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Literature Review: Introduction and Notes

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10 Best Literature Review Templates for Scholars and Researchers [Free PDF Attached]

Imagine being in a new country and taking a road trip without GPS. You would be so lost. Right? Similarly, think about delving into a topic without having a clue or proper understanding of the reason behind studying it. 

That’s when a well-written literature review comes to the rescue. It provides a proper direction to the topic being studied. 

The literature review furnishes a descriptive overview of the existing knowledge relevant to the research statement. It is a crucial step in the research process as it enables you to establish the theoretical roots of your field of interest, elucidate your ideas, and develop a suitable methodology. A literature review can include information from various sources, such as journals, books, documents, and other academic materials. This promotes in-depth understanding and analytical thinking, thereby helping in critical evaluation.

Regardless of the type of literature review — evaluative, exploratory, instrumental, systematic, and meta-analysis, a well-written article consists of three basic elements: introduction, body, and conclusion. Also its essence blooms in creating new knowledge through the process of review, critique, and synthesis.

But writing a literature review can be difficult. Right?

Relax, our collection of professionally designed templates will leave no room for mistakes or anxious feelings as they will help you present background information concisely. 

10 Designs to Rethink Your Literature Reviews

These designs are fully customizable to help you establish links between your proposition and already existing literature. Our PowerPoint infographics are of the highest quality and contain relevant content. Whether you want to write a short summary or review consisting of several pages, these exclusive layouts will serve the purpose. 

Let’s get started.

Template 1: Literature Review PPT Template

This literature review design is a perfect tool for any student looking to present a summary and critique of knowledge on their research statement. Using this layout, you can discuss theoretical and methodological contributions in the related field. You can also talk about past works, books, study materials, etc. The given PPT design is concise, easy to use, and will help develop a strong framework for problem-solving. Download it today.

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Present a comprehensive and cohesive overview of the information related to your topic with this stunning PPT slide. The given layout will enable you to put forward the facts and logic to develop a new hypothesis for testing. With this high-quality design, you can enumerate different books and study materials taken into consideration. You can also analyze and emphasize the technique opted for inquiry. Get this literature review PowerPoint presentation template now.

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Demonstrate your analytical skills and understanding of the topic with this predesigned PowerPoint graphic. The given research overview PPT theme is perfect for explaining what has been done in the area of your topic of interest. Using this impressive design, you can provide an accurate comparison showcasing the connections between the different works being reviewed. Get it right away.  

Creating an effective literature review requires discipline, study, and patience. Our collection of templates will assist you in presenting an extensive and cohesive summary of the relevant works. These PPT layouts are professionally designed, fully editable, and visually appealing. You can modify them and create perfect presentations according to your needs. So download them now!

P.S. Are you looking for a way to communicate your individual story? Save your time with these predesigned book report templates featured in this guide . 

Download the free Literature Review Template PDF .

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Literature Review

Literature review presentation, free google slides theme, powerpoint template, and canva presentation template.

Whether you're a student or an academic, mastering the literature review is a key skill in scholarly writing. This fully customizable Google Slides and PowerPoint template can assist you in structuring your review seamlessly. Featuring a vibrant yellow design with captivating book illustrations, this template is designed to facilitate the organization and presentation of your research. Navigate your audience through chapters, themes, and references with ease and clarity using this versatile academic tool. Utilize this tool to craft an impressive literature review that leaves a lasting impression!

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Related Papers

Nirmal Kumar Raut

• Learning outcomes • The nature of a literature review • Identifying the main subject and themes • Reviewing previous research • Emphasizing leading research studies • Exploring trends in the literature • Summarizing key ideas in a subject area • Summary A literature review is usually regarded as being an essential part of student projects, research studies and dissertations. This chapter examines the reasons for the importance of the literature review, and the things which it tries to achieve. It also explores the main strategies which you can use to write a good literature review.

