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Biotechnology News

Top headlines, latest headlines.

• Switching Off the Light to See Better
• Enhanced Microscopy Analysis With AI
• Immune Response to Viruses in Mammal Cells
• Starving Cells Hijack Protein Transport Stations
• How Tardigrades Can Survive Intense Radiation
• Marine Microbes as Sensors of Ocean Change
• RNA's Hidden Potential: Future Bioengineering
• Algae Manipulates Microorganisms
• How Diet Impacts Aging
• Diagnostic: Faster, Simpler Nanopore System

Earlier Headlines

Wednesday, april 17, 2024.

• Tracking a Protein's Fleeting Shape Changes
• Researchers Uncover Human DNA Repair by Nuclear Metamorphosis

Tuesday, April 16, 2024

• Older Males out-Compete Young Males Outside Breeding Pairs, Bird Study Shows

Monday, April 15, 2024

• Unlocking the 'chain of Worms'
• Millions of Gamers Advance Biomedical Research
• Researchers Resolve Old Mystery of How Phages Disarm Pathogenic Bacteria

Friday, April 12, 2024

• Microbial Food as a Strategy Food Production of the Future
• Innovative Antiviral Defense With New CRISPR Tool

Thursday, April 11, 2024

• First Step to Untangle DNA: Supercoiled DNA Captures Gyrase Like a Lasso Ropes Cattle
• New Approach for Combating 'resting' Bacteria
• Biofortified Rice to Combat Deficiencies
• Genetic Underpinnings of Environmental Stress Identified in Model Plant
• Geobiology: New Placozoan Habitat Discovered

Wednesday, April 10, 2024

• New Drug Prevents Flu-Related Inflammation and Lung Damage
• Researchers Discover How We Perceive Bitter Taste
• Cockayne Syndrome: New Insights Into Cellular DNA Repair Mechanism

Tuesday, April 9, 2024

• Machine Learning Method Reveals Chromosome Locations in Individual Cell Nucleus
• Bacteria in Cancer Unmasked

Monday, April 8, 2024

• Different Means to the Same End: How a Worm Protects Its Chromosomes
• Scientists Grow 'mini Kidneys,' Revealing New Insights Into Metabolic Defects and Potential Therapy for Polycystic Kidney Disease
• Toothed Whale Echolocation Organs Evolved from Jaw Muscles
• Integrated Dataset Enables Genes-to-Ecosystems Research

Friday, April 5, 2024

• Can Language Models Read the Genome? This One Decoded mRNA to Make Better Vaccines
• eDNA Methods Give a Real-Time Look at Coral Reef Health

Thursday, April 4, 2024

• New Method Reveals Hidden Activity of Life Below Ground

Wednesday, April 3, 2024

• New Tools Reveal How Genes Work and Cells Organize
• Giant Phage Holds Promise as Treatment for Lung Infections
• Discovery Could End Global Amphibian Pandemic
• Plastic-Free Vegan Leather That Dyes Itself Grown from Bacteria
• New Discovery Unravels Malaria Invasion Mechanism
• First View of Centromere Variation and Evolution

Tuesday, April 2, 2024

• These Plants Evolved in Florida Millions of Years Ago: They May Be Gone in Decades

Monday, April 1, 2024

• New Antibiotic Class Effective Against Multidrug-Resistant Bacteria
• Pilot Study Shows Ketogenic Diet Improves Severe Mental Illness

Friday, March 29, 2024

• Connecting the Dots to Shape Growth Forces

Thursday, March 28, 2024

• When Inequality Is More Than 'skin-Deep': Social Status Leaves Traces in the Epigenome of Spotted Hyenas in Tanzania
• How the Crimean-Congo Hemorrhagic Fever Virus Enters Our Cells
• Genomic Research May Help Explain Cancer Resistance in Tasmanian Devils
• Researchers Discover Key Gene for Toxic Alkaloid in Barley
• Synaptic Protein Change During Development Offers Clues on Evolution and Disease

Wednesday, March 27, 2024

• A Combination of Approved Drugs Enhances the Delivery of Anti-Bacterial Medications to Treat Tuberculosis
• Sweet Success: Sugarcane's Complex Genetic Code Cracked
• Scientists Extract Genetic Secrets from 4,000-Year-Old Teeth to Illuminate the Impact of Changing Human Diets Over the Centuries
• New Technique for Predicting Protein Dynamics May Prove Big Breakthrough for Drug Discovery
• New Enzymatic Cocktail Can Kill Tuberculosis-Causing Mycobacteria
• Old Immune Systems Revitalized in Mouse Study, Improving Vaccine Response

