autumn Quarter of the second year, the student (with the advice of the Thesis Advisor and the Graduate Program Committee) selects a Doctoral Thesis Supervisory committee and is required to convene a preliminary meeting with the committee. The Doctoral Thesis Supervisory Committee generally includes:

• Pharmacology faculty most familiar with the area of the student’s research.
• At least five but no more than seven members.
• The majority of the Committee members should have primary appointments in Pharmacology.
• At least one, but no more than three (including the Graduate School Representative), should be faculty members that do not hold primary appointments in Pharmacology.
• The chair of the Doctoral Thesis Supervisory Committee (Thesis Advisor) and the Graduate School Representative must be in attendance at the General Exam and at the Final Exam.
• The GSR cannot have an appointment within Pharmacology.
• The GSR cannot have an affiliate or adjunct appointment.

Once selected, the names of the Committee members are submitted to the Graduate Program Specialist, who submits them to the Graduate School with authority of the Graduate Program Advisor.

UW Graduate School references

https://grad.uw.edu/policies-procedures/graduate-school-memoranda/memo-13-supervisory-committee-for-graduate-students/

Written Component of General Examination

The written portion of the General Examination is scheduled during the month of June at the end of their second year. The purpose of this examination is to evaluate the student’s knowledge and understanding of basic pharmacology and the medical sciences (e.g., biochemistry, physiology, molecular/cellular biology, etc.) and their ability to apply this knowledge. The exam is take home and consists of questions submitted by members of the Pharmacology faculty. Questions will be graded by the authoring faculty members and an evaluation of overall performance on the exam will be provided to the student. Areas of perceived weakness will be noted and may be reexamined during the oral portion of the General Examination. Results of the written General Examination will be entered into the file as a permanent part of the student’s record.

For more information please visit the UW Graduate School’s General Examination webpage: https://grad.uw.edu/policies-procedures/doctoral-degree-policies/general-examination-admission-to-candidacy-for-doctoral-degree/

Steps To Your Oral General Examination

• Contact your Thesis Advisor and committee members to find a suitable date. Your Graduate School Representative (GSR), Thesis Advisor and two other committee members must be in attendance. When you have confirmed the date and time with your committee, notify Debbie Bale ([email protected]) and a suitable location will be scheduled.
• After you have identified a date for your oral General Examination, you will need to submit your request for a General Examination online through  MyGrad at least three weeks in advance of the exam date. Notify Debbie after you have submitted your request so that she can approve the date and time of your exam.
• Prior to the exam, your Thesis Advisor should review your academic record (including your performance on the written General Examination) to advise you of any areas of general knowledge that require special attention.
• At least two weeks before the oral General Examination, a short written description of your thesis proposal must be circulated to your supervisory committee for them to review. A copy should be given to Debbie for your file. Specific guidelines for the written thesis research proposal will be provided to students at the beginning of the Fall quarter in their 3rd year.
• Prior to the oral General Examination, your advisor will designate another committee member to chair the oral General Examination. For the examination, be prepared to give a thirty-minute description of your thesis proposal and research progress. This will be followed by thirty to sixty minutes of questions from your committee on issues related to the proposal. After the proposal-related questions, anticipate questions on general knowledge of pharmacology and related disciplines.Debbie will provide the necessary warrant that will be given to your Advisor. Each member of your supervisory committee who is present must sign the document.
• If it is not possible to schedule your oral General Examination by the stated deadline, please speak with Dr. Edith Wang.

Steps to Your Dissertation

The first step to your dissertation is to select a Reading Committee, a subgroup of at least three members of your Supervisory Committee who will be appointed to read and approve your dissertation. It is the responsibility of a Reading Committee to (a) ensure that the dissertation is a significant contribution to knowledge and is an acceptable piece of scholarly writing; (b) determine the appropriateness of a candidate’s dissertation as a basis for issuing a warrant for a Final Examination and; (c) approve a candidate’s dissertation.

Once you have selected the Reading Committee, contact Debbie Bale ( [email protected] ) with the names of your choice, Debbie will enter the Reading Committee member names into MyGrad to inform the Dean of the Graduate School. (After you submit your thesis, your Reading Committee will approve your dissertation online through the MyGrad Committee View portal. Instructions will be given to them by email from the Graduate School.)