Rebekka Tunombili

PS: Political Science & Politics

KABASO OLIVER

oliver kabaso

International Journal of P R O F E S S I O N A L Business Review

With a view to examining the entire proposed structure for an empirical article, this editorial focuses on the Literature Review, also known as the Theoretical Framework. The literature review may be defined as “a documented review of published or unpublished works (articles, books, etc.) in specific fields of interest to the work of the researcher” (Ferreira, 2015: 36). It is to be found in conceptual articles such as empirical articles, whether qualitative or quantitative. It has a clear link to the article as a whole and provides support for the section on the development of the concept and the hypotheses/propositions that follow it in the structure of an empirical article.

yakubu nawati

Mahendra Budhathoki

Literature review or research synthesis is an essential component in research field. Novice and student researchers usually take it as a required burden in research, and present haphazardly under sub-topics in research. There is the problem of application and correlating LR with their studies. The main purpose of this paper is to present introduction of LR/research synthesis, its functions and methods in research. LR/research synthesis consists of searching relevant literature, discussing the findings and evidence, correlating the individual studies, interpreting critically, and synthesizing them to build an argument for future research. It is a review article based on qualitative research, but not based on primary data. This paper contributes to answer the questions of writing a LR or synthesis paper, and becomes a useful reference material to novice and student researchers of higher education.

Frances Slack

This article offers support and guidance for students undertaking a literature review as part of their dissertation during an undergraduate or Masters course. A literature review is a summary of a subject field that supports the identification of specific research questions. A literature review needs to draw on and evaluate a range of different types of sources including academic and professional journal articles, books, and web-based resources. The literature search helps in the identification and location of relevant documents and other sources. Search engines can be used to search web resources and bibliographic databases. Conceptual frameworks can be a useful tool in developing an understanding of a subject area. Creating the literature review involves the stages of: scanning, making notes, structuring the literature review, writing the literature review, and building a bibliography .

Journal of Practical Studies in Education

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LITERATURE REVIEW

Jul 22, 2014

2.14k likes | 6.19k Views

LITERATURE REVIEW. 2.1What is a “Literature Review”?. A literature review is an overview of research on a given topic and answers to related research questions Literature reviews are an important part of research and should be treated as such A well-written literature review:

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• distinguish
• related research questions
• relevant journal articles
• selective use
• low priority
• bibliographic data

Presentation Transcript

2.1What is a “Literature Review”? • A literature review is an overview of research on a given topic and answers to related research questions • Literature reviews are an important part of research and should be treated as such • A well-written literature review: • Organizes literature • Evaluates literature • Identifies patterns and trends in literature • Synthesizes literature

‘the literature’ means the works you consulted in order to understand and investigate your research problem. • A literature review involves providing a rationale for your selection of literature related to the subject studied.

The literature review familiarizes the reader with the subject and the scope of the research topic. • It helps the reader to define key concepts • Finally it establishes the body of knowledge which will be able to contribute towards the research.

2.2 Writing the Literature Review • Firstly decide what you need to read from a broad spectrum of literature available • Refer to books, periodicals, journals, and websites which will be relevant to your study.

Determine what exactly are your objectives • Provide a current and complete overview of your related topic. • Show that you have read extensively and formed a body of knowledge on the subject of field of study

Purpose of writing a literature Review Your review should be in a form of • critical decision, • showing awareness of differing arguments, theories, approaches and methodologies. It should be a synthesis and analysis of the relevant published work, linked at all times to your objective and rationale of your study.

There are several purposes on why we write a literature review: • it reviews knowledge of previous studies on the subject of research • it identifies a conceptual framework for own research • it provides directions for future research • it provides resources previously unknown to the reader • it identifies gaps in past studies

To sum up, a good literature review is: • critical of what has been written, • identifies areas of controversy, • raises questions and identifies areas which need further research.