Tuesday, March 26, 2024

• Researchers Show That Introduced Tardigrade Proteins Can Slow Metabolism in Human Cells
• Severe Hurricanes Boost Influx of Juveniles and Gene Flow in a Coral Reef Sponge
• Discovery of Amino Acid Unveils How Light Makes Plants Open

Monday, March 25, 2024

• Novel Electrochemical Sensor Detects Dangerous Bacteria
• Maize Genes Control Little Helpers in the Soil

Friday, March 22, 2024

• Natural Recycling at the Origin of Life

Thursday, March 21, 2024

• As We Age, Our Cells Are Less Likely to Express Longer Genes
• Decoding the Plant World's Complex Biochemical Communication Networks

Wednesday, March 20, 2024

• Decoding the Easter Bunny -- An Eastern Finnish Brown Hare to Represent the Standard for the Species' Genome
• Craving Snacks After a Meal? It Might Be Food-Seeking Neurons, Not an Overactive Appetite

Tuesday, March 19, 2024

• Empty 'backpacks' Activate the Immune System Against Cancer
• A Protein Found in Human Sweat May Protect Against Lyme Disease

Monday, March 18, 2024

• Genetic Basis for the Evolution of Hair Discovered in the Clawed Frog
• How Cells Are Ahead of the Curve
• Engineers Measure pH in Cell Condensates

Friday, March 15, 2024

• DNA Origami-Based Vaccines Toward Safe and Highly-Effective Precision Cancer Immunotherapy
• Protein Fragments ID Two New 'extremophile' Microbes--and May Help Find Alien Life
• Breakthrough Could Make Automated Dosing Systems Universal

Thursday, March 14, 2024

• New Study on Mating Behaviors Offers Clues Into the Evolution of Attraction
• It's Hearty, It's Meaty, It's Mold
• Alzheimer's Drug Fermented With Help from AI and Bacteria Moves Closer to Reality
• New Bioengineered Protein Design Shows Promise in Fighting COVID-19
• Even Cells Know the Importance of Recycling
• New Simpler and Cost-Effective Forensics Test Helps Identify Touch DNA

Wednesday, March 13, 2024

• Steroid Drugs Used for HRT Can Combat E. Coli and MRSA
• New Computational Strategy Boosts the Ability of Drug Designers to Target Proteins Inside the Membrane
• Simple Trick Could Improve Accuracy of Plant Genetics Research
• Milk to the Rescue for Diabetics? Cow Produces Human Insulin in Milk

Tuesday, March 12, 2024

• A Simple and Robust Experimental Process for Protein Engineering
• How a Natural Compound from Sea Squirts Combats Cancer
• Gene Flow in Giraffes and What It Means for Their Conservation

Monday, March 11, 2024

• New Study Reveals Transgenerational Effects of Pesticide Linuron on Frogs
• Unveiling Inaoside A: An Antioxidant Derived from Mushrooms
• Anemonefish Are Better Taxonomists Than Humans
• Study Illuminates the Protective Role of Fluorescence in Neon-Colored Sea Anemones

Friday, March 8, 2024

• Research Sheds Light on New Strategy to Treat Infertility
• New Study Discovers How Altered Protein Folding Drives Multicellular Evolution
• Researchers Develop Artificial Building Blocks of Life
• Researchers Open New Leads in Anti-HIV Drug Development, Using a Compound Found in Nature
• Mutation Solves a Century-Old Mystery in Meiosis

Thursday, March 7, 2024

• Vitamin A May Play a Central Role in Stem Cell Biology and Wound Repair
• How Does a Virus Hijack Insect Sperm to Control Disease Vectors and Pests?
• The Malaria Parasite Generates Genetic Diversity Using an Evolutionary 'copy-Paste' Tactic
• What Makes a Pathogen Antibiotic-Resistant?
• First Atom-Level Structure of Packaged Viral Genome Reveals New Properties, Dynamics
• Cracking Epigenetic Inheritance: Biologists Discovered the Secrets of How Gene Traits Are Passed on

Wednesday, March 6, 2024

• Early Life Adversity Leaves Long-Term Signatures in Baboon DNA
• The World's Most Prolific CO2-Fixing Enzyme Is Slowly Getting Better
• Marine Algae Implants Could Boost Crop Yields
• Revealing the Evolutionary Origin of Genomic Imprinting
• Universal Tool for Tracking Cell-to-Cell Interactions
• Synthetic Gene Helps Explain the Mysteries of Transcription Across Species
• Decoding the Language of Epigenetic Modifications

Tuesday, March 5, 2024

• Tiny Worms Tolerate Chornobyl Radiation
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Research articles

Discovery of tumor-reactive T cell receptors by massively parallel library synthesis and screening

Tumor-specific T cell receptors (TCRs) are identified by functional screening of synthetic TCR libraries.