Next, you will need to select a date for the thesis defense that is acceptable to your Supervisory Committee members and you. Contact Debbie with the date and time for room reservations. After a room has been reserved, go to your MyGrad account to schedule your doctoral final exam. Debbie will approve the date and time; an email confirmation from the Graduate School will be sent to all your committee members after approval.

The other formalities regarding the final submission of your dissertation are all detailed very nicely, with each step delineated, on the UW Graduate School Thesis/Dissertation webpage.

If you have any questions, please contact Debbie ([email protected]).

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• Pharmacology and Toxicology PhD Program

Pharmacology & Toxicology PhD Program at the Medical College of Wisconsin

Message from the Director

Christopher Olsen, PhD

Associate Professor of Pharmacology & Toxicology Director, Graduate Program in Pharmacology & Toxicology

[email protected] (414) 955-7629

Welcome to the Pharmacology Graduate Program at MCW! Research in our department focuses on cancer biology, cardiovascular disease, neuropharmacology, and structural biology. We offer a flexible program for students interested in basic biological processes, translational science, and/or drug discovery.

Pharmacology and Toxicology

About the program, current students, tuition and fees.

Find out more about our current Pharmacology & Toxicology students.

The doctoral program in the Department of Pharmacology and Toxicology at the Medical College of Wisconsin has two major components: graduate level coursework and the completion of a novel, publishable research project.

The coursework requirements of the doctoral program are flexible and tailored to the needs of individual students as much as possible. Typically, the first-year curriculum for doctoral students consists of a set of core courses covering the fundamentals of biochemistry, molecular genetics, molecular biology of the cell and cellular signal transduction. However, an alternative translational core curriculum is available with focus on organ system biology and translational science.  Subsequently, students may take semester long graduate courses on pharmacological principles, receptors and second messengers, ion channels and drug discovery. The option to take a medical pharmacology course is available.

After completion of the initial coursework, students take a qualifying examination. The qualifying examination consists of writing and defending a research proposal in an area different from the student's dissertation research. The exam typically takes place in the second year of the doctoral program.

After a student has successfully passed his or her qualifying examination and completed the basic coursework, his or her time is spent engaged in a cutting edge research project in the laboratory of a member of the department's graduate faculty. The final requirement of the program is for the student to write and defend a dissertation describing their research project

Requirements and Guidelines for PhD Program  (PDF) 

The objective of the graduate training program in the Department of Pharmacology and Toxicology at the Medical College of Wisconsin is to train biomedical researchers for the 21st Century. Our goal is to give our students the skills to conduct independent research at the cutting edge of biomedical science. Candidates can pursue their PhD degree by applying to either the Interdisciplinary Program in Biomedical Sciences (IDP) , the Neuroscience Research Program (NDP) , or direct admission into the Pharmacology and Toxicology  program.

Doctor of Philosophy; Master of Science (special arrangement only). These programs expose students to a variety of perspectives in biomedical research and allow exploration of multiple fields within the biomedical sciences before choosing a specific program for their dissertation.

A Bachelor’s degree (either completed or in the process of completing) is required for admission to any MCW graduate program. Applicants will ideally have a 3.0 or higher grade point average (GPA). Personal statements and letters of recommendation from professors, advisors, research supervisors, etc. who know you well are highly regarded in the admission process. An official test score, GRE or otherwise, is no longer required for admission consideration. However, test score submissions will be consider if they are submitted voluntarily. Prior research experience is also strongly considered.

The MCW Graduate School operates on a rolling admissions basis. However, applications accepted by the priority application deadline of December 15 th will receive first priority for admission the following Fall. Students are admitted once per year.

If you have questions regarding tuition or your account, please contact the Office of Student Accounts, at (414) 955-8172 or  [email protected] . Please refer to the  All Student Handbook  (PDF) for tuition payment policies and information.