2.3 Process of Writing a Literature Review • There are several stages in developing a literature review(Biddlek, 1997). The stages are : • Identify • Record • Relevance • Retrieve • Review • Write

Stage 1 – Identify • Compile a list of references. • Use a kind of index system either a hard copy or a software referencing system. • i)work through key catalogues, databases, indexes, bibliographies and websites for relevant resources • ii)check the references and in the articles you have read • iii)locate and use research reviews

Stage 2-Record • Make a record of any literature that relates to your topic. • You should have citation details, where it is located, and should also write a few sentences that help you remember what the article is about

Stage 3 –Relevance • i)Prioritize the literature, after having read the abstract, rank them if it should be high, medium or low priority • ii)On the website scan through the literature for relevance before you decide to download or print it out • iii) You need to focus on the literature and sources you have identified and ranked as most important, the most recent development from the periodicals. • iv) Distinguish between textbooks and research articles from journals and books. They contain different kinds of information that will be more or less relevant to your research

Stage 4 -Retrieve • i) Make hard copies of the most important literature. Print relevant journal articles from databases and photocopy articles from journals

Stage 5 –Review • Use the reading log which allows you to record different kinds of information: the bibliographic details, a description, and relationship to other readings. • Also record where the literature is located so that you can easily refer to the quotes or ideas paraphrased when you are editing. • As you are taking notes, ensure you are clear about what you are quoting and paraphrasing. You cannot risk unintentionally plagiarizing ideas.

Stage 6 -Write • Start with an introductory paragraph • Discuss the literature on the subject in a logical and coherent way • Conclude with a paragraph that is relevant to the literature of the research

2.4 Five Phases of Writing a Literature Review • Phase 1 – Specify the scope of your review • i)Ensure you have a precise topic • you must be precise about having a topic. It should not be too broad or unspecific. Look at the following topic which is too broad • Example: ‘Life and Times of Sigmund Freud” • The title below seems to be limited, but still considered too broad • Example: “Psychological Theories of Sigmund Freud • However, a more manageable and appropriate topic would be • ‘Freud’s Theory of Personality Applied to Mental Health” • If your research question is too broad or defined vaguely or abstractly, you may end up reading and compiling too much information for your literature review. However if your research question is specified too narrowly or defined concisely, you may miss out more general information

ii)Scope of the Literature Review You have to determine the precise scope of the literature review. Questions which need to be answered are as follows :- • What will I cover in my review? • How comprehensive will it be? • How current are my materials? • What type of materials/documents will be needed?

Phase 2: Locating and Accessing Information • Obtain all the necessary materials for your literature review by searching relevant bibliographies, print indexes and online databases i)Using Existing Literature Reviews • Many journals on different subject areas publish review articles. In these journals you may find commentaries on research articles. You may find these reviews relevant to your literature review.

Phase 3 Recording the Information • You can develop a systematic way of recording information through: note cards with citations • Photocopied articles with points highlighted or underlined with notes in the margins • Traditional taking down notes or in laptops

i)Tips on Recording Information • A quick skimming and scanning through the introduction and the conclusion of an article, would give you an idea of the article and general points. • a)Start with the most recent studies and work backwards. Refer to the list of references on a recent article;   • b)Read, first the report or article’s abstract - this will give you some clues about the article • c)When taking down notes, remember to write out the complete bibliographic citation for each work. It is essential you note down the page numbers as these will be necessary later for footnotes and bibliography. For internet citations note the URL • d)Write all direct quotations precisely when taking down notes. You should use quotations marks, so it can recognize as a directly quoted text and not a paraphrase. If you fail to put a direct text in quotation marks or to credit the authors, it amounts to plagiarism.

Phase 4 Evaluating the Information • After having read all the articles, you must now decide and evaluate what should be included in the review. • Be selective - you have to consider issues and themes that link different articles.