• Ziva Moravec
• Wouter Scheper

Therapeutic application of circular RNA aptamers in a mouse model of psoriasis

A circular RNA aptamer shows therapeutic efficacy in vivo in a psoriasis model.

• Chu-Xiao Liu
• Ling-Ling Chen

Computational scoring and experimental evaluation of enzymes generated by neural networks

Metrics that predict the success of folding and the activity of designed protein sequences are developed and experimentally validated.

• Sean R. Johnson
• Kevin K. Yang

Improving microbial phylogeny with citizen science within a mass-market video game

Gamification of the multiple sequence alignment problem improves microbial phylogeny estimates.

• Roman Sarrazin-Gendron
• Parham Ghasemloo Gheidari
• Jérôme Waldispühl

Inferring gene regulatory networks from single-cell multiome data using atlas-scale external data

Accuracy of gene regulatory network inference is increased by combining multiome single-cell and atlas-scale bulk data.

• Qiuyue Yuan
• Zhana Duren

Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors

AAV vectors form difficult-to-detect concatemers at Cas9 target sites.

• Fabian P. Suchy
• Daiki Karigane
• Hiromitsu Nakauchi

Gene trajectory inference for single-cell data by optimal transport metrics

Gene dynamics of concurrent biological processes are unraveled by considering gene trajectories instead of cell trajectories.

• Xiuyuan Cheng
• Yuval Kluger

Self-pigmenting textiles grown from cellulose-producing bacteria with engineered tyrosinase expression

Genetic engineering of material-producing bacteria creates pigmented products.

• Kenneth T. Walker

The covariance environment defines cellular niches for spatial inference

Using gene–gene covariance structure to represent cellular neighborhoods improves the integration of single-cell RNA sequencing and spatial transcriptomics data.

• Doron Haviv

De novo and somatic structural variant discovery with SVision-pro

SVision-pro enables pairwise genome comparison and improves de novo and somatic structural variant calling.

• Songbo Wang
• Jiadong Lin

Branched chemically modified poly(A) tails enhance the translation capacity of mRNA

mRNA with engineered poly(A) tails produces prolonged higher levels of protein.

• Hongyu Chen
• Dangliang Liu

Starfysh integrates spatial transcriptomic and histologic data to reveal heterogeneous tumor–immune hubs

Reference-free integrative analysis of spatial transcriptomics data is achieved with archetype analysis.

• Elham Azizi

High-throughput evaluation of genetic variants with prime editing sensor libraries

Prime editing sensor libraries evaluate diverse genetic variants in their endogenous genomic contexts.

• Samuel I. Gould
• Alexandra N. Wuest
• Francisco J. Sánchez Rivera

A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models

An AI-generated small-molecule inhibitor treats fibrosis in vivo and in phase I clinical trials.

• Alex Aliper
• Alex Zhavoronkov

Prediction of tumor-reactive T cell receptors from scRNA-seq data for personalized T cell therapy

Tumor-reactive T cell receptors are rapidly identified from lymphocyte scRNA-seq data.

• E. W. Green

Near-cognate tRNAs increase the efficiency and precision of pseudouridine-mediated readthrough of premature termination codons

Disease-related premature stop codons are efficiently corrected by harnessing near-cognate tRNAs.

• Qiang Huang

Characterizing the impacts of dataset imbalance on single-cell data integration

Iniquitate quantifies the effects of cell type imbalance on single-cell RNA sequencing data integration.

• Hassaan Maan

Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain

Transplantation of glia-enriched organoids into the mouse brain enables the study of astrocyte subtypes.

• Meiyan Wang
• Fred H. Gage

All-atom RNA structure determination from cryo-EM maps

RNA structures are built from cryogenic electron microscopy maps using deep learning and backbone tracing.

• Sheng-You Huang

Quality assessment of gene repertoire annotations with OMArk

A new tool checks the quality of gene annotations in genome sequences.

• Yannis Nevers
• Alex Warwick Vesztrocy
• Natasha M. Glover

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