• Tuition and Fees Schedule  (PDF)
• View your Tuition Statement  (login required)

PhD Students All full-time PhD degree-seeking students in good academic and professional standing receive the following financial support package:

• Full tuition coverage
• Yearly stipend ($33,612 for the '23-'24 academic year)
• Complimentary health insurance

There is no additional process to secure this package aside from accepting an offer of admission. Further, this package is guaranteed from the time of enrollment through completion of degree requirements.

Current MCW Employees Tuition Course Approval Form - Human Resources  (PDF)

Late Fees There is a $250 late payment fee for tuition not paid on time according to the Tuition Payments policy in the  All Student Handbook  (PDF).

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Graduate Program Student Information Requirements and Guidelines - Student and Faculty Handbook (PDF) Effective July 1, 2009 (updated version April 2019) for the Pharmacology & Toxicology Graduate Program

PhD and Master's Degree Forms

Please refer to the Graduate School webpage for more information

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Pharmacology and Toxicology PhD

Saint Joseph’s University’s  Pharmacology and Toxicology PhD,  housed in the School of Health Professions’ historic Philadelphia College of Pharmacy, trains you to contribute to this growing body of scientific and medical research with a curriculum that combines theory with experiment. Pharmacology and toxicology lie on the cutting edge of medicine, where researchers discover and determine the effects of chemicals.

This doctoral degree in pharmacology and toxicology offers the opportunity to conduct doctoral-level research, defend a PhD thesis and publish and present your research. With a PhD, you’ll gain a competitive edge to advance your career in academia, the government or the pharmaceutical industry.

What Sets Our Program Apart

You’ll conduct groundbreaking research shoulder-to-shoulder with faculty in your coursework and laboratory rotations. Our pharmacology and toxicology faculty are conducting research in areas including:

• Cancer pharmacology
• Metabolism and cellular mechanisms of drug toxicity and xenobiotics
• Cancer motility and signaling
• Cardiovascular pharmacology and neuropharmacology

As a pharmacology and toxicology PhD student, you’ll get to examine how drugs work — and why some are toxic — in our well-equipped laboratories inside Griffith Hall. We have a lab dedicated to pharmacology research, and equipment to maximize your learning experience, which contains:

• A real-time PCR for nucleic acid amplification
• Flow cytometers
• Fluorescence microscopes
• A fully automated flash chromatography system

Our long-standing relationships with many companies and organizations provide you with fieldwork and job opportunities. For example, a majority of our graduates have launched their professional careers at pharmaceutical companies including GlaxoSmithKline, Merck and Johnson & Johnson.

The PhD program in pharmacology and toxicology is taught by expert faculty in the field. This program is designed to accommodate small classes and laboratory sessions, enabling valuable connections with your peers and professors.

You can find more information on our faculty and their research below:

Isabelle Mercier, PhD

Adeboye Adejare, PhD

Shanaz Butt, PhD

Bin Chen, PhD

Peter Harvison, PhD

Jean-Francois Jasmin, PhD

Zhiyu Li, PhD

Asha Suryanarayanan, PhD

Ruy Tchao, PhD

Jason Wallach, PhD

What Can You Do With a PhD in Pharmacology and Toxicology?

With a doctorate in pharmacology and toxicology, you’ll have a thorough theoretical knowledge and hours of laboratory experience that can immediately improve your career prospects. Numerous pharmacologist jobs and toxicologist jobs exist in diverse settings including:

• Clinical Researcher
• Forensic Scientist/Toxicologist
• Drug/Toxicant Information Specialist
• Pharmacologist
• Pharmaceutical Marketing
• Pharmaceutical Manufacturing

Program Details

Pre-doctoral students must pass written and oral comprehensive qualifying exams to achieve doctoral candidacy.

The PhD degree requires the completion of at least 20 credits of coursework and a minimum of 20 credits of research. Courses fulfilling the didactic course requirement for the PhD degree should be primarily core courses at the 700 or 800 level required by the program and Research Advisor/Advisory Committee. A maximum of 6 credits of courses at the 300 or 400 level can be accounted for this requirement. You will also need to prepare and defend a research thesis.

View required courses for this program in the  academic catalog . Please contact us if you have any questions about the program curriculum.

As a PhD student in the pharmacology and toxicology program, you are required to propose, develop and perform an independent research project under the guidance of a faculty research advisor and advisory committee. Once you complete your research project, you must write a thesis and defend it before an examination committee, which includes the advisory committee and an external reviewer.