Phase 5 Organizing and Writing the Literature Review • After accessing, reading and evaluating the material, these materials need to be organized. • You may organize the selected readings by theoretical approaches, by specific concepts or issues, and by methodologies

Some tips on writing After you have located, read, analyzed and evaluated the literature, the next stage is actual writing. Here are some tips: • Keep your paragraphs short • Subheadings are essential, as it clarifies the structure. They break up the materials into more readable units • Avoid too many long direct quotations from the studies. Paraphrase other writers’ works rather than quote lengthy passages • Don’t cite references that you haven’t read

Some traps to avoid • Trying to read everything! • not to provide a summary of all the published work that relates to your research, but a survey of the most relevant and significant work. • Reading but not writing! • Writing can help you understand and find relationships between the work you’ve read, so don’t put writing off until you’ve “finished” reading. • Not keeping bibliographic information! - Source: http://www.clpd.bbk.ac.uk/students/litreview web.pdx.edu/~bertini/literature_review.pdf

Final Checklist Here is a checklist from University of Melbourne: (http://www.lib.unimelb.eduau/postgrad/litreview/finalchecklist.html) • Have you indicated the purpose of the review? • Have you ascertained the parameters of the review and are they reasonable? • Have you emphasized on recent development of the research? • Have you focused on primary sources with only selective use of secondary sources? • Is the literature selected relevant to your study? • Is your bibliographic data complete?

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Open Access

Peer-reviewed

Research Article

Scoping review of hearing loss attributed to congenital syphilis

Roles Data curation, Writing – original draft, Writing – review & editing

Affiliation Department of Pediatrics, Queen’s University, Kingston, Ontario, Canada

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Research Investigator, University of Alberta, Edmonton, Alberta, Canada

Roles Data curation, Writing – review & editing

Affiliation Department of Nursing, University of Alberta, Edmonton, Alberta, Canada

Affiliation Department of Anesthesiology, University of Alberta, Edmonton, Alberta, Canada

Roles Conceptualization, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

* E-mail: [email protected]

Affiliation Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada

Roles Conceptualization, Data curation, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Division of Otolaryngology-Head & Neck Surgery, University of Alberta, Edmonton, Alberta, Canada

• Aleena Amjad Hafeeez, 
• Karina Cavalcanti Bezerra, 
• Zaharadeen Jimoh, 
• Francesca B. Seal, 
• Joan L. Robinson, 
• Nahla A. Gomaa

• Published: April 26, 2024
• https://doi.org/10.1371/journal.pone.0302452
• Peer Review
• Reader Comments

There are no narrative or systematic reviews of hearing loss in patients with congenital syphilis.

The aim of this study was to perform a scoping review to determine what is known about the incidence, characteristics, prognosis, and therapy of hearing loss in children or adults with presumed congenital syphilis.

Eligibility criteria

PROSPERO, OVID Medline, OVID EMBASE, Cochrane Library (CDSR and Central), Proquest Dissertations and Theses Global, and SCOPUS were searched from inception to March 31, 2023. Articles were included if patients with hearing loss were screened for CS, ii) patients with CS were screened for hearing loss, iii) they were case reports or case series that describe the characteristics of hearing loss, or iv) an intervention for hearing loss attributed to CS was studied.

Sources of evidence

Thirty-six articles met the inclusion criteria.

Five studies reported an incidence of CS in 0.3% to 8% of children with hearing loss, but all had a high risk of bias. Seven reported that 0 to 19% of children with CS had hearing loss, but the only one with a control group showed comparable rates in cases and controls. There were 18 case reports/ case series (one of which also reported screening children with hearing loss for CS), reporting that the onset of hearing loss was usually first recognized during adolescence or adulthood. The 7 intervention studies were all uncontrolled and published in 1983 or earlier and reported variable results following treatment with penicillin, prednisone, and/or ACTH.

Conclusions

The current literature is not informative with regard to the incidence, characteristics, prognosis, and therapy of hearing loss in children or adults with presumed congenital syphilis.

Citation: Amjad Hafeeez A, Cavalcanti Bezerra K, Jimoh Z, Seal FB, Robinson JL, Gomaa NA (2024) Scoping review of hearing loss attributed to congenital syphilis. PLoS ONE 19(4): e0302452. https://doi.org/10.1371/journal.pone.0302452

Editor: Bolajoko O. Olusanya, Center for Healthy Start Initiative, NIGERIA

Received: October 6, 2023; Accepted: April 2, 2024; Published: April 26, 2024

Copyright: © 2024 Hafeeez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Data Availability: All data are in the manuscript and/or supporting information files.

Funding: The author(s) received no specific funding for this work.

Competing interests: The authors have declared that no competing interests exist.

Introduction

Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum . If not recognized and treated early in pregnancy, fetal transmission commonly occurs [ 1 ]. According to the international Joint Committee on Infant Hearing, congenital syphilis (CS) is a risk indicator for hearing loss [ 2 , 3 ]. The Centers for Disease Control and Prevention state: “Otosyphilis is caused by an infection of the cochleovestibular system with T . pallidum and typically presents with sensorineural hearing loss, tinnitus, or vertigo. Hearing loss can be unilateral or bilateral, have a sudden onset, and progress rapidly.” ( Neurosyphilis, Ocular Syphilis, and Otosyphilis ( cdc.gov ) ). Almost all cases of CS are treated with penicillin which is not known to be ototoxic.

For decades, congenital syphilis had almost disappeared in Canada and the United States due to low rates of syphilis in the community and universal prenatal screening.. The number of cases of confirmed early congenital syphilis born to women aged 15–39 years in Canada rose from 17 cases in 2018 to 117 in 2022 [ 4 ]. Trends in the United States (US) mirror this with an increase from 1325 congenital syphilis cases in 2018 to 3755 in 2022 [ 5 ].

The recent resurgence has increased interest in the clinical manifestations and complications of congenital syphilis. There are no published data summarizing the incidence or characteristics of hearing loss due to congenital syphilis. Despite the larger number of cases now occurring in Canada and the US, there are no evidence-based guidelines on screening or management of hearing loss in children with congenital syphilis. We therefore performed a scoping review. Our specific questions were:

• How often is hearing loss due to congenital syphilis?
• What is the incidence of hearing loss in children with congenital syphilis?
• When hearing loss occurs from congenital syphilis, what is the usual age of onset? Is it unilateral or bilateral? How severe is it? How rapidly does it progress?
• Is there evidence for any interventions for treatment of hearing loss attributed to congenital syphilis?

This will inform the studies that need to be done to determine the incidence and age of onset of hearing loss from CS, the severity of hearing loss, and interventions that warrant further study.

The methodology was based on the Preferred Reporting Items for a Systematic Review and Meta-analysis Extension for Scoping Reviews: The PRISMA-ScR statement [ 6 ] (See attached S1 Checklist ). A search was executed by a health librarian on the following databases: PROSPERO, OVID Medline, OVID EMBASE, Cochrane Library (CDSR and Central), Proquest Dissertations and Theses Global, and SCOPUS using controlled vocabulary (e.g.: MeSH, Emtree, etc.) and selecting key words representing the concepts “congenital syphilis" or "hearing loss” ( S1 Appendix ). Databases were searched from inception to October 17, 2021, with an updated search to March 31, 2023.

Articles were included if they described persons of any age with hearing loss that the authors of the article attributed to congenital syphilis. To delineate the burden and incidence of hearing loss from congenital syphilis, we included any studies that i) screened children with hearing loss for evidence of congenital syphilis or ii) screened children with congenital syphilis for hearing loss. We also included randomized controlled trials (RCTs), cross-sectional studies, case series, and case reports that described the characteristics of hearing loss, the long-term outcomes of hearing loss, or the results of any interventions for hearing loss. We excluded autopsy reports, animal studies, studies focusing solely on acquired syphilis and those published in a language other than English, French, or Portuguese.

Articles published in English were screened by two reviewers independently [AH, KC], and conflicts were resolved by a senior author [JR, NG]. Articles published in French had a single reviewer [FS]. There were no articles published in Portuguese. Because of the small number of recent articles, preprints were included. The protocol has not been published.