Affordable tuition options start at $1,200 per credit.*

  *Pricing does not include room and board, health insurance or any professional, clinical or transportation fees. Visit our Tuition & Fees page for a detailed breakdown.

Financial aid in the form of scholarships, student loans, graduate assistantships and discount eligibility may be available to you to help offset the cost of your degree. Explore your options on our Financial Aid page .

Why Study Pharmacology and Toxicology in Philadelphia?

Saint Joseph’s University City location in Philadelphia is in the heart of the biotech and health science industry — we’re surrounded by 250+ facilities and within two hours of 75% of all U.S. pharmaceutical firms. The city's diverse population and variety of health science employers offers the unique opportunity to gain experience in pharmacology and toxicology research. Here, you’ll make numerous connections in the industry and get a competitive edge in the job market.

Admission Information

You must meet the following prerequisites to be considered for admission to the Pharmacology and Toxicology PhD program:

• Have a bachelor’s degree from an accredited university or college or be currently enrolled in an undergraduate or first degree program at Saint Joseph’s
• Fluent in both spoken and written English (see below for language requirements for international applicants)
• Anatomy & Physiology
• Basic Pharmacology
• Biostatistics

GRE scores are optional. You can submit them if you think they’ll strengthen your application.

• Apply online .
• Submit official college transcripts from all colleges attended. If you attended Saint Joseph’s, we will obtain this transcript for you.
• Submit a ​1000-word ​personal statement explaining your short and long-term study and career goals. ​You must also identify at least two of the program’s faculty whose research interests align most closely with yours. Personal statements may be submitted as part of application via the application portal. 
• Submit resume or CV.
• Submit three letters of recommendation.

The application deadlines for admission to Saint Joseph’s PhD in pharmacology and toxicology program are:

• Priority Review for ALL applicants: March 1
• Domestic Student Deadline: June 1
• International Student Deadline: March 1

International applicants must show proof of English language proficiency such as TOEFL or IELTS scores. Check the Graduate Admission page for additional requirements.

Frequently Asked Questions

The master's program is taught in a similar style to that of an undergraduate degree. Students enrolled in the MS in Pharmacology and Toxicology will be taught lecture-style, along with assignments and projects to complete. The master's program can be completed within two years if enrolled as a full-time student. 

The PhD program allows the student to work independently on a research-based project that will be presented at the end of the program. Students will work alongside Saint Joseph's expert pharmacology and toxicology professors to help guide their research. Due to the intensive coursework of the PhD, it can take up to six years to complete. 

Both programs require you to complete further research on a specific topics to be presented at the end of your study. The master's program culminates in a thesis statement to be presented, while doctoral students will complete a dissertation. A thesis is compilation of small research assignments based on the information gathered throughout the program. The dissertation allows you to formulate new research on a specific topic of your choosing, contributing to a new theory or practice in your field. 

Pharmacology is an important basic science discipline in health professions such as medicine, nursing and pharmacy. Toxicology expands our knowledge of pharmacology and other biological and chemical sciences to explain and predict the nature and extent of the harmful effects chemicals have on living things.

Pharmacologists learn how drugs modify living organisms by studying and measuring drug actions at molecular, biochemical, cellular and physiological levels. Toxicologists extend this work by examining the adverse effects of chemical substances and assessing risks associated with them.

Yes. The demand for pharmacologists and toxicologists has increased with the explosion of research the scientific community has experienced. In addition to advancements in drug therapy, our society has been faced with the reality of the toxic effects of many chemicals, such as food additives and environmental pollutants. Pharmacologists and toxicologists play an important role in the discovery, development, testing and control of these drugs and chemicals.

While there are entry- and mid-level roles in pharmacology and toxicology that only require a bachelor’s or master’s degree, many employers require a PhD for pharmacologist and toxicologist positions.

Related Programs

Pharmaceutics ms.

Saint Joseph’s University’s accredited master’s in pharmaceutics program explores how best to administer a drug to the human body and turn chemicals into effective medications. With a pharmaceutics graduate degree, you’ll advance to the forefront of medical progress.