Studies were divided into four types: i) those that screened patients with hearing loss for congenital syphilis, ii) those that screened patients with congenital syphilis for hearing loss, iii) case reports or case series that describe the characteristics of hearing loss in patients with congenital syphilis, and iv) studies that describe an intervention for hearing loss attributed to congenital syphilis. Data were collected and managed using Research Electronic Data Capture (REDCap) tools [ 7 ] hosted at the University of Alberta with the extracted data determined by the study type. Data were entered by a single investigator. The JBI critical appraisal tool was used as appropriate to assess all included studies [ 8 – 11 ] ( S2 Appendix ). The critical appraisal and bias risk assessment was completed by a single reviewer [NG], and all studies were rated as high, unclear or low risk of bias.

The search yielded 1983 records of which 832 were duplicates. Screening led to 159 records for full-text review of which 36 met inclusion criteria ( Fig 1 ). The figure outlines the reasons for exclusion of other records.

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https://doi.org/10.1371/journal.pone.0302452.g001

Screening of patients with hearing loss for congenital syphilis

There were 5 studies where patients with hearing loss were screened for CS. They were published from 1900 to 1990 and all had a high risk of bias (Tables 1 and 2 ). The incidence of CS ranged from 0.3% to 8% in children attending schools for the hearing impaired and was 2% in children seen at a clinic for the hearing impaired.

https://doi.org/10.1371/journal.pone.0302452.t001

https://doi.org/10.1371/journal.pone.0302452.t002

Screening of patients with CS for hearing loss

There were 7 studies of which 4 were published from 2016 to 2022 ( Table 3 ). The risk of bias was high for 1, unclear for 3, and low for 3. Hearing loss was reported in 0 to 19% of children with probable or proven CS. One study from the modern era showed an incidence of 6% (22/342) (12). However, a small recent study reported no hearing loss for 7 infants treated in utero, a 5% incidence for 37 treated at birth, and a 6% incidence in 49 controls [ 23 ].

https://doi.org/10.1371/journal.pone.0302452.t003

Case series and case reports of hearing loss attributed to CS

There were 10 case series (one of which was also included in Table 2 ) ( Table 4A ) and 8 case reports ( Table 4B ) of which all but 6 were published prior to 1980. The risk of bias was high for 5 articles, unclear for 3 and low for 10. In these reports, hearing loss was often first noted in adolescence or adulthood with the youngest being 5 years old at diagnosis. Many cases also had interstitial keratitis. Follow-up was too variable to allow determination of the expected rate of progression of hearing loss. A wide variety of therapies are reported with small numbers of patients and inconsistent results that were often subjective.

A ‐ Case series of hearing loss attributed to congenital syphilis. B ‐ Case reports of hearing loss attributed to congenital syphilis.

https://doi.org/10.1371/journal.pone.0302452.t004

Studies with interventions for hearing loss

The 7 studies included a range of 6 to 39 patients with the most recent one being from 1983 ( Table 5 ). All were observational. Most commonly patients were prescribed penicillin with addition of prednisone followed by ACTH if response was poor or transient. Outcomes were often subjective and inconsistent. Risk of bias was unclear for 5 studies and low for 2 studies.

https://doi.org/10.1371/journal.pone.0302452.t005

The scoping review shows that studies of hearing loss due to congenital syphilis are limited and low quality. All but one study reported as a pre-print [ 23 ] are observational studies and only 15 of 36 studies (42%) were at low risk of bias. One cannot determine the incidence or characteristics of hearing loss from congenital syphilis or the efficacy of interventions from this review. It seems unlikely that a systematic review would find further studies that could answer these questions.

As expected, there were major variations in the study methodologies employed to diagnose hearing loss. In the early 1900s, investigators used basic tuning fork tests and subjective behavioral responses [ 24 ]. Studies performed after the year 2000, used full diagnostic tests or Auditory Brainstem Responses (ABR) for neonates [ 21 ].