Pharmacology and Toxicology MS

Build your mastery of how drugs and chemicals work with a Master of Science in Pharmacology and Toxicology from Saint Joseph’s. Our program combines theory with experiment and features a thesis-based curriculum, faculty-supervised laboratory research and small class sizes.

Drug Development & Industrial Pharmacy MS

Saint Joseph’s Drug Development and Industrial Pharmacy MS prepares students to learn the science and practice of how drug delivery systems are developed. Working one-on-one with expert faculty, students will gain insight and foresight as they uncover new areas of research in our state-of-the-art laboratories. 

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• UB schools among the best in U.S. News & World Report’s Best Graduate Schools rankings

UB schools among the best in U.S. News & World Report’s Best Graduate Schools rankings

Photo: Douglas Levere

By David J. Hill

Release Date: April 9, 2024

BUFFALO, N.Y. – Several schools within the University at Buffalo, New York’s flagship, are ranked among the top nationwide in U.S. News & World Report’s Best Graduate Schools rankings , released this morning.

The School of Pharmacy and Pharmaceutical Sciences is among the top 20 in the country, coming in at No. 19 overall and 18th among public universities.

“This achievement is a testament to our relentless pursuit of groundbreaking research, transformative discoveries, and unwavering commitment to the success of our students,” said Gary Pollack, PhD, dean of the School of Pharmacy and Pharmaceutical Sciences. “Our top 20 ranking reaffirms our steadfast commitment to cultivating the next generation of pharmacy and pharmaceutical science leaders who will push the boundaries of scientific inquiry, drive innovation in patient care, and elevate the standards of pharmaceutical research on a global scale.”

The School of Social Work is once again in the top 25, coming in at 24th nationally and No. 13 among public universities.

The School of Nursing’s Doctor of Nursing Practice (DNP) program moved up 11 spots to 34th in the country and No. 24 among public universities. In addition, the nursing anesthesia program was ranked 22nd.

“We are immensely proud to rank among the best DNP programs in the United States,” says School of Nursing Dean Annette Wysocki, PhD. “Our commitment to exceptional nursing education cultivates discipline of the mind to educate highly discerning nurse practitioners, who are indispensable in addressing the nation’s critical shortage of primary care providers. Quality nursing education remains paramount in safeguarding the health and wellness of our community.”

UB’s Graduate School of Education moved up four spots to No. 54 in Best Education Schools. Among public universities, the Graduate School of Education ranks 42nd. “Our steady climb in the rankings over the years is a testament to the hard work and high-quality research of GSE faculty,” says dean Suzanne Rosenblith, PhD.

The School of Public Health and Health Professions moved up four spots, to No. 46 nationally and No. 29 among public universities. Its programs in occupational therapy (41) and physical therapy (74) were also ranked, as was biostatistics (22).

Meanwhile, the School of Law moved up 17 places to No. 108 among Best Law Schools nationwide and 56th among public universities.

The School of Management’s MBA program came in at No. 74 in Best Business Schools and 38th among public universities, making it the highest rated business school within SUNY.

In addition, UB’s graduate programs in audiology (22) and speech language pathology (32) were also ranked this year.

Media Contact Information

David J. Hill Director of Media Relations Public Health, Architecture, Urban and Regional Planning, Sustainability Tel: 716-645-4651 [email protected]

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Johns Hopkins graduate programs again ranked among nation's best

'u.s. news & world report' includes 38 jhu programs among the top 10 in the u.s. in its annual rankings, including no. 1 ranked programs in nursing and public health.

By Hub staff report

Johns Hopkins University has 38 graduate schools, academic programs, and specialties ranked among the top 10 in the nation, including nine with No. 1 rankings, according to the latest edition of "Best Graduate Schools" from U.S. News & World Report , published earlier today.

Two schools at Hopkins—the Bloomberg School of Public Health and the School of Nursing —earned No. 1 rankings overall, and the School of Education entered the top 10, according to U.S. News & World Report .

Portions of the publication's annual list were released today but rankings for schools of medicine and engineering were delayed and will be released at a later date.