A small percentage of children attending schools for the hearing impaired had evidence of congenital syphilis. However, these data are of limited value without a control group from the same jurisdiction. The percentage of hearing loss that is due to congenital syphilis no doubt varies considerably by country and over time.

It is perhaps unexpected that almost all case reports and case series describe recognition of hearing loss only in adolescence or adulthood. It is possible that hearing loss started years prior but was not recognized, particularly, if the hearing loss was slowly progressive. The major problem with all these reports is that they do not exclude the possibility that the patient had acquired syphilis or had another etiology for their hearing loss.

Clearly, there is paucity of up-to-date literature regarding this important health problem. The majority of articles were published before 1980. The recent surge in congenital syphilis cases in Canada and the United States may lead to further studies. Recent results from neonatal hearing screening programs in low- or middle-income countries where the incidence of congenital syphilis never waned are informative. Besen reported screening 21,434 newborns in Brazil 2017 through 2019 and reported a prevalence of test failure in the Universal Neonatal Hearing Screening Program (UNHS) of 1.6% (95% CI: 1.4; 1.8). This study used Otoacoustic Emission and ABR to identify both cochlear and retrocochlear damage. They report that 1.7% (95% CI: 1.5; 1.8) had congenital syphilis but do not report how many with congenital syphilis had hearing loss [ 22 ]. In a follow-up report of 34,801 infants screened 2017 through 2021, they report that neonates with congenital syphilis were 2.38 times as likely to fail in the UNHS as those without congenital syphilis [ 48 ]. However, another small study from Brazil reported as a pre-print examined failed hearing screens at 2 months of life did not find an association between congenital syphilis and failed hearing screens [ 23 ].

It is not clear whether there is a treatment for hearing loss due to congenital syphilis. Antibiotics were presumably always given at the time of diagnosis of hearing loss if the patient had not previously been adequately treated. There are no convincing reports that this alone resulted in sustained improved hearing. Uncontrolled studies that included corticosteroids with or without ACTH reported variable response and improvement in hearing was often subjective.

The main limitation of this scoping review is the lack of high-quality studies.

Our scoping review outlines a general map of the trend of publications across the decades and shows that the incidence of hearing loss due to congenital syphilis is completely unknown. It is not clear whether the stage of maternal syphilis or the age at which infants are treated changes outcomes. The literature does not inform us as to whether treatment in-utero prevents development of hearing loss. Until there are high quality long-term observational studies, it is difficult to know what hearing screening to recommend for children with congenital syphilis. Hearing loss attributed to congenital syphilis is often first recognized in adolescence or adulthood. Therefore, there is a need to increase awareness that people of all ages with unexplained hearing loss of sudden or gradual onset should be screened for syphilis. Other than treatment of the congenital syphilis, no other treatments can be recommended until there are RCTs or cohort studies with valid control groups.

Supporting information

S1 checklist. preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews (prisma-scr) checklist..

https://doi.org/10.1371/journal.pone.0302452.s001

S1 Appendix. Systematic review search strategy.

https://doi.org/10.1371/journal.pone.0302452.s002

S2 Appendix. Joanna Briggs Institute (JBI) critical appraisal checklist.

https://doi.org/10.1371/journal.pone.0302452.s003

• 1. Public Health Agency of Canada T. The Chief Public Health Officer’s Report on the State of Public Health in Canada. Canada: Public Health Agency of Canada; 2014.
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• 3. Joint Committee on Infant Hearing T. Year 2007 Position Statement: Principles and Guidelines for Early Hearing Detection and Intervention Programs. Pediatrics. 2007;120(4):898–921.
• 4. Public Health Agency of Canada T. Infectious syphilis and congenital syphilis in Canada, 2022.) CCDR: Volume 49–10, October 2023: Influenza and Other Respiratory Infections ‐ Canada.ca
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