Among the new rankings released today:

The School of Nursing's DNP program ranked No. 1 for the third year in a row. Its master's degree programs tied at No. 1, up from No. 2 last year. In gerontology, the school moved up two spots to No. 1 for primary care, and up one spot to No. 2 for acute care. In other specialty areas, the School of Nursing's doctoral programs ranked:

• Psychiatric/mental health: No. 1
• Family: No. 3 (tied)
• Leadership: No. 4 (tied)
• Nursing Anesthesia: No. 36 (tie)

Public Health

The Bloomberg School retained its longtime No. 1 overall ranking among public health programs—it has held the top spot since 1994, the year the rankings began. In specialty areas, the Bloomberg School ranked:

• Environmental Health Sciences: No. 1
• Epidemiology: No. 1
• Health Policy and Management (Public Health): No. 1
• Social and Behavioral Sciences: No. 1
• Biostatistics: No. 2

Johns Hopkins tied at No. 8 in the Education category, up from No. 13 last year. The school also tied at No. 23 in higher education administration programs.

Public Affairs

Overall, Johns Hopkins programs in public affairs tied at No. 39. In subcategories, Johns Hopkins tied at No. 6 in Health Policy and Management (Public Affairs), No. 11 in International/Global Policy and Administration, and tied at No. 35 in Public Policy Analysis.

U.S. News & World Report updates some of its rankings each year and republishes the most recent rankings in other areas. Among the republished rankings for Hopkins, which are still current:

Biological Sciences

Hopkins is tied for No. 6 overall with six top 10 specialty rankings:

• Molecular biology: No. 3 (tie)
• Cell biology: No. 4
• Neuroscience: No. 4 (tie)
• Immunology: No. 5
• Genetics, genomics, and bioinformatics: No. 6 (tie)
• Biochemistry, biophysics, and structural biology: No. 8

Biostatistics

Hopkins is ranked No. 1 (tie) for Biostatistics at the doctoral level. (Note: U.S. News & World Report also ranks biostatistics as a sub-category of public health, where Hopkins is No. 2.)

The university is tied at No. 20 in Chemistry and ranks No. 9 in the Biochemistry subcategory.

Computer Science

The university is tied for No. 24 overall and tied at No. 21 in the specialty of Artificial Intelligence.

Earth Sciences

The university is tied at No. 30 in Earth Sciences.

Johns Hopkins' program in economics is tied at No. 22.

English tied at No. 13 overall with the following specialty rankings:

• Literary criticism and theory: No. 3
• British literature: No. 10 (tie)
• American literature after 1865: No. 17

Health Care Management

The university is No. 7.

Johns Hopkins ranks No. 10 overall, with the following specialty rankings:

• African-American history: No. 3 (tie)
• Cultural history: No. 4 (tie)
• U.S. Colonial history: No. 5 (tie)
• Women's history: No. 6 (tie)
• African history: No. 7 (tie)
• European history: No. 7 (tie)
• Modern U.S. history: No. 16 (tie)

Mathematics

Johns Hopkins is tied at No. 20 in Mathematics with the following specialty rankings: + Analysis: No. 18 (tie) + Algebra: No. 23 (tie) + Applied Math: No. 25

Overall, the university is tied at No. 13 with the following specialty rankings: + Living Systems: No. 5 (tie) + Cosmology: No. 7 + Condensed Matter: No. 13 (tie)

Political science

Overall, political science is tied at No. 41. In sub-categories, Johns Hopkins ranked: + Political theory: No. 8 (tie) + International politics: No. 24 (tie)

The university's graduate program in psychology is tied at No. 12 overall and tied at No. 5 in the subcategory of behavioral neuroscience.

Overall, sociology is tied at No. 29. The sub-category of sociology of population is tied at No. 17.

Posted in University News

Tagged u.s. news and world report , university rankings

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April 8, 2024

UM Pharmacology has recently submitted its nominations for the  2024 OGPS Graduate Student Awards/Phyllis M. Wise Graduate Student Awards in Biomedical Sciences. The nominations are as follows:

Catherine Demery: Excellence in Service

Livia Stanger: Excellence in Research

James Teuber: Excellence in Leadership

Congratulations to our nominees!

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